bekhterevОбозрение психиатрии и медицинской психологии имени В.М.БехтереваV.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY2313-70532713-055XV. M. BEKHTEREV NATIONAL RESEARCH MEDICAL CENTER FOR PSYCHIATRY AND NEUROLOGY OF THE RUSSIAN FEDERATION MINISTRY OF HEALTH10.31363/2313-7053-2025-4-1121bekhterev-1228Research ArticleИССЛЕДОВАНИЯINVESTIGATIONSПоиск модели предикции индекса массы тела на основе социо-демографических, клинико-биологических и анамнестических параметров у пациентов с тяжёлыми психическими расстройствамиPredictive modeling for body mass index based on socio-demographic, clinical-biological and anamnestic parameters in patients with severe mental disordershttps://orcid.org/0000-0002-9481-7411ЛутоваН. Б.LutovaN. B.

Лутова Наталия Борисовна – доктор медицинских наук, главный научный сотрудник отделения интегративной фармако-психотерапии больных с психическими расстройствами

Санкт-Петербург, 192019, ул. Бехтерева, д.3

Natalia B. Lutova

St. Petersburg

lutova@mail.ruhttps://orcid.org/0000-0001-6058-8289МакаревичО. В.MakarevichO. V.

Макаревич Ольга Владимировна – кандидат медицинских наук, научный сотрудник отделения интегративной фармако-психотерапии больных с психическими расстройствами

Санкт-Петербург, 192019, ул. Бехтерева, д.3

Olga V. Makarevich

St. Petersburg

lysska@mail.ruhttps://orcid.org/0000-0002-8860-986XХобейшМ. А.KhobeyshM. A.

Хобейш Мария Александровна – младший научный сотрудник отделения интегративной фармако-психотерапии больных с психическими расстройствами

Санкт-Петербург, 192019, ул. Бехтерева, д.3

Maria A. Khobeysh

St. Petersburg

mariakhobeysh@mail.ruhttps://orcid.org/0000-0001-7546-2910СушковаВ. Ю.SushkovaV. Yu.

Сушкова Вера Юрьевна – кандидат медицинских наук, научный сотрудник отделения интегративной фармако-психотерапии больных с психическими расстройствами

Санкт-Петербург, 192019, ул. Бехтерева, д.3

Vera Yu. Sushkova

St. Petersburg

vera_orehovaya@mail.ruhttps://orcid.org/0000-0002-2914-8223ШаманинаМ. В.ShamaninaM. V.

Шаманина Мария Валерьевна – кандидат медицинских наук, старший научный сотрудник отделения биологической терапии психически больных

Санкт-Петербург, 192019, ул. Бехтерева, д.3

Maria V. Shamanina

St. Petersburg

shamaninamv@list.ruhttps://orcid.org/0000-0003-2526-0530ЯковлеваЯ. В.YakovlevaYa. V.

Яковлева Яна Викторовна – младший научный сотрудник отделения социальной нейропсихиатрии

Санкт-Петербург, 192019, ул. Бехтерева, д.3

Yana V. Yakovleva

St. Petersburg

yanakov97@yandex.ruhttps://orcid.org/0000-0001-9647-7628ЯковлеваЮ. А.YakovlevaYu. A.

Яковлева Юлия Александровна – кандидат медицинских наук, ведущий научный сотрудник отделения терапии психических расстройств у лиц молодого возраста

Санкт-Петербург, 192019, ул. Бехтерева, д.3

Yulia A. Yakovleva

St. Petersburg

yya.08@mail.ruhttps://orcid.org/0000-0002-6317-5778ГерасимчукЕ. С.GerasimchukE. S.

Герасимчук Екатерина Сергеевна – младший научный сотрудник отделения интегративной фармако-психотерапии больных с психическими расстройствами

Санкт-Петербург, 192019, ул. Бехтерева, д.3

Ekaterina S. Gerasimchuk

St. Petersburg

katherine.gerasimchuk@mail.ruhttps://orcid.org/0000-0003-2502-6365СорокинМ. Ю.SorokinM. Yu.

Сорокин Михаил Юрьевич – кандидат медицинских наук, ведущий научный сотрудник отделения интегративной фармако-психотерапии больных с психическими расстройствами

Санкт-Петербург, 192019, ул. Бехтерева, д.3

Mikhail Yu. Sorokin

St. Petersburg

m.sorokin@list.ruНациональный медицинский исследовательский центр психиатрии и неврологии им. В. М. БехтереваРоссияV.M. Bekhterev National Medical Research Centre for Psychiatry and NeurologyRussian Federation2025090120265948090Copyright © Лутова Н.Б., Макаревич О.В., Хобейш М.А., Сушкова В.Ю., Шаманина М.В., Яковлева Я.В., Яковлева Ю.А., Герасимчук Е.С., Сорокин М.Ю., 20262026Лутова Н.Б., Макаревич О.В., Хобейш М.А., Сушкова В.Ю., Шаманина М.В., Яковлева Я.В., Яковлева Ю.А., Герасимчук Е.С., Сорокин М.Ю.Lutova N.B., Makarevich O.V., Khobeysh M.A., Sushkova V.Y., Shamanina M.V., Yakovleva Y.V., Yakovleva Y.A., Gerasimchuk E.S., Sorokin M.Y.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.bekhterevreview.com/jour/article/view/1228

