bekhterevОбозрение психиатрии и медицинской психологии имени В.М.БехтереваV.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY2313-70532713-055XV. M. BEKHTEREV NATIONAL RESEARCH MEDICAL CENTER FOR PSYCHIATRY AND NEUROLOGY OF THE RUSSIAN FEDERATION MINISTRY OF HEALTH10.31363/2313-7053-2026-2-1140bekhterev-1388Research ArticleИССЛЕДОВАНИЯINVESTIGATIONSЗрительные вызванные потенциалы на сигнал совершить саккаду и функциональная связанность сетей головного мозга в покое при клинически высоком риске психозаVisual evoked potentials to the cue to perform a saccade and resting-state functional connectivity of brain networks in subjects at clinical high risk for psychosishttps://orcid.org/0009-0004-5266-6151ДжемА. П.DzhemA. P.

Джем Анастасия Павловна — младший научный сотрудник лаборатории нейровизуализации и мультимодального анализа

Каширское ш., 34, Москва

Anastasiia P. Dzhem

npjam@mail.ruhttps://orcid.org/0000-0002-5698-4251ПаникратоваЯ. Р.PanikratovaY. R.

Паникратова Яна Романовна — к.п.н., старший научный сотрудник лаборатории нейровизуализации и мультимодального анализа

Yana R. Panikratova

panikratova@mail.ruhttps://orcid.org/0000-0002-6674-4171ПавловА. В.PavlovA. V.

Павлов Александр Владимирович — аспирант кафедры высшей нервной деятельности биологического факультета

ул. Колмогорова, 1 строение 12, Москва, 119234

Alexandr V. Pavlov

alexandersun121@gmail.comhttps://orcid.org/0000-0001-8343-168XОмельченкоМ. А.OmelchenkoM. A.

Омельченко Мария Анатольевна — д.м.н., ведущий научный сотрудник Отдела юношеской психиатрии

Maria A. Omelchenko

omelchenko-ma@yandex.ruhttps://orcid.org/0000-0002-1209-1443КаледаВ. Г.KaledaV. G.

Каледа Василий Глебович — д.м.н., заведующий Отделом юношеской психиатрии

Vasiliy G. Kaleda

kaleda-vg@yandex.ruhttps://orcid.org/0000-0003-1548-758XСлавуцкаяМ. В.SlavutskayaM. V.

Славуцкая Мария Валерьевна — д.б.н., ведущий научный сотрудник кафедры высшей нервной деятельности биологического факультета; ведущий научный сотрудник лаборатории нейровизуализации и мультимодального анализа

Maria V. Slavutskaya

mvslav@yandex.ruhttps://orcid.org/0000-0002-0649-6663ЛебедеваИ. С.LebedevaI. S.

Лебедева Ирина Сергеевна — д.б.н., руководитель лаборатории нейровизуализации и мультимодального анализа

Irina S. Lebedeva

lebedeva-i@yandex.ruНаучный центр психического здоровьяРоссияMental Health Research CenterRussian FederationМосковский государственный университетРоссияMoscow State UniversityRussian FederationНаучный центр психического здоровья; Московский государственный университетРоссияMental Health Research Center; Moscow State UniversityRussian Federation20262805202660296108Copyright © Джем А.П., Паникратова Я.Р., Павлов А.В., Омельченко М.А., Каледа В.Г., Славуцкая М.В., Лебедева И.С., 20262026Джем А.П., Паникратова Я.Р., Павлов А.В., Омельченко М.А., Каледа В.Г., Славуцкая М.В., Лебедева И.С.Dzhem A.P., Panikratova Y.R., Pavlov A.V., Omelchenko M.A., Kaleda V.G., Slavutskaya M.V., Lebedeva I.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.bekhterevreview.com/jour/article/view/1388

Цель работы. Исследование особенностей мозгового обеспечения процессов зрительного внимания и произвольных движений глаз у пациентов с клинически высоким риском психоза (КВР). Материалы и методы. В исследовании применялась задача «саккады/антисаккады по памяти» с регистрацией электроэнцефалограммы и электроокулограммы пациентов с КВР (n = 16) и психически здоровых участников (n = 20). Оценивались поведенческие параметры (количество ошибок и латентность саккад и антисаккад), а также амплитуда и латентность пиков зрительных вызванных потенциалов (ВП) на сигнал совершить саккаду. Часть пациентов (n = 12) и другая контрольная группа (n = 17) также прошли обследование методом фМРТ покоя; анализировалась функциональная связанность (ФС) внутри и между тремя сетями: дорсальная сеть внимания, сеть определения значимости и зрительная сеть. Результаты. Участники из группы КВР совершали антисаккады с бо́льшим латентным периодом, однако по параметрам ВП не было обнаружено межгрупповых различий. В группе КВР была обнаружена повышенная ФС сети определения значимости со зрительной сетью и дорсальной сетью внимания. Меньший латентный период антисаккад был ассоциирован с большей ФС между передней поясной корой и медиальной затылочной корой, однако данный результат не прошел поправку на множественные тестирования. Заключение. По результатам анализа данных ЭЭГ в исследованной группе КВР не было обнаружено признаков дефицита нейрофизиологических процессов, ассоциируемых с ранними и промежуточными компонентами зрительных ВП. Обнаруженные в группе КВР особенности ФС могут отражать компенсаторные процессы, однако результаты корреляционного анализа не позволили на данном этапе подтвердить наличие ассоциаций ФС с поведенческими характеристиками выполнения задачи «саккады/антисаккады по памяти».

