<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">bekhterev</journal-id><journal-title-group><journal-title xml:lang="ru">Обозрение психиатрии и медицинской психологии имени В.М.Бехтерева</journal-title><trans-title-group xml:lang="en"><trans-title>V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2313-7053</issn><issn pub-type="epub">2713-055X</issn><publisher><publisher-name>V. M. BEKHTEREV  NATIONAL  RESEARCH  MEDICAL  CENTER  FOR  PSYCHIATRY  AND  NEUROLOGY                           OF    THE  RUSSIAN  FEDERATION   MINISTRY  OF  HEALTH</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31363/2313-7053-2019-4-2-19-28</article-id><article-id custom-type="elpub" pub-id-type="custom">bekhterev-338</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НАУЧНЫЕ ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SCIENTIFIC REVIEW</subject></subj-group></article-categories><title-group><article-title>Сопутствующие психические расстройства и нарушение эмоциональной регуляции у пациентов с рассеянным склерозом</article-title><trans-title-group xml:lang="en"><trans-title>Associated Psychological Disorders and Impairment of Emotional Regulation among Patients with Multiple Sclerosis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Андреева</surname><given-names>М. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Andreeva</surname><given-names>M. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Андреева Мария Трофимовна — врач — невролог Санкт-Петербургского городского центра рассеянного склероза и других аутоиммунный заболеваний (СПбГБУЗ ГКБ№31); аспирант кафедры медицинской психологии и психофизиологии СПбГУ. </p><p>Санкт-Петербург.</p></bio><bio xml:lang="en"/><email xlink:type="simple">ascella777@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Караваева</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Karavaeva</surname><given-names>T. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Караваева  Татьяна  Артуровна — доктор  медицинских  наук,  главный  научный  сотрудник,  руководитель  отделения  лечения  пограничных  психических  расстройств  и  психотерапии  НМИЦ ПН им. В.М. Бехтерева;  профессор  кафедры  медицинской  психологии  и  психофизиологии  СПбГУ.</p><p>Санкт-Петербург.</p></bio><bio xml:lang="en"/><email xlink:type="simple">tania_kar@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Санкт-Петербургский городской центр рассеянного склероза и других аутоиммунный заболеваний; Санкт-Петербургский государственный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>St. Petersburg City Center for Multiple Sclerosis and Other Autoimmune Diseases; Saint-Petersburg State University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева Минздрава России; Санкт-Петербургский государственный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V. M. Bekhterev National Research Medical Center for Psychiatry and Neurology; Saint-Petersburg State University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>02</day><month>01</month><year>2020</year></pub-date><volume>0</volume><issue>4-2</issue><fpage>19</fpage><lpage>28</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Андреева М.Т., Караваева Т.А., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Андреева М.Т., Караваева Т.А.</copyright-holder><copyright-holder xml:lang="en">Andreeva M.T., Karavaeva T.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.bekhterevreview.com/jour/article/view/338">https://www.bekhterevreview.com/jour/article/view/338</self-uri><abstract><p>В обзоре литературных данных приведены результаты изучения коморбидных психических расстройств при рассеянном склерозе, освещены научные публикации отечественных и зарубежных исследований. Большая распространенность аффективных и адаптационных нарушений связана как с нейрофизиологическими особенностями протекания этого хронического прогредиентного нейродегенеративного заболевания, так и с психологическими факторами — индивидуальными личностными особенностями, отношением к заболеванию, изменению социального функционирования,  прогнозу. Показано, что у пациентов  с рассеянным склерозом частота развития  депрессивных, тревожных нарушений, посттравматического стрессового расстройства существенно выше, чем в общей популяции, что определяет необходимость комплексного персонализированного подхода к этой группе больных.</p></abstract><trans-abstract xml:lang="en"><p>The review of data  from  the  available literature  cites the  results of studies of psychological disorders  comorbid  to  multiple  sclerosis and  highlights  scientific papers  detailing  domestic  and  foreign research. The high prevalence of affective and adaptive impairment  is linked both to the neurophysiological particularities of this chronic, progressive, neurodegenerative illness and to psychological factors — individual personality traits and the attitude of those afflicted to their illness, to the change in their social functioning and  to  their  prognosis. It  is demonstrated  that  patients  with multiple  sclerosis have a significantly higher frequency of depressive and anxiety disorders than  the general population,  which suggests the need for an integrated, personalized approach to people with this illness.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рассеянный  склероз</kwd><kwd>коморбидные  психические расстройства</kwd><kwd>биполярное  расстройство</kwd><kwd>депрессия</kwd><kwd>тревожные расстройства</kwd><kwd>посттравматическое стрессовое расстройство</kwd></kwd-group><kwd-group xml:lang="en"><kwd>multiple  sclerosis</kwd><kwd>comorbid  psychological disorders</kwd><kwd>bipolar  disorder</kwd><kwd>depression</kwd><kwd>anxiety disorders</kwd><kwd>posttraumatic  stress disorder</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Бойко О.В., Татаринова М.Ю., Попова Е.В., Гусева М.Р., Бойко А.Н., Гусев Е.И. Улучшение показателей качества жизни больных рассеянным склерозом за 15-летний период. Журнал неврологии и психиатрии им С.С. Корсакова. 2018; 2:23-28. doi.org/10.17116/jnevro201811808223</mixed-citation><mixed-citation xml:lang="en">Boyko O.V., Tatarinova M.YU., Popova E.V., Guseva M.R., Boyko A.N., Gusev E.I. The improvement of quality of life of patients with multiple sclerosis over 15-year period. