bekhterevОбозрение психиатрии и медицинской психологии имени В.М.БехтереваV.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY2313-70532713-055XV. M. BEKHTEREV NATIONAL RESEARCH MEDICAL CENTER FOR PSYCHIATRY AND NEUROLOGY OF THE RUSSIAN FEDERATION MINISTRY OF HEALTH10.31363/2313-7053-2020-1-39-44bekhterev-382Research ArticleИССЛЕДОВАНИЯINVESTIGATIONSАссоциация полиморфизма гена MAOA-uVNTR с враждебностью в открытой популяции мужчин 45-64 лет в России/Сибири (международные программы: ВОЗ «MONICA-psychosocial», «HAPIEE»)Association of MAOA-uVNTR gene polymorphism with hostility in an open population of males aged 45-64 in Russia / Siberia (international program: WHO «MONICA-psychosocial», «HAPIEE»)ГафаровВ. В.GafarovV. V.

Гафаров Валерий Васильевич — доктор медицинских наук, профессор, руководитель лаборатории психологических и социологических проблем терапевтических заболеваний, Научно-исследовательский институт терапии и профилактической медицины филиал ФГБНУ ФИЦ Института цитологии и Генетики СО РАН; руководитель Межведомственной лаборатории эпидемиологии сердечно-сосудистых заболеваний, Новосибирск.

Novosibirsk

valery.gafarov@gmail.comГромоваЕ. А.GromovaE. A.

Громова Елена Алексеевна — доктор медицинских наук, ведущий научный сотрудник лаборатории психологических и социологических проблем терапевтических заболеваний.

Новосибирск

Novosibirsk

elena.a.gromova@gmail.comПановД. О.PanovD. O.

Панов Дмитрий Олегович — кандидат медицинских наук, старший научный сотрудник лаборатории психологических и социологических проблем терапевтических заболеваний

Новосибирск

Novosibirsk

dimitriy2004@inbox.ruГагулинИ. В.GagulinI. V.

Гагулин Игорь Вячеславович — старший научный сотрудник лаборатории психологических и социологических проблем терапевтических заболеваний 

Новосибирск

Novosibirsk

gagulin@ngs.ruМаксимовВ. Н.MaksimovV. N.

Максимов Владимир Николаевич — доктор медицинских наук, профессор, руководитель лаборатории молекулярно-генетических исследований терапевтических заболеваний 

Новосибирск

Novosibirsk

medik11@mail.ruГафароваА. В.GafarovaA. V.

Гафарова Альмира Валерьевна — кандидат медицинских наук, старший научный сотрудник лаборатории психологических и социологических проблем терапевтических заболеваний

Новосибирск

Novosibirsk

gafarov@ngs.ruНаучно-исследовательский институт терапии и профилактической медицины, филиал ФИЦ ФГБНУ Института Цитологии и Генетики СО РАН; Межведомственная лаборатория эпидемиологии сердечно-сосудистых заболеваний, НовосибирскРоссияInstitute of Internal and Preventive Medicine — branch of Institute of Cytology and Genetics SB RAS; Collaborative laboratory of Cardiovascular Diseases EpidemiologyRussian FederationНаучно-исследовательский институт терапии и профилактической медицины, филиал ФИЦ ФГБНУ Института Цитологии и Генетики СО РАНРоссияInstitute of Internal and Preventive Medicine — branch of Institute of Cytology and Genetics SB RASRussian Federation202001042020013944Copyright © Гафаров В.В., Громова Е.А., Панов Д.О., Гагулин И.В., Максимов В.Н., Гафарова А.В., 20202020Гафаров В.В., Громова Е.А., Панов Д.О., Гагулин И.В., Максимов В.Н., Гафарова А.В.Gafarov V.V., Gromova E.A., Panov D.O., Gagulin I.V., Maksimov V.N., Gafarova A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.bekhterevreview.com/jour/article/view/382

