References

bekhterev

Обозрение психиатрии и медицинской психологии имени В.М.Бехтерева

V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY

2313-70532713-055X

V. M. BEKHTEREV NATIONAL RESEARCH MEDICAL CENTER FOR PSYCHIATRY AND NEUROLOGY OF THE RUSSIAN FEDERATION MINISTRY OF HEALTH

bekhterev-46

Research Article

НАУЧНО-ИССЛЕДОВАТЕЛЬСКИЕ РАБОТЫ

RESEARCH PAPERS

Изучение механизмов метаболических нарушений, индуцированных антипсихотическими препаратами: возможности использования клеточных моделей

Study of mechanisms of antipsychotic-induced metabolic disturbances: potential for application of cellular models

Насырова

Р. Ф.

Nasyrova

R. F.

reginaf@bekhterev.ru

Тепляшина

В. В.

Teplyashina

V. V.

tepvera@gmail.com

Иващенко

Д. В.

Ivashchenko

D. V.

dvi1991@yandex.ru

Снопов

С. А.

Snopov

S. A.

serge812snop@gmail.com

Санкт-Петербургский научно-исследовательский психоневрологический институт им. В.М. БехтереваРоссияSPb V.M. Bekhterev PNRIRussian Federation

ФБГУН «Институт цитологии» РАНРоссияFBSSI Cytology Institute of RASRussian Federation

2016

19072018

045260

2018

Насырова Р.Ф., Тепляшина В.В., Иващенко Д.В., Снопов С.А.

Nasyrova R.F., Teplyashina V.V., Ivashchenko D.V., Snopov S.A.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.bekhterevreview.com/jour/article/view/46

Терапия антипсихотическими препаратами и первой, и второй генерации сопровождается метаболическими побочными эффектами. Работами последних лет выявлены некоторые механизмы реализации антипсихотик-индуцированных метаболических нарушений - центральные (индукция резистентности к гормону насыщения лептину, изменение уровня адипонектина, угнетающего глюко-неогенез и повышающего чувствительность клеток к инсулину) и периферические (активация системы белков SREBP, осуществляющих транскрипцию генов биосинтеза холестерина и жирных кислот, наряду с ингибированием поздних этапов синтеза холестерина; а также изменения внутриклеточного транспорта холестерина). Перспективным является изучение взаимосвязи возникновения метаболических нарушений при лечении АП с изменениями продукции цитокинов и других факторов воспаления. Часть таких исследований, также как и исследований периферических механизмов побочных эффектов АП могут быть эффективно выполнены in vitro на моделях культивируемых клеток, в первую очередь, печеночного происхождения.

The therapy with antipsychotic drugs (AD) of the first and second generations is accompanied by metabolic side effects. The papers of recent years have revealed both central (induction of resistance to the satiety hormone leptin, change in level of adiponectin suppressing glyconeogenesis and elevating sensitivity of cells to insulin) and peripheral (activation of system of sterol regulatory element-binding proteins (SREBPs), performing transcription of genes of cholesterol and fatty acid biosynthesis along with inhibition of late phases of synthesis of cholesterol as well as change in intracellular cholesterol transport) mechanisms of realization of antipsychotic-induced metabolic disturbances. The study of the interrelationship between emergence of metabolic disturbances under therapy with AD and changes in production of cytokines and other inflammation factors is promising. A part of such studies as well as studies of peripheral mechanisms of side effects of AD can by efficiently performed in vitro on the models of cultivated cells, first of all, hepatogenic ones.

психические расстройстваантипсихотикиметаболические нарушенияклеточные культурыгепатоцитывоспалениеmental disordersantipsychoticsmetabolic disturbancescell cultureshepatocytesinflammation

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The authors declare that there are no conflicts of interest present.