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2018; 2:23-28 (In Russ.). doi.org/10.17116/jnevro201811808223</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Васильева А.В., Караваева Т.А., Лукошкина Е.П., Карпов А.В. Социально-психологические факторы риска развития посттравматического стрессового расстройства у пациентов с онкологическими заболеваниями прямой кишки, подвергшихся хирургическому лечению с формированием колостомы. Обозрение психиатрии и медицинской психологии им. В.М. Бехтерева. 2018; 2:44-53.</mixed-citation><mixed-citation xml:lang="en">Vasileva A.V., Karavaeva T.A., Lukoshkina E.P., Karpov A.V. Socio-psychological risk factors for the development of posttraumatic stress disorder in patients with rectum cancer, who undergone colostomia. Obozrenie psikhiatrii i meditsinskoi psikhologii im. V.M. Bekhtereva. 2018; 2:44-53 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Каплин А., Кэролл К. Рассеянный склероз. В кн.: К. Ликетос , Питер В. Рэбинс, Джон Р. Липси, Филлип Р. Слэвни. Психиатрические аспекты неврологических заболеваний: Подходы к ведению больных. Пер. с англ. Под ред. Акад. РАН Н.Н. Яхно. — М.: МЕДпресс — информ. 2017:116¬136.</mixed-citation><mixed-citation xml:lang="en">Kaplin A., Carroll K., Rasseyannyi skleroz. V kn.: C. Lyketsos, P. Rabins, J. Lipsey, P. Slavney. Psychiatric aspects of neurologic diseases. Practical approaches to patient care. MEDpress — inform. 2017:116-136. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Карвасарский Б.Д. Клиническая психология: учебник для вузов. 5-е изд. СПб.: Питер. 2016; 896.</mixed-citation><mixed-citation xml:lang="en">Karvasarskii B.D. Klinicheskaya psikhologiya: uchebnik dlya vuzov. 5-e izd. SPb.: Piter. 2016; 896 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Лурия А.Р. Высшие корковые функции человека. — СПб.: Питер. 2019; 768:47-104.</mixed-citation><mixed-citation xml:lang="en">Luriya A.R. Vysshie korkovye funktsii cheloveka. — SPb.: Piter. 2019;768:47-104 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Мартынихин И.А. Эпидемиология, особенности и специфические факторы риска расстройств депрессивного спектра у женщин. Женское психическое здоровье — от истерии к гендерно-сенситивному подходу. Под общей редакцией: Н.Г. Незнанова. Авторы-составители: А.В. Васильева, Т.А. Караваева. Санкт-Петербург: Издательский Дом «Алеф-Пресс». 2018; 208-222.</mixed-citation><mixed-citation xml:lang="en">Martynikhin I.A. Epidemiologiya, osobennosti i spetsificheskie faktory riska rasstroistv depressivnogo spektra u zhenshchin. Zhenskoe psikhicheskoe zdorove — ot isterii k genderno-sensitivnomu podkhodu. Pod obshchei redaktsiei: N. G. Neznanova. Avtory-sostaviteli: A.V. Vasileva, T.A. Karavaeva. Sankt-Peterburg: Izdatel’skii Dom «Alef-Press». 2018; 208-222 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Николаев Е.Л., Караваева Т.А., Васильева Н.В., Чехлатый Е.И. Персонализированный подход в медико-психологическом сопровождении больных с рассеянным склерозом. Вестник пси-хотерапии. 2018; 65(70) 86-97.</mixed-citation><mixed-citation xml:lang="en">Nikolaev E.L., Karavaeva T.A., Vasileva N.V., Chekhlatyi E.I. The personalized approach in medical and psychological support of multiple sclerosis patients. Vestnik psikhoterapii. 2018; 65(70) 86-97 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Николаев Е.Л., Караваева Т.А., Васильева Н.В. Медико-психологическое сопровождение больных с рассеянным склерозом: основные принципы и задачи. Обозрение психиатрии и медицинской психологии им. В.М. Бехтерева. 2018; 1:120-124.</mixed-citation><mixed-citation xml:lang="en">Nikolaev E.L., Karavaeva T.A., Vasileva N.V. Medical and psychological support of multiple sclerosis patients: basic principles and objectives. Obozrenie psikhiatrii i meditsinskoi psikhologii im. V.M. Bekhtereva. 2018; 1:120-124 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Сирота Н.А., Московченко Д.В., Ялтонский В.М., Ялтонская А.В. Беспокойство о прогрессировании онкологического заболевания: современные теоретические концепции и подходы. Медицинская психология в России: электрон. науч. журн. 2016; 6:41 URL: http://mprj.ru (дата обращения: 30.04.2018).</mixed-citation><mixed-citation xml:lang="en">Sirota N.A., Moskovchenko D.V., Yaltonskii V.M., Yaltonskaya A.V Аnxiety on the progression of oncological diseases: modern theoretical concepts and approaches. Meditsinskaya psikhologiya v Rossii: elektron. nauch. zhurn. 2016; 6:41 (data obrashenia: 30.04.2018 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Хомская Е.Д. Нейропсихология: учебник для вузов. 4-е изд. — СПб.: Питер. 2018; 496.</mixed-citation><mixed-citation xml:lang="en">Khomskaya E.D. Neiropsikhologiya: uchebnik dlya vuzov. 4-e izd. — SPb.: Piter. 2018; 496 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Шмидт Т.Е., Яхно Н.Н. Рассеянный склероз: руководство для врачей. 3-е изд. — М.: МЕД-пресс — информ. 2012; 272:13-64.</mixed-citation><mixed-citation xml:lang="en">Shmidt T.E., Yakhno N.N. Rasseyannyi skleroz: rukovodstvo dlya vrachei. 3-e izd. — M.: MEDpress — inform. 2012; 272:13 — 64 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Anderson D, Ellenberg J, Leventhal C, Reingold S, Rodriguez M, Silberberg D. Revised estimate of the prevalence of multiple sclerosis in the united states. Ann Neurol. 1992; 31(3):333-336. doi:10.1002/ana.410310317</mixed-citation><mixed-citation xml:lang="en">Anderson D, Ellenberg J, Leventhal C, Reingold S, Rodriguez M, Silberberg D. Revised estimate of the prevalence of multiple sclerosis in the united states. Ann Neurol. 1992; 31(3):333-336. doi:10.1002/ana.410310317</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Aronson K, Cleghorn G, Goldenberg E. Assistance arrangements and use of services among persons with multiple sclerosis and their care-givers. Disabil Rehabil. 1996; 18(7):354-361. doi:10.3109/09638289609165894</mixed-citation><mixed-citation xml:lang="en">Aronson K, Cleghorn G, Goldenberg E. Assistance arrangements and use of services among persons with multiple sclerosis and their care-givers. Disabil Rehabil. 