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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">bekhterev</journal-id><journal-title-group><journal-title xml:lang="ru">Обозрение психиатрии и медицинской психологии имени В.М.Бехтерева</journal-title><trans-title-group xml:lang="en"><trans-title>V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2313-7053</issn><issn pub-type="epub">2713-055X</issn><publisher><publisher-name>V. M. BEKHTEREV  NATIONAL  RESEARCH  MEDICAL  CENTER  FOR  PSYCHIATRY  AND  NEUROLOGY                           OF    THE  RUSSIAN  FEDERATION   MINISTRY  OF  HEALTH</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31363/2313-7053-2021-56-3-110-118</article-id><article-id custom-type="elpub" pub-id-type="custom">bekhterev-590</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>В ПОМОЩЬ ПРАКТИКУЮЩЕМУ ВРАЧУ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GUIDELINES FOR THE PRACTITIONER</subject></subj-group></article-categories><title-group><article-title>Обратимая регрессия у детей раннего возраста</article-title><trans-title-group xml:lang="en"><trans-title>Reversible regression in early childhood</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0176-3846</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Макаров</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Makarov</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Макаров Игорь Владимирович</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Igor V. Makarov</p><p>St. Petersburg</p></bio><email xlink:type="simple">ppsy@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0697-5944</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Краснощеков</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Krasnoshchekov</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Краснощеков Степан Александрович</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Stepan A. Krasnoshchekov</p><p>St. Petersburg</p></bio><email xlink:type="simple">chuhonastov@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева; Северо-Западный государственный медицинский университет им. И.И. Мечникова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.M. Bekhterev National research medical center for psychiatry and neurology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.M. Bekhterev National research medical center for psychiatry and neurology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>03</day><month>10</month><year>2021</year></pub-date><volume>55</volume><issue>3</issue><fpage>110</fpage><lpage>118</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Макаров И.В., Краснощеков С.А., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Макаров И.В., Краснощеков С.А.</copyright-holder><copyright-holder xml:lang="en">Makarov I.V., Krasnoshchekov S.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.bekhterevreview.com/jour/article/view/590">https://www.bekhterevreview.com/jour/article/view/590</self-uri><abstract><p>Резюме. Статья (дидактический материал) затрагивает следующие аспекты исследования обратимой регрессии у детей раннего возраста: историю вопроса, систематику, симптоматику регрессии, в том числе, при детском аутизме. Авторы анализируют имеющиеся данные, высказывают мнение о том, что практически не изучены возможности терапии обратимой регрессии у детей, нет точных данных о патогенезе данных расстройств, указывают на необходимость оценки динамики состояния, учет факторов возраста и пола ребенка. Авторы приходят к выводу, что обратимая регрессия — патологическое состояние, развивающееся на фоне относительно благоприятного развития ребенка, при котором наблюдается продолжительный распад ранее приобретенных навыков с последующим частичным или полным восстановлением. В отличие от деменции, которая является необратимым процессом, регрессия имеет этап восстановления утерянных функций. В изучении вопроса важными станут клинико-динамический анализ вариантов обратимой регрессии раннего детского возраста, понимание гендерных и возрастных различий в симптоматике расстройства, критерии прогноза при выходе из данного состояния.