<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">bekhterev</journal-id><journal-title-group><journal-title xml:lang="ru">Обозрение психиатрии и медицинской психологии имени В.М.Бехтерева</journal-title><trans-title-group xml:lang="en"><trans-title>V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2313-7053</issn><issn pub-type="epub">2713-055X</issn><publisher><publisher-name>V. M. BEKHTEREV  NATIONAL  RESEARCH  MEDICAL  CENTER  FOR  PSYCHIATRY  AND  NEUROLOGY                           OF    THE  RUSSIAN  FEDERATION   MINISTRY  OF  HEALTH</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">bekhterev-171</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>В ПОМОЩЬ ПРАКТИКУЮЩЕМУ ВРАЧУ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GUIDELINES FOR THE PRACTITIONER</subject></subj-group></article-categories><title-group><article-title>Церебролизин: обзор литературы (часть I)</article-title><trans-title-group xml:lang="en"><trans-title>Cerebrolysin: spectrum of activity and research data</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Букреева</surname><given-names>Наталья Дмитриевна</given-names></name><name name-style="western" xml:lang="en"><surname>Bukreeva</surname><given-names>N. D.</given-names></name></name-alternatives><email xlink:type="simple">ndbukreeva@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ракитянская</surname><given-names>Елизавета Александровна</given-names></name><name name-style="western" xml:lang="en"><surname>Rakityanskaya</surname><given-names>E. A.</given-names></name></name-alternatives><email xlink:type="simple">earakityanskaya@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ФГБУ «ФМИЦПН им. В.П. Сербского» Минздрава России</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>19</day><month>07</month><year>2018</year></pub-date><volume>0</volume><issue>1</issue><fpage>89</fpage><lpage>96</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Букреева Н.Д., Ракитянская Е.А., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Букреева Н.Д., Ракитянская Е.А.</copyright-holder><copyright-holder xml:lang="en">Bukreeva N.D., Rakityanskaya E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.bekhterevreview.com/jour/article/view/171">https://www.bekhterevreview.com/jour/article/view/171</self-uri><abstract><p>Как показывают результаты анализа экспериментальных и клинических исследований, применение церебролизина является эффективной и безопасной терапией при многих неврологических расстройствах, начиная от инсульта и заканчивая болезнью Альцгеймера. Первичный эффект препарата связан с влиянием церебролизина на определенные зоны гиппокампа и их функцию. Препарат обладает уникальным органоспецифическим мультимодальным действием на головной мозг, способен к метаболической регуляции, нейропротекции, функциональной нейромодуляции и нейротрофической активности, установленным в многочисленных экспериментальных исследованиях. Клиническая эффективность препарата подтверждена в ходе клинических испытаний, проводившихся с учетом требований GCP. Побочные эффекты препарата незначительны.</p></abstract><trans-abstract xml:lang="en"><p>The results of analysis of experimental and clinical studies have shown that Cerebrolysin application is safe and effective therapy for many neurological disorders ranging from stroke and ending Alzheimer’s disease. The primary effect of the medicine is associated with the influence of Cerebrolysin on certain areas of the hippocampus and their function. The medicine has a unique organ-multimodal action on the brain, it is capable of metabolic regulation, neuroprotection, functional neuromodulation and neurotrophic activity, detected in numerous experimental studies. The clinical efficacy of the medicine is confirmed by clinical trials performed based on GCP requirements. Side effects of the medicine are negligible.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>церебролизин</kwd><kwd>лекарственная терапия</kwd><kwd>психиатрия</kwd><kwd>неврология</kwd><kwd>фармакология</kwd><kwd>нейропротектор</kwd><kwd>метаболическая регуляция</kwd><kwd>функциональная нейромодуляция</kwd><kwd>нейротрофическая активность</kwd><kwd>cerebrolysin</kwd><kwd>medical therapy</kwd><kwd>psychiatry</kwd><kwd>neurology</kwd><kwd>pharmacology</kwd><kwd>neuroprotective</kwd><kwd>metabolic regulation</kwd><kwd>functional neuromodulation</kwd><kwd>neurotrophic activity</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Akai F., Hiruma S., Sato T., Iwamoto N., Fuji-moto M., Ioku M. and Hashimoto S. Neurotrophic factor-like effect of FPF1070 on septal cholinergic neurons after transections of fimbria-fornix in the rat brain. - Histol Histopathol. - 1992. - Vol. 7. - P. 213-221.</mixed-citation><mixed-citation xml:lang="en">Akai F., Hiruma S., Sato T., Iwamoto N., Fuji-moto M., Ioku M. and Hashimoto S. Neurotrophic factor-like effect of FPF1070 on septal cholinergic neurons after transections of fimbria-fornix in the rat brain. - Histol Histopathol. - 1992. - Vol. 7. - P. 213-221.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Alvarez X.A., Cacabelos R., Laredo M., Couceiro V., Sampedro C., Varela M., Corzo L., Fernandez-Novoa L., Vargas M., Aleixandre M., Linares C., Granizo E., Muresanu D. and Moessler H. A 24-week, doubleblind, placebo-controlled study of three dosages of Cerebrolysin in patients with mild to moderate Alzheimer’s disease. - Eur J Neurol. - 2006. - Vol. 3. - P. 43-54.</mixed-citation><mixed-citation xml:lang="en">Alvarez X.A., Cacabelos R., Laredo M., Couceiro V., Sampedro C., Varela M., Corzo L., Fernandez-Novoa L., Vargas M., Aleixandre M., Linares C., Granizo E., Muresanu D. and Moessler H. A 24-week, doubleblind, placebo-controlled study of three dosages of Cerebrolysin in patients with mild to moderate Alzheimer’s disease. - Eur J Neurol. - 2006. - Vol. 3. - P. 43-54.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Alvarez X.A., Lombardi V.R., Corzo L., Perez P., Pichel V., Laredo M., Hernandez A., Freixeiro F., Sampedro C., Lorenzo R., Alcaraz M., Windisch M. and Cacabelos R. [2000]. Oral Cerebrolysin enhances brain alpha activity and improves cognitive performance in elderly control subjects. - J Neural Transm Suppl. - 2000. - Vol. 59. - P. 315-328.</mixed-citation><mixed-citation xml:lang="en">Alvarez X.A., Lombardi V.R., Corzo L., Perez P., Pichel V., Laredo M., Hernandez A., Freixeiro F., Sampedro C., Lorenzo R., Alcaraz M., Windisch M. and Cacabelos R. [2000]. Oral Cerebrolysin enhances brain alpha activity and improves cognitive performance in elderly control subjects. - J Neural Transm Suppl. - 2000. - Vol. 59. - P. 315-328.