1996; 18(7):354-361. doi:10.3109/09638289609165894</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Association between bipolar affective disorder and multiple sclerosis. American Journal of Psychiatry. 1986; 143(1):94-95. doi:10.1176/ajp.143.1.94</mixed-citation><mixed-citation xml:lang="en">Association between bipolar affective disorder and multiple sclerosis. American Journal of Psychiatry. 1986; 143(1):94-95. doi:10.1176/ajp.143.1.94</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Bakshi R, Czarnecki D, Shaikh Z et al. Brain MRI lesions and atrophy are related to depression in multiple sclerosis. Neuroreport. 2000; 11(6):1153-1158. doi:10.1097/00001756-200004270-00003</mixed-citation><mixed-citation xml:lang="en">Bakshi R, Czarnecki D, Shaikh Z et al. Brain MRI lesions and atrophy are related to depression in multiple sclerosis. Neuroreport. 2000; 11(6):1153-1158. doi:10.1097/00001756-200004270-00003</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Barak Y, Achiron A, Elizur A, Gabbay U, Noy S, Sarova-Pinhas I. Sexual dysfunction in relapsing-remitting multiple aclerosis: Clinical, psychological and MRI correlates. J Neuroimmunol. 1995; 56-63:56-56. doi:10.1016/0165-5728(95)99052-k</mixed-citation><mixed-citation xml:lang="en">Barak Y, Achiron A, Elizur A, Gabbay U, Noy S, Sarova-Pinhas I. Sexual dysfunction in relapsing-remitting multiple aclerosis: Clinical, psychological and MRI correlates. J Neuroimmunol. 1995; 56-63:56-56. doi:10.1016/0165-5728(95)99052-k</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Benedict R, Carone D, Bakshi R. Correlating Brain Atrophy With Cognitive Dysfunction, Mood Disturbances, and Personality Disorder in Multiple Sclerosis. Journal of Neuroimaging. 2004; 14:36S-45S. doi:10.1111/j.1552-6569.2004.tb00277.x</mixed-citation><mixed-citation xml:lang="en">Benedict R, Carone D, Bakshi R. Correlating Brain Atrophy With Cognitive Dysfunction, Mood Disturbances, and Personality Disorder in Multiple Sclerosis. Journal of Neuroimaging. 2004; 14:36S-45S. doi:10.1111/j.1552-6569.2004.tb00277.x</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Boeschoten R, Braamse A, Beekman A et al. Prevalence of depression and anxiety in Multiple Sclerosis: A systematic review and meta-analysis. J Neurol Sci. 2017; 372:331-341. doi:10.1016/j.jns.2016.11.067</mixed-citation><mixed-citation xml:lang="en">Boeschoten R, Braamse A, Beekman A et al. Prevalence of depression and anxiety in Multiple Sclerosis: A systematic review and meta-analysis. J Neurol Sci. 2017; 372:331-341. doi:10.1016/j.jns.2016.11.067</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Brown S. The mental symptoms of multiple sclerosis. Arch Neurol Psychiatry 1922; 7(5):629.</mixed-citation><mixed-citation xml:lang="en">Brown S. The mental symptoms of multiple sclerosis. Arch Neurol Psychiatry 1922; 7(5):629.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">doi:10.1001/archneurpsyc.1922.02190110080008</mixed-citation><mixed-citation xml:lang="en">doi:10.1001/archneurpsyc.1922.02190110080008</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Butler E, Matcham F, Chalder T. A systematic review of anxiety amongst people with Multiple Sclerosis. Mult Scler Relat Disord. 2016; 10:145-168. doi:10.1016/j.msard.2016.10.003</mixed-citation><mixed-citation xml:lang="en">Butler E, Matcham F, Chalder T. A systematic review of anxiety amongst people with Multiple Sclerosis. Mult Scler Relat Disord. 2016; 10:145-168. doi:10.1016/j.msard.2016.10.003</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Chahraoui K, Pinoit J, Viegas N, Adnet J, Bonin B, Moreau T. Alexithymie et liens avec la depression et lanxiete dans la sclerose en plaques. Rev Neu¬rol (Paris). 2008; 164(3):242-245. doi:10.1016/j.neurol.2007.09.006</mixed-citation><mixed-citation xml:lang="en">Chahraoui K, Pinoit J, Viegas N, Adnet J, Bonin B, Moreau T. Alexithymie et liens avec la depression et lanxiete dans la sclerose en plaques. Rev Neu¬rol (Paris). 2008; 164(3):242-245. doi:10.1016/j.neurol.2007.09.006</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Chalah M, Ayache S. Psychiatric event in multiple sclerosis: could it be the tip of the iceberg?. Revista Brasileira de Psiquiatria. 2017; 39(4):365-368. doi:10.1590/1516-4446-2016-2105</mixed-citation><mixed-citation xml:lang="en">Chalah M, Ayache S. Psychiatric event in multiple sclerosis: could it be the tip of the iceberg?. Revista Brasileira de Psiquiatria. 2017; 39(4):365-368. doi:10.1590/1516-4446-2016-2105</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Chalfant A, Bryant R, Fulcher G. Posttraumatic stress disorder following diagnosis of multiple sclerosis. J Trauma Stress. 2004; 17(5):423-428. doi:10.1023/b:jots.0000048955.65891.4c</mixed-citation><mixed-citation xml:lang="en">Chalfant A, Bryant R, Fulcher G. Posttraumatic stress disorder following diagnosis of multiple sclerosis. J Trauma Stress. 2004; 17(5):423-428. doi:10.1023/b:jots.0000048955.65891.4c</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Charcot J, Seigerson G. “Lectures 6 through 8,” in Lectures on the Diseases of the Nervous System. Delivered at La Salpetriere. Am J Med Sci. 1877; 148(4):532-533. doi:10.1097/00000441-187710000-00035</mixed-citation><mixed-citation xml:lang="en">Charcot J, Seigerson G. “Lectures 6 through 8,” in Lectures on the Diseases of the Nervous System. Delivered at La Salpetriere. Am J Med Sci. 1877; 148(4):532-533. doi:10.1097/00000441-187710000-00035</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Cottrell S, Wilson S. Original Papers: The affective symptomatology of disseminated sclerosis: a study of 100 cases. Journal of Neurology, Neurosurgery &amp; Psychiatry. 1926; s1-7(25):1-30. doi:10.1136/jnnp.s1-7.25.1</mixed-citation><mixed-citation xml:lang="en">Cottrell S, Wilson S. Original Papers: The affective symptomatology of disseminated sclerosis: a study of 100 cases. Journal of Neurology, Neurosurgery &amp; Psychiatry. 