</p></abstract><trans-abstract xml:lang="en"><p>Summary. The article (didactic material) addresses the following aspects of the study of reversible regression in early childhood: question history, systematics, regression symptoms, including in childhood autism. The authors analyze the available data, express the opinion that the possibilities of reversible regression therapy in children have not been studied, there are no accurate data on the pathogenesis of these disorders, indicate the need to assess the dynamics of the condition, taking into account the age and sex factors of the child.The authors conclude that reversible regression is a pathological condition developing against a background of relatively favorable child development, in which there is a prolonged decay of previously acquired skills followed by partial or complete recovery. Unlike dementia, which is an irreversible process, regression has the stage of restoring lost functions. In studying the issue, clinical-dynamic analysis of variants of reversible regression of early childhood, an understanding of gender and age differences in the symptoms of the disorder, and prognosis criteria.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>обратимая регрессия</kwd><kwd>дети</kwd><kwd>ранний возраст</kwd><kwd>развитие</kwd><kwd>аутизм</kwd></kwd-group><kwd-group xml:lang="en"><kwd>reversible regression</kwd><kwd>children</kwd><kwd>early childhood</kwd><kwd>development</kwd><kwd>autism</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Барыкина А.И. О состоянии обратимого слабоумия у детей. IV годичная научная сессия : Тезисы докладов. — Л. 1953.</mixed-citation><mixed-citation xml:lang="en">Barykina A.I. O sostoyanii obratimogo slaboumiya u detei. IV godichnaja nauchnaja sessija : Tezisy dokladov. — L. 1953. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Башина В.М., Симашкова Н.В., Красноперова М.Г. Атипичный аутизм в свете ICD-10 (1992), МКБ-10 (1999). Вопросы психического здоровья детей и подростков. 2003; 1(3):97-101.</mixed-citation><mixed-citation xml:lang="en">Bashina VM, Simashkova NV, Krasnoperova MG. Atypical autism in ICD-10 (1992), MKB-10 (1999). Voprosy psihicheskogo zdorov’ja deteĭ i podrostkov. 2003; 1(3):97-101. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Боднянская Н.Н. Некоторые вопросы психиатрии детского возраста. Экзогении и нервнопсихическая патология. — Свердловск: Средне-Уральское книжное издательство. 1973.</mixed-citation><mixed-citation xml:lang="en">Bodnjanskaja N.N. Nekotorye voprosy psikhiatrii detskogo vozrasta. Ekzogenii i nervno-psikhicheskaya patologiya — Sverdlovsk: Sredne-Ural’skoe knizhnoe izdatel’stvo. 1973. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Быховская В.М. и др. Исходы острых энцефалитов у детей. Всероссийская научная конференция по психоневрологии детского возраста 18-20 января 1966 г. Материалы конференции. Л. 1966.</mixed-citation><mixed-citation xml:lang="en">Byhovskaja V.M. i dr. Iskhody ostrykh entsefalitov u detei. Vserossijskaja nauchnaja konferencija po psihonevrologii detskogo vozrasta 18-20 janvarja 1966 g. Materialy konferencii. L. 1966. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Винокурова А.И. О «Dementia infantilis» Геллера. Вопросы психоневрологии детей и подростков. Т.3. Под общей ред. Э.Ю. Шурпе. — М.;Л.: БИОМЕДГИЗ. 1936.</mixed-citation><mixed-citation xml:lang="en">Vinokurova A.I. O «Dementia infantilis» Gellera. Voprosy psihonevrologii detej i podrostkov. T.3. Pod obshhej red. Je.Ju. Shurpe. — M.;L.: BIOMEDGIZ. 1936. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Гуревич М.О. Последствия параинфекционных энцефалитов в детском возрасте. Вопросы психоневрологии детей и подростков. Т.2. под общей ред. Э.Ю. Шурпе. — М.: Государственное медицинское издательство. 1934.</mixed-citation><mixed-citation xml:lang="en">Gurevich M.O. Posledstviya parainfektsionnykh entsefalitov v detskom vozraste. Voprosy psihonevrologii detej i podrostkov. T.2. pod obshhej red. Je.Ju. Shurpe. — M.: Gosudarstvennoe medicinskoe izdatel’stvo. 1934. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ковалев В.