References

bekhterev

Обозрение психиатрии и медицинской психологии имени В.М.Бехтерева

V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY

2313-70532713-055X

V. M. BEKHTEREV NATIONAL RESEARCH MEDICAL CENTER FOR PSYCHIATRY AND NEUROLOGY OF THE RUSSIAN FEDERATION MINISTRY OF HEALTH

10.31363/2313-7053-2020-2-47-56

bekhterev-421

Research Article

НАУЧНЫЕ ОБЗОРЫ

SCIENTIFIC REVIEW

Клинические варианты аффективных, диссомнических и двигательных проявлений краниоцервикальной дистонии (обзор литературы)

Clinical variety of affective, sleep and motor manifestations in craniocervical dystonia (a literature review)

Хаятова

З. Г.

Khaiatova

Z. G.

Хаятова Зифа Гумеровна—аспирант кафедры неврологии и реабилитации

hayatova@list.ru

Залялова

З. А.

Zalyalova

Z. A.

Залялова Зулейха Абдуллазяновна—д.м.н., профессор кафедры неврологии и реабилитации

руководитель

z.zalyalova@gmail.com

ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава РФРоссияKazan State Medical UniversityRussian Federation

ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава РФ; Республиканский клинико-диагностический центр экстрапирамидной патологии и ботулинотерапии Республики ТатарстанРоссияKazan State Medical University; Kazan State Medical University, Republican clinical diagnostical center of extrapyramidal disorders and botulinotherapyRussian Federation

2020

09072020

024756

2020

Хаятова З.Г., Залялова З.А.

Khaiatova Z.G., Zalyalova Z.A.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.bekhterevreview.com/jour/article/view/421

В литературе появляется все больше данных, указывающих на наличие у пациентов с дистонией недвигательных нарушений—изменения настроения, когнитивных нарушений, расстройств сна, вегетативной дисфункции и/или боли, являющихся важными составляющими качества жизни. В статье обсуждается вероятность коморбидности аффективных и диссомнических проявлений и дистонии. В настоящий момент доказательства в пользу этой теории спорны, и вопрос остается открытым и требует дальнейшего изучения. Аффективные и диссомнические проявления дистонии—определяющий фактор снижения качества жизни, связанного со здоровьем, а также нетрудоспособности, хотя их вклад в клиническую картину заболевания зачастую остается недооцененным. Важным становится выявление этих проявлений, оценка их выраженности, роли в изменении повседневной активности пациентов с краниоцервикальной дистонией.

Recent research data literature indicates the presence of non-motor symptoms in patients with dystonia such as mood disorders, cognitive impairments, sleep disturbances, autonomic dysfunction and / or pain, which are important components of quality of life. The article discusses possible comorbidity of affective manifestations,sleep disorders and dystonia. Currently, evidence is controversial, and the question requires further study. Affective symptoms and sleep disturbances of dystonia are now recognized as the greater determinant of quality of life in dystonia, being associated with health and disability, although their contribution to the clinical picture of the disease often remains underestimated. It becomes important to identify these manifestations, assess their severity and impact on the daily activity of patients with craniocervical dystonia.

дистонияаффективные нарушениянедвигательные симптомыдиссомниякраниоцервикальная дистония

dystoniaaffectivedisordersnon-motor symptomssleep disturbancescraniocervical dystonia

References1

Залялова З.А. Современные классификации мышечных дистоний, стратегия лечения. Журнал неврологии и психиатрии и им. С.С. Корсакова. 2013;113(3):85-89.

Zalyalova ZA. Modern classifications of muscular dystonia, treatment strategy. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2013;113(3):85-89. (In Russ.).

Захаров Д.В., Залялова З.А., Фурсова И.В., Яковлева Л.А. Опыт применения ботулинического токсина типа А в лечении болезненных дистоний при болезни Паркинсона. Обозрение психиатрии и медицинской психологии имени В.М.Бехтерева. 2014;(1):90-95.