1926; s1-7(25):1-30. doi:10.1136/jnnp.s1-7.25.1</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Dantzer R. Cytokine-Induced Sickness Behavior: Where Do We Stand? Brain Behav Immun. 2001; 15(1):7-24. doi:10.1006/brbi.2000.0613</mixed-citation><mixed-citation xml:lang="en">Dantzer R. Cytokine-Induced Sickness Behavior: Where Do We Stand? Brain Behav Immun. 2001; 15(1):7-24. doi:10.1006/brbi.2000.0613</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Diaz-Olavarrieta C, Cummings J, Velazquez J, Garcia de al Cadena C. Neuropsychiatric Mani-festations of Multiple Sclerosis. J Neuropsychiatry Clin Neurosci. 1999; 11(1):51-57. doi:10.1176/jnp.11.1.51</mixed-citation><mixed-citation xml:lang="en">Diaz-Olavarrieta C, Cummings J, Velazquez J, Garcia de al Cadena C. Neuropsychiatric Mani-festations of Multiple Sclerosis. J Neuropsychiatry Clin Neurosci. 1999; 11(1):51-57. doi:10.1176/jnp.11.1.51</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Duncan A, Malcolm-Smith S, Ameen O, Solms M. Changing definitions of euphoria in multiple sclerosis: A short report. Multiple Sclerosis Journal. 2014; 21(6):776-779. doi:10.1177/1352458514549400</mixed-citation><mixed-citation xml:lang="en">Duncan A, Malcolm-Smith S, Ameen O, Solms M. Changing definitions of euphoria in multiple sclerosis: A short report. Multiple Sclerosis Journal. 2014; 21(6):776-779. doi:10.1177/1352458514549400</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Duncan A, Malcolm-Smith S, Ameen O, Solms M. The Incidence of Euphoria in Multiple Sclerosis: Artefact of Measure. Mult Scler Int. 20116 2016:1-8. doi:10.1155/2016/5738425</mixed-citation><mixed-citation xml:lang="en">Duncan A, Malcolm-Smith S, Ameen O, Solms M. The Incidence of Euphoria in Multiple Sclerosis: Artefact of Measure. Mult Scler Int. 20116 2016:1-8. doi:10.1155/2016/5738425</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Feinstein A, Magalhaes S, Richard J, Audet B, Moore C. The link between multiple sclerosis and depression. Nature Reviews Neurology. 2014; 10(9):507-517. doi:10.1038/nrneurol.2014.139</mixed-citation><mixed-citation xml:lang="en">Feinstein A, Magalhaes S, Richard J, Audet B, Moore C. The link between multiple sclerosis and depression. Nature Reviews Neurology. 2014; 10(9):507-517. doi:10.1038/nrneurol.2014.139</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Feinstein A. An examination of suicidal intent in patients with multiple sclerosis. Neurology. 2002; 59(5):674-678. doi:10.1212/wnl.59.5.674</mixed-citation><mixed-citation xml:lang="en">Feinstein A. An examination of suicidal intent in patients with multiple sclerosis. Neurology. 2002; 59(5):674-678. doi:10.1212/wnl.59.5.674</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Feinstein A. The Neuropsychiatry of Multiple Sclerosis. The Canadian Journal of Psychiatry. 2004; 49(3):157-163. doi:10.1177/070674370404900302</mixed-citation><mixed-citation xml:lang="en">Feinstein A. The Neuropsychiatry of Multiple Sclerosis. The Canadian Journal of Psychiatry. 2004; 49(3):157-163. doi:10.1177/070674370404900302</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Figved N, Klevan G, Myhr K et al. Neuropsychiatric symptoms in patients with multiple sclerosis. Acta Psychiatr Scand. 2005; 112(6):463-468. doi:10.1111/j.1600-0447.2005.00624.x</mixed-citation><mixed-citation xml:lang="en">Figved N, Klevan G, Myhr K et al. Neuropsychiatric symptoms in patients with multiple sclerosis. Acta Psychiatr Scand. 2005; 112(6):463-468. doi:10.1111/j.1600-0447.2005.00624.x</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Filippi M, Alberoni M, Martinelli V et al. Influence of Clinical Variables on Neuropsychological Performance in Multiple Sclerosis. Eur Neurol. 1994; 34(6):324-328. doi:10.1159/000117071</mixed-citation><mixed-citation xml:lang="en">Filippi M, Alberoni M, Martinelli V et al. Influence of Clinical Variables on Neuropsychological Performance in Multiple Sclerosis. Eur Neurol. 1994; 34(6):324-328. doi:10.1159/000117071</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Fishman I, Benedict R, Bakshi R, Priore R, Weinstock-Guttman B. Construct Validity and Frequency of Euphoria Sclerotica in Multiple Sclerosis. J Neuropsychiatry Clin Neurosci. 2004; 16(3):350-356. doi:10.1176/jnp.16.3.350</mixed-citation><mixed-citation xml:lang="en">Fishman I, Benedict R, Bakshi R, Priore R, Weinstock-Guttman B. Construct Validity and Frequency of Euphoria Sclerotica in Multiple Sclerosis. J Neuropsychiatry Clin Neurosci. 2004; 16(3):350-356. doi:10.1176/jnp.16.3.350</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Fisk J, Pontefract A, Ritvo P, Archibald C, Murray T. The Impact of Fatigue on Patients with Multiple Sclerosis. Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 1994; 21(01):9-14. doi:10.1017/s0317167100048691</mixed-citation><mixed-citation xml:lang="en">Fisk J, Pontefract A, Ritvo P, Archibald C, Murray T. The Impact of Fatigue on Patients with Multiple Sclerosis. Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 1994; 21(01):9-14. doi:10.1017/s0317167100048691</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Gay M, Bungener C, Thomas S et al. Anxiety, emotional processing and depression in people with multiple sclerosis. BMC Neurol. 2017; 17(1). doi:10.1186/s12883-017-0803-8</mixed-citation><mixed-citation xml:lang="en">Gay M, Bungener C, Thomas S et al. Anxiety, emotional processing and depression in people with multiple sclerosis. BMC Neurol. 2017; 17(1). doi:10.1186/s12883-017-0803-8</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Gay M, Vrignaud P, Garitte C, Meunier C. Predictors of depression in multiple sclerosis patients. Acta Neurol Scand. 2010; 121(3):161-170. doi:10.1111/j.1600-0404.2009.01232.x</mixed-citation><mixed-citation xml:lang="en">Gay M, Vrignaud P, Garitte C, Meunier C. Predictors of depression in multiple sclerosis patients. Acta Neurol Scand. 