Te appearance of the biopsychosocial model of psychosis near the end of the past century opened the way to the integration of psychopharmacological and psychotherapeutic approaches to the therapy of psychoses. Te studies carried out since the beginning of the present century have demonstrated the undoubted advantage in the evidence-based effectiveness of the integrated models using the cognitive-behavioural therapy of psychoses over the monopharmacotherapy. Te problems of the further practical implementation of the biopsychosocial model in the therapy of psychoses and the ways of their solving are discussed.