Целью исследования стал поиск предикторов высоких значений ИМТ среди социо-демографических, клинико-биологических и анамнестических параметров у пациентов с тяжёлыми психическими расстройствами. Материалы и методы: в ходе исследования собраны социо-демографические, клинико-анамнестические, антропометрические и клинико-биологические данные 103 пациентов с диагнозами в рамках рубрик F31, F32, F33, F20 по МКБ-10 для анализа их влияния на показатель индекса массы тела (ИМТ). Результаты: Создано и протестировано несколько регрессионных моделей для общей выборки. Наилучшая модель показала ассоциированность повышения ИМТ с бóльшим количеством эпизодов обострения, диагнозом шизофрения, возрастом пациента, высокими уровнями инсулина, холестерина, трийодтиронина (Т3 свободного), тромбоцитарно-лимфоцитарного отношения (PLR), умеренной выраженностью психопатологической симптоматики (по шкале PANSS) и общей тяжести состояния (по шкале CGI). Отдельно оценивались факторы, влияющие на ИМТ пациентов с аффективными расстройствами и шизофренией. Заключение: Модели для разных нозологических групп частично имели сходные черты. Общими параметрами стали: количество эпизодов обострения, умеренная тяжесть заболевания, возраст пациента, высокий уровень холестерина. Для аффективных пациентов помимо общих факторов оказался значимым возраст первичного обращения к психиатру. У пациентов с шизофренией — наличие сердечно-сосудистой патологии, длительность заболевания, высокие уровни инсулина, триглицеридов, PLR.

Aim — to find the predictors of high BMI values among socio-demographic, clinical-biological and anamnestic parameters in patients with severe mental disorders. Materials and methods: The study collected socio-demographic, clinical-anamnestic, anthropometric and clinical-biological data of 103 patients with diagnoses within the headings F31, F32, F33, F20 to analyze their impact on the body mass index (BMI). Results: Several regression models were obtained and tested for the total sample. The best model showed an association of increased BMI with a larger number of exacerbation episodes, a diagnosis of schizophrenia, moderate severity of psychopathological symptoms (PANSS) and global clinical impression (CGI), patient age, higher levels of insulin, cholesterol, triiodthyronine (free T3), absolute lymphocyte count, and platelet-to-lymphocyte ratio (PLR). Factors influencing BMI in patients with affective pathology and schizophrenia were assessed separately. Conclusion: Models for different nosological groups partially had similar features. The common parameters were the number of exacerbation episodes, moderate severity of the disease, the patient's age, and high cholesterol. For affective patients, the age of the initial visit to a psychiatrist was another significant indicator for the BMI. For patients with schizophrenia, the indicators are the presence of cardiovascular pathology, the duration of the disease, higher levels of insulin, triglycerides, and PLR.