2010; 121(3):161-170. doi:10.1111/j.1600-0404.2009.01232.x</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">George M, Kellner C, Bernstein H, Goust J. A Magnetic Resonance Imaging Investigation into Mood Disorders in Multiple Sclerosis. J Nerv Ment Dis. 1994; 182(7)408-411. doi:10.1097/00005053-199407000-00008</mixed-citation><mixed-citation xml:lang="en">George M, Kellner C, Bernstein H, Goust J. A Magnetic Resonance Imaging Investigation into Mood Disorders in Multiple Sclerosis. J Nerv Ment Dis. 1994; 182(7)408-411. doi:10.1097/00005053-199407000-00008</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Gerolimatos LA, Edelstein BA. Predictors of health anxiety among older and young adults. International Psychogeriatrics. 2012; 24(12):1998-2008. doi: http://dx.doi.org/10.1017/S1041610212001329.</mixed-citation><mixed-citation xml:lang="en">Gerolimatos LA, Edelstein BA. Predictors of health anxiety among older and young adults. International Psychogeriatrics. 2012; 24(12):1998-2008. doi: http://dx.doi.org/10.1017/S1041610212001329.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Goodin D. The epidemiology of multiple sclero¬sis. Neuroepidemiology. 206:; 173-206. doi:10.1016/b978-0-12-802973-2.00011-2</mixed-citation><mixed-citation xml:lang="en">Goodin D. The epidemiology of multiple sclero¬sis. Neuroepidemiology. 206:; 173-206. doi:10.1016/b978-0-12-802973-2.00011-2</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Haussleiter I, Brune M, Juckel G. Review: Psycho-pathology in multiple sclerosis: diagnosis, preva-lence and treatment. Ther Adv Neurol Disord. 2009; 2(1):13-29. doi:10.1177/1756285608100325</mixed-citation><mixed-citation xml:lang="en">Haussleiter I, Brune M, Juckel G. Review: Psycho-pathology in multiple sclerosis: diagnosis, preva-lence and treatment. Ther Adv Neurol Disord. 2009; 2(1):13-29. doi:10.1177/1756285608100325</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Hemmer B, Kerschensteiner M, Korn T. Role of the innate and adaptive immune responses in the course of multiple sclerosis. The Lancet Neurology. 2015; 14(4):406-419. doi:10.1016/s1474-4422(14)70305-9</mixed-citation><mixed-citation xml:lang="en">Hemmer B, Kerschensteiner M, Korn T. Role of the innate and adaptive immune responses in the course of multiple sclerosis. The Lancet Neurology. 2015; 14(4):406-419. doi:10.1016/s1474-4422(14)70305-9</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Henry A, Tourbah A, Camus G et al. Anxiety and depression in patients with multiple sclero¬sis: The mediating effects of perceived social support. Mult Scler Relat Disord. 2019; 27:46-51. doi:10.1016/j.msard.2018.09.03925.</mixed-citation><mixed-citation xml:lang="en">Henry A, Tourbah A, Camus G et al. Anxiety and depression in patients with multiple sclero¬sis: The mediating effects of perceived social support. Mult Scler Relat Disord. 2019; 27:46-51. doi:10.1016/j.msard.2018.09.03925.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Haussleiter I, Brune M, Juckel G. Review: Psychopathology in multiple sclerosis: diagnosis, prevalence and treatment. Ther Adv Neurol Disord. 2009; 2(1):13-29. doi:10.1177/1756285608100325</mixed-citation><mixed-citation xml:lang="en">Haussleiter I, Brune M, Juckel G. Review: Psychopathology in multiple sclerosis: diagnosis, prevalence and treatment. Ther Adv Neurol Disord. 2009; 2(1):13-29. doi:10.1177/1756285608100325</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Interferon beta-lb in the treatment of multiple sclerosis: Final outcome of the randomized con-trolled trial. Neurology. 1995; 45(7):1277-1285. doi:10.1212/wnl.45.7.1277</mixed-citation><mixed-citation xml:lang="en">Interferon beta-lb in the treatment of multiple sclerosis: Final outcome of the randomized con-trolled trial. Neurology. 1995; 45(7):1277-1285. doi:10.1212/wnl.45.7.1277</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis. Jacobs LD, Beck RW, Simon JH, Kinkel RP, Brownscheidle CM, Murray TJ, Simonian NA, Slasor PJ, Sandrock AW, and the CHAMPS Study Group. N Engl J Med. 2000; 343:898-904. Am J Ophthalmol. 2001; 131(1):154-155. doi:10.1016/s0002-9394(00)00915-6</mixed-citation><mixed-citation xml:lang="en">Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis. Jacobs LD, Beck RW, Simon JH, Kinkel RP, Brownscheidle CM, Murray TJ, Simonian NA, Slasor PJ, Sandrock AW, and the CHAMPS Study Group. N Engl J Med. 2000; 343:898-904. Am J Ophthalmol. 2001; 131(1):154-155. doi:10.1016/s0002-9394(00)00915-6</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson K, Brooks B, Cohen J et al. Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: Results of a phase III multicenter, double-blind, placebo-con-trolled trial. Neurology. 1995; 45(7):1268-1276. doi:10.1212/wnl.45.7.1268</mixed-citation><mixed-citation xml:lang="en">Johnson K, Brooks B, Cohen J et al. Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: Results of a phase III multicenter, double-blind, placebo-con-trolled trial. Neurology. 1995; 45(7):1268-1276. doi:10.1212/wnl.45.7.1268</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Jopson N, Moss-Morris R. The role of illness severity and illness representations in adjusting to multiple sclerosis. J Psychosom Res. 2003; 54(6):503-511. doi:10.1016/s0022-3999(02)00455-Klapper J. Interferon beta treatment of multiple sclerosis. Neurology. 1994; 44(1):188-188. doi:10.1212/wnl.44.1.188-a</mixed-citation><mixed-citation xml:lang="en">Jopson N, Moss-Morris R. The role of illness severity and illness representations in adjusting to multiple sclerosis. J Psychosom Res. 2003; 54(6):503-511. doi:10.1016/s0022-3999(02)00455-Klapper J. Interferon beta treatment of multiple sclerosis. Neurology. 1994; 44(1):188-188. doi:10.1212/wnl.44.1.188-a</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Kubzansky LD, Thurston RC. Emotional vitality and incident coronary heart disease: Benefits of healthy psychological functioning. Archives of General Psychiatry. 2007; 64(12):1393-1401. doi: http://dx.doi.org/10.1001/archpsyc.64.12.1393</mixed-citation><mixed-citation xml:lang="en">Kubzansky LD, Thurston RC. Emotional vitality and incident coronary heart disease: Benefits of healthy psychological functioning. Archives of General Psychiatry. 2007; 64(12):1393-1401. doi: http://dx.doi.org/10.1001/archpsyc.64.12.1393</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Lee B, Dantzer R, Langley K et al. A Cytokine-Based Neuroimmunologic Mechanism of Cancer-Related Symptoms. Neuroimmunomodulation. 