Zakharov DV, Zalyalova ZA, Fursova IV, Yakovleva LA. Application of botulinum toxin type А in the treatment of painful dystoniain Parkinson’s disease. Obozrenie psihiatrii i medicinskoj psihologii im. V.M. Bekhtereva. 2014;(1):90-95. (In Russ.).

Краснов М.Ю., Тимербаева С.Л., Иллариошкин С.Н. Генетика наследственных форм дистонии. Анналы клинической и экспериментальной неврологии. 2013;7(2):55-62.

Krasnov MYu, Timerbaeva SL, Illarioshkin SN. Genetics of hereditary forms of dystonia. Annaly` klinicheskoj i e`ksperimental`noj nevrologii. 2013;7(2):55-62. (In Russ.).

Орлова О.Р. Фокальные дистонии: клиника, патогенез, лечение с использованием токсина ботулизма. Автореф. дис. докт. мед. наук. М.,2000;48.

Orlova O.R. Fokal`ny`e distonii: klinika, patogenez, lechenie s ispol`zovaniem toksina botulizma. Avtoref. dis. dokt. med. nauk. M.,2000;48. (In Russ.).

Орлова О.Р. Фокальные дистонии: современные подходы к диагностике и возможности ботулинотерапии. Нервные болезни. 2016;4:3-13.

Orlova OR. Focal dystonia: modern approaches to diagnosis and possibilities of botulinum therapy. Nervny`e bolezni. 2016;4:3-13. (In Russ.).

Тимербаева С.Л., Коновалов Р.Н., Иллариошкин С.Н. Фокальная дистония: картирование церебральных моторных зон с помощью функциональной МРТ. Неврологический журнал. 2012;17(3):23-29.

Timerbaeva SL, Konovalov RN, Illarioshkin SN. Focal dystonia: mapping of cerebral motor zones using functional MRT. Nevrologicheskij zhurnal. 2012;17(3):23-29. (In Russ.).

Фурсова И.В., Михайлов В.А., Захаров Д.В., Коваленко А.П. Постуральные деформации при болезни Паркинсона (клинические и психосоциальные аспекты). Обозрение психиатрии и медицинской психологии имени В.М.Бехтерева. 2019;4:112-117. https:// doi.org/10.31363/2313-7053-2019-4-2-112-117.

Fursova I.V., Mikhailov V.A., Zakharov D.V., Kovalenko A.P. Postural deformities in patients with Parkinson disease (clinical and social aspects). Obozrenie psihiatrii i medicinskoj psihologii im. V.M. Bekhtereva. 2019;4:112-117.

Фурсова И.В., Михайлов В.А., Захаров Д.В., Хубларова Л.А., Коваленко А.П., Залялова З.А. Постуральные деформации при болезни Паркинсона, обзор проблемы, терапевтические подходы. Неврологический вестник. 2019;50(3):69-73.

Khayatova ZG, Zalyalova ZA. Postural deformities in Parkinson’s disease. Review of the problem, therapeutic approaches. Nevrologicheskij vestnik. 2019;50(3):69-73. (In Russ.).

Хаятова З.Г., Залялова З.А. Тревожнодепрессивные расстройства у пациентов с краниоцервикальными дистониями: клиникоанамнестичекие особенности и модифицирующая роль ботулинотерапии. Неврологический вестник. 2019; 51(1):25-31.

Khayatova ZG, Zalyalova ZA. Anxiety-depressive disorders in patients with craniocervical dystonia: clinical and anamnestic features and modifying role of botulinum therapy. Nevrologicheskij vestnik. 2019;51(1):25-31. (In Russ.).

Хубларова Л.А., Захаров Д.В., Михайлов В.А. Стратификация риска развития поздних лекарственно-индуцированных осложнений. Обозрение психиатрии и медицинской психологии имени В.М.Бехтерева. 2017;(4):111-114.

Khublarova LA, Zakharov DV, Mikhaylov VA. Stratification of the risk of developing tardive drug-induced complications. Obozrenie psihiatrii i medicinskoj psihologii im. V.M. Bekhtereva. 2017;(4):111-114.