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Alvarez X.A., Lombardi V.R., Fernandez-Novoa L., Garcia M., Sampedro C., Cagiao A., Cacabelos R. and Windisch M. Cerebrolysin reduces microglial activation in vivo and in vitro: a potential mechanism of neuroprotection. J Neural Transm Suppl. - 2000. - Vol. 59 - P. 281-292.</mixed-citation><mixed-citation xml:lang="en">Alvarez X.A., Lombardi V.R., Fernandez-Novoa L., Garcia M., Sampedro C., Cagiao A., Cacabelos R. and Windisch M. Cerebrolysin reduces microglial activation in vivo and in vitro: a potential mechanism of neuroprotection. J Neural Transm Suppl. - 2000. - Vol. 59 - P. 281-292.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Babenkova I.V., Teselkin Iu O., Makashova N.V. and Guseva M.R. [Antioxidative activity of histo-chrome and some other drugs used in ophthalmology]. Vestn Oftalmol. - 1999.- Vol. 115.-P. 22-24.</mixed-citation><mixed-citation xml:lang="en">Babenkova I.V., Teselkin Iu O., Makashova N.V. and Guseva M.R. [Antioxidative activity of histo-chrome and some other drugs used in ophthalmology]. Vestn Oftalmol. - 1999.- Vol. 115.-P. 22-24.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Baskys A. and Wojtowicz J.M. Effects of brain tissue hydrolysate on synaptic transmission in the hippocampus. Pharmacol Biochem Behav.- 1994. Vol. 49. - P. 1105-1107.</mixed-citation><mixed-citation xml:lang="en">Baskys A. and Wojtowicz J.M. Effects of brain tissue hydrolysate on synaptic transmission in the hippocampus. Pharmacol Biochem Behav.- 1994. Vol. 49. - P. 1105-1107.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Bayer E. [Therapy with the cerebral hydrolysate cerebrolysin. A practice report]. Med Welt. - 1980. - Vol. 31. - P. 636-637.</mixed-citation><mixed-citation xml:lang="en">Bayer E. [Therapy with the cerebral hydrolysate cerebrolysin. A practice report]. Med Welt. - 1980. - Vol. 31. - P. 636-637.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Belokrylov G.A. and Malchanova I.V. [Levamin and cerebrolysin as immunostimulants]. Biull Eksp Biol Med. - 1992.- Vol. 113. - P. 165-166.</mixed-citation><mixed-citation xml:lang="en">Belokrylov G.A. and Malchanova I.V. [Levamin and cerebrolysin as immunostimulants]. Biull Eksp Biol Med. - 1992.- Vol. 113. - P. 165-166.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Bespalova M.A., Kliaich K., Maksimova S.P., Chaeva L.S. and Mukhina A.P. [The characteristics of the brain cerebrosides, sulfocerebrosides and gan-gliosides in experimental demyelination and cerebrolysin administration]. Nerv Sist.- 1991.- Vol. 30. - P. 64-71.</mixed-citation><mixed-citation xml:lang="en">Bespalova M.A., Kliaich K., Maksimova S.P., Chaeva L.S. and Mukhina A.P. [The characteristics of the brain cerebrosides, sulfocerebrosides and gan-gliosides in experimental demyelination and cerebrolysin administration]. Nerv Sist.- 1991.- Vol. 30. - P. 64-71.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Boado R.J. Brain-derived peptides regulate the steady state levels and increase stability of the blood-brain barrier GLUT1 glucose transporter mRNA. Neurosci Lett. - 1995. - Vol. 197. - P. 179182.</mixed-citation><mixed-citation xml:lang="en">Boado R.J. Brain-derived peptides regulate the steady state levels and increase stability of the blood-brain barrier GLUT1 glucose transporter mRNA. Neurosci Lett. - 1995. - Vol. 197. - P. 179182.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Boado R.J. Brain-derived peptides increase the expression of a blood-brain barrier GLUT1 glucose transporter reporter gene. Neurosci Lett-1996. - Vol. 220. - P. 53-56.</mixed-citation><mixed-citation xml:lang="en">Boado R.J. Brain-derived peptides increase the expression of a blood-brain barrier GLUT1 glucose transporter reporter gene. Neurosci Lett-1996. - Vol. 220. - P. 53-56.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Boado R.J. Brain-derived peptides increase blood-brain barrier GLUT1 glucose transporter gene expression via mRNA stabilization. Neurosci Lett. - 1998. - Vol. 255. - P. 147-150.</mixed-citation><mixed-citation xml:lang="en">Boado R.J. Brain-derived peptides increase blood-brain barrier GLUT1 glucose transporter gene expression via mRNA stabilization. Neurosci Lett. - 1998. - Vol. 255. - P. 147-150.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Boado R.J. Post-transcription modulation of the blood-brain barrier GLUT1 glucose transporter by brain-derived factors. J Neural Transm Suppl. - 2000. - Vol. 59. - P. 255-261.</mixed-citation><mixed-citation xml:lang="en">Boado R.J. Post-transcription modulation of the blood-brain barrier GLUT1 glucose transporter by brain-derived factors. J Neural Transm Suppl. - 2000. - Vol. 59. - P. 255-261.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Boado R.J. Amplification of blood-brain barrier GLUT1 glucose transporter gene expression by brain-derived peptides. Neurosci Res. - 2001. - Vol. 40. - P. 337-342.</mixed-citation><mixed-citation xml:lang="en">Boado R.J. Amplification of blood-brain barrier GLUT1 glucose transporter gene expression by brain-derived peptides. Neurosci Res. - 2001. - Vol. 40. - P. 337-342.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Boado R.J., Wu D. and Windisch M. In vivo upregu-lation of the blood-brain barrier GLUT1 glucose transporter by brain-derived peptides. Neurosci Res. - 1999. - Vol. 34. - P. 217-224.</mixed-citation><mixed-citation xml:lang="en">Boado R.J., Wu D. and Windisch M. In vivo upregu-lation of the blood-brain barrier GLUT1 glucose transporter by brain-derived peptides. Neurosci Res. - 1999. - Vol. 34. - P. 217-224.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Bulon V.V., Kuznetsova N.N., Selina E.N., Kovalenko A.L., Alekseeva L.E. and Sapronov N.S. Neuroprotective effect of cytoflavin during compression injury of the spinal cord. Bull Exp Biol Med. - 2005. - Vol. 139. - P.- 394-396.</mixed-citation><mixed-citation xml:lang="en">Bulon V.V., Kuznetsova N.N., Selina E.N., Kovalenko A.L., Alekseeva L.E. and Sapronov N.S. Neuroprotective effect of cytoflavin during compression injury of the spinal cord. Bull Exp Biol Med. - 2005. - Vol. 139. - P.- 394-396.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Bures J., Koroleva V.I., Korolev O.S. and Mares V. [Shifts in the constant potential in the structures of the rat brain in focal ischemia and systemic hypoxia]. Zh Vyssh Nerv Deiat Im I P Pavlova. - 998 -Vol. 48. - P. 640-653.