bekhterevОбозрение психиатрии и медицинской психологии имени В.М.БехтереваV.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY2313-70532713-055XV. M. BEKHTEREV NATIONAL RESEARCH MEDICAL CENTER FOR PSYCHIATRY AND NEUROLOGY OF THE RUSSIAN FEDERATION MINISTRY OF HEALTH10.31363/2313-7053-2024-1005bekhterev-1072Research ArticleНАУЧНЫЕ ОБЗОРЫSCIENTIFIC REVIEWВоспаление как связующее звено между депрессией и метаболическим синдромомInflammation as a link between depression and metabolic syndromehttps://orcid.org/0009-0005-0351-7157ГорбуноваА. П.GorbunovaA. P.

Горбунова Александра Петровна - м.н.с. отделения геномики психических расстройств

Санкт-Петербург, ул. Бехтерева, д. 3

Aleksandra P. Gorbunova

St. Petersburg

gorbunovasashaa@gmail.comhttps://orcid.org/0000-0002-5282-2036РукавишниковГ. В.RukavishnikovG. V.

Рукавишников Григорий Викторович - к.м.н., ведущий научный сотрудник, руководитель отделения социальной нейропсихиатрии

Санкт-Петербург, ул. Бехтерева, д. 3

Grigory V. Rukavishnikov

St. Petersburg

grigory_v_r@mail.ruhttps://orcid.org/0000-0001-7910-9129МазоГ. Э.MazoG. E.

Мазо Галина Элевна - д.м.н., зам. директора по инновационному развитию, руководитель института трансляционной психиатрии

Санкт-Петербург, ул. Бехтерева, д. 3

Galina E. Mazo

St. Petersburg

galina-mazo@yandex.ruФГБУ «Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева» Минздрава РФРоссияV.M. Bekhterev National Medical Research Center for Psychiatry and NeurologyRussian Federation202415122024584-2819Copyright © Горбунова А.П., Рукавишников Г.В., Мазо Г.Э., 20242024Горбунова А.П., Рукавишников Г.В., Мазо Г.Э.Gorbunova A.P., Rukavishnikov G.V., Mazo G.E.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.bekhterevreview.com/jour/article/view/1072

Депрессия вносит основной вклад в общее глобальное бремя болезней, в том числе, и по причине повышенного риска развития широкого круга сопутствующей соматической патологии—высокий процент смертности психиатрических пациентов обусловлен физическими заболеваниями, преимущественно сердечно-сосудистыми (ССЗ). Одним из факторов риска развития ССЗ и частым коморбидным депрессии состоянием является метаболический синдром (МС). Целью данного обзора является систематизация данных о взаимосвязи МС и депрессии, в частности, за счет общих патогенетических механизмов—системного воспаления. В статье поднимается вопрос использования гематологических коэффициентов системного воспаления (ГКСВ) в диагностике как МС, так и аффективной патологии, а также приводятся данные о новых комбинированных показателях, включающих клеточное звено и показатели липидограммы.

К последним относятся соотношения лимфоцитов и липопротеинов высокой плотности (ЛПВП) (Lymphocyte To High-Density Lipoprotein Ratio, LHR), нейтрофилов/ЛПВП (Neutrophil To High-Density Lipoprotein Ratio, NHR), тромбоцитов/ЛПВП (Platelet To High-Density Lipoprotein Ratio, PHR) и моноцитов/ЛПВП (Monocyte To High-Density Lipoprotein Ratio, MHR). Понимание связи между гематологическими коэффициентами и метаболическим синдромом у пациентов с депрессией может помочь в выявлении лиц с высоким риском его развития и определении своевременных профилактических мер. Различные клинические испытания и проведенные исследования указывают на связь между гематологическими параметрами и метаболическим синдромом, однако, вопрос выбора наиболее эффективных коэффициентов остается открытым. Дальнейшее изучение проблемы может помочь выявить потенциальные риски коморбидных нарушений и проводить своевременные профилактические мероприятия.

Depression makes a major contribution to the overall global burden of disease, including the increased risk of a wide range of concomitant somatic pathology. А high percentage of mortality in psychiatric patients is attributed to physical diseases, mainly cardiovascular (CVD). Metabolic syndrome (MetS) is one of the risk factors for both the CVD and a frequent comorbid depression. The purpose of this review is to systematize data on the relationship between MetS and depression, in particular, on the shared pathogenetic mechanisms as systemic inflammation. The manuscript evaluates the issue of the use of hematological indices of systemic inflammation (HISIs) in the diagnosis of both MetS and affective pathology, and also provides data on new combined indicators, including the cellular link and lipidogram parameters. The latter include the ratios of lymphocytes and high-density lipoproteins (HDL) (Lymphocyte To High-Density Lipoprotein Ratio, LHR), neutrophils/HDL (Neutrophil To High-Density Lipoprotein Ratio, NHR), platelets/HDL (Platelet To High-Density Lipoprotein Ratio, PHR) and monocytes/HDL (Monocyte To High Density Lipoprotein Ratio, MHR). Understanding the relationship between hematological indices and metabolic syndrome in patients with depression can help identify individuals at high risk and identify timely preventive measures. Various clinical trials and studies indicate a link between hematological parameters and metabolic syndrome, but the question of choosing the most effective coefficients remains open. Further study of the problem can help identify potential risks of comorbid disorders and perform adequate preventive strategies.

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The authors declare that there are no conflicts of interest present.