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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">bekhterev</journal-id><journal-title-group><journal-title xml:lang="ru">Обозрение психиатрии и медицинской психологии имени В.М.Бехтерева</journal-title><trans-title-group xml:lang="en"><trans-title>V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2313-7053</issn><issn pub-type="epub">2713-055X</issn><publisher><publisher-name>V. M. BEKHTEREV  NATIONAL  RESEARCH  MEDICAL  CENTER  FOR  PSYCHIATRY  AND  NEUROLOGY                           OF    THE  RUSSIAN  FEDERATION   MINISTRY  OF  HEALTH</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31363/2313-7053-2024-880</article-id><article-id custom-type="elpub" pub-id-type="custom">bekhterev-1021</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НАУЧНЫЕ ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SCIENTIFIC REVIEW</subject></subj-group></article-categories><title-group><article-title>Нейровизуализационные маркеры воспринимаемой стигматизации и ее структурных феноменов у лиц с психическими расстройствами и без них: систематический обзор предметного поля</article-title><trans-title-group xml:lang="en"><trans-title>Neuroimaging markers of phenomena of perceived stigmatization in people  with and without mental disorders: a systematic scoping-review</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9481-7411</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лутова</surname><given-names>Н. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Lutova</surname><given-names>Natalia B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лутова Наталия Борисовна — д.м.н, главный научный сотрудник, руководитель отделения интегративной фармако-психотерапии больных с психическими расстройствами</p><p>920191, г. Санкт-Петербург, ул. Бехтерева, д. 3</p></bio><bio xml:lang="en"><p>St. Petersburg</p></bio><email xlink:type="simple">lutova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8860-986X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хобейш</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Khobeysh</surname><given-names>Maria A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хобейш Мария Александровна — младший научный сотрудник отделения интегративной фармако-психотерапии больных с психическими расстройствами</p><p>920191, г. Санкт-Петербург, ул. Бехтерева, д. 3</p></bio><bio xml:lang="en"><p>St. Petersburg</p></bio><email xlink:type="simple">mariakhobeysh@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6317-5778</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Герасимчук</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Gerasimchuk</surname><given-names>Ekaterina S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Герасимчук Екатерина Сергеевна — младший научный сотрудник отделения интегративной фармако-психотерапии больных с психическими расстройствами</p><p>920191, г. Санкт-Петербург, ул. Бехтерева, д. 3</p></bio><bio xml:lang="en"><p>St. Petersburg</p></bio><email xlink:type="simple">katherine.gerasimchuk@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2113-699X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бочарова</surname><given-names>М. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Bocharova</surname><given-names>Maria O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бочарова Мария Олеговна — к.м.н, младший научный сотрудник отделения интегративной фармако-психотерапии больных с психическими расстройствами; сотрудник</p><p>920191, г. Санкт-Петербург, ул. Бехтерева, д. 3</p><p>SE58AF, Лондон, Де Креспиньи Парк 16</p></bio><bio xml:lang="en"><p>St. Petersburg</p><p>London, United Kingdom </p></bio><email xlink:type="simple">mariia.bocharova@kcl.ac.uk</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6058-8289</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Макаревич</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Makarevich</surname><given-names>Olga V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Макаревич Ольга Владимировна — младший научный сотрудник отделения интегративной фармако-психотерапии больных с психическими расстройствами</p><p>920191, г. Санкт-Петербург, ул. Бехтерева, д. 3</p></bio><bio xml:lang="en"><p>St. Petersburg</p></bio><email xlink:type="simple">mariakhobeysh@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2502-6365</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сорокин</surname><given-names>М. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Sorokin</surname><given-names>Mikhail Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сорокин Михаил Юрьевич — к.м.н, старший научный сотрудник отделения интегративной фармако-психотерапии больных с психическими расстройствами, учёный секретарь</p><p>920191, г. Санкт-Петербург, ул. Бехтерева, д. 3</p></bio><bio xml:lang="en"><p>St. Petersburg</p></bio><email xlink:type="simple">m.sorokin@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева<country>Россия</country></aff><aff xml:lang="en">V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева; Институт психиатрии, психологии и нейронаук лондонского королевского колледжа, Великобритания<country>Россия</country></aff><aff xml:lang="en">V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology; Institute of Psychiatry, Psychology &amp; Neuroscience, King’s College London<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>30</day><month>09</month><year>2024</year></pub-date><volume>58</volume><issue>3</issue><fpage>8</fpage><lpage>25</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лутова Н.