2004; 11(5):279-292. doi:10.1159/000079408</mixed-citation><mixed-citation xml:lang="en">Lee B, Dantzer R, Langley K et al. A Cytokine-Based Neuroimmunologic Mechanism of Cancer-Related Symptoms. Neuroimmunomodulation. 2004; 11(5):279-292. doi:10.1159/000079408</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Lublin F, Reingold S, Cohen J et al. Defining the clinical course of multiple sclerosis: The 2013 revisions. Neurology. 2014; 83(3):278-286. doi:10.1212/wnl.0000000000000560</mixed-citation><mixed-citation xml:lang="en">Lublin F, Reingold S, Cohen J et al. Defining the clinical course of multiple sclerosis: The 2013 revisions. Neurology. 2014; 83(3):278-286. doi:10.1212/wnl.0000000000000560</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Lynch S, Kroencke D, Denney D. The relationship between disability and depression in multiple sclerosis: the role of uncertainty, coping, and hope. Multiple Sclerosis. 2001; 7(6):411-416. doi:10.1191/135245801701566998</mixed-citation><mixed-citation xml:lang="en">Lynch S, Kroencke D, Denney D. The relationship between disability and depression in multiple sclerosis: the role of uncertainty, coping, and hope. Multiple Sclerosis. 2001; 7(6):411-416. doi:10.1191/135245801701566998</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Malik U, Makower D, Wadler S. Interferon-mediated fatigue. Cancer. 2001; 92(S6):1664-1668. doi:10.1002/1097-0142(20010915)92:6+&lt;1664::aid-cncr1494&gt;3.0.co;2-9</mixed-citation><mixed-citation xml:lang="en">Malik U, Makower D, Wadler S. Interferon-mediated fatigue. Cancer. 2001; 92(S6):1664-1668.	doi:10.1002/1097-0142(20010915)92:6+&lt;1664::aid-cncr1494&gt;3.0.co;2-9</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Minden S. Mood disorders in multiple sclerosis: diagnosis and treatment. Journal of Neurovirology. 2000; 6(2):160-167.</mixed-citation><mixed-citation xml:lang="en">Minden S. Mood disorders in multiple sclerosis: diagnosis and treatment. Journal of Neurovirology. 2000; 6(2):160-167.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Minden S, Schiffer R. Affective Disorders in Multiple Sclerosis Review and Recommendations for Clinical Research. Arch Neurol. 1990; 47(1):98-104. doi:10.1001/archneur.1990.00530010124031</mixed-citation><mixed-citation xml:lang="en">Minden S, Schiffer R. Affective Disorders in Multiple Sclerosis Review and Recommendations for Clinical Research. Arch Neurol. 1990; 47(1):98-104. doi:10.1001/archneur.1990.00530010124031</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Minden S, Orav J, Reich P. Depression in multiple sclerosis. Gen Hosp Psychiatry. 1987; 9(6):426-434. doi:10.1016/0163-8343(87)90052-1</mixed-citation><mixed-citation xml:lang="en">Minden S, Orav J, Reich P. Depression in multiple sclerosis. Gen Hosp Psychiatry. 1987; 9(6):426-434. doi:10.1016/0163-8343(87)90052-1</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Mohr D, Hart S, Goldberg A. Effects of Treatment for Depression on Fatigue in Multiple Sclerosis. Psychosom Med. 2003; 65(4):542-547. doi:10.1097/01.psy.0000074757.11682.96</mixed-citation><mixed-citation xml:lang="en">Mohr D, Hart S, Goldberg A. Effects of Treatment for Depression on Fatigue in Multiple Sclerosis. Psychosom Med. 2003; 65(4):542-547. doi:10.1097/01.psy.0000074757.11682.96</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Moller A, Wiedemann G, Rohde U, Backmund H, Sonntag A. Correlates of cognitive impairment and depressive mood disorder in multiple sclerosis. Acta Psychiatr Scand. 1994; 89(2):117-121. doi:10.1111/j.1600-0447.1994.tb01497.x</mixed-citation><mixed-citation xml:lang="en">Moller A, Wiedemann G, Rohde U, Backmund H, Sonntag A. Correlates of cognitive impairment and depressive mood disorder in multiple sclerosis. Acta Psychiatr Scand. 1994; 89(2):117-121. doi:10.1111/j.1600-0447.1994.tb01497.x</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Moriya R, Kutsumi M. Fatigue in Japanese people with multiple sclerosis. Nurs Health Sci. 2010; 12(4):421-428. doi:10.1111/j.1442-2018.2010.00554.x</mixed-citation><mixed-citation xml:lang="en">Moriya R, Kutsumi M. Fatigue in Japanese people with multiple sclerosis. Nurs Health Sci. 2010; 12(4):421-428. doi:10.1111/j.1442-2018.2010.00554.x</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Noy S, Achiron A, Gabbay U et al. A new approach to affective symptoms in relapsing-remitting multiple sclerosis. Compr Psychiatry. 1995; 36(5):390-395. doi:10.1016/s0010-440x(95)90121-3</mixed-citation><mixed-citation xml:lang="en">Noy S, Achiron A, Gabbay U et al. A new approach to affective symptoms in relapsing-remitting multiple sclerosis. Compr Psychiatry. 1995; 36(5):390-395. doi:10.1016/s0010-440x(95)90121-3</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Ostacoli L, Carletto S, Borghi M et al. Prevalence and Significant Determinants of Post-traumatic Stress Disorder in a Large Sample of Patients with Multiple Sclerosis. J Clin Psychol Med Settings. 2012; 20(2):240-246. doi:10.1007/s10880-012-9323-239.</mixed-citation><mixed-citation xml:lang="en">Ostacoli L, Carletto S, Borghi M et al. Prevalence and Significant Determinants of Post-traumatic Stress Disorder in a Large Sample of Patients with Multiple Sclerosis. J Clin Psychol Med Settings. 2012; 20(2):240-246. doi:10.1007/s10880-012-9323-239.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Panda S, Das R, Srivastava K, Ratnam A, Sharma N. Psychiatric comorbidity in multiple sclerosis. Neurol Neurochir Pol. 2018; 52(6):704-709. doi:10.1016/j.pjnns.2018.09.003</mixed-citation><mixed-citation xml:lang="en">Panda S, Das R, Srivastava K, Ratnam A, Sharma N. Psychiatric comorbidity in multiple sclerosis. Neurol Neurochir Pol. 2018; 52(6):704-709. doi:10.1016/j.pjnns.2018.09.003</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Patten S, Marrie R, Carta M. Depression in multiple sclerosis. International Review of Psychiatry. 2017; 29(5):463-472. doi:10.1080/09540261.2017.1 322555</mixed-citation><mixed-citation xml:lang="en">Patten S, Marrie R, Carta M. Depression in multiple sclerosis. International Review of Psychiatry. 