Albanese A, Bhatia K, Bressman SB, Delong MR, Fahn S, Fung VS, Hallett M, Jankovic J, Jinnah HA, Klein C, Lang AE, Mink JW, Teller JK. Phenomenology and classification of dystonia: a consensus update. MovDisord. 2013;28(7):863-873. doi: 10.1002/mds.25475.

Beck Anxiety Inventory. Rezhimdostupa: http:// bluemtassociates.com/wp-content/uploads/2011/12/Beck-Anxiety-Inventroy.pdf Ssylkaaktivnana 04.11.2019.

Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Archives of General Psychiatry. 1961;4:561-571. doi: 10.1001/archpsyc.1961.01710120031004.

Belvisi D, Suppa A, Marsili L, Di Stasio F, Parvez AK, Agostino R, Fabbrini G, Berardelli A. Abnormal experimentally- and behaviorally-induced LTP-like plasticity in focal hand dystonia. Experimental Neurology. 2013;240:64-74. doi: 10.1016/j.expneurol.2012.11.003.

Bradley D, Whelan R, Kimmich O, O’Riordan S, Mulrooney N, Brady P, Walsh R, Reilly RB, Hutchinson S, Molloy F, Hutchinson M. Temporal discrimination thresholds in adult-onset primary torsion dystonia: An analysis by task type and by dystonia phenotype. Journal of Neurology. 2012;259(1):77-82. doi: 10.1007/s00415-011-6125-7.

Bradley D, Whelan R, Walsh R, Reilly RB, Hutchinson S, Molloy F, Hutchinson M. Temporal discrimination threshold: VBM evidence for an endophenotype in adult onset primary torsion dystonia. Brain. 2009;132(9):2327-2335. doi: 10.1093/brain/awp156.

Broocks A, Thiel A, Angerstein D, Dressler D. Higher prevalence of obsessive-compulsive symptoms in patients with blepharospasm than in patients with hemifacial spasm. American Journal of Psychiatry. 1998;155(4):555-557. doi: 10.1176/ajp.155.4.555.

Camfield L, Ben-Shlomo Y, Warner TT. Impact of cervical dystonia on quality of life. Movement Disorders. 2002;17(4):838-841. doi: 10.1002/mds.10127.

Cano SJ, Warner TT, Linacre JM, Bhatia KP, Thompson AJ, Fitzpatrick R, Hobart JC. Capturing the true burden of dystonia on patients: the Cervical Dystonia Impact Profile (CDIP-58). Neurology. 2004;63:1629-1633. doi: 10.1212/01.wnl.0000142962.11881.26.

Conte A, Berardelli I, Ferrazzano G, Pasquini M, Berardelli A, Fabbrini G. Non-motor symptoms in patients with adult-onset focal dystonia: Sensory and psychiatric disturbances. Parkinsonism & Related Disorders. 2016;22:S111-S114. doi: 10.1016/j.parkreldis.2015.09.001.

Defazio G, Berardelli A, Abbruzzese G, Lepore V, Coviello V, Acquistapace D, Capus L, Carella F, De Berardinis MT, Galardi G, Girlanda P, Maurri S, Albanese A, Bertolasi L, Liguori R, Rossi A, Santoro L, Tognoni G, Livrea P. Possible risk factors for primary adult onset dystonia: A case-control investigation by the Italian movement disorders study group. Journal of Neurology, Neurosurgery, and Psychiatry. 1998;64(1):25-32. doi: 10.1136/jnnp.64.1.25.

Defazio G, Jankovic J, Giel JL, Papapetropoulos S. Descriptive epidemiology of cervical dystonia. Tremor and Other Hyperkinetic Movements. 2013;3. doi: 10.7916/D80C4TGJ.

Dias FM, Doyle F, Kummer A, Cardoso F, Fontenelle LF, Teixeira AL. Frequency of psychiatric disorders in blepharospasm does not differ from hemifacial spasm. Acta Neuropsychiatrica. 2010;22(5):223- 227. doi: 10.1111/j.1601-5215.2009.00436.x.

Eichenseer SR, Stebbins GT, Comella CL. Beyond a motor disorder: A prospective evaluation of sleep quality in cervical dystonia. Parkinsonism & Related Disorders. 2014;20(4):405-408. doi: 10.1016/j.parkreldis.2014.01.004.