Objectives. This study aimed to analyze the neural mechanisms of visual attention and voluntary eye movements in subjects at clinical high risk for psychosis (CHR). Materials and methods. We applied a «memory-guided saccades/antisaccades» task with electroencephalogram and electrooculogram recording in CHR (n = 16) and mentally healthy participants (n = 20). Behavioral parameters (latency of saccades and antisaccades and number of errors), as well as peak amplitude and latency of visual evoked potentials (EP) to the cue to perform a saccade were assessed. A part of patients (n = 12) and another control group (n = 17) underwent resting-state fMRI; functional connectivity (FC) was analyzed within and between three networks, namely the dorsal attention, salience, and visual networks. Results. CHR participants performed antisaccades with longer latency but no between-group differences were found in EP parameters. CHR group showed an increased FC of the salience network with visual and dorsal attention networks. Shorter antisaccade latency was associated with higher FC between the anterior cingulate cortex and medial occipital cortex. However, this result did not survive the correction for multiple comparisons. Conclusion. EEG analysis revealed no evidence of deficits in neurophysiological processes associated with early and intermediate visual EP components in the CHR group. The observed FC features in CHR might reflect compensatory processes, although the results of correlation analysis did not allow us to confirm associations between the FC and performance on a «memory-guided saccades/antisaccades» task at this stage.