индекс массы телашизофренияаффективные расстройствабиомаркерыпараметры метаболизмавоспалениеклиническое течениеbody mass indexschizophreniaaffective disordersbiomarkersmetabolic parametersinflammationclinical courseИсследование выполнено в рамках государственного задания ФГБУ «НМИЦ ПН им. В.М. Бехтерева» Минздрава Российской Федерации 2024-2026 гг. (XSOZ 2024 0012).The study was performed within the framework of the state assignment of the FSBI «V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology» of the Ministry of Health of the Russian Federation 2024-2026 (XSOZ 2024 0012).ReferencesАверьянова И.В. Распространенность и частота встречаемости компонентов метаболического синдрома у жителей-северян. Клиническая лабораторная диагностика. 2022;67(8):444-450. https://doi.org/10.51620/0869-2084-2022-67-8-444-450Averyanova IV. Occurrence of metabolic syndrome components in northerners. Klinicheskaya Laboratornaya Diagnostika. 2022;67(8):444-450. (In Russ.). https://doi.org/10.51620/0869-2084-2022-67-8-444-450Василенко Л.М., Горобец Л.Н., Литвинов А.В., Буланов В.С., Литвинова Т.А. Антропометрический и биохимический профиль больных с расстройствами шизофренического спектра и различными вариантами нарушений пищевого поведения. Социальная и клиническая психиатрия. 2022;32(3):12-18.Vasilenko LM, Gorobets LN, Litvinov AV, Bulanov VS, Litvinova TA. Anthropometric and biochemical profile of patients with schizophrenia spectrum disorders and various types of eating behavior and appetite disorders. Social'naya i klinicheskaya psihiatriya. 2022;32(3):12-18. (In Russ.).Герасимчук Е.С., Лутова Н.Б., Сорокин М.Ю., Макаревич О.В., Хобейш М.А. Методы автоматизированного линейного моделирования в биомедицинских исследованиях на примере прогноза психиатрических госпитализаций. Бюллетень медицинской науки. 2024;4(36):47-61. https://doi.org/10.31684/25418475-2024-4-47Gerasimchuk ES, Lutova NB, Sorokin MYu, Makarevich OV, Khobeish MA. Methods of automated linear modeling in biomedical research on the example of predicting psychiatric hospitalizations. Byulleten' medicinskoj nauki. 2024;4(36):47-61. (In Russ.). https://doi.org/10.31684/25418475-2024-4-47Голенков Ф.В., Мадянов И.В., Шмелева С.В., Петрова Г.Д., Камынина Н.Н., Логачев Н.В. Взаимосвязь индекса массы тела и психических расстройств у взрослого населения. Здравоохранение Российской Федерации. 2020;64(6):336-342 https://doi.org/10/46563/0044-197x-2020-64-6-336-342Golenkov AV, Madyanov IV, Shmeleva SV, Petrova GD, Kamynina NN, Logachov NV. The relationship between body mass index and mental disorders in the adult population. Zdravoohranenie Rossijskoj Federacii. 2020;64(6):336-342. (In Russ.). https://doi.org/10/46563/0044-197x-2020-64-6-336-342Горобец Л.Н., Буланов В.С., Василенко Л.М. Метаболические расстройства у больных шизофренией в процессе терапии атипичными антипсихотическими препаратами. Журнал неврологии и психиатрии им. С.С. Корсакова. 2012;112(9):90-96Gorobets LN, Bulanov VS, Vasilenko LM, Litvinov AV, Poliakovskaia TP. Zhurnal nevrologii i psihiatrii im. S.S. Korsakova. 2012;112(9):90-96. (In Russ.).Кобякова О.С., Стародубов В.И., Халтурина Д.А., Зыков В.А., Зубкова Т.С., Замятина Е.С. Перспективные меры по снижению смертности в России: аналитический обзор. Здравоохранение Российской Федерации. 2021;65(6):573-580. https://doi.org/10.47470/0044-197x-2021-65-6-573-580Kobyakova OS, Starodubov VI, Khalturina DA, Zykov VA, Zubkova TS, Zamyatina ES. Promising measures to reduce the mortality in Russia: an analytical review. Zdravookhranenie Rossiiskoi Federatsii. 2021;65(6):573–580. (In Russ.). https://doi.org/10.47470/0044-197x-2021-65-6-573-580Корнетова Е.Г., Галкин С.А., Корнетов А.Н., Счастный Е.Д., Петкун Д.А., Меднова И.А., Бохан Н.А. Сравнительное исследование метаболических нарушений у стационарных пациентов с шизофренией и аффективными расстройствами. Социальная и клиническая психиатрия. 2024;34(2):5-12.Kornetova EG, Galkin SA, Kornetov AN, Schastniy ED, Petkun DA, Mednova IA, Bokhan NA. Comparative study of metabolic disorders in inpatients with schizophrenia and affective disorders. Social'naya i klinicheskaya psihiatriya. 2024;34(2):5-12 (In Russ.).Мазо Г.Э., Кибитов А.О. Риск-менеджмент метаболических нарушений при использовании антипсихотиков. Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева. 2016;(3):85-97Mazo GE, Kibitov AO. Risk management of metabolic disorders in the use of antipsychotics. V.M. Obozrenie psihiatrii i medicinskoj psihologii imeni V.M. Bekhtereva. 2016;(3):85-97. (In Russ.).Перечень поручений по итогам заседания Совета по стратегическому развитию и национальным проектам. №Пр-1383 [kremlin.ru]. kremlin; 2021. Доступно: http://www.kremlin.ru/acts/assignments/orders/66331/printPerechen' poruchenij po itogam zasedaniya Soveta po strategicheskomu razvitiyu i nacional'nym proektam. №Pr-1383. [kremlin.ru]. kremlin; 2021. Available at: http://www.kremlin.ru/acts/assignments/orders/66331/print (In Russ.).Фролова Э.Б., Цибулькин Н.А., Абрахманова А.И. Метаболический синдром как этиологический фактор неотложных состояний. Вестник современной клинической медицины. 2018;11(5):118-124. https://doi.org/10.20969/VSM.2018.11(5).1180124.Frolova EB, Tsybulkin NA, Abdrahmanova AI. Metabolic syndrome as a causative factor of medical emergencies. Vestnik sovremennoj klinicheskoj mediciny. 2018;11(5):118–124. (In Russ.). https://doi.org/10.20969/VSM.2018.11(5).1180124.Abou Abbas L, Salameh P, Nasser W, Nasser Z, Godin I. Obesity and symptoms of depression among adults in selected countries of the Middle East: a systematic review and meta-analysis. Clin Obes. 2015;5(1):2-11. https://doi.org/10.1111/cob.12082.Abou Abbas L, Salameh P, Nasser W, Nasser Z, Godin I. Obesity and symptoms of depression among adults in selected countries of the Middle East: a systematic review and meta-analysis. Clin Obes. 2015;5(1):2-11. https://doi.org/10.1111/cob.12082.Annamalai A, Kosir U, Tek C. Prevalence of obesity and diabetes in patients with schizophrenia. World J Diabetes. 2017;8(8):390-396. https://doi.org/10.4239/wjd.v8.i8.390.Annamalai A, Kosir U, Tek C. Prevalence of obesity and diabetes in patients with schizophrenia. World J Diabetes. 2017;8(8):390-396. https://doi.org/10.4239/wjd.v8.i8.390.Bak M, Fransen A, Janssen J, Van Os J, Drukker M. Almost all antipsychotics result in weight gain: A meta-analysis. PLoS One. 2014;9(4):e94112. https://doi.org/10.1371/journal.pone.0094112.Bak M, Fransen A, Janssen J, Van Os J, Drukker M. Almost all antipsychotics result in weight gain: A meta-analysis. PLoS One. 2014;9(4):e94112. https://doi.org/10.1371/journal.pone.0094112.Blasco BV, García-Jiménez J, Bodoano I, Gutiérrez-Rojas L. Obesity and depression: its prevalence and influence as a prognostic factor: a systematic review. Psychiatry Investig. 2020;17(8):715-724. https://doi.org/10.30773/pi.2020.0099.Blasco BV, García-Jiménez J, Bodoano I, Gutiérrez-Rojas L. Obesity and depression: its prevalence and influence as a prognostic factor: a systematic review. Psychiatry Investig. 2020;17(8):715-724. https://doi.org/10.30773/pi.2020.0099.Bond DJ, Andreazza AC, Hughes J, et al. Association of peripheral inflammation with body mass index and depressive relapse in bipolar disorder. Psychoneuroendocrinology. 2016;65:76-83. https://doi.org/10.1016/j.psyneuen.2015.12.012.Bond DJ, Andreazza AC, Hughes J, et al. Association of peripheral inflammation with body mass index and depressive relapse in bipolar disorder. Psychoneuroendocrinology. 2016;65:76-83. https://doi.org/10.1016/j.psyneuen.2015.12.012.Burrows K, Stewart JL, Antonacci C, et al. Association of poorer dietary quality and higher dietary inflammation with greater symptom severity in depressed individuals with appetite loss. J Affect Disord. 2020;263:99-106. https://doi.org/10.1016/j.jad.2019.11.160.Burrows K, Stewart JL, Antonacci C, et al. Association of poorer dietary quality and higher dietary inflammation with greater symptom severity in depressed individuals with appetite loss. J Affect Disord. 2020;263:99-106. https://doi.org/10.1016/j.jad.2019.11.160.Calkin C, van de Velde C, Růzicková M, Slaney C, Garnham J, Hajek T, et al. Can body mass index help predict outcome in patients with bipolar disorder? Bipolar Disord. 2009;11(6):650-6. https://doi.org/10.1111/j.1399-5618.2009.00730.x.Calkin C, van de Velde C, Růzicková M, Slaney C, Garnham J, Hajek T, et al. Can body mass index help predict outcome in patients with bipolar disorder? Bipolar Disord. 2009;11(6):650-6. https://doi.org/10.1111/j.1399-5618.2009.00730.x.Chen J, Perera G, Shetty H, Broadbent M, Xu Y, Stewart R. Body mass index and mortality in patients with schizophrenia spectrum disorders: a cohort study in a South London catchment area. Gen Psychiatr. 