Fabbrini G, Berardelli I, Moretti G, Pasquini M, Bloise M, Colosimo C, Biondi M, Berardelli A. Psychiatric disorders in adult-onset focal dystonia: A case-control study. Movement Disorders. 2010;25(4):459-465. doi: 10.1002/mds.22983.

Findley L, Aujla M, Bain PG, Baker M, Beech C, Bowman C, Holmes J, Kingdom WK, MacMahon DG, Peto V, Playfer JR. Direct economic impact of Parkinson’s disease: A research survey in the United Kingdom. MovDisord. 2003;18(10):1139-1455. doi: 10.1002/mds.10507.

Fontenelle LF, Pacheco PG, Nascimento PM, de Freitas AR, Rosso AL, Teixeira AL, Lauterbach EC. Obsessive-compulsive symptoms among patients with blepharospasm and hemifacial spasm. General Hospital Psychiatry. 2011;33(5):476-481. doi: 10.1016/j.genhosppsych.2011.05.016.

Frima N, Nasir J, Grünewald RA. Abnormal vibration-induced illusion of movement in idiopathic focal dystonia: An endophenotypic marker? Movement Disorders. 2008;23(3):373-377. doi: 10.1002/mds.21838.

Gong Q, He Y. Depression, neuroimaging and connectomics: a selective overview. Biological Psychiatry. 2015;77:223-235. doi: 10.1016/j.bio-psych.2014.08.009.

Gündel H, Wolf A, Xidara V, Busch R, Ceballos Baumann AO. Social phobia in spasmodic torticollis. J NeurolNeurosurg Psychiatry. 2001;71:499-504. doi: 10.1136/jnnp.71.4.499.

Gündel H, Wolf A, Xidara V, Busch R, Ladwig KH, Jacobi F, von Rad M, Ceballos-Baumann AO. High psychiatric comorbidity in spasmodic torticollis: A controlled study. The Journal of Nervous and Mental Disease. 2003;191(7): 465-473. doi: 10.1097/01.NMD.0000081667.02656.21.

Hall TA, McGwin G Jr, Searcey K, Xie A, Hupp SL, Owsley C, Kline LB. Benign essential blepharospasm: Risk factors with reference to hemifacial spasm. Journal of Neuro- Ophthalmology: The Official Journal of the North American Neuro Ophthalmology Society. 2005;25(4):280-285. doi: 10.1097/01.wno.0000189063.43423.04.

Hallett M. Neurophysiology of dystonia: The role of inhibition. Neurobiol Dis. 2011;42(2):177-184. doi: 10.1016/j.nbd.2010.08.025.

Heiman GA, Ottman R, Saunders-Pullman RJ, Ozelius LJ, Risch NJ, Bressman SB. Increased risk for recurrent major depression in DYT1 dystonia mutation carriers. Neurology. 2004;63:631-637. doi: 10.1212/01.wnl.0000137113.39225.fa.

Hupperta JD, Walthera MR, Hajcakab G, Yadina E, Foa EB, Simpsonc HB, Liebowitzc MR. The OCI-R: Validation of the subscales in a clinical sampleJ Anxiety Disord. 2007;21(3):394-406. doi: 10.1016/j.janxdis.2006.05.006.

Jahanshahi M, Marsden CD. A longitudinal follow-up study of depression, dis- ability, and body concept in torticollis. Behavioural Neurology. 1990;3(4):233-246. doi: 10.3233/BEN-1990-3403.

Jahanshahi M. Psychosocial factors and depression in torticollis. Journal of Psychosomatic Research. 1991;35(4-5):493-507.

Jankovic J, Leder S, Warner D, Schwartz K. Cervical dystonia: Clinical findings and associated movement disorders. Neurology. 1991;41(7):1088-1091. doi: 10.1212/wnl.41.7.1088.

Klepsch R, Zaworka W, Hand I, Jauernig G. Hamburger Zwangsinventar. Weinheim: Beltz;1993.