зрительные вызванные потенциалысаккады/антисаккады по памятиклинически высокий риск психозафМРТ покояфункциональная связанностьvisual evoked potentialsmemory-guided saccades/antisaccadesclinical high risk for psychosisresting-state fMRIfunctional connectivityРабота выполнена в рамках государственного задания Министерства науки и высшего образования Российской Федерации (тема № 124020700033-6).The work was carried out within the framework of the state assignment of the Ministry of Science and Higher Education of the Russian Federation (topic No. 124020700033-6).ReferencesДжем А.П., Павлов А.В., Томышев А.С., Омельченко М.А., Каледа В.Г., Славуцкая М.В., Лебедева И.С. Медленные негативные потенциалы, связанные с подготовкой саккад и антисаккад по памяти, в норме и при клинически высоком риске шизофрении. Физиология человека. 2025;51(3):28-39.Dzhem AP, Pavlov AV, Tomyshev AS, Omelchenko MA, Kaleda VG, Slavutskaya MV, Lebedeva IS. Slow negative potentials associated with preparation period of memory-guided saccades and antisaccades in healthy individuals and subjects at clinical-high risk for schizophrenia. Fiziologiya cheloveka. 2025;51(3):28-39. (In Russ.). https://doi.org/10.31857/S0131164625030034Лебедева И.С., Паникратова Я.Р., Абдуллина Е.Г., Мигалина В.В., Тихонов Д.В., Омельченко М.А., Каледа В.Г. Нейровизуализационные (фМРТ покоя) и нейропсихологические особенности “неманифестировавших” пациентов из группы клинически высокого риска шизофрении. Журнал высшей нервной деятельности им. И.П. Павлова. 2023;73(3):369-383.Lebedeva IS, Panikratova YR, Abdullina EG, Migalina VV, Tikhonov DV, Omelchenko MA, Kaleda VG. Neuroimaging (Resting-state fMRI) and Neuropsychological Characteristics of Non-converters with Clinical High Risk for Psychosis. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 2023;73(3):369–383. (In Russ.). https://doi.org/10.31857/S0044467723030097Омельченко М.А. Негативные симптомы на инициальном этапе шизофрении в юношеском возрасте (современные аспекты дифференциально-диагностической оценки и терапии). Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева. 2019;(4-2):41-48.Omelchenko MA. Negative symptoms at the prodromal stage of schizophrenia at a young age (current problems of diagnostics and treatment). Obozrenie psihiatrii i medicinskoj psihologii imeni V.M. Bekhtereva. 2019;(4-2):41-48. (In Russ.). https://doi.org/10.31363/2313-7053-2019-4-2-41 48Павлов А.В., Славуцкая М.В., Омельченко М.А., Котенев А.В., Лебедева И.С. Вызванная синхронизация тета-ритма ЭЭГ при подготовке саккад и антисаккад по памяти в норме и у больных с клинически высоким риском шизофрении. Российский физиологический журнал им. И.М. Сеченова. 2024;110(9):1440-1454.Pavlov AV, Slavutskaya MV, Omelchenko MA, Kotenev AV, Lebedeva IS. Evoked synchronization of theta EEG rhythm during preparation of memory-guided saccades and antisaccaded in normals and in patients with clinically high risk for schizophrenia. Rossijskij fiziologicheskij zhurnal im. I.M. Sechenova. 2024;110(9):1440–1454. (In Russ.). https://doi.org/10.31857/S0869813924090125Славуцкая М.В., Моисеева В.В., Шульговский В.В. Вызванные потенциалы головного мозга человека на сигнал совершить саккаду по памяти. Журнал высшей нервной деятельности им. И.П. Павлова. 2010;60(6):667-678.Slavutskaya MV, Moiseeva VV, Shulgovsky VV. Cortical Potentials Evoked by the Signal to Make а Memory-Guided Saccade. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 2010;60(6):667– 678. (In Russ.).Albert U, Tomassi S, Maina G, Tosato S. Prevalence of non-psychotic disorders in ultra-high risk individuals and transition to psychosis: A systematic review. Psychiatry Research. 2018;270:1-12. https://doi.org/10.1016/j.psychres.2018.09.028Albert U, Tomassi S, Maina G, Tosato S. Prevalence of non-psychotic disorders in ultra-high risk individuals and transition to psychosis: A systematic review. Psychiatry Research. 2018;270:1-12. https://doi.org/10.1016/j.psychres.2018.09.028Arkin SC, Ruiz-Betancourt D, Jamerson EC, Smith RT, Strauss NE, Klim CC, Javitt DC, Patel GH. Deficits and compensation: Attentional control cortical networks in schizophrenia. Neuroimage: Clinical. 2020;27:102348. https://doi.org/10.1016/j.nicl.2020.102348Arkin SC, Ruiz-Betancourt D, Jamerson EC, Smith RT, Strauss NE, Klim CC, Javitt DC, Patel GH. Deficits and compensation: Attentional control cortical networks in schizophrenia. Neuroimage: Clinical. 