bekhterevОбозрение психиатрии и медицинской психологии имени В.М.БехтереваV.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY2313-70532713-055XV. M. BEKHTEREV NATIONAL RESEARCH MEDICAL CENTER FOR PSYCHIATRY AND NEUROLOGY OF THE RUSSIAN FEDERATION MINISTRY OF HEALTHbekhterev-131Research ArticleВ ПОМОЩЬ ПРАКТИКУЮЩЕМУ ВРАЧУGUIDELINES FOR THE PRACTITIONERМеханизмы формирования коморбидности депрессии и ожиренияMechanisms of formation comorbidity depression and obesityМазоГалина ЭлевнаMazoG. E.galina-mazo@yandex.ruКибитовАлександр ОлеговичKibitovA. O.druggen@mail.ruФГБУ «НМИЦ ПН им. В.М. Бехтерева» Минздрава РоссииРоссияV.M. Bekhterev’ National research medical center of psychiatry and neurologyRussian FederationФГБУ «НМИЦ ПН им. В.П. Сербского» Минздрава России; ФГБУ «НМИЦ ПН им. В.М. Бехтерева» Минздрава РоссииРоссияV.M. Bekhterev’ National research medical center of psychiatry and neurology; Federal State Institution «National Medical Scientific Center of Psychiatry and Narcology named by V.P. Serbsky» of Health Ministry of RussiaRussian Federation201819072018016578Copyright © Мазо Г.Э., Кибитов А.О., 20182018Мазо Г.Э., Кибитов А.О.Mazo G.E., Kibitov A.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.bekhterevreview.com/jour/article/view/131

В статье представлены современные данные о коморбидности депрессии и ожирения с точки зрения причинно-следственных связей, общих патофизиологических механизмов формирования и развития, а также влияния одного из коморбидных заболеваний на успешность терапии другого заболевания в рамках поиска путей повышения эффективности терапии депрессии. Показана целесообразность выделения специфического депрессивно-метаболического эндофенотипа, что позволит получить новые знания об этиологии и патогенезе депрессии, а также оптимизировать терапию.

The article presents modern data on the comorbidity of depression and obesity in terms of causation, general pathophysiological mechanisms of formation and development. It presents also the impact of one of the comorbid diseases on the success of the treatment another disease in the search for ways to improve the effectiveness of depression therapy. The expediency of isolation of specific depressive-metabolic endophenotype is shown. It allow to gain new knowledge about etiology and pathogenesis of depression, and to optimize therapy.

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The authors declare that there are no conflicts of interest present.