В. Психиатрия детского возраста. — М.: Медицина. 1979.</mixed-citation><mixed-citation xml:lang="en">Kovalev V.V. Child psychiatry. — M.: Medicina. 1979. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Кравченко И.В., Краснощеков С.А. Динамический аспект регрессий раннего детского возраста. Материалы 77-й международной научно-практической конференции молодых ученых и студентов «Актуальные проблемы экспериментальной и клинической медицины». 2019.</mixed-citation><mixed-citation xml:lang="en">Kravchenko I.V., Krasnoshchekov S.A. Dinamicheskii aspekt regressii rannego detskogo vozrasta. Materialy 77-j mezhdunarodnoj nauchno-prakticheskoj konferencii molodyh uchenyh i studentov «Aktual’nye problemy jeksperimental’noj i klinicheskoj mediciny». 2019. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Малинина Е.В. Регрессивные психические расстройства у детей раннего возраста. Вопросы психического здоровья детей и подростков. 2007; 7:119-120.</mixed-citation><mixed-citation xml:lang="en">Malinina EV. Regressive mental disorders in early childhood. Voprosy psihicheskogo zdorov’ja detej i podrostkov. 2007; 7:119-120. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Мнухин С.С., Исаев Д.Н. Актуальные вопросы клинической психопатологии и лечения психических заболеваний. — Л.: 1969.</mixed-citation><mixed-citation xml:lang="en">Mnuhin S.S., Isaev D.N. Aktual’nye voprosy klinicheskoĭ psikhopatologii i lecheniya psikhicheskikh zabolevaniĭ. — L.:1969. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Мнухин С.С. О роли ранних острых диспепсий в происхождении стойких нервно-психических нарушений у детей. Тезисы Всесоюзной научно-практической конференции по психиатрии детского возраста 21-24 марта 1957 г. М. 1957.</mixed-citation><mixed-citation xml:lang="en">Mnuhin S.S. O roli rannikh ostrykh dispepsii v proiskhozhdenii stoikikh nervno-psikhicheskikh narushenii u detei. Tezisy Vsesojuznoj nauchnoprakticheskoj konferencii po psihiatrii detskogo vozrasta 21-24 marta 1957 g. M. 1957. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Радзивил М.Г. Структура задержки психического развития при процессуальном детском аутизме. Социальная и клиническая психиатрия. 2006; 16:10-20.</mixed-citation><mixed-citation xml:lang="en">Radzivil MG. Structure of mental development delay in processual childhood autism. Social’naja i klinicheskaja psihiatrija. 2006; 16:10-20. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Симашкова Н.В., Коваль-Зайцев А.А., Клюшник Т.П., Якупова Л.П. Мультидисциплинарные дифференциально- диагностические подходы при расстройствах аутистического спектра у детей (клинические, психологические, биологические, абилитационные аспекты). Вопросы психического здоровья детей и подростков. 2015; 15:23-25.</mixed-citation><mixed-citation xml:lang="en">Simashkova NV, Koval’-Zaĭcev AA, Kljushnik TP, Jakupova LP. Multidisciplinary differential diagnostic approaches for autism spectrum disorders in children (clinical, psychological, biological, habilitation aspects). Voprosy psihicheskogo zdorov’ja deteĭ i podrostkov. 2015; 15(2):23-25. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Симсон Т.П. Шизофрения раннего детского возраста. Глава IX. Галопирующая форма шизофрении раннего детского возраста. — Издательство академии Медицинских наук. Москва. 1948.</mixed-citation><mixed-citation xml:lang="en">Simson T.P. Shizofreniya rannego detskogo vozrasta. Glava IX. Galopirujushhaja forma shizofrenii rannego detskogo vozrasta. — Izdatel’stvo akademii Medicinskih nauk. Moskva. 1948. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Фролова, без инициалов. Случаи функциональных нарушений интеллекта у детей, внешне сходных с олигофренией. Тезисы Всесоюзной научно-практической конференции по психиатрии детского возраста 21-24 марта 1957 г. М. 1957.</mixed-citation><mixed-citation xml:lang="en">Frolova, no initials. Sluchai funktsional’nykh narushenii intellekta u detei, vneshne skhodnykh s oligofreniei. Tezisy Vsesojuznoj nauchno-prakticheskoj konferencii po psihiatrii detskogo vozrasta 21-24 marta 1957 g. M. 1957. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Хайретдинов О.З., Рубакова Л.И. Варианты регресса навыков при аутистических расстройствах у детей. Вопросы психического здоровья детей и подростков. 2017; 17:247-248.</mixed-citation><mixed-citation xml:lang="en">Hajretdinov OZ, Rubakova LI. Skills regression options in autistic disorders in children. Voprosy psihicheskogo zdorov’ja detej i podrostkov. 2017; 17:247-248. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Barger B, Campbell J, McDonough J. Prevalence and Onset of Regression within Autism Spectrum Disorders: A Meta-analytic Review. J Autism Dev Disord. 2012; 43(4):817-828.</mixed-citation><mixed-citation xml:lang="en">Barger B, Campbell J, McDonough J. Prevalence and Onset of Regression within Autism Spectrum Disorders: A Meta-analytic Review. J Autism Dev Disord. 2012; 43(4):817-828.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Barger B, Campbell J, Simmons C. The relationship between regression in autism spectrum disorder, epilepsy, and atypical epileptiform EEGs: A meta-analytic review. J Intellect Dev Disabil. 2016; 42(1):45-60.</mixed-citation><mixed-citation xml:lang="en">Barger B, Campbell J, Simmons C. The relationship between regression in autism spectrum disorder, epilepsy, and atypical epileptiform EEGs: A meta-analytic review. J Intellect Dev Disabil. 2016; 42(1):45-60.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Creak E. Childhood Psychosis. British Journal of Psychiatry. 1963; 109(458):84-89.</mixed-citation><mixed-citation xml:lang="en">Creak E. Childhood Psychosis. British Journal of Psychiatry. 1963; 109(458):84-89.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Gadow K, DeVincent C. Comparison of children with autism spectrum disorder with and without schizophrenia spectrum traits: gender, season of birth, and mental health risk factors. J Autism Dev Disord. 2012; 42(11):2285-2296.</mixed-citation><mixed-citation xml:lang="en">Gadow K, DeVincent C. Comparison of children with autism spectrum disorder with and without schizophrenia spectrum traits: gender, season of birth, and mental health risk factors. J Autism Dev Disord. 2012; 42(11):2285-2296.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Gadow K, Perlman G, Weber R. Parent-Reported Developmental Regression in Autism: Epilepsy, IQ, Schizophrenia Spectrum Symptoms, and Special Education. J Autism Dev Disord. 2017; 47(4):918-926.</mixed-citation><mixed-citation xml:lang="en">Gadow K, Perlman G, Weber R. Parent-Reported Developmental Regression in Autism: Epilepsy, IQ, Schizophrenia Spectrum Symptoms, and Special Education. J Autism Dev Disord. 2017; 47(4):918-926.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Goldberg W, Osann K, Filipek P, Laulhere T, Jarvis K, Modahl C, Flodman P, Spence M. Language and Other Regression: Assessment and Timing. J Autism Dev Disord. 2003; 33(6):607-616.</mixed-citation><mixed-citation xml:lang="en">Goldberg W, Osann K, Filipek P, Laulhere T, Jarvis K, Modahl C, Flodman P, Spence M. Language and Other Regression: Assessment and Timing. J Autism Dev Disord. 2003; 33(6):607-616.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Hansen R, Ozonoff S, Krakowiak P, Angkustsiri K, Jones C, Deprey L, Le D, Croen L, Hertz-Piciotto I. Regression in Autism: Prevalence and Associated Factors in the CHARGE Study. Ambulatory Pediatrics. 2008; 8(1):25-31.</mixed-citation><mixed-citation xml:lang="en">Hansen R, Ozonoff S, Krakowiak P, Angkustsiri K, Jones C, Deprey L, Le D, Croen L, Hertz-Piciotto I. Regression in Autism: Prevalence and Associated Factors in the CHARGE Study. Ambulatory Pediatrics. 2008; 8(1):25-31.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Harris J. New terminology for mental retardation in DSM-5 and ICD-11. Curr Opin Psychiatry. 2013; 26(3):260-262.</mixed-citation><mixed-citation xml:lang="en">Harris J. New terminology for mental retardation in DSM-5 and ICD-11. Curr Opin Psychiatry. 2013; 26(3):260-262.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Holland J, Brown R. Developmental regression: assessment and investigation. Paediatr Child Health (Oxford). 