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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">bekhterev</journal-id><journal-title-group><journal-title xml:lang="ru">Обозрение психиатрии и медицинской психологии имени В.М.Бехтерева</journal-title><trans-title-group xml:lang="en"><trans-title>V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2313-7053</issn><issn pub-type="epub">2713-055X</issn><publisher><publisher-name>V. M. BEKHTEREV  NATIONAL  RESEARCH  MEDICAL  CENTER  FOR  PSYCHIATRY  AND  NEUROLOGY                           OF    THE  RUSSIAN  FEDERATION   MINISTRY  OF  HEALTH</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">bekhterev-19</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>В ПОМОЩЬ ПРАКТИКУЮЩЕМУ ВРАЧУ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GUIDELINES FOR THE PRACTITIONER</subject></subj-group></article-categories><title-group><article-title>Проблемы долгосрочной терапии деменции</article-title><trans-title-group xml:lang="en"><trans-title>Problems of long-term therapy of dementia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Залуцкая</surname><given-names>Наталья Михайловна</given-names></name><name name-style="western" xml:lang="en"><surname>Zalutskaya</surname><given-names>N. M.</given-names></name></name-alternatives><email xlink:type="simple">nzalutskaya@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Санкт-Петербургский научно-исследовательский психоневрологический институт им. В.М. Бехтерева</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.M. Bekhterev Psychoneurological Research Institute, Saint</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>19</day><month>07</month><year>2018</year></pub-date><volume>0</volume><issue>2</issue><fpage>78</fpage><lpage>85</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Залуцкая Н.М., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Залуцкая Н.М.</copyright-holder><copyright-holder xml:lang="en">Zalutskaya N.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.bekhterevreview.com/jour/article/view/19">https://www.bekhterevreview.com/jour/article/view/19</self-uri><abstract><p>В работе обсуждаются проблемы долгосрочной терапии деменции, приводятся сведения о факторах, играющих роль в формировании приверженности терапии больных, страдающих болезнью Альцгеймера, рассматриваются факторы, оказывающие влияние на организацию помощи дементным больным. Приводятся сведения о клинической и экономической эффективности применения акати-нола мемантина и возможности улучшения приверженности лечению при применении его однократной суточной дозы.</p></abstract><trans-abstract xml:lang="en"><p>The article discusses the problem of long-term therapy of dementia, provides information on factors playing a role in the formation of commitment to therapy in patients with Alzheimer’s disease, discusses factors that influence the organization of care to patients with dementia. The article presents data on the clinical and economical effectiveness of akatinol memantine and opportunities to improve adherence to treatment at application of a once-daily memantine</p></trans-abstract><kwd-group xml:lang="ru"><kwd>болезнь Альцгеймера</kwd><kwd>деменция</kwd><kwd>антидементивные препараты</kwd><kwd>акатинол меман-тин</kwd><kwd>приверженность</kwd><kwd>долгосрочная терапия</kwd><kwd>Alzheimer’s disease</kwd><kwd>dementia</kwd><kwd>antidementiv drug</kwd><kwd>akatinol memantine</kwd><kwd>adherence</kwd><kwd>long-term therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Белоусов Ю.Б. Зырянов С.К., Белоусов Д.Ю., Бекетов А.С. Клинико-экономические аспекты терапии болезни Альцгеймера в России. Качественная клиническая практика. - 2009. - № 1. - С. 3-28.</mixed-citation><mixed-citation xml:lang="en">Белоусов Ю.Б. 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