Klingelhoefer L, Martino D, Martinez-Martin P, Sauerbier A, Rizos A, Jost W, Warner T, Chaudhuriet K. Nonmotor symptoms and focal cervical dystonia: Observations from 102 patients. Basal Ganglia. 2014;4(3-4):117-120. doi: 10.1016/j.baga.2014.10.002.

Kuyper DJ, Parra V, Aerts S, Okun MS, Kluger BM. Nonmotor Manifestations of Dystonia: A Systematic Review. Movement Disorders. 2011;26(7):1206- 1217. doi: 10.1002/mds.23709.

Lauterbach EC, Freeman A, Vogel RL. Differential DSM-III psychiatric disorder prevalence profiles in dystonia and Parkinso’s disease. J Neuropsychiatry ClinNeurosci. 2004;16:29-36. doi:10.1176/jnp.16.1.29.

Lehéricy S, Gerardin E, Poline JB, Meunier S, Van de Moortele PF, Le Bihan D, Vidailhet M. Motor execution and imagination networks in post-stroke dystonia. Neuroreport. 2004;15(12):1887-90. doi: 10.1097/00001756-200408260-00010.

Lehericy S, Tijssen MAJ, Vidailhe M, Kaji R, Meunier S. The anatomical basis of dystonia: Cur- rent view using neuroimaging. Movement Disor- ders. 2013;28(7):944-957. doi: 10.1002/mds.25527.

Lencer R, Steinlechner S, Stahlberg J, Rehling H, Orth M, Baeumer T, Rumpf HJ, Meyer C, Klein C, Muenchau A, Hagenah J. Primary focal dystonia: Evidence for distinct neuropsychiatric and personality profiles. Journal of Neurology, Neuro- surgery, and Psychiatry. 2009;80(10):1176-1179. doi: 10.1136/jnnp.2008.170191.

Lewis L, Butler A, Jahanshahi M. Depression in focal, segmental and generalized dystonia. Journal of Neurology. 2008;255(11):1750-1755. doi: 10.1007/s00415-008-0020-x.

Lobbezoo F, Thu Thon M, Remillard G, Montplaisir JY, Lavigne GJ. Relationship between sleep, neck muscle activity, and pain in cervical dystonia. The Canadian Journal of Neurological Sciences. 1996;23(4):285-290. doi: 10.1017/S0317167100038233.

Löhle M, Storch A, Reichmann H. Beyond tremor and rigidity: non-motor features of Parkinson’s disease. J Neural Transm (Vienna). 2009;116(11):1483- 1492. doi: 10.1007/s00702-009-0274-1.

Martino D, Defazio G, Alessio G, Abbruzzese G, Girlanda P, Tinazzi M, Fabbrini G, Marinelli L, Majorana G, Buccafusca M, Vacca L, Livrea P, Berardelli A. Relationship between eye symptoms and blepharospasm: A multicenter case- control study. Movement Disorders. 2005;20(12):1564-1570. doi: 10.1002/mds.20635.

Miller KM, Okun MS, Fernandez HF, Jacobson CE, Rodriguez RL, Bowers D. Depression symptoms in movement disorders: Comparing Parkinson’s disease, dystonia, and essential tremor. MovDisord. 2007;22:666-672. doi: 10.1002/mds.21376.

Mini-Mental Status Examination. Psychological Assessment Resources, Inc.Р. Rezhimdostupa: https:// web.archive.org/web/20060627004052/http:/www.minimental.com/ Ssylkaaktivnana 04.11.2019.

Molloy FM, Carr TD, Zeuner KE, Dambrosia JM, Hallett M. Abnormalities of spatial discrimination in focal and generalized dystonia. Brain. 2003;126(Pt.10):2175-2182. doi: 10.1093/brain/awg219.

Moraru E, Schnider P, Wimmer A, Wenzel T, Birner P, Griengl H, Auff E. Relation between depression and anxiety in dystonic patients: implications for clinical management. Depress Anxiety. 2002;16:100-103. doi: 10.1002/da.10039.

