bekhterevОбозрение психиатрии и медицинской психологии имени В.М.БехтереваV.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY2313-70532713-055XV. M. BEKHTEREV NATIONAL RESEARCH MEDICAL CENTER FOR PSYCHIATRY AND NEUROLOGY OF THE RUSSIAN FEDERATION MINISTRY OF HEALTH10.31363/2313-7053-2019-3-10-18bekhterev-267Research ArticleНАУЧНЫЕ ОБЗОРЫSCIENTIFIC REVIEWАнгедония как базовый синдром и мишень для терапевтического воздействия при депрессивном расстройствеAnhedonia as a basic syndrome and a target for treatment for depressive disorderМазоГ. Э.MazoG. E.

Мазо Галина Элевна — д.м.н., ученый секретарь, руководитель отделения эндокринологической психиатрии

galina-mazo@yandex.ruКибитовА. О.KibitovA. O.

Кибитов Александр Олегович — д.м.н., руководитель лаборатории молекулярной генетики; ведущий научный сотрудник отделения эндокринологической психиатрии

druggen@mail.ruФГБУ «Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева» Минздрава РоссииРоссияV.M. Bekhterev National Medical Research Center for Psychiatry and NeurologyRussian FederationФГБУ «Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева» Минздрава России; ФГБУ «Национальный медицинский исследовательский центр психиатрии и наркологии им. В.П. Сербского» Минздрава РоссииРоссияV.M. Bekhterev National Medical Research Center for Psychiatry and Neurology; V.P. Serbsky National Medical Research Center on Psychiatry and AddictionsRussian Federation201906102019031018Copyright © Мазо Г.Э., Кибитов А.О., 20192019Мазо Г.Э., Кибитов А.О.Mazo G.E., Kibitov A.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.bekhterevreview.com/jour/article/view/267

В статье представлен аналитический обзор, нацеленный на определение влияния ангедонии на течение и терапевтический прогноз при депрессии. В настоящее время не существует определенного и специфического фармакологического подхода к лечению ангедонии при депрессии, хотя ясно, что все антидепрессанты, влияющие на симптомы депрессии в целом, действуют в определенной степени на ангедонию. Описаны современные взгляды на биологические механизмы, вовлеченные в формирование ангедонии, на основании которых возможен поиск препаратов с антиангедонической активностью. Представлены данные, на основании которых вортиоксетин может быть рассмотрен как анти- депрессант со специфическим антиангедоническим эффектом.

The article presents an analytical review aimed at determining the effect of anhedonia on the course and therapeutic prognosis of depression. Currently, there is no specific pharmacological approach to the treatment of anhedonia in depression.It is clear all antidepressants that affect the symptoms of depression in general act to a certain extent on anhedonia. Modern views on the biological mechanisms involved in the formation of anhedonia are described, on the basis of which a search for drugs with anti-anhedonic activity is possible. Vortioxetine can be considered as an antidepressant with a specific anti-anhedonic effect.

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The authors declare that there are no conflicts of interest present.