bekhterevОбозрение психиатрии и медицинской психологии имени В.М.БехтереваV.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY2313-70532713-055XV. M. BEKHTEREV NATIONAL RESEARCH MEDICAL CENTER FOR PSYCHIATRY AND NEUROLOGY OF THE RUSSIAN FEDERATION MINISTRY OF HEALTH10.31363/2313-7053-2019-4-1-55-57bekhterev-305Research ArticleНАУЧНО-ИССЛЕДОВАТЕЛЬСКИЕ РАБОТЫRESEARCH PAPERSМногофакторные полигенные модели в персонифицированной психиатрииMultivariate polygenic models in personalized psychiatryАлфимоваМ. В.AlfimovaМ. V.m.alfimova@gmail.comФГБНУ «Научный центр психического здоровья»РоссияMental Health Research CenterRussian Federation20190712201904-15557Copyright © Алфимова М.В., 20192019Алфимова М.В.Alfimova М.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.bekhterevreview.com/jour/article/view/305

Одним из важнейших вызовов психиатрии в постгеномную эру является персонификация помощи на основе использования индивидуальной полногеномной информации. Многообещающим инструментом представляются прогностические многофакторные модели с применением полигенных баллов риска (PGRS). В статье обсуждается потенциал полностью полигенных моделей, в которых все предикторы представлены в виде PGRS соответствующих фенотипов, и моделей, в которых индивидуальная генетическая информация, заложенная в PGRS, дополнена эпигенетическими данными.

Personalizing patient care through the use of individual genome-wide information is one of the key challenges for psychiatry in the post-genomic era. Prognostic multivariate models incorporating polygenic risk scores (PGRS) seem to be a promising tool. The article discusses the potential of fully polygenic models, in which all predictors are represented as PGRS of the corresponding phenotypes, and models, in which the individual genetic information embedded in the PGRS is supplemented with epigenetic data.

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The authors declare that there are no conflicts of interest present.