2022;35(5):e100819. https://doi.org/10.1136/gpsych-2022-100819.Chen J, Perera G, Shetty H, Broadbent M, Xu Y, Stewart R. Body mass index and mortality in patients with schizophrenia spectrum disorders: a cohort study in a South London catchment area. Gen Psychiatr. 2022;35(5):e100819. https://doi.org/10.1136/gpsych-2022-100819.Chen X, Fan Y, Ren W, Sun M, Guan X, Xiu M, et al. Baseline BMI is associated with clinical symptom improvements in first-episode schizophrenia: a longitudinal study. Front Pharmacol. 2023;14:1264591. https://doi.org/10.3389/fphar.2023.1264591.Chen X, Fan Y, Ren W, Sun M, Guan X, Xiu M, et al. Baseline BMI is associated with clinical symptom improvements in first-episode schizophrenia: a longitudinal study. Front Pharmacol. 2023;14:1264591. https://doi.org/10.3389/fphar.2023.1264591.Correll CU, Detraux J, De Lepeleire J, De Hert M. Effects of antipsychotics, antidepressants and mood stabilizers on risk for physical diseases in people with schizophrenia, depression and bipolar disorder. World Psychiatry. 2015;14(2):119-36. https://doi.org/10.1002/wps.20204.Correll CU, Detraux J, De Lepeleire J, De Hert M. Effects of antipsychotics, antidepressants and mood stabilizers on risk for physical diseases in people with schizophrenia, depression and bipolar disorder. World Psychiatry. 2015;14(2):119-36. https://doi.org/10.1002/wps.20204.Feng X, Zhu J, Hua Z, et al. The prevalence and determinant of overweight and obesity among residents aged 40–69 years in high-risk regions for upper gastrointestinal cancer in southeast China. Sci Rep. 2023;13:8172. https://doi.org/10.1038/s41598-023-35477-x.Feng X, Zhu J, Hua Z, et al. The prevalence and determinant of overweight and obesity among residents aged 40–69 years in high-risk regions for upper gastrointestinal cancer in southeast China. Sci Rep. 2023;13:8172. https://doi.org/10.1038/s41598-023-35477-x.Fleischman A, Lurie I. Cardiovascular mortality and related risk factors among persons with schizophrenia: a review of the published literature. Public Health Rev. 2012;34:11. https://doi.org/10.1007/BF03391679.Fleischman A, Lurie I. Cardiovascular mortality and related risk factors among persons with schizophrenia: a review of the published literature. Public Health Rev. 2012;34:11. https://doi.org/10.1007/BF03391679.Gao Z, Xiu M, Liu J, et al. Obesity, antioxidants and negative symptom improvement in first-episode schizophrenia patients treated with risperidone. Schizophr. 2023;9:17. https://doi.org/10.1038/s41537-023-00346-z.Gao Z, Xiu M, Liu J, et al. Obesity, antioxidants and negative symptom improvement in first-episode schizophrenia patients treated with risperidone. Schizophr. 2023;9:17. https://doi.org/10.1038/s41537-023-00346-z.Harrison RNS, Gaughran F, Murray RM, et al. Development of multivariable models to predict change in body mass index within a clinical trial population of psychotic individuals. Sci Rep. 2017;7:14738. https://doi.org/10.1038/s41598-017-15137-7.Harrison RNS, Gaughran F, Murray RM, et al. Development of multivariable models to predict change in body mass index within a clinical trial population of psychotic individuals. Sci Rep. 2017;7:14738. https://doi.org/10.1038/s41598-017-15137-7.Hartwig F, Bowden J, Loret de Mola C, et al. Body mass index and psychiatric disorders: a Mendelian randomization study. Sci Rep. 2016;6:32730. https://doi.org/10.1038/srep32730.Hartwig F, Bowden J, Loret de Mola C, et al. Body mass index and psychiatric disorders: a Mendelian randomization study. Sci Rep. 2016;6:32730. https://doi.org/10.1038/srep32730.Heald A, Daly C, Warner-Levy JJ, et al. Weight change following diagnosis with psychosis: a retrospective cohort study in Greater Manchester, UK. Ann Gen Psychiatry. 2024;23:1. https://doi.org/10.1186/s12991-023-00485-8.Heald A, Daly C, Warner-Levy JJ, et al. Weight change following diagnosis with psychosis: a retrospective cohort study in Greater Manchester, UK. Ann Gen Psychiatry. 2024;23:1. https://doi.org/10.1186/s12991-023-00485-8.Kassem M, Haddad C, Daccache C, Hayek C, Hallit S, Kazour F. Factors associated with overweight and obesity in Lebanese male patients with schizophrenia. Perspect Psychiatr Care. 2021;57:1347-55. https://doi.org/10.1111/ppc.12697.Kassem M, Haddad C, Daccache C, Hayek C, Hallit S, Kazour F. Factors associated with overweight and obesity in Lebanese male patients with schizophrenia. Perspect Psychiatr Care. 2021;57:1347-55. https://doi.org/10.1111/ppc.12697.Kornetova EG, Kornetov AN, Mednova IA, et al. Body fat parameters, glucose and lipid profiles, and thyroid hormone levels in schizophrenia patients with or without metabolic syndrome. Diagnostics. 