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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">bekhterev</journal-id><journal-title-group><journal-title xml:lang="ru">Обозрение психиатрии и медицинской психологии имени В.М.Бехтерева</journal-title><trans-title-group xml:lang="en"><trans-title>V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2313-7053</issn><issn pub-type="epub">2713-055X</issn><publisher><publisher-name>V. M. BEKHTEREV  NATIONAL  RESEARCH  MEDICAL  CENTER  FOR  PSYCHIATRY  AND  NEUROLOGY                           OF    THE  RUSSIAN  FEDERATION   MINISTRY  OF  HEALTH</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31363/2313-7053-2019-4-1-73-7</article-id><article-id custom-type="elpub" pub-id-type="custom">bekhterev-311</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НАУЧНО-ИССЛЕДОВАТЕЛЬСКИЕ РАБОТЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>RESEARCH PAPERS</subject></subj-group></article-categories><title-group><article-title>Генетический риск наркологических заболеваний  у несовершеннолетних: фенотипические эффекты</article-title><trans-title-group xml:lang="en"><trans-title>Genetic risks of addictive disorders in adolescents: phenotypic effects</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Яковлев</surname><given-names>А. Н</given-names></name><name name-style="western" xml:lang="en"><surname>Yakovlev</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"/><email xlink:type="simple">yakovlev_an75@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пашкевич</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pashkevich</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><email xlink:type="simple">pnata.marti@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Витчинкина</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Vitchinkina</surname><given-names>V. I.</given-names></name></name-alternatives><bio xml:lang="ru"/><email xlink:type="simple">valentule@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГУЗ «Липецкий областной наркологический диспансер»</institution><country>Беларусь</country></aff><aff xml:lang="en"><institution>Lipetsk regional narcological dispensary</institution><country>Belarus</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>07</day><month>12</month><year>2019</year></pub-date><volume>0</volume><issue>4-1</issue><fpage>73</fpage><lpage>74</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Яковлев А.Н., Пашкевич Н.В., Витчинкина В.И., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Яковлев А.Н., Пашкевич Н.В., Витчинкина В.И.</copyright-holder><copyright-holder xml:lang="en">Yakovlev A.N., Pashkevich N.V., Vitchinkina V.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.bekhterevreview.com/jour/article/view/311">https://www.bekhterevreview.com/jour/article/view/311</self-uri><abstract><p>В нескольких несвязанных малых выборках изучены корреляции между генетическим риском химической зависимости, рассчитанным на основании вклада геномаркеров дофаминовой системы, и фенотипом подростков 14-17 лет, не страдающих зависимостью. При повышении генетического риска возрастает склонность к поведенческим расстройствам, склонность к отказу от позитивных форм самоутверждения, усиливается интенсивность эйфории при первых пробах наркотика, а способность прогнозировать последствия потребления наркотиков снижается. Полученные корреляции могут быть важны для понимания механизма формирования зависимости у подростков с высоким ГР и разработки индивидуальных профилактических программ. Однако эти наблюдения нуждаются в подтверждении в ходе более представительных исследований.</p></abstract><trans-abstract xml:lang="en"><p>In several unrelated small samples examined correlation between genetic risk of chemical dependence, calculated on the basis of the contribution of geomarkers dopamine system, and phenotype of adolescents 14-17 years of age, not suffering from addiction. When genetic risk increases, the tendency to behavioural disorders increases, the tendency to abandon positive forms of self-assertion increases, the intensity of euphoria increases at the first drug samples, and the ability to predict the consequences of drug use decreases. The obtained correlations may be important for understanding the mechanism of dependence formation in adolescents with high genetic risk and development of individual prevention programs. However, these observations need to be confirmed in more representative studies.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>дофамин</kwd><kwd>генетический риск</kwd><kwd>фенотип</kwd><kwd>алкоголь наркотик</kwd></kwd-group><kwd-group xml:lang="en"><kwd>dopamine</kwd><kwd>genetic risk</kwd><kwd>phenotype</kwd><kwd>alcohol</kwd><kwd>drug</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