</mixed-citation><mixed-citation xml:lang="en">Bures J., Koroleva V.I., Korolev O.S. and Mares V. [Shifts in the constant potential in the structures of the rat brain in focal ischemia and systemic hypoxia]. Zh Vyssh Nerv Deiat Im I P Pavlova. - 998 -Vol. 48. - P. 640-653.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Buresh Y., Koroleva V.I., Korolev O.S. and Maresh V. Changes in the constant potential in brain structures in rats during focal ischemia and systemic hypoxia. Neurosci Behav Physiol. - 1999. - Vol. 29. - P. 569-579.</mixed-citation><mixed-citation xml:lang="en">Buresh Y., Koroleva V.I., Korolev O.S. and Maresh V. Changes in the constant potential in brain structures in rats during focal ischemia and systemic hypoxia. Neurosci Behav Physiol. - 1999. - Vol. 29. - P. 569-579.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Crook T.H., Ferris S.H., Alvarez X.A., Laredo M. and Moessler H. Effects of N-PEP-12 on memory among older adults. Int Clin Psychopharmacol.- 2005. - Vol. 20. - P. 97-100.</mixed-citation><mixed-citation xml:lang="en">Crook T.H., Ferris S.H., Alvarez X.A., Laredo M. and Moessler H. Effects of N-PEP-12 on memory among older adults. Int Clin Psychopharmacol.- 2005. - Vol. 20. - P. 97-100.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Cruz R., Francis L., Diaz-Suarez C.M. and Gonzalez-Fraguela M.E. [Short-term effects of septohippocampal pathway transsection and cerebrolysin effects on glutathione-related enzymes in the rat brain]. Rev Neurol. - 1998. - Vol. 26. - P. 551-554.</mixed-citation><mixed-citation xml:lang="en">Cruz R., Francis L., Diaz-Suarez C.M. and Gonzalez-Fraguela M.E. [Short-term effects of septohippocampal pathway transsection and cerebrolysin effects on glutathione-related enzymes in the rat brain]. Rev Neurol. - 1998. - Vol. 26. - P. 551-554.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Deigner H.P., Haberkorn U. and Kinscherf R. Apoptosis modulators in the therapy of neurodegenerative diseases. Expert Opin Investig Drugs. -2000. - Vol. 9. - P. 747-764.</mixed-citation><mixed-citation xml:lang="en">Deigner H.P., Haberkorn U. and Kinscherf R. Apoptosis modulators in the therapy of neurodegenerative diseases. Expert Opin Investig Drugs. -2000. - Vol. 9. - P. 747-764.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Domzal T. and Zaleska B. [Cerebrolysin in treatment of acute ischemic stroke]. Neurol Neurochir Pol. - 1995. - Vol. 29. - P. 325-331.</mixed-citation><mixed-citation xml:lang="en">Domzal T. and Zaleska B. [Cerebrolysin in treatment of acute ischemic stroke]. Neurol Neurochir Pol. - 1995. - Vol. 29. - P. 325-331.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Eder P., Reinprecht I., Schreiner E., Skofitsch G. and Windisch M. Increased density of glutamate receptor subunit 1 due to Cerebrolysin treatment: an immunohistochemical study on aged rats. Histochem J. - 2001. - Vol. 33. - P. 605-612.</mixed-citation><mixed-citation xml:lang="en">Eder P., Reinprecht I., Schreiner E., Skofitsch G. and Windisch M. Increased density of glutamate receptor subunit 1 due to Cerebrolysin treatment: an immunohistochemical study on aged rats. Histochem J. - 2001. - Vol. 33. - P. 605-612.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Francis-Turner L. and Valouskova V. Nerve growth factor and nootropic drug Cerebrolysin but not fibroblast growth factor can reduce spatial memory impairment elicited by fimbria-fornix transection: short-term study. Neurosci Lett. - 1996. - Vol. 202. - P. 193-196.</mixed-citation><mixed-citation xml:lang="en">Francis-Turner L. and Valouskova V. Nerve growth factor and nootropic drug Cerebrolysin but not fibroblast growth factor can reduce spatial memory impairment elicited by fimbria-fornix transection: short-term study. Neurosci Lett. - 1996. - Vol. 202. - P. 193-196.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Francis-Turner L., Valouskova V. and Mokry J. The long-term Cerebrolysin Review - Wise Young -Page 25 effect of NGF, b-FGF and Cerebrolysin on the spatial memory after fimbria-fornix lesion in rats. J Neural Transm Suppl. - 1996. - Vol. 47 - P 277.</mixed-citation><mixed-citation xml:lang="en">Francis-Turner L., Valouskova V. and Mokry J. The long-term Cerebrolysin Review - Wise Young -Page 25 effect of NGF, b-FGF and Cerebrolysin on the spatial memory after fimbria-fornix lesion in rats. J Neural Transm Suppl. - 1996. - Vol. 47 - P 277.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Gannushkina I.V., Antelava A.L. and Baranchikova M.V. [Effect of the nootropic agent cerebrolysin in cerebral ischemia in rats with varying behavioral reactions in the open field test]. Patol Fiziol Eksp Ter. - 1998. - P. 3-8.</mixed-citation><mixed-citation xml:lang="en">Gannushkina I.V., Antelava A.L. and Baranchikova M.V. [Effect of the nootropic agent cerebrolysin in cerebral ischemia in rats with varying behavioral reactions in the open field test]. Patol Fiziol Eksp Ter. - 1998. - P. 3-8.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Gavrilova S.I., Kolykhalov I.V., Korovaitseva G.I., Zharikov G.A., Kalyn Ia B. and Selezneva N.D. [ApoE genotype and efficacy of neurotrophic and cholinergic therapy in Alzheimer’s disease]. Zh Nevrol Psikhiatr Im S S Korsakova. - 2005. - Vol. 105. - P. 27-34.</mixed-citation><mixed-citation xml:lang="en">Gavrilova S.I., Kolykhalov I.V., Korovaitseva G.I., Zharikov G.A., Kalyn Ia B. and Selezneva N.D. [ApoE genotype and efficacy of neurotrophic and cholinergic therapy in Alzheimer’s disease]. Zh Nevrol Psikhiatr Im S S Korsakova. - 2005. - Vol. 105. - P. 27-34.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Gershman R.N. and Vasilenko M.A. [Use of cerebrolysin and ATP in treating infantile cerebral paralysis]. Pediatr Akus Ginekol. - 1975. - P. 22-23.</mixed-citation><mixed-citation xml:lang="en">Gershman R.N. and Vasilenko M.A. [Use of cerebrolysin and ATP in treating infantile cerebral paralysis]. Pediatr Akus Ginekol. - 1975. - P. 22-23.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Gomazkov O.A. [Apoptosis in neuronal structures and the role of neurotrophic growth factors. Biochemical mechanisms of brain derived peptide preparations]. Zh Nevrol Psikhiatr Im S.S. Korsakova. - 2002. - P. 17-21.</mixed-citation><mixed-citation xml:lang="en">Gomazkov O.A. [Apoptosis in neuronal structures and the role of neurotrophic growth factors. Biochemical mechanisms of brain derived peptide preparations]. Zh Nevrol Psikhiatr Im S.S. Korsakova. - 2002. - P. 17-21.