2020;10(9):683. https://doi.org/10.3390/diagnostics10090683.Kornetova EG, Kornetov AN, Mednova IA, et al. Body fat parameters, glucose and lipid profiles, and thyroid hormone levels in schizophrenia patients with or without metabolic syndrome. Diagnostics. 2020;10(9):683. https://doi.org/10.3390/diagnostics10090683.Lasić D, Bevanda M, Bošnjak N, et al. Metabolic syndrome and inflammation markers in patients with schizophrenia and recurrent depressive disorder. Psychiatr Danub. 2014;26(3):214-9.Lasić D, Bevanda M, Bošnjak N, et al. Metabolic syndrome and inflammation markers in patients with schizophrenia and recurrent depressive disorder. Psychiatr Danub. 2014;26(3):214-9.Leucht S, Cipriani A, Spineli L, et al. Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: A multiple-treatments meta-analysis. Lancet. 2013;382(9896):951-62. https://doi.org/10.1016/S0140-6736(13)60733-3.Leucht S, Cipriani A, Spineli L, et al. Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: A multiple-treatments meta-analysis. Lancet. 2013;382(9896):951-62. https://doi.org/10.1016/S0140-6736(13)60733-3.Liang J, Cai Y, Xue X, et al. Does schizophrenia itself cause obesity? Front Psychiatry. 2022;13:934384. https://doi.org/10.3389/fpsyt.2022.934384.Liang J, Cai Y, Xue X, et al. Does schizophrenia itself cause obesity? Front Psychiatry. 2022;13:934384. https://doi.org/10.3389/fpsyt.2022.934384.Limosin F, Gasquet I, Leguay D, et al. Body mass index and prevalence of obesity in a French cohort of patients with schizophrenia. Acta Psychiatr Scand. 2008;118(1):19-25. https://doi.org/10.1111/j.1600-0447.2008.01208.x.Limosin F, Gasquet I, Leguay D, et al. Body mass index and prevalence of obesity in a French cohort of patients with schizophrenia. Acta Psychiatr Scand. 2008;118(1):19-25. https://doi.org/10.1111/j.1600-0447.2008.01208.x.Mansoor B, Rengasamy M, Hilton R, et al. The bidirectional relationship between body mass index and treatment outcome in adolescents with treatment-resistant depression. J Child Adolesc Psychopharmacol. 2013;23. https://doi.org/10.1089/cap.2012.0095.Mansoor B, Rengasamy M, Hilton R, et al. The bidirectional relationship between body mass index and treatment outcome in adolescents with treatment-resistant depression. J Child Adolesc Psychopharmacol. 2013;23. https://doi.org/10.1089/cap.2012.0095.Manu P, Khan S, Radhakrishnan R, et al. Body mass index identified as an independent predictor of psychiatric readmission. J Clin Psychiatry. 2014;75(6):e573-7. https://doi.org/10.4088/JCP.13m08795.Manu P, Khan S, Radhakrishnan R, et al. Body mass index identified as an independent predictor of psychiatric readmission. J Clin Psychiatry. 2014;75(6):e573-7. https://doi.org/10.4088/JCP.13m08795.McElroy SL, Keck PE Jr. Obesity in bipolar disorder: an overview. Curr Psychiatry Rep. 2012;14(6):650-8. https://doi.org/10.1007/s11920-012-0313-8.McElroy SL, Keck PE Jr. Obesity in bipolar disorder: an overview. Curr Psychiatry Rep. 2012;14(6):650-8. https://doi.org/10.1007/s11920-012-0313-8.Monem RG, Okusaga OO. Repetitive transcranial magnetic stimulation: A potential treatment for obesity in patients with schizophrenia. Behav Sci (Basel). 2021;11(6):86. https://doi.org/10.3390/bs11060086.Monem RG, Okusaga OO. Repetitive transcranial magnetic stimulation: A potential treatment for obesity in patients with schizophrenia. Behav Sci (Basel). 2021;11(6):86. https://doi.org/10.3390/bs11060086.Muntané G, Vázquez-Bourgon J, Sada E, et al. Polygenic risk scores enhance prediction of body mass index increase in individuals with a first episode of psychosis. Eur Psychiatry. 2023;66(1):e28. https://doi.org/10.1192/j.eurpsy.2023.9.Muntané G, Vázquez-Bourgon J, Sada E, et al. Polygenic risk scores enhance prediction of body mass index increase in individuals with a first episode of psychosis. Eur Psychiatry. 2023;66(1):e28. https://doi.org/10.1192/j.eurpsy.2023.9.Nigatu YT, Bültmann U, Reijneveld SA. The prospective association between obesity and major depression in the general population: does single or recurrent episode matter? BMC Public Health. 