2020;27:102348. https://doi.org/10.1016/j.nicl.2020.102348Camchong J, Dyckman KA, Austin BP, Clementz BA, McDowell JE. Common neural circuitry supporting volitional saccades and its disruption in schizophrenia patients and relatives. Biological Psychiatry. 2008;64(12):1042-1050. https://doi.org/10.1016/j.biopsych.2008.06.015Camchong J, Dyckman KA, Austin BP, Clementz BA, McDowell JE. Common neural circuitry supporting volitional saccades and its disruption in schizophrenia patients and relatives. Biological Psychiatry. 2008;64(12):1042-1050. https://doi.org/10.1016/j.biopsych.2008.06.015Cermakova P, Chlapecka A, Csajbok Z, Andrysko va L, Brazdil M, Mareckova K. Parental education, cognition and functional connectivity of the salience network. Scientific Reports. 2023;13(1):2761. https://doi.org/10.1038/s41598-023-29508-wCermakova P, Chlapecka A, Csajbok Z, Andrysko va L, Brazdil M, Mareckova K. Parental education, cognition and functional connectivity of the salience network. Scientific Reports. 2023;13(1):2761. https://doi.org/10.1038/s41598-023-29508-wCieslik EC, Seidler I, Laird AR, Fox PT, Eickhoff SB. Different involvement of subregions within dorsal premotor and medial frontal cortex for pro and antisaccades. Neuroscience & Biobehavioral Re views. 2016;68:256-269. https://doi.org/10.1016/j.neubiorev.2016.05.012Cieslik EC, Seidler I, Laird AR, Fox PT, Eickhoff SB. Different involvement of subregions within dorsal premotor and medial frontal cortex for pro and antisaccades. Neuroscience & Biobehavioral Re views. 2016;68:256-269. https://doi.org/10.1016/j.neubiorev.2016.05.012Collin G, Nieto-Castanon A, Shenton ME, Pasternak O, Kelly S, Keshavan MS, et al. Brain function al connectivity data enhance prediction of clinical outcome in youth at risk for psychosis. Neuroimage: Clinical. 2020;26:102108. https://doi.org/10.1016/j.nicl.2019.102108Collin G, Nieto-Castanon A, Shenton ME, Pasternak O, Kelly S, Keshavan MS, et al. Brain function al connectivity data enhance prediction of clinical outcome in youth at risk for psychosis. Neuroimage: Clinical. 2020;26:102108. https://doi.org/10.1016/j.nicl.2019.102108Coors A, Imtiaz MA, Boenniger MM, Aziz NA, Breteler MMB, Ettinger U. Polygenic risk scores for schizophrenia are associated with oculomotor endophenotypes. Psychological Medicine. 2023;53(4):1611-1619. https://doi.org/10.1017/S0033291721003251Coors A, Imtiaz MA, Boenniger MM, Aziz NA, Breteler MMB, Ettinger U. Polygenic risk scores for schizophrenia are associated with oculomotor endophenotypes. Psychological Medicine. 2023;53(4):1611-1619. https://doi.org/10.1017/S0033291721003251Curtis CE, Connolly JD. Saccade preparation signals in the human frontal and parietal cortices. Journal of Neurophysiology. 2008;99(1):133-145. https://doi.org/10.1152/jn.00899.2007Curtis CE, Connolly JD. Saccade preparation signals in the human frontal and parietal cortices. Journal of Neurophysiology. 2008;99(1):133-145. https://doi.org/10.1152/jn.00899.2007Damiani S, Fusar-Poli L, Brondino N, Provenzani U, Baldwin H, Fusar-Poli P, Politi P. World/self am bivalence: A shared mechanism in different subsets of psychotic experiences? Linking symptoms with resting-state fMRI. Psychiatry Research: Neuroimaging. 2020;299:111068. https://doi.org/10.1016/j.pscychresns.2020.111068Damiani S, Fusar-Poli L, Brondino N, Provenzani U, Baldwin H, Fusar-Poli P, Politi P. World/self am bivalence: A shared mechanism in different subsets of psychotic experiences? Linking symptoms with resting-state fMRI. Psychiatry Research: Neuroimaging. 2020;299:111068. https://doi.org/10.1016/j.pscychresns.2020.111068Dong D, Wang Y, Chang X, Luo C, Yao D. Dysfunction of Large-Scale Brain Networks in Schizophrenia: A Meta-analysis of Resting-State Functional Connectivity. Schizophrenia Bulletin. 2018;44(1):168-181. https://doi.org/10.1093/schbul/sbx034Dong D, Wang Y, Chang X, Luo C, Yao D. Dysfunction of Large-Scale Brain Networks in Schizophrenia: A Meta-analysis of Resting-State Functional Connectivity. Schizophrenia Bulletin. 2018;44(1):168-181. https://doi.org/10.1093/schbul/sbx034Donkers FC, van Boxtel GJ. The N2 in go/no-go tasks reflects conflict monitoring not response inhibition. Brain and Cognition. 2004;56(2):165-176. https://doi.org/10.1016/j.bandc.2004.04.005Donkers FC, van Boxtel GJ. The N2 in go/no-go tasks reflects conflict monitoring not response inhibition. Brain and Cognition. 