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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">bekhterev</journal-id><journal-title-group><journal-title xml:lang="ru">Обозрение психиатрии и медицинской психологии имени В.М.Бехтерева</journal-title><trans-title-group xml:lang="en"><trans-title>V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2313-7053</issn><issn pub-type="epub">2713-055X</issn><publisher><publisher-name>V. M. BEKHTEREV  NATIONAL  RESEARCH  MEDICAL  CENTER  FOR  PSYCHIATRY  AND  NEUROLOGY                           OF    THE  RUSSIAN  FEDERATION   MINISTRY  OF  HEALTH</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31363/2313-7053-2019-4-2-14-18</article-id><article-id custom-type="elpub" pub-id-type="custom">bekhterev-337</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРОБЛЕМНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PROBLEM-S0LVING ARTICLES</subject></subj-group></article-categories><title-group><article-title>Методологические аспекты констатации болезни Альцгеймера в качестве причины смерти у пожилых</article-title><trans-title-group xml:lang="en"><trans-title>Methodological aspects of constatation of Alzheimer disease as a cause of death in the elderly</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Незнанов</surname><given-names>Н. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Neznanov</surname><given-names>N. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Незнанов Николай Григорьевич — доктор медицинских наук, профессор, заслуженный деятель науки РФ, директор НМИЦ ПН им. В.М. Бехтерева МЗ РФ, научный руководитель отделения гериатрической психиатрии НМИЦ ПН им. В.М.Бехтерева; заведующий кафедрой психиатрии и наркологии с курсом психосоматической медицины ПСПбГМУ им. ак. И.П. Павлова. </p><p>Санкт-Петербург.</p></bio><bio xml:lang="en"/><email xlink:type="simple">spbinstb@bekhterev.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Круглов</surname><given-names>Л. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kruglov</surname><given-names>L. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Круглов  Лев  Саввич — доктор  медицинских наук, профессор, главный научный сотрудник отделения  гериатрической психиатрии  НМИЦПН  им. В.М.Бехтерева; профессор  кафедры психиатрии  и наркологии  Медицинского факультета СПбГУ.</p><p>Санкт-Петербург.</p></bio><bio xml:lang="en"/><email xlink:type="simple">levsavkrug@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева; Первый СПбГУ им. акад. И.П. Павлова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Center of Psychiatry and Neurology named after V.M.Bekhterev; First St.Petersburg Medical University named after academician I.P.Pavlov</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева; Санкт-Петербургский государственный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Center of Psychiatry and Neurology named after V.M.Bekhterev; St.Petersburg University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>02</day><month>01</month><year>2020</year></pub-date><volume>0</volume><issue>4-2</issue><fpage>14</fpage><lpage>18</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Незнанов Н.Г., Круглов Л.С., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Незнанов Н.Г., Круглов Л.С.</copyright-holder><copyright-holder xml:lang="en">Neznanov N.G., Kruglov L.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.bekhterevreview.com/jour/article/view/337">https://www.bekhterevreview.com/jour/article/view/337</self-uri><abstract><p>В связи с увеличением доли пожилого населения в последнее время широко обсуждается многогранное неблагоприятное значение болезни Альцгеймера, в том числе — ее роль в качестве причины смерти. Однако, не всегда очевидное влияние данного заболевания на жизненно важные функции диктует необходимость дифференцированного  методологического подхода в этом вопросе.</p><p>Авторы работы рассматривают различия  во влиянии  общепринятых  вариантов  течения  болезни Альцгеймера на прогноз  жизни  пациентов,  а также  факт  все более частого выявления  клинически и морфологически  смешанных форм  данной патологии с цереброваскулярным  заболеванием, что, в свою очередь, выводит осложнения последнего на ведущее место как причины смерти в соответствующих случаях.</p><p>Сформулированы  общие  принципы  подхода к  решению  вопроса  о  причине  летального  исхода у лиц  пожилого  и  старческого возраста  в  условиях сочетанного влияния  описанных  церебрально-атрофических изменений. При этом в алгоритмизированной  форме предлагается последовательность аргументации в качестве таковой причины собственно болезни Альцгеймера.</p></abstract><trans-abstract xml:lang="en"><p>In connection  with the increase in the proportion  of the elderly population,  the multifaceted adverse significance of Alzheimer’s  disease has recently been widely discussed, including its role as a cause of death. However, not  always obvious influence of this disease on  vital functions  dictates the need for a differentiated methodological approach in this matter.</p><p>The authors consider the differences in the effects of generally accepted variants of the course of Alzheimer’s disease on the prognosis of patients, as well as the fact that clinically and morphologically mixed forms of this pathology with cerebrovascular disease are increasingly detected, which in turn  leads the complications of the latter to be a cause of death in respective cases.</p><p>The general principles of the approach  to solving the issue of the cause of death  in elderly and  senile people under the combined effect of the described cerebro-atrophic changes are formulated. At the same time, a sequence of arguments is proposed to consider Alzheimer’s  disease as the cause of death.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>болезнь Альцгеймера</kwd><kwd>пожилой возраст</kwd><kwd>причины смерти</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Alzheimer disease</kwd><kwd>old age</kwd><kwd>causes of death</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Гаврилова С. И. Деменция. В кн.: Руководство по гериатрической психиатрии. Под ред. С.И. Гавриловой. М: Пульс, 2014; 23–145.</mixed-citation><mixed-citation xml:lang="en">Gavrilova SI  Demencia.  V  kn.:  SI  Gavrilova. Rukovodstvo  po  geriatricheskoy psychiatrii.  Pod red. SI Gavrilovoi.M.: Puls. 2014; 23-145.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Дамулин И.В. 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