2015;15:350. https://doi.org/10.1186/s12889-015-1682-9Nigatu YT, Bültmann U, Reijneveld SA. The prospective association between obesity and major depression in the general population: does single or recurrent episode matter? BMC Public Health. 2015;15:350. https://doi.org/10.1186/s12889-015-1682-9Perry BI, Burgess S, Jones HJ, et al. The potential shared role of inflammation in insulin resistance and schizophrenia: A bidirectional two sample mendelian randomization study. PLoS Med. 2021;18(3):e1003455. https://doi.org/10.1371/journal.pmed.1003455Perry BI, Burgess S, Jones HJ, et al. The potential shared role of inflammation in insulin resistance and schizophrenia: A bidirectional two sample mendelian randomization study. PLoS Med. 2021;18(3):e1003455. https://doi.org/10.1371/journal.pmed.1003455Perry BI., Bowker N, Burgess S, et al. Evidence for Shared Genetic Aetiology Between Schizophrenia, 2022 Cardiometabolic, and Inflammation-Related Traits: Genetic Correlation and Colocalization Analyses. Schizophr Bull Open. 2022;11;3(1):sgac001. https://doi.org/10.1093/schizbullopen/sgac001Perry BI., Bowker N, Burgess S, et al. Evidence for Shared Genetic Aetiology Between Schizophrenia, 2022 Cardiometabolic, and Inflammation-Related Traits: Genetic Correlation and Colocalization Analyses. Schizophr Bull Open. 2022;11;3(1):sgac001. https://doi.org/10.1093/schizbullopen/sgac001Peters T, Nüllig L, Antel J, et al. The Role of Genetic Variation of BMI, Body Composition, and Fat Distribution for Mental Traits and Disorders: A Look-Up and Mendelian Randomization Study. Front Genet. 2020;11(373):1–17. https://doi.org/10.3389/fgene.2020.00373Peters T, Nüllig L, Antel J, et al. The Role of Genetic Variation of BMI, Body Composition, and Fat Distribution for Mental Traits and Disorders: A Look-Up and Mendelian Randomization Study. Front Genet. 2020;11(373):1–17. https://doi.org/10.3389/fgene.2020.00373Puzhko S, Aboushawareb SAE, Kudrina I, et al. Excess body weight as a predictor of response to treatment with antidepressants in patients with depressive disorder. J. Affect Disord. 2020;267:153-170. https://doi.org/10.1016/j.jad.2020.01.113Puzhko S, Aboushawareb SAE, Kudrina I, et al. Excess body weight as a predictor of response to treatment with antidepressants in patients with depressive disorder. J. Affect Disord. 2020;267:153-170. https://doi.org/10.1016/j.jad.2020.01.113Ratliff JC, Palmese LB, Reutenauer EL, et al. Obese schizophrenia spectrum patients have significantly higher 10-year general cardiovascular risk and vascular ages than obese individuals without severe mental illness. Psychosomatics. 2013;54(1):67-73. https://doi.org/10.1016/j.psym.2012.03.001.Ratliff JC, Palmese LB, Reutenauer EL, et al. Obese schizophrenia spectrum patients have significantly higher 10-year general cardiovascular risk and vascular ages than obese individuals without severe mental illness. Psychosomatics. 2013;54(1):67-73. https://doi.org/10.1016/j.psym.2012.03.001.Rødevand L, Rahman Z, Hindley GFL, et al. Characterizing the Shared Genetic Underpinnings of Schizophrenia and Cardiovascular Disease Risk Factors. Am J Psychiatry. 2023;180(11):815-826. https://doi.org/10.1176/appi.ajp.20220660Rødevand L, Rahman Z, Hindley GFL, et al. Characterizing the Shared Genetic Underpinnings of Schizophrenia and Cardiovascular Disease Risk Factors. Am J Psychiatry. 2023;180(11):815-826. https://doi.org/10.1176/appi.ajp.20220660Sattar A, Baig S, Naveed ur Rehman, Bashir B. Factors affecting BMI; Assessment of the effect of sociodemographic factors on BMI In the population of Ghulam Mohammad Abad Faisalabad. Professional Med J. 2013;20(6):956-964Sattar A, Baig S, Naveed ur Rehman, Bashir B. Factors affecting BMI; Assessment of the effect of sociodemographic factors on BMI In the population of Ghulam Mohammad Abad Faisalabad. Professional Med J. 2013;20(6):956-964Shah P, Iwata Yu, Caravaggio F, et al. Alterations in body mass index and waist-to-hip ratio in never and minimally treated patients with psychosis: A systematic review and meta-analysis, Schizophrenia Res. 2019;208:420-429. https://doi.org/10.1016/j.schres.2019.01.005Shah P, Iwata Yu, Caravaggio F, et al. Alterations in body mass index and waist-to-hip ratio in never and minimally treated patients with psychosis: A systematic review and meta-analysis, Schizophrenia Res. 2019;208:420-429. https://doi.org/10.1016/j.schres.2019.01.005Strassnig M, Kotov R, Cornaccio D, et al. Twenty-year progression of body mass index in a county-wide cohort of people with schizophrenia and bipolar disorder identified at their first episode of psychosis. Bipolar Disord. 