bekhterevОбозрение психиатрии и медицинской психологии имени В.М.БехтереваV.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY2313-70532713-055XV. M. BEKHTEREV NATIONAL RESEARCH MEDICAL CENTER FOR PSYCHIATRY AND NEUROLOGY OF THE RUSSIAN FEDERATION MINISTRY OF HEALTH10.31363/2313-7053-2019-2-20-36bekhterev-245Research ArticleНАУЧНО-ИССЛЕДОВАТЕЛЬСКИЕ РАБОТЫRESEARCH PAPERSКогнитивные нарушения у пациентов с заболеваниями системы крови, перенесших трансплантацию аллогенных гемопоэтических стволовых клетокCognitive impairments in patients with hematological malignancies prior and after allogeneic hematopoietic stem cells transplantationВыборныхД. Э.VybornykhD. E.

Выборных Дмитрий Эдуардович ‒ доктор медицинских наук, заведующий лабораторией по изучению психических и неврологических расстройств при заболеваниях системы крови

Москва

dvyb@yandex.ruФедороваС. Ю.FedorovaS. Yu.

Фёдорова Светлана Юрьевна ‒ врач-невролог лаборатории по изучению психических и неврологических расстройств при заболеваниях системы крови

Москва

neuro_blood@mail.ruХрущевС. О.KhrushchevS. O.

Хрущёв Сергей Олегович ‒ медицинский психолог лаборатории по изучению психических и неврологических расстройств при заболеваниях системы крови

Москва

khrushchevsergei@gmail.comДроковМ. Ю.DrokovM. Yu.

Дроков Михаил Юрьевич ‒ кандидат медицинских наук, старший научный сотрудник отдела химиотерапии гемобластозов, депрессий кроветворения и трансплантации костного мозга

Москва

mdrokov@gmail.comГемджянЭ. Г.GemdzhianE. G.

Гемджян Эдуард Георгиевич ‒ старший научный сотрудник лаборатории биостатистики

Москва

edstat@mail.ruКузьминаЛ. А.KuzminaL. A.

Кузьмина Лариса Анатольевна ‒ кандидат медицинских наук, заведующая отделением интенсивной высокодозной химиотерапии и трансплантации костного мозга с круглосуточным и дневным стационарами

Москва

ПаровичниковаЕ. Н.ParovichnikovaE. N.

Паровичникова Елена Николаевна ‒ доктор медицинских наук, руководитель отдела химиотерапии гемобластозов, депрессий кроветворения и трансплантации костного мозга

Москва

elenap@blood.ruФГБУ «НМИЦ гематологии» Минздрава РоссииRussian FederationФГБУ «НМИЦ гематологии» Минздрава РоссииРоссияNational Research Center for HematologyRussian Federation201911072019022036Copyright © Выборных Д.Э., Федорова С.Ю., Хрущев С.О., Дроков М.Ю., Гемджян Э.Г., Кузьмина Л.А., Паровичникова Е.Н., 20192019Выборных Д.Э., Федорова С.Ю., Хрущев С.О., Дроков М.Ю., Гемджян Э.Г., Кузьмина Л.А., Паровичникова Е.Н.Vybornykh D.E., Fedorova S.Y., Khrushchev S.O., Drokov M.Y., Gemdzhian E.G., Kuzmina L.A., Parovichnikova E.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.bekhterevreview.com/jour/article/view/245

Лечение пациентов с заболеваниями системы крови нередко осложняется рядом негативных побочных эффектов, к числу которых относятся психические расстройства, среди которых особое место занимают когнитивные нарушения. Когнитивные нарушения у пациентов с заболеваниями системы крови до и после алло-ТГСК развиваются на фоне совокупности факторов риска, провоцирующих данное состояние и изменение его динамики.

The treatment of patients with hematological malignancies is often complicated by a number of negative side effects, which include mental disorders, among which cognitive impairment occupies a special place. Psychopathological, psychological, neuropsychological, neurophysiological and neurovisual methods were used to examine 46 patients with various hematological malignancies during periods prior to allo-HSCT, 1-3 months after allo-HSCT, and 6 months after transplantation. When statistical analysis of data was performed correlation and multivariate analyzes. Patients at each stage of the study identified cognitive impairment caused by a combination of risk factors — the presence of a hematological malignancy, the encephalotropic activity of chemotherapy drugs, and mental, neurological disorders. The characteristic and stable dynamics of CN in the post-transplantation period is traced — a sharp decline in cognitive functions in almost all indicators at once in the early post-transplant period with their gradual recovery by 6 months after allo-HSCT. The attitude of patients to cognitive deficiency also changes during the period of treatment: from anozognosic and hyponozognosic at the pre-transplantation stage to hypernosognostic at long-term periods after allo-HSCT.

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The authors declare that there are no conflicts of interest present.