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Gorbachevskaya N, Bashina V, Gratchev V and Iznak A [2001]. Cerebrolysin therapy in Rett syndrome: clinical and EEG mapping study. Brain Dev. 23 Suppl 1:S90-3.</mixed-citation><mixed-citation xml:lang="en">Gorbachevskaya N, Bashina V, Gratchev V and Iznak A [2001]. Cerebrolysin therapy in Rett syndrome: clinical and EEG mapping study. Brain Dev. 23 Suppl 1:S90-3.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Grechko A.T. [The neurotropic activity of peptide immunomodulators]. Eksp Klin Farmakol. - 1998. - Vol. 61. - P. 14-16.</mixed-citation><mixed-citation xml:lang="en">Grechko A.T. [The neurotropic activity of peptide immunomodulators]. Eksp Klin Farmakol. - 1998. - Vol. 61. - P. 14-16.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Gromova O.A., Kudrin A.V, Kataev S.I., Mazina S.S. and Volkov A. [Effects of cerebrolysin on trace element homeostasis in the brain]. Zh Nevrol Psikhiatr Im S.S. Korsakova. - 2003.- Vol. 103. - P. 59-61.</mixed-citation><mixed-citation xml:lang="en">Gromova O.A., Kudrin A.V, Kataev S.I., Mazina S.S. and Volkov A. [Effects of cerebrolysin on trace element homeostasis in the brain]. Zh Nevrol Psikhiatr Im S.S. Korsakova. - 2003.- Vol. 103. - P. 59-61.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Grundman M., Corey-Bloom J. and Thal L.J. Perspectives in clinical Alzheimer’s disease research and the development of Cerebrolysin Review - Wise Young - Page 19 antidementia drugs. J Neural Transm Suppl. - 1998. - Vol. 53. - P. 255-275.</mixed-citation><mixed-citation xml:lang="en">Grundman M., Corey-Bloom J. and Thal L.J. Perspectives in clinical Alzheimer’s disease research and the development of Cerebrolysin Review - Wise Young - Page 19 antidementia drugs. J Neural Transm Suppl. - 1998. - Vol. 53. - P. 255-275.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Gschanes A. and Windisch M. The influence of Cerebrolysin and E021 on spatial navigation of young rats. J Neural Transm Suppl. - 1996. - Vol. 47. - P. 278.</mixed-citation><mixed-citation xml:lang="en">Gschanes A. and Windisch M. The influence of Cerebrolysin and E021 on spatial navigation of young rats. J Neural Transm Suppl. - 1996. - Vol. 47. - P. 278.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Gschanes A. and Windisch M. Early postnatal treatment with peptide preparations influences spatial navigation of young and adult rats. Behav Brain Res. - 1999. - Vol. 100. - P. 161-166.</mixed-citation><mixed-citation xml:lang="en">Gschanes A. and Windisch M. Early postnatal treatment with peptide preparations influences spatial navigation of young and adult rats. Behav Brain Res. - 1999. - Vol. 100. - P. 161-166.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Gschanes A., Boado R., Sametz W. and Windisch M. The drug cerebrolysin and its peptide fraction E021 increase the abundance of the blood-brain barrier GLUT1 glucose transporter in brains of young and old rats. Histochem J. - 2000. - Vol. 32. - P. 71-77.</mixed-citation><mixed-citation xml:lang="en">Gschanes A., Boado R., Sametz W. and Windisch M. The drug cerebrolysin and its peptide fraction E021 increase the abundance of the blood-brain barrier GLUT1 glucose transporter in brains of young and old rats. Histochem J. - 2000. - Vol. 32. - P. 71-77.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Gusev E.I., Burd G.S., Gekht A.B., Skvortsova V.I., Bogomolova M.A., Selikhova M.V. and Fidler S.M. [The clinico-neurophysiological study of the effect of cerebrolysin on brain function in the acute and early recovery periods of hemispheric ischemic stroke]. Zh Nevropatol Psikhiatr Im S.S. Korsakova. - 1994. - Vol. 94. - P. 9-13.</mixed-citation><mixed-citation xml:lang="en">Gusev E.I., Burd G.S., Gekht A.B., Skvortsova V.I., Bogomolova M.A., Selikhova M.V. and Fidler S.M. [The clinico-neurophysiological study of the effect of cerebrolysin on brain function in the acute and early recovery periods of hemispheric ischemic stroke]. Zh Nevropatol Psikhiatr Im S.S. Korsakova. - 1994. - Vol. 94. - P. 9-13.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Guseva M.R. and Dubovsakia L.A. [The efficiency of the use of cerebrolysin in optic nerve diseases in children of different age]. Vestn Oftalmol. - 2005. - Vol. 121. - P. 17-20.</mixed-citation><mixed-citation xml:lang="en">Guseva M.R. and Dubovsakia L.A. [The efficiency of the use of cerebrolysin in optic nerve diseases in children of different age]. Vestn Oftalmol. - 2005. - Vol. 121. - P. 17-20.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Gutmann B., Hutter-Paier B., Skofitsch G., Windisch M. and Gmeinbauer R. In vitro models of brain ischemia: the peptidergic drug cerebrolysin protects cultured chick cortical neurons from cell death. Neurotox Res. - 2002. - Vol. 4. - P. 59-65.</mixed-citation><mixed-citation xml:lang="en">Gutmann B., Hutter-Paier B., Skofitsch G., Windisch M. and Gmeinbauer R. In vitro models of brain ischemia: the peptidergic drug cerebrolysin protects cultured chick cortical neurons from cell death. Neurotox Res. - 2002. - Vol. 4. - P. 59-65.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Haninec P., Dubovy P., Samal F., Houstava L. and Stejskal L. Reinnervation of the rat musculocutaneous nerve stump after its direct reconnection with the C5 spinal cord segment by the nerve graft following avulsion of the ventral spinal roots: a comparison of intrathecal administration of brain-derived neurotrophic factor and Cerebrolysin. Exp Brain Res. - 2004. - Vol. 159. - P. 425-432.</mixed-citation><mixed-citation xml:lang="en">Haninec P., Dubovy P., Samal F., Houstava L. and Stejskal L. Reinnervation of the rat musculocutaneous nerve stump after its direct reconnection with the C5 spinal cord segment by the nerve graft following avulsion of the ventral spinal roots: a comparison of intrathecal administration of brain-derived neurotrophic factor and Cerebrolysin. Exp Brain Res. - 2004. - Vol. 159. - P. 425-432.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Haninec P., Houstava L., Stejskal L. and Dubovy P. Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin. Ann Anat. - 2003. - Vol. 185. - P. 233-238.</mixed-citation><mixed-citation xml:lang="en">Haninec P., Houstava L., Stejskal L. and Dubovy P. Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin. Ann Anat. - 2003. - Vol. 185. - P. 233-238.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Hartbauer M., Hutter-Paie B. and Windisch M. Cerebrolysin on the outgrowth and protection of processes of cultured brain neurons. J Neural Transm. - 2001. - Vol. 108. - P. 581-592.