2004;56(2):165-176. https://doi.org/10.1016/j.bandc.2004.04.005Ekin M, Akdal G, Bora E. Antisaccade error rates in first-episode psychosis, ultra-high risk for psychosis and unaffected relatives of schizophrenia: A systematic review and meta-analysis. Schizophrenia Bulletin. 2024;266:41-49. doi: 10.1016/j.schres.2024.02.016Ekin M, Akdal G, Bora E. Antisaccade error rates in first-episode psychosis, ultra-high risk for psychosis and unaffected relatives of schizophrenia: A systematic review and meta-analysis. Schizophrenia Bulletin. 2024;266:41-49. doi: 10.1016/j.schres.2024.02.016Fusar-Poli P. The Clinical High-Risk State for Psychosis (CHR-P), Version II. Schizophrenia Bulletin. 2017;43(1):44-47. https://doi.org/10.1093/schbul/sbw158Fusar-Poli P. The Clinical High-Risk State for Psychosis (CHR-P), Version II. Schizophrenia Bulletin. 2017;43(1):44-47. https://doi.org/10.1093/schbul/sbw158Ghosh P, Roy D, Banerjee A. Organization of directed functional connectivity among nodes of ventral attention network reveals the common network mechanisms underlying saliency processing across distinct spatial and spatiotemporal scales. Neuro image. 2021;231:117869. https://doi.org/10.1016/j.neuroimage.2021.117869Ghosh P, Roy D, Banerjee A. Organization of directed functional connectivity among nodes of ventral attention network reveals the common network mechanisms underlying saliency processing across distinct spatial and spatiotemporal scales. Neuro image. 2021;231:117869. https://doi.org/10.1016/j.neuroimage.2021.117869Harsay HA, Cohen MX, Spaan M, Weeda WD, Nieuwenhuis S, Ridderinkhof KR. Error blindness and motivational significance: Shifts in networks centering on anterior insula co-vary with error awareness and pupil dilation. Behavioural Brain Research. 2018;355:24-35. https://doi.org/10.1016/j.bbr.2017.10.030Harsay HA, Cohen MX, Spaan M, Weeda WD, Nieuwenhuis S, Ridderinkhof KR. Error blindness and motivational significance: Shifts in networks centering on anterior insula co-vary with error awareness and pupil dilation. Behavioural Brain Research. 2018;355:24-35. https://doi.org/10.1016/j.bbr.2017.10.030Herrmann CS, Knight RT. Mechanisms of human attention: event-related potentials and oscillations. Neuroscience & Biobehavioral Reviews. 2001;25(6):465-76. https://doi.org/10.1016/s0149-7634(01)00027-6Herrmann CS, Knight RT. Mechanisms of human attention: event-related potentials and oscillations. Neuroscience & Biobehavioral Reviews. 2001;25(6):465-76. https://doi.org/10.1016/s0149-7634(01)00027-6Hutton SB, Huddy V, Barnes TR, Robbins TW, Crawford TJ, Kennard C, Joyce EM. The relationship between antisaccades, smooth pursuit, and executive dysfunction in first-episode schizophrenia. Biological Psychiatry. 2004;56(8):553-9. https://doi.org/10.1016/j.biopsych.2004.07.002Hutton SB, Huddy V, Barnes TR, Robbins TW, Crawford TJ, Kennard C, Joyce EM. The relationship between antisaccades, smooth pursuit, and executive dysfunction in first-episode schizophrenia. Biological Psychiatry. 2004;56(8):553-9. https://doi.org/10.1016/j.biopsych.2004.07.002Ishida T, Nakamura Y, Tanaka SC, Mitsuyama Y, Yokoyama S, Shinzato H, et al. Aberrant Large-Scale Network Interactions Across Psychiatric Disorders Revealed by Large-Sample Multi-Site Resting-State Functional Magnetic Resonance Imaging Datasets. Schizophrenia Bulletin. 2023;49(4):933-943. https://doi.org/10.1093/schbul/sbad022Ishida T, Nakamura Y, Tanaka SC, Mitsuyama Y, Yokoyama S, Shinzato H, et al. Aberrant Large-Scale Network Interactions Across Psychiatric Disorders Revealed by Large-Sample Multi-Site Resting-State Functional Magnetic Resonance Imaging Datasets. Schizophrenia Bulletin. 2023;49(4):933-943. https://doi.org/10.1093/schbul/sbad022Jin Z, Jin DG, Xiao M, Ding A, Tian J, Zhang J, Li L. Structural and functional MRI evidence for significant contribution of precentral gyrus to flexible oculomotor control: evidence from the antisaccade task. Brain Structure & Function. 2022;227(8):2623-2632. https://doi.org/10.1007/s00429-022-02557-zJin Z, Jin DG, Xiao M, Ding A, Tian J, Zhang J, Li L. Structural and functional MRI evidence for significant contribution of precentral gyrus to flexible oculomotor control: evidence from the antisaccade task. Brain Structure & Function. 2022;227(8):2623-2632. https://doi.org/10.1007/s00429-022-02557-zJohannes S, Munte TF, Heinze HJ, Mangun GR. Luminance and spatial attention effects on ear ly visual processing. Cognitive Brain Research. 