bekhterevОбозрение психиатрии и медицинской психологии имени В.М.БехтереваV.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY2313-70532713-055XV. M. BEKHTEREV NATIONAL RESEARCH MEDICAL CENTER FOR PSYCHIATRY AND NEUROLOGY OF THE RUSSIAN FEDERATION MINISTRY OF HEALTH10.31363/2313-7053-2019-4-1-70-72bekhterev-310Research ArticleНАУЧНО-ИССЛЕДОВАТЕЛЬСКИЕ РАБОТЫRESEARCH PAPERSВозможности применения нейрофизиологических тестов — эндофенотипов шизофрении для изучения роли генетических факторов в организации когнитивных процессов в норме и при психическихThe opportunity of application of neurophysiological tests — schizophrenia endophenotypes for studying the role of genetic factors in cognitive processes in healthy subjects and in psychiatric diseasesКиренскаяА. В.KirenskayaA. V.

Киренская Анна Валерьевна — д.б.н., руководитель лаборатории клинической нейрофизиологии

neuro11@yandex.ruСторожеваЗ. И.StorozhevaZ. I.storozheva_zi@mail.ruКибитовА. О.KibitovF. O.druggen@mail.ruФГБУ «НМИЦ ПН им. В.П. Сербского» Минздрава РоссииРоссияFederal State Budgetary Institution “V. Serbsky National Medical Research Centre for Psychiatry and Narcology” of the Ministry of HealthRussian FederationФГБУ «НМИЦ ПН им. В.П. Сербского» Минздрава России; Российский национальный консорциум по психиатрической генетикеРоссияFederal State Budgetary Institution “V. Serbsky National Medical Research Centre for Psychiatry and Narcology” of the Ministry of HealthRussian Federation20190712201904-17072Copyright © Киренская А.В., Сторожева З.И., Кибитов А.О., 20192019Киренская А.В., Сторожева З.И., Кибитов А.О.Kirenskaya A.V., Storozheva Z.I., Kibitov F.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.bekhterevreview.com/jour/article/view/310

Исследование эффектов генетических полиморфизмов, оказывающих влияние на дофаминэргическую (КОМТ, DRD2) и ГАМК-эргическую (ГДК1) нейротрансмиссию в префронтальной коре на показатели антисаккад (АС) и вызванных потенциалов P300 проведено с участием 55 здоровых лиц и 72 больных шизофренией. Взаимодействие эффектов генотипа и фактора заболевания выявлено для большинства исследованных показателей АС и P300. Для полиморфизмов, ассоциированных с риском шизофрении, обнаружено ухудшение качества выполнения тестов и снижение эффективности активации коры мозга.

The study of effects of genetic polymorphisms implicated in dopamine (COMT, DRD2) and GABA (GAD1) activities in the prefrontal cortex on antisaccades (AS) and evoked potential P300 measures was conducted with participation of 55 healthy subjects and 72 schizophrenic patients. The significant interaction of genotype and disease was found for most of the studied AS and P300 measures. The worse task performance and decreased efficacy of cortical activation were revealed for the associated with schizophrenia risk polymorphisms.

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The authors declare that there are no conflicts of interest present.