</mixed-citation><mixed-citation xml:lang="en">Hartbauer M., Hutter-Paie B. and Windisch M. Cerebrolysin on the outgrowth and protection of processes of cultured brain neurons. J Neural Transm. - 2001. - Vol. 108. - P. 581-592.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Hutter-Paier B., Eggenreich U. and Windisch M. Dosedependent behavioural effects of two proteinfree peptide derivatives on the passive avoidance reaction of rats. Arzneimittelforschung. - 1996. - Vol. 46. - P. 242-246.</mixed-citation><mixed-citation xml:lang="en">Hutter-Paier B., Eggenreich U. and Windisch M. Dosedependent behavioural effects of two proteinfree peptide derivatives on the passive avoidance reaction of rats. Arzneimittelforschung. - 1996. - Vol. 46. - P. 242-246.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Hutter-Paier B., Eggenreich U. and Windisch M. Effects of two protein-free peptide derivatives on passive avoidance behaviour of 24-month-old rats. Arzneimittelforschung. - 1996. - Vol. 46. - P. 237-241.</mixed-citation><mixed-citation xml:lang="en">Hutter-Paier B., Eggenreich U. and Windisch M. Effects of two protein-free peptide derivatives on passive avoidance behaviour of 24-month-old rats. Arzneimittelforschung. - 1996. - Vol. 46. - P. 237-241.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Hutter-Paier B., Fruhwirth M., Grygar E. and Windisch M. Cerebrolysin protects neurons from ischemia-induced loss of microtubule-associated protein 2. J Neural Transm Suppl. - 1996. - Vol. 47. - P. 276.</mixed-citation><mixed-citation xml:lang="en">Hutter-Paier B., Fruhwirth M., Grygar E. and Windisch M. Cerebrolysin protects neurons from ischemia-induced loss of microtubule-associated protein 2. J Neural Transm Suppl. - 1996. - Vol. 47. - P. 276.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Hutter-Paier B., Grygar E. and Windisch M. Death of cultured telencephalon neurons induced by glutamate is reduced by the peptide derivative Cerebrolysin. J Neural Transm Suppl. - 1996. - Vol. 47. - P. 267-273.</mixed-citation><mixed-citation xml:lang="en">Hutter-Paier B., Grygar E. and Windisch M. Death of cultured telencephalon neurons induced by glutamate is reduced by the peptide derivative Cerebrolysin. J Neural Transm Suppl. - 1996. - Vol. 47. - P. 267-273.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Hutter-Paier B., Grygar E., Fruhwirth M., Temmel I. and Windisch M. Further evidence that Cerebrolysin protects cortical neurons from neurodegeneration in vitro. J Neural Transm Suppl. - 1998. - Vol. 53. - P. 363-372.</mixed-citation><mixed-citation xml:lang="en">Hutter-Paier B., Grygar E., Fruhwirth M., Temmel I. and Windisch M. Further evidence that Cerebrolysin protects cortical neurons from neurodegeneration in vitro. J Neural Transm Suppl. - 1998. - Vol. 53. - P. 363-372.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Hutter-Paier B., Steiner E. and Windisch M. Cerebrolysin protects isolated cortical neurons from neurodegeneration after brief histotoxic hypoxia. J Neural Transm Suppl. - 1998. - Vol. 53. - P. 351361.</mixed-citation><mixed-citation xml:lang="en">Hutter-Paier B., Steiner E. and Windisch M. Cerebrolysin protects isolated cortical neurons from neurodegeneration after brief histotoxic hypoxia. J Neural Transm Suppl. - 1998. - Vol. 53. - P. 351361.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Ishchenko M.M. and Ostrovskaia O.S. [The effect of combined drug treatment on rheologic properties of the blood in patients with disordered circulatory encephalopathy]. Vrach Delo. - 1990. - P. 58-60.</mixed-citation><mixed-citation xml:lang="en">Ishchenko M.M. and Ostrovskaia O.S. [The effect of combined drug treatment on rheologic properties of the blood in patients with disordered circulatory encephalopathy]. Vrach Delo. - 1990. - P. 58-60.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Kofler B., Erhart C., Erhart P. and Harrer G. [The usefulness of event-related negativity in demonstrating the therapeutic effects of nootropic drugs using cerebrolysin as an example]. EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb. - 1990. - Vol. 21. - P. 145-149.</mixed-citation><mixed-citation xml:lang="en">Kofler B., Erhart C., Erhart P. and Harrer G. [The usefulness of event-related negativity in demonstrating the therapeutic effects of nootropic drugs using cerebrolysin as an example]. EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb. - 1990. - Vol. 21. - P. 145-149.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Koppi S. and Barolin G.S. [Hemodilution therapy with neuron metabolism specific therapy in ischemic stroke-encouraging results of a comparative study]. Wien Med Wochenschr. - 1996. - Vol. 146. - P. 41-48.</mixed-citation><mixed-citation xml:lang="en">Koppi S. and Barolin G.S. [Hemodilution therapy with neuron metabolism specific therapy in ischemic stroke-encouraging results of a comparative study]. Wien Med Wochenschr. - 1996. - Vol. 146. - P. 41-48.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Koroleva V.I., Korolev O.S., Loseva E. and Bures. The effect of MK-801 and of brain-derived polypeptides on the development of ischemic lesion induced by photothrombotic occlusion of the distal middle cerebral artery in rats. Brain Res. - 1998. - Vol. 786. - P. 104-114.</mixed-citation><mixed-citation xml:lang="en">Koroleva V.I., Korolev O.S., Loseva E. and Bures. The effect of MK-801 and of brain-derived polypeptides on the development of ischemic lesion induced by photothrombotic occlusion of the distal middle cerebral artery in rats. Brain Res. - 1998. - Vol. 786. - P. 104-114.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Koroleva V.I., Korolev O.S., Mares V., Pastalkova E. and Bures J. Hippocampal damage induced by carbon monoxide poisoning and spreading depression is alleviated by chronic treatment with brain derived polypeptides. Brain Res. - 1999. - Vol. 816. - P. 618-627.</mixed-citation><mixed-citation xml:lang="en">Koroleva V.I., Korolev O.S., Mares V., Pastalkova E. and Bures J. Hippocampal damage induced by carbon monoxide poisoning and spreading depression is alleviated by chronic treatment with brain derived polypeptides. Brain Res. - 1999. - Vol. 816. - P. 618-627.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Krasnoperova M.G., Bashina V.M., Skvortsov I.A. and Simashkova N.V. [The effect of cerebrolysin on cognitive functions in childhood autism and in Asperger syndrome]. Zh Nevrol Psikhiatr Im S.S. Korsakova. - 2003. - Vol. 103. - P. 15-18.