Цель исследования: изучить ассоциацию враждебности с высоко и низко активными вариантами гена MAOA в открытой популяции мужчин 45-64 лет. С помощью методик, предложенных международной программой ВОЗ «MONICA-psychosocial» и «HAPIEE», была обследована репрезентативная выборка мужчин 45-64 лет (n=781 мужчина, средний возраст — 56,48±0,2 года) в 2003-2005 гг. Все респонденты самостоятельно заполнили опросник по враждебности. Из обследованной выборки с помощью метода случайных чисел было выбрано 156 мужчин, которым было проведено генотипирование полиморфизма MAOA-uVNTR. Уставлено, что уровень враждебности в популяции мужчин составил 60,3%. Выявлено, что среди лиц с низко активными аллелями гена MAOA-L (аллель 2 и 3) чаще встречался высокий уровень враждебности — 50,9%. Результаты построения логистистической регрессионной модели показали, что наличие низко активных аллелей (2; 3) гена MAOA повышает вероятность возникновения враждебности OR=2,103 (95%CI 1,137-3,889, p=0,018). Полученные результаты позволяют сделать вывод, что низко активный аллель гена MAOA-L связан с враждебностью.

Objective: to study the association of hostility with high and low-active variants of the MAOA gene in an open population of men 45-64 years old. Using the methods proposed by the WHO International Program “MONICA-psychosocial” and “HAPIEE”, a representative sample of men aged 45–64 years old (n = 781 men, average age was 56.48 ± 0.2 years) in 2003-2005. All respondents independently completed a questionnaire on hostility. From the surveyed sample, using the random number method, 156 men were selected who were genotyped for MAOA-uVNTR polymorphism. It was approved that the level of hostility in the population of men was 60.3%. It was revealed that among persons with low-active alleles of the MAOA-L gene (allele 2 and 3) a high level of hostility was more common — 50.9%. The results of building a logistic regression model showed that the presence of low-active alleles (2; 3) of the MAOA gene increases the likelihood of hostility OR = 2,103 (95% CI 1,137-3,889, p = 0.018). The results obtained allow us to conclude that the low-active allele of the MAOA-L gene is associated with hostility.

