bekhterevОбозрение психиатрии и медицинской психологии имени В.М.БехтереваV.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY2313-70532713-055XV. M. BEKHTEREV NATIONAL RESEARCH MEDICAL CENTER FOR PSYCHIATRY AND NEUROLOGY OF THE RUSSIAN FEDERATION MINISTRY OF HEALTH10.31363/2313-7053-2019-4-1-8-11bekhterev-291Research ArticleНАУЧНО-ИССЛЕДОВАТЕЛЬСКИЕ РАБОТЫRESEARCH PAPERSПрименение подходов с использованием полигенных шкал риска для изучения генетической архитектуры шизофренииUsing polygenic risk score approaches to investigate the common-variant genetic architecture of schizophreniaЭскотт-ПрайсВ.Escott-PriceV.Исследовательский институт нейронаук и психического здоровья, Институт исследования деменции, Кардиффский университетВеликобританияNeuroscience and Mental health research institute, Dementia Research institute, Cardiff UniversityUnited Kingdom20190612201904-1811Copyright © Эскотт-Прайс В., 20192019Эскотт-Прайс В.Escott-Price V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.bekhterevreview.com/jour/article/view/291

В данной статье представлено резюме нашего ассоциативного исследования шкал полигенного риска шизофрении с различными фенотипами в крупной когорте населения Великобритании (N=442,192). Мы показали, что у людей с более высоким генетическим грузом по шизофрении без диагностированных нарушений развития нервной системы с большей вероятностью отмечались некоторые когнитивные нарушения. Хотя данные нарушения могли быть выражены в мягкой степени, они значительно влияли на уровень образования и профессиональные достижения. Мы также отметили, что  взаимосвязь между подверженностью шизофрении и плодовитостью согласуется с половым отбором, при этом подверженность у не затронутых шизофренией индивидуумов связана с чистым повышением плодовитости. Это в свою очередь ведет к сохранению аллелей риска шизофрении в популяции.

Is this paper we present a summary of our association analyses of schizophrenia polygenic risk score with a number of phenotypes in a large cohort of people from the UK population (N=442,192). We show that individuals with higher genetic loading to schizophrenia who have not been diagnosed with neurodevelopmental disorders are likely to have some cognitive deficits. Although these deficits may be subtle, they can result in significant effects on educational attainment and professional occupation. We also show that the relationship between schizophrenia liability and fecundity is consistent with sexual selection, with liability in unaffected people being associated with a net increase in fecundity, thereby supporting the persistence of schizophrenia risk alleles.

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The authors declare that there are no conflicts of interest present.