</mixed-citation><mixed-citation xml:lang="en">Krasnoperova M.G., Bashina V.M., Skvortsov I.A. and Simashkova N.V. [The effect of cerebrolysin on cognitive functions in childhood autism and in Asperger syndrome]. Zh Nevrol Psikhiatr Im S.S. Korsakova. - 2003. - Vol. 103. - P. 15-18.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Ladurner G., Kalvach P. and Moessler H. Neuro-protective treatment with cerebrolysin in patients with acute stroke: a randomised controlled trial. J Neural Transm. - 2005. - Vol. 112. - P. 415-428.</mixed-citation><mixed-citation xml:lang="en">Ladurner G., Kalvach P. and Moessler H. Neuro-protective treatment with cerebrolysin in patients with acute stroke: a randomised controlled trial. J Neural Transm. - 2005. - Vol. 112. - P. 415-428.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Lindner G., Grosse G., Matthies H. and Kirsche W. [Effects of brain extract and hydrolysate on nerve tissue in vitro]. Z Mikrosk Anat Forsch. - 1975. - Vol. 89. - P. 815-823.</mixed-citation><mixed-citation xml:lang="en">Lindner G., Grosse G., Matthies H. and Kirsche W. [Effects of brain extract and hydrolysate on nerve tissue in vitro]. Z Mikrosk Anat Forsch. - 1975. - Vol. 89. - P. 815-823.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Litvintsev S.V., Shamrei V.K., Reznik A.M. and Arbuzov A.L. [Perspectives on the treatment of organic mental disorders by the use of nootropic agents]. Voen Med Zh. - 2002. - Vol. 323. - P. 59-62.</mixed-citation><mixed-citation xml:lang="en">Litvintsev S.V., Shamrei V.K., Reznik A.M. and Arbuzov A.L. [Perspectives on the treatment of organic mental disorders by the use of nootropic agents]. Voen Med Zh. - 2002. - Vol. 323. - P. 59-62.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Lombardi V.R., Windisch M., Garcia M. and Cacabelos R. Effects of Cerebrolysin on in vitro primary microglial and astrocyte rat cell cultures. Methods Find Exp Clin Pharmacol. - 1999. - Vol. 21. - P. 331-338.</mixed-citation><mixed-citation xml:lang="en">Lombardi V.R., Windisch M., Garcia M. and Cacabelos R. Effects of Cerebrolysin on in vitro primary microglial and astrocyte rat cell cultures. Methods Find Exp Clin Pharmacol. - 1999. - Vol. 21. - P. 331-338.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Makarenko A.N., Kositsin N.S., Nazimov I.V., Svinov M.M., Goloborod’ko E.V. and Pasikova N.V. [A comparative study of antistroke activity of the new drug “cerebral” and its fractions in rats]. Eksp Klin Farmakol. - 2005. - Vol. 68. - P. 15-20.</mixed-citation><mixed-citation xml:lang="en">Makarenko A.N., Kositsin N.S., Nazimov I.V., Svinov M.M., Goloborod’ko E.V. and Pasikova N.V. [A comparative study of antistroke activity of the new drug “cerebral” and its fractions in rats]. Eksp Klin Farmakol. - 2005. - Vol. 68. - P. 15-20.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Mallory M., Honer W., Hsu L., Johnson R., Rockenstein E. and Masliah E. In vitro synaptotrophic effects of Cerebrolysin in NT2N cells. Acta Neuropathol [Berl]. -1999. - Vol. 97. - P. 437-446.</mixed-citation><mixed-citation xml:lang="en">Mallory M., Honer W., Hsu L., Johnson R., Rockenstein E. and Masliah E. In vitro synaptotrophic effects of Cerebrolysin in NT2N cells. Acta Neuropathol [Berl]. -1999. - Vol. 97. - P. 437-446.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Masliah E., Armasolo F., Veinbergs I., Mallory M. and Samuel W. Cerebrolysin ameliorates performance deficits, and neuronal damage in apo-lipoprotein E-deficient mice. Pharmacol Biochem Behav. - 1999. - Vol. 62. - P. 239-245.</mixed-citation><mixed-citation xml:lang="en">Masliah E., Armasolo F., Veinbergs I., Mallory M. and Samuel W. Cerebrolysin ameliorates performance deficits, and neuronal damage in apo-lipoprotein E-deficient mice. Pharmacol Biochem Behav. - 1999. - Vol. 62. - P. 239-245.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Matula C. and Schoeggl A. Cerebral protection before, during and after neurosurgical procedures. Stereotact Funct Neurosurg. - 2000. - Vol. 75. - P. 142-146.</mixed-citation><mixed-citation xml:lang="en">Matula C. and Schoeggl A. Cerebral protection before, during and after neurosurgical procedures. Stereotact Funct Neurosurg. - 2000. - Vol. 75. - P. 142-146.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Medvecky J., Jassova Z. and Medvecka E. [Findings in treatment with cerebrolysin]. Cesk Psychi-atr. -1982. - Vol. 78. - P. 308-311.</mixed-citation><mixed-citation xml:lang="en">Medvecky J., Jassova Z. and Medvecka E. [Findings in treatment with cerebrolysin]. Cesk Psychi-atr. -1982. - Vol. 78. - P. 308-311.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Molloy D.W. and Standish T.I. Clinical experience with Cerebrolysin. J Neural Transm Suppl. - 2000. - Vol. 59. - P. 293-300.</mixed-citation><mixed-citation xml:lang="en">Molloy D.W. and Standish T.I. Clinical experience with Cerebrolysin. J Neural Transm Suppl. - 2000. - Vol. 59. - P. 293-300.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Mukhamedzhanov N.Z., Kurbanova D.U. and Tashkhodzhaeva Sh I. [The principles of the combined rehabilitation of patients with perinatal encephalopathy and its sequelae]. Vopr Kurortol Fizioter Lech Fiz Kult. - 1992. - P. 24-28.</mixed-citation><mixed-citation xml:lang="en">Mukhamedzhanov N.Z., Kurbanova D.U. and Tashkhodzhaeva Sh I. [The principles of the combined rehabilitation of patients with perinatal encephalopathy and its sequelae]. Vopr Kurortol Fizioter Lech Fiz Kult. - 1992. - P. 24-28.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Naidin V.L and Krotkova O.A. [Cerebrolysin electrophoresis in the correction of the mental defects in neurosurgery patients]. Zh Vopr Neirokhir Im N.N. Burdenko. - 1993. - P. 28-30.</mixed-citation><mixed-citation xml:lang="en">Naidin V.L and Krotkova O.A. [Cerebrolysin electrophoresis in the correction of the mental defects in neurosurgery patients]. Zh Vopr Neirokhir Im N.N. Burdenko. - 1993. - P. 28-30.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Nikolov R. Alzheimer’s disease therapy - an update. Drug News Perspect. - 1998. - Vol. 11. - P. 248-255.</mixed-citation><mixed-citation xml:lang="en">Nikolov R. Alzheimer’s disease therapy - an update. Drug News Perspect. - 1998. - Vol. 11. - P. 248-255.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Panisset M., Gauthier S., Moessler H. and Windisch M. Cerebrolysin in Alzheimer’s disease: a randomized, double-blind, placebo-controlled trial with a neurotrophic agent. J Neural Transm. - 2002. - Vol. 109. - P. 1089-1104.