ген MAOAвраждебностьоткрытая популяциямужчиныMAOA genehostilitypopulationmenReferencesБююль А, Цёфель П SPSS: искусство обработки информации. Анализ статистических данных и восстановление скрытых закономерностей. СПб.: ООО «DiaSoftЮП». 2015: 608.Byul A, Tzofel P SPSS: the art of information processing. Analysis of statistical data and restoration of hidden patterns. SPb: OOO DiaSoftUP. 2015: 608. (in Russ.)Beach SRH, Brody GH, Gunter TD, Packer H, Wernett P, Philibert RA. Child maltreatment moderates the association of MAOA with symptoms of depression and antisocial personality disorder. J Fam Psychol. 2010; 24(1):12–20. doi: 10.1037/a0018074.Beach SRH, Brody GH, Gunter TD, Packer H, Wernett P, Philibert RA. Child maltreatment moderates the association of MAOA with symptoms of depression and antisocial personality disorder. J Fam Psychol. 2010; 24(1):12–20. doi: 10.1037/a0018074.Beaver KM, Wright JP, Boutwell BB., Barnes JC, DeLisi M, Vaughn MG. Exploring the association between the 2-repeat allele of the MAOA gene promoter polymorphism and psychopathic personality traits, arrests, incarceration, and lifetime antisocial behavior. Pers Indiv Differ. 2013; 54:164–168. https://doi.org/10.1016/j.paid.2012.08.014Beaver KM, Wright JP, Boutwell BB., Barnes JC, DeLisi M, Vaughn MG. Exploring the association between the 2-repeat allele of the MAOA gene promoter polymorphism and psychopathic personality traits, arrests, incarceration, and lifetime antisocial behavior. Pers Indiv Differ. 2013; 54:164–168. https://doi.org/10.1016/j.paid.2012.08.014Bortolato M, Chen K, Shih JC. Monoamine oxidase inactivation: from pathophysiology to therapeutics. Adv Drug Deliver Rev. 2008; 60:1527–1533. doi: 10.1016/j.addr.2008.06.002.Bortolato M, Chen K, Shih JC. Monoamine oxidase inactivation: from pathophysiology to therapeutics. Adv Drug Deliver Rev. 2008; 60:1527–1533. doi: 10.1016/j.addr.2008.06.002.Byrd AL, Manuck SB. MAOA, childhood maltreatment, and antisocial behavior: meta-analysis of a gene–environment interaction. Biol Psychiatry. 2014; 75(1):9–17. doi: 10.1016/j.biopsych.2013.05.004.Byrd AL, Manuck SB. MAOA, childhood maltreatment, and antisocial behavior: meta-analysis of a gene–environment interaction. Biol Psychiatry. 2014; 75(1):9–17. doi: 10.1016/j.biopsych.2013.05.004.Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, Poulton R. Role of genotype in the cycle of violence in maltreated children. Science. 2002; 297(5582):851–854. doi: 10.1126/science.1072290.Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, Poulton R. Role of genotype in the cycle of violence in maltreated children. Science. 2002; 297(5582):851–854. doi: 10.1126/science.1072290.Deckert J, Catalano M, Syagailo YV, Bosi M, Okladnova O, Di Bella D, Nothen MM, Maffei P, Franke P, Fritze J, Maier W, Propping P, Beckmann H, Bellodi L, Lesch KP. Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder. Hum Mol Genet. 1999; 8(4):621–624. doi: 10.1093/hmg/8.4.621.Deckert J, Catalano M, Syagailo YV, Bosi M, Okladnova O, Di Bella D, Nothen MM, Maffei P, Franke P, Fritze J, Maier W, Propping P, Beckmann H, Bellodi L, Lesch KP. Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder. Hum Mol Genet. 1999; 8(4):621–624. doi: 10.1093/hmg/8.4.621.Ferguson CJ, Beaver KM. Natural born killers: The genetic origins of extreme violence. Aggress Violent Behav. 2009; 14:286–294. doi:10.1016/j.avb.2009.03.005Ferguson CJ, Beaver KM. Natural born killers: The genetic origins of extreme violence. Aggress Violent Behav. 2009; 14:286–294. doi:10.1016/j.avb.2009.03.005Ferguson CJ. Genetic contributions to antisocial personality and behavior: a meta-analytic review from an evolutionary perspective. J Soc Psychol. 2010; 150:160–180. doi:10.1080/00224540903366503Ferguson CJ. Genetic contributions to antisocial personality and behavior: a meta-analytic review from an evolutionary perspective. J Soc Psychol. 2010; 150:160–180. doi:10.1080/00224540903366503Godar SC, Fite PJ, McFarlin1 KM, Bortolato M. The role of monoamine oxidase A in aggression: current translational developments and future challenges. Neuropsychopharmacol Biol Psychiatry. 2016; 69: 90–100. doi:10.1016/j.pnpbp. 2016.01.001.Godar SC, Fite PJ, McFarlin1 KM, Bortolato M. The role of monoamine oxidase A in aggression: current translational developments and future challenges. Neuropsychopharmacol Biol Psychiatry. 2016; 69: 90–100. doi:10.1016/j.pnpbp. 