2017; 29(5):463-472. doi:10.1080/09540261.2017.1 322555</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Patten S, Metz L. Interferon 1a and depression in secondary progressive MS: Data from the SPEC-TRIMS Trial. Neurology. 2002; 59(5):744-746. doi:10.1212/wnl.59.5.744</mixed-citation><mixed-citation xml:lang="en">Patten S, Metz L. Interferon 1a and depression in secondary progressive MS: Data from the SPEC-TRIMS Trial. Neurology. 2002; 59(5):744-746. doi:10.1212/wnl.59.5.744</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Patten S, Metz L. Interferon fi-1a and depression in relapsing — remitting multiple sclerosis: an analysis of depression data from the PRISMS clinical trial. Multiple Sclerosis Journal. 2001; 7(4):243-248. doi:10.1177/135245850100700406</mixed-citation><mixed-citation xml:lang="en">Patten S, Metz L. Interferon fi-1a and depression in relapsing — remitting multiple sclerosis: an analysis of depression data from the PRISMS clinical trial. Multiple Sclerosis Journal. 2001; 7(4):243-248. doi:10.1177/135245850100700406</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Patten S, Metz L, Reimer M. Biopsychosocial correlates of lifetime major depression in a multiple sclerosis population. Multiple Sclerosis. 2000; 6(2):115-120. doi:10.1191/135245800678827536</mixed-citation><mixed-citation xml:lang="en">Patten S, Metz L, Reimer M. Biopsychosocial correlates of lifetime major depression in a multiple sclerosis population. Multiple Sclerosis. 2000; 6(2):115-120. doi:10.1191/135245800678827536</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Pujol J, Bello J, Deus J, Marti-Vilalta J, Capdevila A. Lesions in the left arcuate fasciculus region and depressive symptoms in multiple sclerosis. Neurology. 1997; 49(4):1105-1110. doi:10.1212/wnl.49.4.1105</mixed-citation><mixed-citation xml:lang="en">Pujol J, Bello J, Deus J, Marti-Vilalta J, Capdevila A. Lesions in the left arcuate fasciculus region and depressive symptoms in multiple sclerosis. Neurology. 1997; 49(4):1105-1110. doi:10.1212/wnl.49.4.1105</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Rabins P, Brooks B, O’Donnell P et al. Structural brain correlates of emotional disorder in multiple sclerisis. Brain. 1986; 109(4):585-597. doi:10.1093/brain/109.4.585</mixed-citation><mixed-citation xml:lang="en">Rabins P, Brooks B, O’Donnell P et al. Structural brain correlates of emotional disorder in multiple sclerisis. Brain. 1986; 109(4):585-597. doi:10.1093/brain/109.4.585</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Rabkin J, Albert S, Del Bene M et al. Prevalence of depressive disorders and change over time in late-stage ALS. Neurology. 2005; 65(1):62-67. doi:10.1212/01.wnl.0000167187.14501.0c</mixed-citation><mixed-citation xml:lang="en">Rabkin J, Albert S, Del Bene M et al. Prevalence of depressive disorders and change over time in late-stage ALS. Neurology. 2005; 65(1):62-67. doi:10.1212/01.wnl.0000167187.14501.0c</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Raison C, Demetrashvili M, Capuron L, Miller A. Neuropsychiatric Adverse Effects of Interferon-alpha. CNS Drugs. 2005; 19(2):105-123. doi:10.2165/00023210-200519020-00002</mixed-citation><mixed-citation xml:lang="en">Raison C, Demetrashvili M, Capuron L, Miller A. Neuropsychiatric Adverse Effects of Interferon-alpha. CNS Drugs. 2005; 19(2):105-123. doi:10.2165/00023210-200519020-00002</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Reischies F. Cerebral Magnetic Resonance Imaging Findings in Multiple Sclerosis. Arch Neurol. 1988; 45(10):1114. doi:10.1001/archneur.1988.00520340068014</mixed-citation><mixed-citation xml:lang="en">Reischies F. Cerebral Magnetic Resonance Imaging Findings in Multiple Sclerosis. Arch Neurol. 1988; 45(10):1114. doi:10.1001/archneur.1988.00520340068014</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Sabatini U, Pozzilli C, Pantano P et al. Involvement of the limbic system in multiple sclerosis patients with depressive disorders. Biol Psychiatry. 1996; 39(11):970-975. doi:10.1016/0006-3223(95)00291-%</mixed-citation><mixed-citation xml:lang="en">Sabatini U, Pozzilli C, Pantano P et al. Involvement of the limbic system in multiple sclerosis patients with depressive disorders. Biol Psychiatry. 1996; 39(11):970-975. doi:10.1016/0006-3223(95)00291-%</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Sadovnick A, Eisen K, Ebers G, Paty D. Cause of death in patients attending multiple sclerosis clinics. Neurology. 1991; 41(8):1193-1193. doi:10.1212/wnl.41.8.1193</mixed-citation><mixed-citation xml:lang="en">Sadovnick A, Eisen K, Ebers G, Paty D. Cause of death in patients attending multiple sclerosis clinics. Neurology. 1991; 41(8):1193-1193. doi:10.1212/wnl.41.8.1193</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">Sai-Halasz A. Psychic Alterations in Disseminated Sclerosis A General, Statistical and Rorschach-Test Study on 200 Patients. Eur Neurol. 1956; 132(2-3):129-154. doi:10.1159/000139628</mixed-citation><mixed-citation xml:lang="en">Sai-Halasz A. Psychic Alterations in Disseminated Sclerosis A General, Statistical and Rorschach-Test Study on 200 Patients. Eur Neurol. 1956; 132(2-3):129-154. doi:10.1159/000139628</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">Sanfilipo M, Benedict R, Weinstock-Guttman B, Bakshi R. Gray and white matter brain atrophy and neuropsychological impairment in multiple sclerosis. Neurology. 2006; 66(5):685-692. doi:10.1212/01.wnl.0000201238.93586.d9</mixed-citation><mixed-citation xml:lang="en">Sanfilipo M, Benedict R, Weinstock-Guttman B, Bakshi R. Gray and white matter brain atrophy and neuropsychological impairment in multiple sclerosis. Neurology. 2006; 66(5):685-692. doi:10.1212/01.wnl.0000201238.93586.d9</mixed-citation></citation-alternatives></ref><ref id="cit78"><label>78</label><citation-alternatives><mixed-citation xml:lang="ru">Schaefer M, Engelbrechta M, Gut O et al. Interferon alpha (IFNa) and psychiatric syndromes. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2002; 26(4):731-746. doi:10.1016/s0278-5846(01)00324-4</mixed-citation><mixed-citation xml:lang="en">Schaefer M, Engelbrechta M, Gut O et al. Interferon alpha (IFNa) and psychiatric syndromes. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2002; 26(4):731-746. doi:10.1016/s0278-5846(01)00324-4</mixed-citation></citation-alternatives></ref><ref id="cit79"><label>79</label><citation-alternatives><mixed-citation xml:lang="ru">Schiffer R. Multiple Sclerosis and Affective Disorder. Arch Neurol. 1988;45(12):1345. doi:10.1001/ archneur.1988.00520360063013</mixed-citation><mixed-citation xml:lang="en">Schiffer R. Multiple Sclerosis and Affective Disorder. Arch Neurol. 1988;45(12):1345. doi:10.1001/ archneur.1988.00520360063013</mixed-citation></citation-alternatives></ref><ref id="cit80"><label>80</label><citation-alternatives><mixed-citation xml:lang="ru">Siegert R. Depression in multiple sclerosis: a review. Journal of Neurology, Neurosurgery &amp; Psychiatry. 2005; 76(4):469-475. doi:10.1136/jnnp.2004.054635</mixed-citation><mixed-citation xml:lang="en">Siegert R. Depression in multiple sclerosis: a review. Journal of Neurology, Neurosurgery &amp; Psychiatry. 2005; 76(4):469-475. doi:10.1136/jnnp.2004.054635</mixed-citation></citation-alternatives></ref><ref id="cit81"><label>81</label><citation-alternatives><mixed-citation xml:lang="ru">Sugar C, Nadell R. Mental symptoms in multiple sclerosis. J Nerv Ment Dis. 1943; 98(3):267-280. doi:10.1097/00005053-194309000-00004</mixed-citation><mixed-citation xml:lang="en">Sugar C, Nadell R. Mental symptoms in multiple sclerosis. J Nerv Ment Dis. 1943; 98(3):267-280. doi:10.1097/00005053-194309000-00004</mixed-citation></citation-alternatives></ref><ref id="cit82"><label>82</label><citation-alternatives><mixed-citation xml:lang="ru">Tedman B, Young C, Williams I. Assessment of depression in patients with motor neuron disease and other neurologically disabling illness. J Neurol Sci. 1997; 152s75s79. doi:10.1016/s0022-510x(97)00249-9</mixed-citation><mixed-citation xml:lang="en">Tedman B, Young C, Williams I. Assessment of depression in patients with motor neuron disease and other neurologically disabling illness. J Neurol Sci. 1997; 152s75s79. doi:10.1016/s0022-510x(97)00249-9</mixed-citation></citation-alternatives></ref><ref id="cit83"><label>83</label><citation-alternatives><mixed-citation xml:lang="ru">Trask P, Paterson A, Esper P, Pau J, Redman B. Longitudinal course of depression, fatigue, and quality of life in patients with high risk melanoma receiving adjuvant interferon. Psychooncology. 2004; 13(8)526-536. doi:10.1002/pon.770</mixed-citation><mixed-citation xml:lang="en">Trask P, Paterson A, Esper P, Pau J, Redman B. Longitudinal course of depression, fatigue, and quality of life in patients with high risk melanoma receiving adjuvant interferon. Psychooncology. 2004; 13(8)526-536. doi:10.1002/pon.770</mixed-citation></citation-alternatives></ref><ref id="cit84"><label>84</label><citation-alternatives><mixed-citation xml:lang="ru">Vercoulen J. The Measurement of Fatigue in Patients With Multiple Sclerosis. Arch Neurol. 1996; 53(7):642. doi:10.1001/arch-neur.1996.00550070080014</mixed-citation><mixed-citation xml:lang="en">Vercoulen J. The Measurement of Fatigue in Patients With Multiple Sclerosis. Arch Neurol. 1996; 53(7):642. doi:10.1001/arch-neur.1996.00550070080014</mixed-citation></citation-alternatives></ref><ref id="cit85"><label>85</label><citation-alternatives><mixed-citation xml:lang="ru">Weinshenker B, Bass B, Rice G et al. The natural history of multiple sclerosi : a geographically based study. Brain. 1989; 112(1):133-146. doi:10.1093/brain/112.1.133</mixed-citation><mixed-citation xml:lang="en">Weinshenker B, Bass B, Rice G et al. The natural history of multiple sclerosi : a geographically based study. Brain. 1989; 112(1):133-146. doi:10.1093/brain/112.1.133</mixed-citation></citation-alternatives></ref><ref id="cit86"><label>86</label><citation-alternatives><mixed-citation xml:lang="ru">Wierenga K, Lehto R, Given B. Emotion Regulation in Chronic Disease Populations: An Integrative Re-view. Res Theory Nurs Pract. 2017; 31(3):247-271. doi:10.1891/1541-6577.31.3.247</mixed-citation><mixed-citation xml:lang="en">Wierenga K, Lehto R, Given B. Emotion Regulation in Chronic Disease Populations: An Integrative Re-view. Res Theory Nurs Pract. 2017; 31(3):247-271. doi:10.1891/1541-6577.31.3.247</mixed-citation></citation-alternatives></ref><ref id="cit87"><label>87</label><citation-alternatives><mixed-citation xml:lang="ru">Whitlock F, Siskind M. Depression as a major symptom of multiple sclerosis. Journal of Neurology, Neurosurgery &amp; Psychiatry. 1980; 43(10):861-865. doi:10.1136/jnnp.43.10.861</mixed-citation><mixed-citation xml:lang="en">Whitlock F, Siskind M. Depression as a major symptom of multiple sclerosis. Journal of Neurology, Neurosurgery &amp; Psychiatry. 1980; 43(10):861-865. doi:10.1136/jnnp.43.10.861</mixed-citation></citation-alternatives></ref><ref id="cit88"><label>88</label><citation-alternatives><mixed-citation xml:lang="ru">Wood B, van der Mei I, Ponsonby A et al. Prevalence and concurrence of anxiety, depression and fatigue over time in multiple sclerosis. Multiple Sclerosis Journal. 2012; 19(2):217-224. doi:10.1177/1352458512450351</mixed-citation><mixed-citation xml:lang="en">Wood B, van der Mei I, Ponsonby A et al. Prevalence and concurrence of anxiety, depression and fatigue over time in multiple sclerosis. Multiple Sclerosis Journal. 2012; 19(2):217-224. doi:10.1177/1352458512450351</mixed-citation></citation-alternatives></ref><ref id="cit89"><label>89</label><citation-alternatives><mixed-citation xml:lang="ru">Zephir H, De Seze J, Stojkovic T et al. Multiple sclerosis and depression: influence of interferon b therapy. Multiple Sclerosis Journal. 2003; 9(3):284-288. doi:10.1191/1352458503ms915oaa</mixed-citation><mixed-citation xml:lang="en">Zephir H, De Seze J, Stojkovic T et al. Multiple sclerosis and depression: influence of interferon b therapy. Multiple Sclerosis Journal. 2003; 9(3):284-288. doi:10.1191/1352458503ms915oaa</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
