bekhterevОбозрение психиатрии и медицинской психологии имени В.М.БехтереваV.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY2313-70532713-055XV. M. BEKHTEREV NATIONAL RESEARCH MEDICAL CENTER FOR PSYCHIATRY AND NEUROLOGY OF THE RUSSIAN FEDERATION MINISTRY OF HEALTH10.31363/2313-7053-2019-4-1-51-52bekhterev-303Research ArticleНАУЧНО-ИССЛЕДОВАТЕЛЬСКИЕ РАБОТЫRESEARCH PAPERSМеждународный консорциум генетики лития (ConLiGen): достижения и сотрудничествоThe International Consortium of Lithium Genetics (ConLiGen): Achievements and CollaborationsХейлброннерУ.HeilbronnerU.Институт психиатрической геномики и феномики, Университетский госпиталь, Мюнхенский университет Людвига-МаксимилианаГерманияInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU MunichGermany20190712201904-15152Copyright © Хейлброннер У., 20192019Хейлброннер У.Heilbronner U.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.bekhterevreview.com/jour/article/view/303

Литий является незаменимым инструментом современной психиатрии. Хотя общеизвестно, что ответ на терапию литием является наследуемой чертой, имеющиеся исследования фармакогенетики терапии лечения литием в прошлом дали мало воспроизводимых результатов. Консорциум генетики лития (ConLiGen) был создан Thomas G. Schulze и Francis J. McMahon в 2008 году для преодоления этих ограничений. В настоящее время исследователи из 39 стран присоединились к консорциуму, что делает его по-настоящему международным мероприятием. Отличительной чертой консорциума является использование 11-балльной шкалы ответа на терапию литием, сформированной Martin Alda и его коллегами. Объединение данных по генотипам более чем 2500 пациентов, фенотипированных при помощи этой стандартизированной шкалы ответов, привело к первоначальным успехам, которые формируют основу для дальнейших исследований.

Lithium is an indispensable tool of modern psychiatry. Although it is well-known that response to lithium is a familial trait, available research on pharmacogenetics regarding lithium treatment has, in the past, produced few reproducible results. The Consortium of Lithium Genetics (ConLiGen) was initiated by Thomas G. Schulze and Francis J. McMahon in 2008 to overcome these limitations. To date, researchers from 39 countries have joined the consortium, making it a truly international effort. A hallmark of the consortium is the use of an 11-point lithium response rating scale defined by Martin Alda and colleagues. The pooling of genotype data from over 2,500 patients phenotyped with this standardized response scale, have led to initial successes, which form the basis for further research.

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The authors declare that there are no conflicts of interest present.