</mixed-citation><mixed-citation xml:lang="en">Panisset M., Gauthier S., Moessler H. and Windisch M. Cerebrolysin in Alzheimer’s disease: a randomized, double-blind, placebo-controlled trial with a neurotrophic agent. J Neural Transm. - 2002. - Vol. 109. - P. 1089-1104.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Panteleeva G.P., Bondar V.V., Krasnikova N.I. and Raiushkin V.A. [Cerebrolysin and magnesium-B6 in the treatment of side effects of psychotropic drugs]. Zh Nevrol Psikhiatr Im S.S. Korsakova. - 1999. - Vol. 99. - P. 37-41.</mixed-citation><mixed-citation xml:lang="en">Panteleeva G.P., Bondar V.V., Krasnikova N.I. and Raiushkin V.A. [Cerebrolysin and magnesium-B6 in the treatment of side effects of psychotropic drugs]. Zh Nevrol Psikhiatr Im S.S. Korsakova. - 1999. - Vol. 99. - P. 37-41.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Patockova J., Krsiak M., Marhol P. and Tumova E. Cerebrolysin inhibits lipid peroxidation induced by insulin hypoglycemia in the brain and heart of mice. Physiol Res. - 2003. - Vol. 52. - P. 455-460.</mixed-citation><mixed-citation xml:lang="en">Patockova J., Krsiak M., Marhol P. and Tumova E. Cerebrolysin inhibits lipid peroxidation induced by insulin hypoglycemia in the brain and heart of mice. Physiol Res. - 2003. - Vol. 52. - P. 455-460.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Reinprecht I., Gschanes A., Windisch M. and Fachbach G. Two peptidergic drugs increase the synaptophysin immunoreactivity in brains of 24-month-old rats. Histochem J. - 1999. - Vol. 31. - P. 395-401.</mixed-citation><mixed-citation xml:lang="en">Reinprecht I., Gschanes A., Windisch M. and Fachbach G. Two peptidergic drugs increase the synaptophysin immunoreactivity in brains of 24-month-old rats. Histochem J. - 1999. - Vol. 31. - P. 395-401.</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Riley C., Hutter-Paier B., Windisch M., Doppler E., Moessler H. and Wronski R. A peptide preparation protects cells in organotypic brain slices against cell death after glutamate intoxication. J Neural Transm. - 2006. - Vol. 113. - P. 103-110.</mixed-citation><mixed-citation xml:lang="en">Riley C., Hutter-Paier B., Windisch M., Doppler E., Moessler H. and Wronski R. A peptide preparation protects cells in organotypic brain slices against cell death after glutamate intoxication. J Neural Transm. - 2006. - Vol. 113. - P. 103-110.</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Rockenstein E., Torrance M., Mante M., Adame A., Paulino A., Rose J.B., Crews L., Moessler H. and Masliah E. Cerebrolysin decreases amyloid-beta production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer’s disease. J Neurosci Res. - 2006.</mixed-citation><mixed-citation xml:lang="en">Rockenstein E., Torrance M., Mante M., Adame A., Paulino A., Rose J.B., Crews L., Moessler H. and Masliah E. Cerebrolysin decreases amyloid-beta production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer’s disease. J Neurosci Res. - 2006.</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Roshchina I.F., Gavrilova S.I., Zharikov G.A., Kalyn Ia B., Kolykhalov I.V. and Selezneva N.D. [Neuropsychological evaluation of longterm therapy of Alzheimer’s disease using different cerebrolysin dosages]. Zh Nevrol Psikhiatr Im S.S. Korsakova. - 2005. - Vol. 105. - P. 52-55.</mixed-citation><mixed-citation xml:lang="en">Roshchina I.F., Gavrilova S.I., Zharikov G.A., Kalyn Ia B., Kolykhalov I.V. and Selezneva N.D. [Neuropsychological evaluation of longterm therapy of Alzheimer’s disease using different cerebrolysin dosages]. Zh Nevrol Psikhiatr Im S.S. Korsakova. - 2005. - Vol. 105. - P. 52-55.</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Safarova E.R., Shram S.I., Grivennikov I.A. and Myasoedov N.F Trophic effects of nootropic peptide preparations cerebrolysin and semax on cultured rat pheochromocytoma. Bull Exp Biol Med. - 2002. - Vol. 133. - P. 401-403.</mixed-citation><mixed-citation xml:lang="en">Safarova E.R., Shram S.I., Grivennikov I.A. and Myasoedov N.F Trophic effects of nootropic peptide preparations cerebrolysin and semax on cultured rat pheochromocytoma. Bull Exp Biol Med. - 2002. - Vol. 133. - P. 401-403.</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">Satou T., Itoh T., Tamai Y., Ohde H., Anderson A.J. and Hashimoto S. Neurotrophic effects of FPF-1070 [Cerebrolysin] on cultured neurons from chicken embryo dorsal root ganglia, ciliary ganglia, and sympathetic trunks. J Neural Transm. - 2000. - Vol. 107. - P. 1253-1262.</mixed-citation><mixed-citation xml:lang="en">Satou T., Itoh T., Tamai Y., Ohde H., Anderson A.J. and Hashimoto S. Neurotrophic effects of FPF-1070 [Cerebrolysin] on cultured neurons from chicken embryo dorsal root ganglia, ciliary ganglia, and sympathetic trunks. J Neural Transm. - 2000. - Vol. 107. - P. 1253-1262.</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">Schauer E., Wronski R., Patockova J., Moessler H., Doppler E., Hutter-Paier B. and Windisch M. Neuroprotection of Cerebrolysin in tissue culture models of brain ischemia: post lesion application indicates a wide therapeutic window. J Neural Transm. - 2005.</mixed-citation><mixed-citation xml:lang="en">Schauer E., Wronski R., Patockova J., Moessler H., Doppler E., Hutter-Paier B. and Windisch M. Neuroprotection of Cerebrolysin in tissue culture models of brain ischemia: post lesion application indicates a wide therapeutic window. J Neural Transm. - 2005.</mixed-citation></citation-alternatives></ref><ref id="cit78"><label>78</label><citation-alternatives><mixed-citation xml:lang="ru">Schwab M., Antonow-Schlorke I., Zwiener U. and Bauer R. Brain-derived peptides reduce the size of cerebral infarction and loss of MAP2 immunoreac-tivity after focal ischemia in rats. J Neural Transm Suppl. - 1998. - Vol. 53. - P. 299-311.</mixed-citation><mixed-citation xml:lang="en">Schwab M., Antonow-Schlorke I., Zwiener U. and Bauer R. Brain-derived peptides reduce the size of cerebral infarction and loss of MAP2 immunoreac-tivity after focal ischemia in rats. J Neural Transm Suppl. - 1998. - Vol. 53. - P. 299-311.</mixed-citation></citation-alternatives></ref><ref id="cit79"><label>79</label><citation-alternatives><mixed-citation xml:lang="ru">Schwab M., Bauer R. and Zwiener U. Physiological effects and brain protection by hypothermia and cerebrolysin after moderate forebrain ischemia in rats. Exp Toxicol Pathol. - 1997. - Vol. 49. - P. 105-116.</mixed-citation><mixed-citation xml:lang="en">Schwab M., Bauer R. and Zwiener U. Physiological effects and brain protection by hypothermia and cerebrolysin after moderate forebrain ischemia in rats. Exp Toxicol Pathol. - 1997. - Vol. 49. - P. 105-116.