2017; 27(6):253-259.</mixed-citation><mixed-citation xml:lang="en">Holland J, Brown R. Developmental regression: assessment and investigation. Paediatr Child Health (Oxford). 2017; 27(6):253-259.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Hviid A, Hansen J, Frisch M, Melbye M. Measles, Mumps, Rubella Vaccination and Autism. Ann Intern Med. 2019; 171(5):388.</mixed-citation><mixed-citation xml:lang="en">Hviid A, Hansen J, Frisch M, Melbye M. Measles, Mumps, Rubella Vaccination and Autism. Ann Intern Med. 2019; 171(5):388.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Jain A, Marshall J, Buikema A, Bancroft T, Kelly J, Newschaffer C. Autism Occurrence by MMR Vaccine Status Among US Children With Older Siblings With and Without Autism. JAMA. 2015; 313(15):1534.</mixed-citation><mixed-citation xml:lang="en">Jain A, Marshall J, Buikema A, Bancroft T, Kelly J, Newschaffer C. Autism Occurrence by MMR Vaccine Status Among US Children With Older Siblings With and Without Autism. JAMA. 2015; 313(15):1534.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Jones L, Campbell J. Clinical Characteristics Associated with Language Regression for Children with Autism Spectrum Disorders. J Autism Dev Disord. 2009; 40(1):54-62.</mixed-citation><mixed-citation xml:lang="en">Jones L, Campbell J. Clinical Characteristics Associated with Language Regression for Children with Autism Spectrum Disorders. J Autism Dev Disord. 2009; 40(1):54-62.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Kaat A, Gadow K, Lecavalier L. Psychiatric Symptom Impairment in Children with Autism Spectrum Disorders. J Abnorm Child Psychol. 2013; 41(6):959-969.</mixed-citation><mixed-citation xml:lang="en">Kaat A, Gadow K, Lecavalier L. Psychiatric Symptom Impairment in Children with Autism Spectrum Disorders. J Abnorm Child Psychol. 2013; 41(6):959-969.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Klin A, Shultz S, Jones W. Social visual engagement in infants and toddlers with autism: Early developmental transitions and a model of pathogenesis. Neuroscience &amp; Biobehavioral Reviews. 2015; 50:189-203.</mixed-citation><mixed-citation xml:lang="en">Klin A, Shultz S, Jones W. Social visual engagement in infants and toddlers with autism: Early developmental transitions and a model of pathogenesis. Neuroscience &amp; Biobehavioral Reviews. 2015; 50:189-203.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Lainhart J, Ozonoff S, Coon H, Krasny L, Dinh E, Nice J, McMahon W. Autism, regression, and the broader autism phenotype. Am J Med Genet. 2002; 113(3):231-237.</mixed-citation><mixed-citation xml:lang="en">Lainhart J, Ozonoff S, Coon H, Krasny L, Dinh E, Nice J, McMahon W. Autism, regression, and the broader autism phenotype. Am J Med Genet. 2002; 113(3):231-237.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Lord C, Shulman C, DiLavore P. Regression and word loss in autistic spectrum disorders. Journal of Child Psychology and Psychiatry. 2004; 45(5):936-955.</mixed-citation><mixed-citation xml:lang="en">Lord C, Shulman C, DiLavore P. Regression and word loss in autistic spectrum disorders. Journal of Child Psychology and Psychiatry. 2004; 45(5):936-955.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Makarov IV, Rubina LP. Mental disorders in hospitalized children. Problemy Sotsial’noi Gigieny, Zdravookhraneniia i Istorii Meditsiny. 2002; 5:16-18.</mixed-citation><mixed-citation xml:lang="en">Makarov IV, Rubina LP. Mental disorders in hospitalized children. Problemy Sotsial’noi Gigieny, Zdravookhraneniia i Istorii Meditsiny. 2002; 5:16-18.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Matson J, Mahan S. Current status of research on childhood disintegrative disorder. Res Autism Spectr Disord. 2009; 3(4):861-867.</mixed-citation><mixed-citation xml:lang="en">Matson J, Mahan S. Current status of research on childhood disintegrative disorder. Res Autism Spectr Disord. 2009; 3(4):861-867.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Matson J, Wilkins J, Fodstad J. Children with autism spectrum disorders: A comparison of those who regress vs. those who do not. Dev Neurorehabil. 