Müller J, Kemmler G, Wissel J, Schneider A, Voller B, Grossmann J, Diez J, Homann N, Wenning GK, Schnider P, Poewe W; Austrian Botulinum Toxin and Dystonia Study Group. The impact of blepharospasm and cervical dystonia on healthrelated quality of life and depression. J Neurol. 2002;249(7):842-846. doi: 10.1007/s00415-002-0733-1.

Munhoz RP, Teive HA, Della Coletta MV, Germiniani FM, Iwamoto FM, Camargo CH, Werneck LC. Frequency of obsessive and compulsive symptoms in patients with blepharospasm and hemifacial spasm. Arquivos de Neuro-Psiquiatria. 2005;63(2):213- 216. doi: 10.1590/s0004-282x2005000200004.

Papathanasiou I, MacDonald L, Whurr R, Jahanshahi M. Perceived stigma in spasmodic torticol- lis. Movement Disorders. 2001;16(2):280-285. doi: 10.1002/mds.1055.

Paus S, Gross J, Moll-Müller M, Hentschel F, Spottke A, Wabbels B, Klockgether T, Abele M. Impaired sleep quality and restless legs syndrome in idiopathic focal dystonia: A controlled study. Journal of Neurology. 2011;258(10):1835-1840. doi: 10.1007/s00415-011-6029-6.

Peall KJ, Smith DJ, Kurian MA, Wardle M, Waite AJ, Hedderly T, Lin JP, Smith M, Whone A, Pall H, White C, Lux A, Jardine P, Bajaj N, Lynch B, Kirov G, O’Riordan S, Samuel M, Lynch T, King MD, Chinnery PF, Warner TT, Blake DJ, Owen MJ, Morris HR. SGCE mutations cause psychiatric disorders: Clinical and genetic characterization. Brain. 213;136(Pt1):294-303. doi: 10.1093/brain/aws308.

Pekmezovic T, Svetel M, Ivanovic N, Dragasevic N, Petrovic I, Tepavcevic DK, Kostic VS. Quality of life in patients with focal dystonia. ClinNeurolNeurosurg. (2009);111(2):161-164. doi: 10.1016/j.clineuro.2008.09.023.

Putzki N, Stude P, Konczak J, Graf K, Diener HC, Maschke M. Kinesthesia is impaired in focal dystonia. Movement Disorders. 2006;21(6):754-760. doi: 10.1002/mds.20799.

Romano R, Bertolino A, Gigante A, Martino D, Livrea P, Defazio G. Impaired cognitive functions in adult-onset primary cranial cervical dystonia. Parkinsonism & Related Disorders. 2014;20(2):162- 165. doi: 10.1016/j.parkreldis.2013.10.008.

Rome S, Grünewald RA. Abnormal perception of vibration-induced illusion of movement in dystonia. Neurology. 1999;53(8):1794-800. doi:10.1212/wnl.53.8.1794.

Scheidt CE, Schuller B, Rayki O, Kommerell G, Deuschl G. Relative absence of psychopathology in benign essential blepharospasm and hemifacial spasm. Neurology. 1996;47(1):43-45.

Sexton CE, Mackay CE, Ebmeier KP. A systematic review and meta‐analysis of magnetic resonance imaging studies in late‐life depression. American Journal of Geriatric Psychiatry. 2013;21(2):184- 195. doi: 10.1016/j.jagp.2012.10.019.

Sforza E, Montagna P, Defazio G, Lugaresi E. Sleep and cranial dystonia. Electroencephalography and Clinical Neurophysiology. 1991;79(3):166-169. doi: 10.1016/0013-4694(91)90135-q.

Silvestri R, De Domenico P, Di Rosa AE, Bramanti P, Serra S, Di Perri R. The effect of nocturnal physiological sleep on various movement disorders. Mov. Disord. 1990;5(1):8-14. doi: 10.1002/mds.870050104.

Slawek J, Friedman A, Potulska A, Krystkowiak P, Gervais C, Banach M, Ochudlo S, Budrewicz S, Reclawowicz D, Rynkowski M, Opala G. Factors affecting the health-related quality of life of patients with cervical dystonia and the impact of botulinum toxin type A injections. Functional Neurology. 2007;22(2):95-100.

