bekhterevОбозрение психиатрии и медицинской психологии имени В.М.БехтереваV.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY2313-70532713-055XV. M. BEKHTEREV NATIONAL RESEARCH MEDICAL CENTER FOR PSYCHIATRY AND NEUROLOGY OF THE RUSSIAN FEDERATION MINISTRY OF HEALTH10.31363/2313-7053-2026-23-1213bekhterev-1422Research ArticleИССЛЕДОВАНИЯINVESTIGATIONSИнтерлейкин-6 связан с ангедонией, но не с тяжестью биполярной и униполярной депрессииInterleukin-6 is associated with anxiety and anhedonia, but not with the severity of bipolar and unipolar depressionhttps://orcid.org/0000-0002-8467-5368КасьяноваА. А.KasyanovaA. A.

Касьянова Анастасия Александровна - младший научный сотрудник, аспирант кафедры психиатрии и наркологии Медицинского института

199034, Санкт-Петербург, Университетская наб., д. 7–9

Anastasia A. Kasyanova

Saint Petersburg

aa.kasyanova@yandex.ruhttps://orcid.org/0009-0003-8314-1326СарыковаА. С.SarykovaA. S.

Сарыкова Анастасия Сергеевна - лаборант-исследователь Медицинского института

199034, Санкт-Петербург, Университетская наб., д. 7–9

Anastasia S. Sarykova

Saint Petersburg

anastasia.sarykova@yandex.comhttps://orcid.org/0000-0001-6318-7536ЛиманкинО. В.LimankinO. V.

Лиманкин Олег Васильевич - доктор медицинских наук, профессор, главный врач; старший научный сотрудник Медицинского института

199034, Санкт-Петербург, Университетская наб., д. 7–9

188357, Ленинградская область, Гатчинский район, село Никольское, ул. Меньковская, д. 10

Oleg V. Limankin

Saint Petersburg

limankin@mail.ruhttps://orcid.org/0000-0003-4096-6208ПетроваН. Н.PetrovaN. N.

Петрова Наталия Николаевна - доктор медицинских наук, профессор, заведующая кафедрой психиатрии и наркологии

199034, Санкт-Петербург, Университетская наб., д. 7–9

Natalia N. Petrova

Saint Petersburg

petrova_nn@mail.ruСанкт-Петербургский государственный университетРоссияSaint-Petersburg State UniversityRussian FederationСанкт-Петербургский государственный университет; Психиатрическая больница №1 им. П.П. КащенкоРоссияSaint-Petersburg State University; Psychiatric Hospital No. 1 named after P.P. KaschenkoRussian Federation2026200720266034249Copyright © Касьянова А.А., Сарыкова А.С., Лиманкин О.В., Петрова Н.Н., 20262026Касьянова А.А., Сарыкова А.С., Лиманкин О.В., Петрова Н.Н.Kasyanova A.A., Sarykova A.S., Limankin O.V., Petrova N.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.bekhterevreview.com/jour/article/view/1422Цель

Цель: сравнить уровни интерлейкина-6 (ИЛ-6) у пациентов с текущим депрессивным эпизодом (ДЭ) при биполярном аффективном расстройстве (БАР) и рекуррентном депрессивном расстройстве (РДР), а также оценить связи ИЛ-6 с клиническими характеристиками, включая ангедонию и тревогу. Материал и методы: участники исследования были обследованы с помощью полуструктурированного диагностического интервью и психометрических инструментов, таких как шкала Монтгомери Асберг для оценки депрессии (MADRS), шкала оценки ангедонии Снайта Гамильтона (SHAPS), Госпитальная шкала тревоги и депрессии (HADS), Колумбийская шкала оценки тяжести суицида (C-SSRS). Уровни ИЛ-6 в сыворотке крови определяли методом иммуноферментного анализа. Для статистической обработки применялись непараметрические методы, корреляционный и регрессионный анализ.

Результаты

Результаты: В исследование включены 50 пациентов с текущим ДЭ (БАР: n=20, РДР: n=30). Между группами БАР и РДР не выявлено различий по уровню ИЛ-6, а также по выраженности ангедонии (SHAPS) и тревоги (HADS-A). Пациенты с БАР имели более ранний дебют расстройства и большее число ДЭ по сравнению с РДР. При стратификации по диагнозу у БАР ИЛ-6 коррелировал с тревогой (HADS-A) и возрастом дебюта, тогда как у РДР с ангедонией (SHAPS). Тем не менее в регрессионном анализе, проведённом после корреляционного этапа, более высокие уровни ИЛ-6 демонстрировали устойчивую, независимую положительную связь только с выраженностью ангедонии; эффект сохранялся при учёте диагноза (БАР/РДР) и клинических ковариат. Заключение: у пациентов с текущим ДЭ ИЛ-6 может быть в большей степени связан с отдельными доменами симптомов, а именно с выраженностью ангедонии, нежели с общей тяжестью депрессии. Причём данная связь проявляется независимо от диагноза БАР и РДР, что указывает на её ключевую роль в иммуновоспалительных механизмах развития расстройств настроения.

Objective

Objective: to compare the levels of interleukin-6 (IL-6) in patients with a current depressive episode (DE) in bipolar disorder (BD) and major depressive disorder (MDD), as well as to evaluate the associations of IL-6 with clinical characteristics, including anhedonia and anxiety. Material and methods: the study participants were examined using a semi–structured diagnostic interview and psychometric tools such as the Montgomery–Asberg Depression Rating Scale (MADRS), the Snaith-Hamilton Pleasure Scale (SHAPS), the Hospital Anxiety and Depression Scale (HADS), and the Columbia-Suicide Severity Rating Scale (C-SSRS). Serum levels of IL-6 were determined by enzyme immunoassay. Nonparametric methods, correlation and regression analysis were used for statistical processing.

Results

Results: The study included 50 patients with current DE (BD: n=20, MDD: n=30). There were no differences between the BD and MDD groups in IL-6 levels, as well as in the severity of anhedonia (SHAPS) and anxiety (HADS-A). Patients with BD had an earlier onset of the disorder and a higher number of DE compared with MDD. In BD diagnosis stratification, IL-6 correlated with anxiety (HADS-A) and age of onset, while in MDD it correlated with anhedonia (SHAPS). Nevertheless, in the regression analysis conducted after the correlation stage, higher levels of IL-6 showed a stable, independent positive association only with the severity of anhedonia; the effect persisted when the diagnosis was taken into account (BD/ MDD) and clinical covariates. Conclusion: in patients with current DE, IL-6 may be more associated with individual domains of symptoms, namely, the severity of anhedonia, rather than the overall severity of depression. Moreover, this relationship manifests itself regardless of the diagnosis of BD and MDD, which indicates its key role in the immune-inflammatory mechanisms of mood disorders.

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The authors declare that there are no conflicts of interest present.