1995;2(3):189-205. https://doi.org/10.1016/0926-6410(95)90008-xJohannes S, Munte TF, Heinze HJ, Mangun GR. Luminance and spatial attention effects on ear ly visual processing. Cognitive Brain Research. 1995;2(3):189-205. https://doi.org/10.1016/0926-6410(95)90008-xKim MS, Kim YY, Yoo SY, Kwon JS. Electrophysiological correlates of behavioral response inhibition in patients with obsessive-compulsive disorder. Depression and Anxiety. 2007;24(1):22-31. https://doi.org/10.1002/da.20195Kim MS, Kim YY, Yoo SY, Kwon JS. Electrophysiological correlates of behavioral response inhibition in patients with obsessive-compulsive disorder. Depression and Anxiety. 2007;24(1):22-31. https://doi.org/10.1002/da.20195Kleineidam L, Frommann I, Ruhrmann S, Klosterkotter J, Brockhaus-Dumke A, Wolwer W, Gaebel W, Maier W, Wagner M, Ettinger U. Antisaccade and prosaccade eye movements in individuals clinically at risk for psychosis: comparison with first-episode schizophrenia and prediction of conversion. European Archives of Psychiatry and Clinical Neuroscience. 2019;269(8):921-930. https://doi.org/10.1007/s00406-018-0973-4Kleineidam L, Frommann I, Ruhrmann S, Klosterkotter J, Brockhaus-Dumke A, Wolwer W, Gaebel W, Maier W, Wagner M, Ettinger U. Antisaccade and prosaccade eye movements in individuals clinically at risk for psychosis: comparison with first-episode schizophrenia and prediction of conversion. European Archives of Psychiatry and Clinical Neuroscience. 2019;269(8):921-930. https://doi.org/10.1007/s00406-018-0973-4Lencz T, Smith CW, Auther A, Correll CU, Cornblatt B. Nonspecific and attenuated negative symptoms in patients at clinical high-risk for schizophrenia. Schizophrenia Bulletin. 2004;68(1):37-48. https://doi.org/10.1016/S0920-9964(03)00214-7Lencz T, Smith CW, Auther A, Correll CU, Cornblatt B. Nonspecific and attenuated negative symptoms in patients at clinical high-risk for schizophrenia. Schizophrenia Bulletin. 2004;68(1):37-48. https://doi.org/10.1016/S0920-9964(03)00214-7Luck SJ, Woodman GF, Vogel EK. Event-related potential studies of attention. Trends in Cognitive Sciences. 2000;4(11):432-440. https://doi.org/10.1016/s1364-6613(00)01545-xLuck SJ, Woodman GF, Vogel EK. Event-related potential studies of attention. Trends in Cognitive Sciences. 2000;4(11):432-440. https://doi.org/10.1016/s1364-6613(00)01545-xMcAteer SM, McGregor A, Smith DT. Oculomotor rehearsal in visuospatial working memory. Attention, Perception, & Psychophysics. 2023;85(1):261 275. https://doi.org/10.3758/s13414-022-02601-4McAteer SM, McGregor A, Smith DT. Oculomotor rehearsal in visuospatial working memory. Attention, Perception, & Psychophysics. 2023;85(1):261 275. https://doi.org/10.3758/s13414-022-02601-4Nieto-Castanon A, Whitfield-Gabrieli S. CONN functional connectivity toolbox: RRID SCR_009550, release 22. Hilbert Press; 2022.Nieto-Castanon A, Whitfield-Gabrieli S. CONN functional connectivity toolbox: RRID SCR_009550, release 22. Hilbert Press; 2022.Obyedkov I, Skuhareuskaya M, Skugarevsky O, Obyedkov V, Buslauski P, Skuhareuskaya T, Waszkiewicz N. Saccadic eye movements in different dimensions of schizophrenia and in clinical high-risk state for psychosis. BMC Psychiatry. 2019;19(1):110. https://doi.org/10.1186/s12888-019-2093-8Obyedkov I, Skuhareuskaya M, Skugarevsky O, Obyedkov V, Buslauski P, Skuhareuskaya T, Waszkiewicz N. Saccadic eye movements in different dimensions of schizophrenia and in clinical high-risk state for psychosis. BMC Psychiatry. 2019;19(1):110. https://doi.org/10.1186/s12888-019-2093-8Oribe N, Hirano Y, Del Re E, Mesholam-Gately RI, Woodberry KA, Ueno T, et al. Longitudinal evaluation of visual P300 amplitude in clinical high-risk subjects: An event-related potential study. Psychiatry and Clinical Neurosciences. 2020;74(10):527-534. https://doi.org/10.1111/pcn.13083Oribe N, Hirano Y, Del Re E, Mesholam-Gately RI, Woodberry KA, Ueno T, et al. Longitudinal evaluation of visual P300 amplitude in clinical high-risk subjects: An event-related potential study. Psychiatry and Clinical Neurosciences. 2020;74(10):527-534. https://doi.org/10.1111/pcn.13083Osborne KJ, Zhang W, Farrens J, Geiger M, Kraus B, Glazer J, Nusslock R, Kappenman ES, Mittal VA. Neural mechanisms of motor dysfunction in individuals at clinical high-risk for psychosis: Evidence for impairments in motor activation. Journal of Psychopathology and Clinical Science. 