Б., Хобейш М.А., Герасимчук Е.С., Бочарова М.О., Макаревич О.В., Сорокин М.Ю., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Лутова Н.Б., Хобейш М.А., Герасимчук Е.С., Бочарова М.О., Макаревич О.В., Сорокин М.Ю.</copyright-holder><copyright-holder xml:lang="en">Lutova N.B., Khobeysh M.A., Gerasimchuk E.S., Bocharova M.O., Makarevich O.V., Sorokin M.Y.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.bekhterevreview.com/jour/article/view/1021">https://www.bekhterevreview.com/jour/article/view/1021</self-uri><abstract><sec><title>Резюме</title><p>Резюме. Наряду с традиционными исследованиями психиатрической стигмы в последнее время возрастает интерес к нейробиологическим факторам, ассоциированным со стигматизацией.</p></sec><sec><title>Цель исследования</title><p>Цель исследования: изучить по данным научной литературы наиболее распространенные методы исследований нейробиологических коррелятов феномена стигматизации и ее компонентов, а также систематизировать результаты проведённых исследований с учетом их методологических ограничений.</p></sec><sec><title>Материал и методы</title><p>Материал и методы: Обзор был проведен в соответствии с расширением PRISMA-ScR. Поиск исследований проводился в MEDLINE, EMBASE, PsycINFO с использованием платформы Ovid. В результате оценки 2358 статей в соответствии с критериями включения, невключения, исключения в окончательный анализ были включены 20 статей.</p></sec><sec><title>Результаты</title><p>Результаты: Большая доля исследований проводилась на выборках здоровых респондентов и не имели группу контроля (14 статей). Средний возраст респондентов варьировал от 18,8 [1,0] до 42,7 [14,7] лет. Непосредственно психиатрическая стигма изучалась в 2 исследованиях, в остальных работах — различные составляющие стигмы, среди которых наиболее часто исследовалась чувствительность к социальному отвержению (13 статей). Наиболее популярной фМРТ-парадигмой была симуляция с применением Cyberball social exclusion task (10 статей). Изменения нейронной активности, коррелирующие с выраженностью стигмы и ее составляющих конструктов, были описаны передней поясной, префронтальной коре, островковой доле, таламусе, гипоталамусе, гиппокампе, парагиппокампальной извилине, вентральной области стриатума, скорлупе, амигдале.</p></sec><sec><title>Заключение</title><p>Заключение: Функциональные магнитно-резонансные исследования могут быть эффективным инструментом верификации и оценки динамики психологического состояния лиц, переживающих явление стигматизации.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Summary</title><p>Summary. Along with traditional research on psychiatric stigma, there has recently been increasing interest in the neurobiological factors associated with stigmatization.</p></sec><sec><title>Aim</title><p>Aim: to study the most common research methods in the studies of the neurobiological correlates of stigmatization phenomenon and its components, as well as to systematize their results, taking into account their methodological limitations.</p></sec><sec><title>Materials and Methods</title><p>Materials and Methods: The review was conducted in accordance with the PRISMA-ScR extension. Studies were searched in MEDLINE, EMBASE, PsycINFO using the Ovid platform. After evaluating 2358 articles according to inclusion, non-inclusion, and exclusion criteria, 20 articles were included in the final analysis.</p></sec><sec><title>Results</title><p>Results: The most of the studies were conducted on samples of healthy respondents without a control group (14 articles). The mean age of respondents ranged from 18.8 [1.0] to 42.7 [14.7] years. Psychiatric stigma was studied in 2 studies; in the remaining articles, various components of stigma were studied, among which social rejection sensitivity was most often studied (13 articles). Among fMRI paradigm the Cyberball social exclusion task was used more often (10 articles). Changes in neural activity, correlating with the severity of stigma and its constituent constructs, were found in the anterior cingulate cortex, prefrontal cortex, insula, thalamus, hypothalamus, hippocampus, parahippocampal gyrus, ventral region of the striatum, putamen, amygdala.</p></sec><sec><title>Conclusion</title><p>Conclusion: Functional magnetic resonance studies can be an effective tool for verifying and assessing the dynamics of the psychological state of people experiencing the phenomenon of stigmatization.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>стигма</kwd><kwd>самостигма</kwd><kwd>социальное отвержение</kwd><kwd>нейробиология</kwd><kwd>психические рас- стройства</kwd><kwd>функциональная нейровизуализация</kwd><kwd>магнитно-резонансная томография</kwd></kwd-group><kwd-group xml:lang="en"><kwd>stigma</kwd><kwd>self-stigma</kwd><kwd>social rejection</kwd><kwd>neuroscience</kwd><kwd>mental disorders</kwd><kwd>functional neuroimaging</kwd><kwd>magnetic resonance imaging</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Бойкина Е.Э. 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