2016.01.001.Guo G, Ou X-M, Roettger M, Shih JC. The VNTR 2 repeat in MAOA and delinquent behavior in adolescence and young adulthood: associations and MAOA promoter activity. Eur J Hum Genet. 2008; 16:626–634. doi: 10.1038/sj.ejhg.5201999.Guo G, Ou X-M, Roettger M, Shih JC. The VNTR 2 repeat in MAOA and delinquent behavior in adolescence and young adulthood: associations and MAOA promoter activity. Eur J Hum Genet. 2008; 16:626–634. doi: 10.1038/sj.ejhg.5201999.Huang YY, Cate SP, Battistuzzi C, Oquendo MA, Brent D, Mann JJ. An association between a functional polymorphism in the monoamine oxidase a gene promoter, impulsive traits and early abuse experiences. Neuropsychopharmacology. 2004; 29(8):1498–1505. doi: 10.1038/sj.npp.1300455.Huang YY, Cate SP, Battistuzzi C, Oquendo MA, Brent D, Mann JJ. An association between a functional polymorphism in the monoamine oxidase a gene promoter, impulsive traits and early abuse experiences. Neuropsychopharmacology. 2004; 29(8):1498–1505. doi: 10.1038/sj.npp.1300455.Kim-Cohen J, Caspi A, Taylor A, Williams B, Newcombe R, Craig IW, Moffitt TE. MAOA, maltreatment, and gene–environment interaction predicting children’s mental health: new evidence and a meta-analysis. Mol Psychiatry. 2006; 11(10):903–913. doi: 10.1038/sj.mp.4001851.Kim-Cohen J, Caspi A, Taylor A, Williams B, Newcombe R, Craig IW, Moffitt TE. MAOA, maltreatment, and gene–environment interaction predicting children’s mental health: new evidence and a meta-analysis. Mol Psychiatry. 2006; 11(10):903–913. doi: 10.1038/sj.mp.4001851.Kuepper Y, Grant P, Wielpuetz C, Hennig J. MAOA-uVNTR genotype predicts interindividual differences in experimental aggressiveness as a function of the degree of provocation. Behav Brain Res. 2013; 247:73–78. doi: 10.1016/j.bbr.2013.03.002.Kuepper Y, Grant P, Wielpuetz C, Hennig J. MAOA-uVNTR genotype predicts interindividual differences in experimental aggressiveness as a function of the degree of provocation. Behav Brain Res. 2013; 247:73–78. doi: 10.1016/j.bbr.2013.03.002.Lavigne JV Herzing LBK, Cook EH, Lebailly SA, Gouze KR, Hopkins J, Bryant FB. Gene × environment effects of serotonin transporter, dopamine receptor D4, and monoamine oxidase A genes with contextual and parenting risk factors on symptoms of oppositional defiant disorder, anxiety, and depression in a community sample of 4-year-old children. Dev Psychopathol. 2013; 25(2):555–575. doi: 10.1017/S0954579412001241.Lavigne JV Herzing LBK, Cook EH, Lebailly SA, Gouze KR, Hopkins J, Bryant FB. Gene × environment effects of serotonin transporter, dopamine receptor D4, and monoamine oxidase A genes with contextual and parenting risk factors on symptoms of oppositional defiant disorder, anxiety, and depression in a community sample of 4-year-old children. Dev Psychopathol. 2013; 25(2):555–575. doi: 10.1017/S0954579412001241.MONICA Monograph and Multimedia Sourcebook. Helsinki. 2003; 237p.MONICA Monograph and Multimedia Sourcebook. Helsinki. 2003; 237p.Murdock KW., LeRoy A S., Fagundes C P. Trait Hostility and Cortisol Sensitivity Following a Stressor: The Moderating Role of Stress-Induced Heart Rate Variability. Psychoneuroendocrinology. 2017; 75:222–227. doi:10.1016/j.psyneuen.2016.10.014Murdock KW., LeRoy A S., Fagundes C P. Trait Hostility and Cortisol Sensitivity Following a Stressor: The Moderating Role of Stress-Induced Heart Rate Variability. Psychoneuroendocrinology. 2017; 75:222–227. doi:10.1016/j.psyneuen.2016.10.014Pandis N. The chi-square test. Am J Orthod Dentofacial Orthop. 2016; 150(5):898-899. doi: 10.1016/j.ajodo.2016.08.009.Pandis N. The chi-square test. Am J Orthod Dentofacial Orthop. 2016; 150(5):898-899. doi: 10.1016/j.ajodo.2016.08.009.Sabol SZ, Hu S, Hamer D. A functional polymorphism in the monoamine oxidase A gene promoter. Hum Genet. 1998; 103(3):273–279. doi: 10.1007/s004390050816.Sabol SZ, Hu S, Hamer D. A functional polymorphism in the monoamine oxidase A gene promoter. Hum Genet. 1998; 103(3):273–279. doi: 10.1007/s004390050816.UCL DEPARTMENT OF EPIDEMIOLOGY AND PUBLIC HEALTH CENTRAL AND EASTERN EUROPE RESEARCH GROUP HAPIEE Study [электронный ресурс]-режим доступа/Available for: http://www.ucl.ac.uk/easteurope/hapiee-cohort.htm Заглавие с экранаUCL DEPARTMENT OF EPIDEMIOLOGY AND PUBLIC HEALTH CENTRAL AND EASTERN EUROPE RESEARCH GROUP HAPIEE Study [электронный ресурс]-режим доступа/Available for: http://www.ucl.ac.uk/easteurope/hapiee-cohort.htm Заглавие с экрана

The authors declare that there are no conflicts of interest present.