2022;131(4):375-391. https://doi.org/10.1037/abn0000754Osborne KJ, Zhang W, Farrens J, Geiger M, Kraus B, Glazer J, Nusslock R, Kappenman ES, Mittal VA. Neural mechanisms of motor dysfunction in individuals at clinical high-risk for psychosis: Evidence for impairments in motor activation. Journal of Psychopathology and Clinical Science. 2022;131(4):375-391. https://doi.org/10.1037/abn0000754Palaniyappan L, Liddle PF. Does the salience network play a cardinal role in psychosis? An emerging hypothesis of insular dysfunction. Journal of Psychiatry & Neuroscience. 2012;37(1):17-27. https://doi.org/10.1503/jpn.100176Palaniyappan L, Liddle PF. Does the salience network play a cardinal role in psychosis? An emerging hypothesis of insular dysfunction. Journal of Psychiatry & Neuroscience. 2012;37(1):17-27. https://doi.org/10.1503/jpn.100176Rahmati M, Saber GT, Curtis CE. Population Dynamics of Early Visual Cortex during Work ing Memory. Journal of Cognitive Neuroscience. 2018;30(2):219-233. https://doi.org/10.1162/jocn_a_01196Rahmati M, Saber GT, Curtis CE. Population Dynamics of Early Visual Cortex during Work ing Memory. Journal of Cognitive Neuroscience. 2018;30(2):219-233. https://doi.org/10.1162/jocn_a_01196Ritter W, Simson R, Vaughan HG, Jr. Event-related potential correlates of two stages of information processing in physical and semantic discrimination tasks. Psychophysiology. 1983;20(2):168-79. https://doi.org/10.1111/j.1469-8986.1983.tb03283.xRitter W, Simson R, Vaughan HG, Jr. Event-related potential correlates of two stages of information processing in physical and semantic discrimination tasks. Psychophysiology. 1983;20(2):168-79. https://doi.org/10.1111/j.1469-8986.1983.tb03283.xRong B, Huang H, Gao G, Sun L, Zhou Y, Xiao L, Wang H, Wang G. Widespread Intra and Inter-Network Dysconnectivity among Large-Scale Resting State Networks in Schizophrenia. Journal of Clinical Medicine. 2023;12(9). https://doi.org/10.3390/jcm12093176Rong B, Huang H, Gao G, Sun L, Zhou Y, Xiao L, Wang H, Wang G. Widespread Intra and Inter-Network Dysconnectivity among Large-Scale Resting State Networks in Schizophrenia. Journal of Clinical Medicine. 2023;12(9). https://doi.org/10.3390/jcm12093176Slavutskaya MV, Karelin SA, Kotenev AV, Shulgovsky VV. The Positive Components of the Evoked Response to Visual Stimuli in the Saccadic “Go/NoGo” Paradigm in Humans. Human Physiology. 2019;45(2):115-125. https://doi.org/10.1134/S0362119719010134Slavutskaya MV, Karelin SA, Kotenev AV, Shulgovsky VV. The Positive Components of the Evoked Response to Visual Stimuli in the Saccadic “Go/NoGo” Paradigm in Humans. Human Physiology. 2019;45(2):115-125. https://doi.org/10.1134/S0362119719010134Smith JL, Johnstone SJ, Barry RJ. Response priming in the Go/NoGo task: the N2 reflects neither inhibition nor conflict. Clinical Neurophysiology. 2007;118(2):343-55. https://doi.org/10.1016/j.clinph.2006.09.027Smith JL, Johnstone SJ, Barry RJ. Response priming in the Go/NoGo task: the N2 reflects neither inhibition nor conflict. Clinical Neurophysiology. 2007;118(2):343-55. https://doi.org/10.1016/j.clinph.2006.09.027Smith SM, Nichols TE. Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Neuroimage. 2009;44(1):83-98. https://doi.org/10.1016/j.neuroimage.2008.03.061Smith SM, Nichols TE. Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Neuroimage. 2009;44(1):83-98. https://doi.org/10.1016/j.neuroimage.2008.03.061Souto D, Kerzel D. Visual selective attention and the control of tracking eye movements: a critical review. Journal of Neurophysiology. 2021;125(5):1552-1576. https://doi.org/10.1152/jn.00145.2019Souto D, Kerzel D. Visual selective attention and the control of tracking eye movements: a critical review. Journal of Neurophysiology. 2021;125(5):1552-1576. https://doi.org/10.1152/jn.00145.2019Sulejmanpasic G, Memic-Serdarevic A, Sabanagic-Hajric S, Bajramagic N. The Correlation of PANSS Scores and P100 Latency in Patients with Schizophrenia and Migrene Hedache Using Visual Evoked Potentials (VEPS) According to Gender and Age. Acta Informatica Medica. 2022;30(4):318-323. https://doi.org/10.5455/aim.2022.30.318-323Sulejmanpasic G, Memic-Serdarevic A, Sabanagic-Hajric S, Bajramagic N. The Correlation of PANSS Scores and P100 Latency in Patients with Schizophrenia and Migrene Hedache Using Visual Evoked Potentials (VEPS) According to Gender and Age. Acta Informatica Medica. 2022;30(4):318-323. https://doi.org/10.5455/aim.2022.30.318-323Tamber-Rosenau BJ, Asplund CL, Marois R. Functional dissociation of the inferior frontal junction from the dorsal attention network in top-down attentional control. Journal of Neurophysiology. 