2010; 13(1):37-45.</mixed-citation><mixed-citation xml:lang="en">Matson J, Wilkins J, Fodstad J. Children with autism spectrum disorders: A comparison of those who regress vs. those who do not. Dev Neurorehabil. 2010; 13(1):37-45.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Robinson R, Baird G, Robinson G, Simonoff E. Landau–Kleffner syndrome: course and correlates with outcome. Dev Med Child Neurol. 2001; 43(04):243.</mixed-citation><mixed-citation xml:lang="en">Robinson R, Baird G, Robinson G, Simonoff E. Landau–Kleffner syndrome: course and correlates with outcome. Dev Med Child Neurol. 2001; 43(04):243.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Rosenberg R, Kaufmann W, Law J, Law P. Parent Report of Community Psychiatric Comorbid Diagnoses in Autism Spectrum Disorders. Autism Res Treat. 2011; 2011:1-10.</mixed-citation><mixed-citation xml:lang="en">Rosenberg R, Kaufmann W, Law J, Law P. Parent Report of Community Psychiatric Comorbid Diagnoses in Autism Spectrum Disorders. Autism Res Treat. 2011; 2011:1-10.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Sahoo T, Theisen A, Rosenfeld J, Lamb A, Ravnan J, Shultz R, Torchia B, Neill N, Casci I, Bejjani B, Shaffer L. Copy number variants of schizophrenia susceptibility loci are associated with a spectrum of speech and developmental delays and behavior problems. Genetics in Medicine. 2011; 13(10):868-880.</mixed-citation><mixed-citation xml:lang="en">Sahoo T, Theisen A, Rosenfeld J, Lamb A, Ravnan J, Shultz R, Torchia B, Neill N, Casci I, Bejjani B, Shaffer L. Copy number variants of schizophrenia susceptibility loci are associated with a spectrum of speech and developmental delays and behavior problems. Genetics in Medicine. 2011; 13(10):868-880.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Shoffner J, Hyams L, Langley G, Cosette S, Mylacrain L, Dale J, Ollis L, Kuoch S, Bennet K, Aliberti A, Hyland K. Fever Plus Mitochondrial Disease Could Be Risk Factors for Autistic Regression. J Child Neurol. 2009; 25(4):429-434.</mixed-citation><mixed-citation xml:lang="en">Shoffner J, Hyams L, Langley G, Cosette S, Mylacrain L, Dale J, Ollis L, Kuoch S, Bennet K, Aliberti A, Hyland K. Fever Plus Mitochondrial Disease Could Be Risk Factors for Autistic Regression. J Child Neurol. 2009; 25(4):429-434.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Simonoff E, Pickles A, Charman T, Chandler S, Loucas T, Baird G. Psychiatric Disorders in Children With Autism Spectrum Disorders: Prevalence, Comorbidity, and Associated Factors in a Population- Derived Sample. Journal of the American Academy of Child &amp; Adolescent Psychiatry. 2008; 47(8):921-929.</mixed-citation><mixed-citation xml:lang="en">Simonoff E, Pickles A, Charman T, Chandler S, Loucas T, Baird G. Psychiatric Disorders in Children With Autism Spectrum Disorders: Prevalence, Comorbidity, and Associated Factors in a Population- Derived Sample. Journal of the American Academy of Child &amp; Adolescent Psychiatry. 2008; 47(8):921-929.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Smith T, Ram D. Fifteen-minute consultation: A practical approach to developmental regression in children. Archives of disease in childhood — Education &amp; practice edition. 2018; 104(4):173-177.</mixed-citation><mixed-citation xml:lang="en">Smith T, Ram D. Fifteen-minute consultation: A practical approach to developmental regression in children. Archives of disease in childhood — Education &amp; practice edition. 2018; 104(4):173-177.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Stefanatos G. Regression in Autistic Spectrum Disorders. Neuropsychol Rev. 2008; 18(4):305-319.</mixed-citation><mixed-citation xml:lang="en">Stefanatos G. Regression in Autistic Spectrum Disorders. Neuropsychol Rev. 2008; 18(4):305-319.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Thomas M, Annaz D, Ansari D, Scerif G, Jarrold C, Karmiloff-Smith A. Using Developmental Trajectories to Understand Developmental Disorders. Journal of Speech, Language, and Hearing Research. 