2017;19(5):336-343. https://doi.org/10.1111/bdi.12505.Strassnig M, Kotov R, Cornaccio D, et al. Twenty-year progression of body mass index in a county-wide cohort of people with schizophrenia and bipolar disorder identified at their first episode of psychosis. Bipolar Disord. 2017;19(5):336-343. https://doi.org/10.1111/bdi.12505.Sugawara N, Yasui-Furukori N, Sato Y. et al. Body mass index and quality of life among outpatients with schizophrenia in Japan. BMC Psychiatry. 2013;13:108. https://doi.org/10.1186/1471-244X-13-108Sugawara N, Yasui-Furukori N, Sato Y. et al. Body mass index and quality of life among outpatients with schizophrenia in Japan. BMC Psychiatry. 2013;13:108. https://doi.org/10.1186/1471-244X-13-108Swinburn BA, Sacks G, Hall KD, et al. The global obesity pandemic: shaped by global drivers and local environments. Lancet. 2011;378(9793):804-14. https://doi.org/10.1016/S0140-6736(11)60813-1.Swinburn BA, Sacks G, Hall KD, et al. The global obesity pandemic: shaped by global drivers and local environments. Lancet. 2011;378(9793):804-14. https://doi.org/10.1016/S0140-6736(11)60813-1.Teasdale SB, Ward PB, Samaras K, et al. Dietary intake of people with severe mental illness: Systematic review and meta-analysis. Br J Psychiatry. 2019;214(5):251–9. https://doi.org/10.1192/bjp.2019Teasdale SB, Ward PB, Samaras K, et al. Dietary intake of people with severe mental illness: Systematic review and meta-analysis. Br J Psychiatry. 2019;214(5):251–9. https://doi.org/10.1192/bjp.2019Tseng PT, Wang HY, Cheng YS, et al. The metabolic syndrome and risk of coronary artery disease in patients with chronic schizophrenia or schizoaffective disorder in a chronic mental institute. Kaohsiung J Med Sci. 2014;30(11):579-86. https://doi.org/10.1016/j.kjms.2014.09.002.Tseng PT, Wang HY, Cheng YS, et al. The metabolic syndrome and risk of coronary artery disease in patients with chronic schizophrenia or schizoaffective disorder in a chronic mental institute. Kaohsiung J Med Sci. 2014;30(11):579-86. https://doi.org/10.1016/j.kjms.2014.09.002.Vochoskova K, McWhinney SR, Fialova M, et al. Weight and metabolic changes in early psychosis-association with daily quantification of medication exposure during the first hospitalization. Acta Psychiatr Scand. 2023;148(3):265-276. https://doi.org/10.1111/acps.13594.Vochoskova K, McWhinney SR, Fialova M, et al. Weight and metabolic changes in early psychosis-association with daily quantification of medication exposure during the first hospitalization. Acta Psychiatr Scand. 2023;148(3):265-276. https://doi.org/10.1111/acps.13594.Zaki N, Sadek H, Hewedi D, et al. Metabolic profile and indices in a sample of drug-naive patients with schizophrenia and bipolar disorder. Middle East Current Psychiatry. 2014;21(1):22-27. https://doi.org/10.1097/01.XME.0000438128.94669.57Zaki N, Sadek H, Hewedi D, et al. Metabolic profile and indices in a sample of drug-naive patients with schizophrenia and bipolar disorder. Middle East Current Psychiatry. 2014;21(1):22-27. https://doi.org/10.1097/01.XME.0000438128.94669.57Zhang J-J, Wang X-Q, Zeng Q, et al. Prevalence and associated clinical factors for overweight and obesity in young first-episode and drug-naïve Chinese patients with major depressive disorder. Front. Psychiatry. 2023;14:1278566. https://doi.org/10.3389/fpsyt.2023.1278566Zhang J-J, Wang X-Q, Zeng Q, et al. Prevalence and associated clinical factors for overweight and obesity in young first-episode and drug-naïve Chinese patients with major depressive disorder. Front. Psychiatry. 2023;14:1278566. https://doi.org/10.3389/fpsyt.2023.1278566Zhuo C, Zhang Q, Wang L, et al. Insulin Resistance/Diabetes and Schizophrenia: Potential Shared Genetic Factors and Implications for Better Management of Patients with Schizophrenia. CNS Drugs. 2024;38:33–44. https://doi.org/10.1007/s40263-023-01057-wZhuo C, Zhang Q, Wang L, et al. Insulin Resistance/Diabetes and Schizophrenia: Potential Shared Genetic Factors and Implications for Better Management of Patients with Schizophrenia. CNS Drugs. 2024;38:33–44. https://doi.org/10.1007/s40263-023-01057-w

The authors declare that there are no conflicts of interest present.