bekhterevОбозрение психиатрии и медицинской психологии имени В.М.БехтереваV.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY2313-70532713-055XV. M. BEKHTEREV NATIONAL RESEARCH MEDICAL CENTER FOR PSYCHIATRY AND NEUROLOGY OF THE RUSSIAN FEDERATION MINISTRY OF HEALTH10.31363/2313-7053-2024-1033bekhterev-1075Research ArticleНАУЧНЫЕ ОБЗОРЫSCIENTIFIC REVIEWКоморбидность депрессии и метаболического синдрома: к вопросу о каузальных или ассоциативных связяхComorbidity of depression and metabolic syndrome: on the question of causal or associative connectionshttps://orcid.org/0000-0003-4096-6208ПетроваН. Н.PetrovaN. N.

Петрова Наталия Николаевна - д.м.н. профессор, заведующая кафедрой психиатрии и наркологии

197022, г. Санкт-Петербург, ул. Льва Толстого, 6-8

Natalia N. Petrova

St. Petersburg

petrova_nn@mail.ruhttps://orcid.org/0000-0002-2798-8800СеменоваН. В.SemenovaN. V.

Семенова Наталия Владимировна - д.м.н., заместитель директора

192019, СанктПетербург, ул. Бехтерева, д. 3

Natalia V. Semenova

St. Petersburg

 

nvs@bekhterev.ruhttps://orcid.org/0000-0002-5470-4359МалышкоЛ. В.MalyshkoL. V.

Малышко Лариса Владимировна - младший научный сотрудник научно-организационного отделения

192019, СанктПетербург, ул. Бехтерева, д. 3

Larisa V. Malyshko

St. Petersburg

lora5497@yandex.ruСанкт-Петербургского государственного университетаРоссияSt. Petersburg State UniversityRussian FederationФГБУ «Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева» Минздрава России по научно-организационной и методической работеРоссияV.M. Bekhterev National Medical Research Center for Psychiatry and NeurologyRussian FederationФГБУ «Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева» Минздрава РоссииРоссияV.M. Bekhterev National Medical Research Center for Psychiatry and NeurologyRussian Federation202416122024584-23946Copyright © Петрова Н.Н., Семенова Н.В., Малышко Л.В., 20242024Петрова Н.Н., Семенова Н.В., Малышко Л.В.Petrova N.N., Semenova N.V., Malyshko L.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.bekhterevreview.com/jour/article/view/1075

Проблема частой коморбидности между депрессией и метаболическим синдромом известна медицине давно. Однако, появляется все больше данных о совместном течении данных состояний. В нарративном обзоре представлены актуальные научные данные о взаимосвязи метаболического синдрома и депрессии, а также результаты исследований влияния антидепрессантов на развитие метаболических нарушений. Обзор базируется на анализе 75 публикаций, размещенных в библиографических базах РИНЦ и Medline.

Несмотря на многочисленные результаты исследований, доказывающих коморбидность депрессии и метаболического синдрома, вопрос об их причинно-следственной связи остается открытым. Представленные материалы дополняют представления об ассоциациях метаболического синдрома и депрессии, а также позволяют учитывать механизмы коморбидности данных состояний при выборе антидепрессантов.

The problem of frequent comorbidity between depression and metabolic syndrome has been known to medicine for a long time. However, there is more and more data on the joint course of these states. The narrative review presents current scientific data on the relationship between metabolic syndrome and depression, as well as the results of studies on the effect of antidepressants on the development of metabolic disorders. The review is based on an analysis of 75 publications published in the bibliographic databases of the RSCI and Medline. Despite numerous research results proving the comorbidity of depression and metabolic syndrome, the question of their causal relationship remains open. The presented materials complement the understanding of the associations of metabolic syndrome and depression, and also allow us to take into account the mechanisms of comorbidity of these conditions when choosing antidepressants.

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The authors declare that there are no conflicts of interest present.