</mixed-citation></citation-alternatives></ref><ref id="cit80"><label>80</label><citation-alternatives><mixed-citation xml:lang="ru">Sugita Y., Kondo T., Kanazawa A., Itou T. and Mizuno Y. [Protective effect of FPF 1070 [cerebrolysin] on delayed neuronal death in the gerbil-detec-tion of hydroxyl radicals with salicylic acid]. No To Shinkei. - 1993. - Vol. 45. - P. 325-331.</mixed-citation><mixed-citation xml:lang="en">Sugita Y., Kondo T., Kanazawa A., Itou T. and Mizuno Y. [Protective effect of FPF 1070 [cerebrolysin] on delayed neuronal death in the gerbil-detec-tion of hydroxyl radicals with salicylic acid]. No To Shinkei. - 1993. - Vol. 45. - P. 325-331.</mixed-citation></citation-alternatives></ref><ref id="cit81"><label>81</label><citation-alternatives><mixed-citation xml:lang="ru">Trojanova M., Karasek F., Pruzkova V. and Mourek J. Influence of cerebrolysin[r] on the resistance of rats to anoxia. Physiol Bohemoslov. - 1976. - Vol. 25. - P. 319-323.</mixed-citation><mixed-citation xml:lang="en">Trojanova M., Karasek F., Pruzkova V. and Mourek J. Influence of cerebrolysin[r] on the resistance of rats to anoxia. Physiol Bohemoslov. - 1976. - Vol. 25. - P. 319-323.</mixed-citation></citation-alternatives></ref><ref id="cit82"><label>82</label><citation-alternatives><mixed-citation xml:lang="ru">Valouskova V. and Gschanes A. Effects of NGF, b-FGF, and cerebrolysin on water maze performance and on motor activity of rats: short- and longterm study. Neurobiol Learn Mem. - 1999. - Vol. 71. - P. 132-149.</mixed-citation><mixed-citation xml:lang="en">Valouskova V. and Gschanes A. Effects of NGF, b-FGF, and cerebrolysin on water maze performance and on motor activity of rats: short- and longterm study. Neurobiol Learn Mem. - 1999. - Vol. 71. - P. 132-149.</mixed-citation></citation-alternatives></ref><ref id="cit83"><label>83</label><citation-alternatives><mixed-citation xml:lang="ru">Veinbergs I., Mante M., Mallory M. and Masliah E. Neurotrophic effects of Cerebrolysin in animal models of excitotoxicity. J Neural Transm Suppl. - 2000. - Vol. 59. - P. 273-280.</mixed-citation><mixed-citation xml:lang="en">Veinbergs I., Mante M., Mallory M. and Masliah E. Neurotrophic effects of Cerebrolysin in animal models of excitotoxicity. J Neural Transm Suppl. - 2000. - Vol. 59. - P. 273-280.</mixed-citation></citation-alternatives></ref><ref id="cit84"><label>84</label><citation-alternatives><mixed-citation xml:lang="ru">Wenzel J., Stender G. and Duwe G. [Development of neuron structure of the fascia dentata in the rat. Neurohistologicomorphometric, ultrastructural and experimental study]. J Hirnforsch. - 1981. - Vol. 22. - P. 629-683.</mixed-citation><mixed-citation xml:lang="en">Wenzel J., Stender G. and Duwe G. [Development of neuron structure of the fascia dentata in the rat. Neurohistologicomorphometric, ultrastructural and experimental study]. J Hirnforsch. - 1981. - Vol. 22. - P. 629-683.</mixed-citation></citation-alternatives></ref><ref id="cit85"><label>85</label><citation-alternatives><mixed-citation xml:lang="ru">Windisch M. and Piswanger A. [Modification of rat brain metabolism by long-term treatment with a peptide derivative]. Arzneimittelforschung. - 1985. - Vol. 35. - P. 1353-1356.</mixed-citation><mixed-citation xml:lang="en">Windisch M. and Piswanger A. [Modification of rat brain metabolism by long-term treatment with a peptide derivative]. Arzneimittelforschung. - 1985. - Vol. 35. - P. 1353-1356.</mixed-citation></citation-alternatives></ref><ref id="cit86"><label>86</label><citation-alternatives><mixed-citation xml:lang="ru">Wronski R., Kronawetter S., Hutter-Paier B., Crailsheim K. and Windisch M. A brain derived peptide preparation reduces the translation dependent loss of a cytoskeletal protein in primary cultured chicken neurons. J Neural Transm Suppl. - 2000. - Vol. 59. - P. 263-272.</mixed-citation><mixed-citation xml:lang="en">Wronski R., Kronawetter S., Hutter-Paier B., Crailsheim K. and Windisch M. A brain derived peptide preparation reduces the translation dependent loss of a cytoskeletal protein in primary cultured chicken neurons. J Neural Transm Suppl. - 2000. - Vol. 59. - P. 263-272.</mixed-citation></citation-alternatives></ref><ref id="cit87"><label>87</label><citation-alternatives><mixed-citation xml:lang="ru">Xiong H., Baskys A. and Wojtowicz J.M. Brainderived peptides inhibit synaptic transmission via presynaptic GABAB receptors in CA1 area of rat hippocampal slices. Brain Res. - 1996. - Vol. 737. - P. 188-194.</mixed-citation><mixed-citation xml:lang="en">Xiong H., Baskys A. and Wojtowicz J.M. Brainderived peptides inhibit synaptic transmission via presynaptic GABAB receptors in CA1 area of rat hippocampal slices. Brain Res. - 1996. - Vol. 737. - P. 188-194.</mixed-citation></citation-alternatives></ref><ref id="cit88"><label>88</label><citation-alternatives><mixed-citation xml:lang="ru">Zemkova H., Kruek J. and Vyskocil F. Potentiation of GABAA receptor in cultured mouse hippocampal cells by brain-derived peptide mixture cerebrolysin. Physiol Res. - 1995. - Vol. 44. - P. 151-155.</mixed-citation><mixed-citation xml:lang="en">Zemkova H., Kruek J. and Vyskocil F. Potentiation of GABAA receptor in cultured mouse hippocampal cells by brain-derived peptide mixture cerebrolysin. Physiol Res. - 1995. - Vol. 44. - P. 151-155.</mixed-citation></citation-alternatives></ref><ref id="cit89"><label>89</label><citation-alternatives><mixed-citation xml:lang="ru">Zommer K. and Kvandt I. [The effect of brain hydrolysate on central nervous system structure]. Zh Nevropatol Psikhiatr Im S.S. Korsakova. -1975. - Vol. 75. - P. 1021-1025.</mixed-citation><mixed-citation xml:lang="en">Zommer K. and Kvandt I. [The effect of brain hydrolysate on central nervous system structure]. Zh Nevropatol Psikhiatr Im S.S. Korsakova. -1975. - Vol. 75. - P. 1021-1025.</mixed-citation></citation-alternatives></ref><ref id="cit90"><label>90</label><citation-alternatives><mixed-citation xml:lang="ru">Zuber V.L. [The effect of cerebrolysin on the metabolism of brain phospholipids in growing animals with experimental demyelination]. Nerv Sist. - 1991. - Vol. 30. - P. 85-90.</mixed-citation><mixed-citation xml:lang="en">Zuber V.L. [The effect of cerebrolysin on the metabolism of brain phospholipids in growing animals with experimental demyelination]. Nerv Sist. - 1991. - Vol. 30. - P. 85-90.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