2018;120(5):2498-2512. https://doi.org/10.1152/jn.00506.2018Tamber-Rosenau BJ, Asplund CL, Marois R. Functional dissociation of the inferior frontal junction from the dorsal attention network in top-down attentional control. Journal of Neurophysiology. 2018;120(5):2498-2512. https://doi.org/10.1152/jn.00506.2018Watters AJ, Rupert PE, Wolf DH, Calkins ME, Gur RC, Gur RE, Turetsky BI. Social aversive conditioning in youth at clinical high risk for psychosis and with psychosis: An ERP study. Schizophrenia Bulletin. 2018;202:291-296. https://doi.org/10.1016/j.schres.2018.06.027Watters AJ, Rupert PE, Wolf DH, Calkins ME, Gur RC, Gur RE, Turetsky BI. Social aversive conditioning in youth at clinical high risk for psychosis and with psychosis: An ERP study. Schizophrenia Bulletin. 2018;202:291-296. https://doi.org/10.1016/j.schres.2018.06.027Whitfield-Gabrieli S., Nieto-Castanon A., Ghosh S. Artifact detection tools (ART). Cambridge, MA; 2009.Whitfield-Gabrieli S., Nieto-Castanon A., Ghosh S. Artifact detection tools (ART). Cambridge, MA; 2009.Wolf C, Lappe M. Top-down control of saccades requires inhibition of suddenly appearing stimuli. Attention, Perception, & Psychophysics. 2020;82(8):3863-3877. https://doi.org/10.3758/s13414-020-02101-3Wolf C, Lappe M. Top-down control of saccades requires inhibition of suddenly appearing stimuli. Attention, Perception, & Psychophysics. 2020;82(8):3863-3877. https://doi.org/10.3758/s13414-020-02101-3Woods SW, Miller TJ, McGlashan TH. The «prodromal» patient: both symptomatic and at-risk. CNS Spectrums. 2001;6(3):223-32. https://doi.org/10.1017/s1092852900008609Woods SW, Miller TJ, McGlashan TH. The «prodromal» patient: both symptomatic and at-risk. CNS Spectrums. 2001;6(3):223-32. https://doi.org/10.1017/s1092852900008609Yeap S, Kelly SP, Sehatpour P, Magno E, Garavan H, Thakore JH, Foxe JJ. Visual sensory processing deficits in Schizophrenia and their relationship to disease state. European Archives of Psychiatry and Clinical Neuroscience. 2008;258(5):305-16. https://doi.org/10.1007/s00406-008-0802-2Yeap S, Kelly SP, Sehatpour P, Magno E, Garavan H, Thakore JH, Foxe JJ. Visual sensory processing deficits in Schizophrenia and their relationship to disease state. European Archives of Psychiatry and Clinical Neuroscience. 2008;258(5):305-16. https://doi.org/10.1007/s00406-008-0802-2Yung AR, McGorry PD, McFarlane CA, Jackson HJ, Patton GC, Rakkar A. Monitoring and care of young people at incipient risk of psychosis. Schizophrenia Bulletin. 1996;22(2):283-303. https://doi.org/10.1093/schbul/22.2.283Yung AR, McGorry PD, McFarlane CA, Jackson HJ, Patton GC, Rakkar A. Monitoring and care of young people at incipient risk of psychosis. Schizophrenia Bulletin. 1996;22(2):283-303. https://doi.org/10.1093/schbul/22.2.283Zhang D, Xu L, Liu X, Cui H, Wei Y, Zheng W, et al. Eye Movement Characteristics for Predicting a Transition to Psychosis: Longitudinal Changes and Implications. Schizophrenia Bulletin. 2025;51(2):422-431. https://doi.org/10.1093/schbul/sbae001Zhang D, Xu L, Liu X, Cui H, Wei Y, Zheng W, et al. Eye Movement Characteristics for Predicting a Transition to Psychosis: Longitudinal Changes and Implications. Schizophrenia Bulletin. 2025;51(2):422-431. https://doi.org/10.1093/schbul/sbae001Zhang D, Xu L, Xie Y, Tang X, Hu Y, Liu X, et al. Eye movement indices as predictors of conversion to psychosis in individuals at clinical high risk. European Archives of Psychiatry and Clinical Neuroscience. 2023;273(3):553-563. https://doi.org/10.1007/s00406-022-01463-zZhang D, Xu L, Xie Y, Tang X, Hu Y, Liu X, et al. Eye movement indices as predictors of conversion to psychosis in individuals at clinical high risk. European Archives of Psychiatry and Clinical Neuroscience. 2023;273(3):553-563. https://doi.org/10.1007/s00406-022-01463-zZhou Y, Friston KJ, Zeidman P, Chen J, Li S, Razi A. The Hierarchical Organization of the De fault, Dorsal Attention and Salience Networks in Adolescents and Young Adults. Cerebral Cortex. 2018;28(2):726-737. https://doi.org/10.1093/cercor/bhx307Zhou Y, Friston KJ, Zeidman P, Chen J, Li S, Razi A. The Hierarchical Organization of the De fault, Dorsal Attention and Salience Networks in Adolescents and Young Adults. Cerebral Cortex. 2018;28(2):726-737. https://doi.org/10.1093/cercor/bhx307

The authors declare that there are no conflicts of interest present.