2009; 52(2):336-358.</mixed-citation><mixed-citation xml:lang="en">Thomas M, Annaz D, Ansari D, Scerif G, Jarrold C, Karmiloff-Smith A. Using Developmental Trajectories to Understand Developmental Disorders. Journal of Speech, Language, and Hearing Research. 2009; 52(2):336-358.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Thurm A, Manwaring S, Luckenbaugh D, Lord C, Swedo S. Patterns of skill attainment and loss in young children with autism. Dev Psychopathol. 2013; 26(1):203-214.</mixed-citation><mixed-citation xml:lang="en">Thurm A, Manwaring S, Luckenbaugh D, Lord C, Swedo S. Patterns of skill attainment and loss in young children with autism. Dev Psychopathol. 2013; 26(1):203-214.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Tuchman R, Rapin I. Regression in Pervasive Developmental Disorders: Seizures and Epileptiform Electroencephalogram Correlates. Pediatrics. 1997; 99(4):560-566.</mixed-citation><mixed-citation xml:lang="en">Tuchman R, Rapin I. Regression in Pervasive Developmental Disorders: Seizures and Epileptiform Electroencephalogram Correlates. Pediatrics. 1997; 99(4):560-566.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Verity C, Winstone A, Stellitano L, Will R, Nicoll A. The epidemiology of progressive intellectual and neurological deterioration in childhood. Arch Dis Child. 2009; 95(5):361-364.</mixed-citation><mixed-citation xml:lang="en">Verity C, Winstone A, Stellitano L, Will R, Nicoll A. The epidemiology of progressive intellectual and neurological deterioration in childhood. Arch Dis Child. 2009; 95(5):361-364.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Verity C. Surveillance for rare disorders by the BPSU. Arch Dis Child. 2002; 87(4):269-271.</mixed-citation><mixed-citation xml:lang="en">Verity C. Surveillance for rare disorders by the BPSU. Arch Dis Child. 2002; 87(4):269-271.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Wasilewska J, Kaczmarski M, Stasiak-Barmuta A, Tobolczyk J, Kowalewska E. Low serum IgA and increased expression of CD23 on B lymphocytes in peripheral blood in children with regressive autism aged 3-6 years old. Archives of Medical Science. 2012; 2:324-331.</mixed-citation><mixed-citation xml:lang="en">Wasilewska J, Kaczmarski M, Stasiak-Barmuta A, Tobolczyk J, Kowalewska E. Low serum IgA and increased expression of CD23 on B lymphocytes in peripheral blood in children with regressive autism aged 3-6 years old. Archives of Medical Science. 2012; 2:324-331.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Weber R, Gadow K. Relation of Psychiatric Symptoms with Epilepsy, Asthma, and Allergy in Youth with ASD vs. Psychiatry Referrals. J Abnorm Child Psychol. 2016; 45(6):1247-1257.</mixed-citation><mixed-citation xml:lang="en">Weber R, Gadow K. Relation of Psychiatric Symptoms with Epilepsy, Asthma, and Allergy in Youth with ASD vs. Psychiatry Referrals. J Abnorm Child Psychol. 2016; 45(6):1247-1257.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Werner E, Dawson G. Validation of the Phenomenon of Autistic Regression Using Home Videotapes. Arch Gen Psychiatry. 2005; 62(8):889.</mixed-citation><mixed-citation xml:lang="en">Werner E, Dawson G. Validation of the Phenomenon of Autistic Regression Using Home Videotapes. Arch Gen Psychiatry. 2005; 62(8):889.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Wing L, Gould J. Severe impairments of social interaction and associated abnormalities in children: Epidemiology and classification. J Autism Dev Disord. 1979; 9(1):11-29.</mixed-citation><mixed-citation xml:lang="en">Wing L, Gould J. Severe impairments of social interaction and associated abnormalities in children: Epidemiology and classification. J Autism Dev Disord. 1979; 9(1):11-29.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Wolff S, Chess S. A BEHAVIOURAL STUDY OF SCHIZOPHRENIC CHILDREN. Acta Psychiatr Scand. 1964; 40(4):438-466.</mixed-citation><mixed-citation xml:lang="en">Wolff S, Chess S. A BEHAVIOURAL STUDY OF SCHIZOPHRENIC CHILDREN. Acta Psychiatr Scand. 1964; 40(4):438-466.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