Smit M, Kuiper A, Han V, Jiawan VC, Douma G, van Harten B, Oen JM, Pouwels ME, Dieks HJ, Bartels AL, Tijssen MA. Psychiatric co-morbidity is highly prevalent in idiopathic cervical dystonia and significantly influences health-related quality of life: Results of a controlled study. Parkinsonism&RelatedDisorders. 2017;30:7-12. doi: 10.1016/j.parkreldis.2016.06.004.

Soeder A, Kluger BM, Okun MS, Garvan CW, Soeder T, Jacobson CE, Rodriguez RL, Turner R, Fernandez HH. Mood and energy determinants of quality of life in dystonia. J Neurol. 2009;256:996- 1001. doi: 10.1007/s00415-009-5060-3.

Stamelou M, Edwards MJ, Hallett M, Bhatia KP. The non-motor syndrome of primary dystonia: Clinical and pathophysiological implications. Brain. 2012;135(6):1668-1681. doi: 10.1093/brain/awr224.

Steeves TD, Day L, Dykeman J, Jette N, Pringsheim T. The prevalence of primary dystonia: a systematic review and meta-analysis. MovDisord. 2012;27(14):1789-1796. doi: 10.1002/mds.25244.

Tamura Y, Matsuhashi M, Lin P, Ou B, Vorbach S, Kakigi R, Hallett M. Impaired intracortical inhibition in the primary somatosensory cortex in focal hand dystonia. Movement Disorders. 2008;23(4):558-565. doi: 10.1002/mds.21870.

Tiple D, Strano S, Colosimo C, Fabbrini G, Calcagnini G, Prencipe M, Berardelli A. Autonomic cardiovascular function and baroreflex sensitivity in patients with cervical dystonia receiving treatment with botulinum toxin type A. J Neurol. 2008;255:843-847. doi: 10.1007/s00415-008-0753-6.

Torres JAKL, Rosales RL. Nonmotor Symptoms in Dystonia. International Review of Neurobiology. 2017;134:1335-1371. doi: 10.1016/bs.irn.2017.05.003.

Trotti LM, Esper CD, Feustel PJ, Bliwise DL, Factor SA. Excessive daytime sleepiness in cervical dystonia. Parkinsonism & Related Disorders. 2009;15(10):784-786. doi: 10.1016/j.parkreldis.2009.04.007.

Vuilleumier P, Chicherio C, Assal F, Schwartz S, Slosman D, Landis T. Functional neuroanatomical correlates of hysterical sensorimotor loss. Brain. 2001;124(Pt 6):1077-1090. doi: 10.1093/brain/124.6.1077.

Walsh RA, Whelan R, O’Dwyer J, O’Riordan S, Hutchinson S, O’Laoide R, Malone K, Reilly R, Hutchinson M. Striatal morphology correlates with sensory abnormalities in unaffected relatives of cervical dystonia patients. Journal of Neurology. 2009;256(8):1307-1313. doi: 10.1007/s00415-009-5119-1.

Wenzel T, Schnider P, Wimmer A, Steinhoff N, Moraru E, Auff E. Psychiatric comorbidity in patients with spasmodic torticollis. J Psycho- som Res. 1998;44:687-690. doi: 10.1016/s0022-3999(97)00229-8.

Whurr R, Nye C, Lorch M. Meta-analysis of botulinum toxin treatment of spasmodic dysphonia: a review of 22 studies. Int J Lang CommunDisord. 1998;33:327-329. doi: 10.3109/13682829809179445.

Wolters ECh. Non-motor extranigral signs and symptoms in Parkinson’s disease. Parkinsonism RelatDisord. 2009;15:6-12. doi: 10.1016/S1353-8020(09)70770-9.

Yang J, Shao N, Song W, Wei Q, Ou R, Wu Y, Shang HF. Nonmotor symptoms in primary adultonset cervical dystonia and blepharospasm. Brain Behav. 2016;7(2):e00592. doi: 10.1002/brb3.592.

The authors declare that there are no conflicts of interest present.