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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">bekhterev</journal-id><journal-title-group><journal-title xml:lang="ru">Обозрение психиатрии и медицинской психологии имени В.М.Бехтерева</journal-title><trans-title-group xml:lang="en"><trans-title>V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2313-7053</issn><issn pub-type="epub">2713-055X</issn><publisher><publisher-name>V. M. BEKHTEREV  NATIONAL  RESEARCH  MEDICAL  CENTER  FOR  PSYCHIATRY  AND  NEUROLOGY                           OF    THE  RUSSIAN  FEDERATION   MINISTRY  OF  HEALTH</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31363/2313-7053-2023-762</article-id><article-id custom-type="elpub" pub-id-type="custom">bekhterev-762</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>В ПОМОЩЬ ПРАКТИКУЮЩЕМУ ВРАЧУ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GUIDELINES FOR THE PRACTITIONER</subject></subj-group></article-categories><title-group><article-title>Алгоритм лекарственной терапии посттравматического стрессового расстройства</article-title><trans-title-group xml:lang="en"><trans-title>Pharmacotherapy algorithm for post-traumatic stress disorder</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5116-836X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Васильева</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasileva</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Васильева Анна Владимировна - доктор медицинских наук, главный научный сотрудник отделения лечения пограничных психических расстройств и психотерапии; доцент кафедры психотерапии и сексологии</p><p>г. Санкт-Петербург</p></bio><bio xml:lang="en"><p>Anna V. Vasileva</p><p>Saint Petersburg</p></bio><email xlink:type="simple">annavdoc@yahoo.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8798-3702</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Караваева</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Karavaeva</surname><given-names>T. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Караваева Татьяна Артуровна: доктор медицинских наук, главный научный сотрудник, руководитель отделения лечения пограничных психических расстройств и психотерапии; профессор кафедры медицинской психологии и психофизиологии; профессор кафедры общей и прикладной психологии с курсами медико-биологических дисциплин и педагогики; ведущий научный сотрудник научного отдела инновационных методов терапевтической онкологии и реабилитации</p><p>г. Санкт-Петербург</p></bio><bio xml:lang="en"><p>Tatiana A. Karavaeva</p><p>Saint Petersburg</p></bio><email xlink:type="simple">tania_kar@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9020-3271</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Радионов</surname><given-names>Д. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Radionov</surname><given-names>D. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Радионов Дмитрий Сергеевич: младший научный сотрудник отделения лечения пограничных психических расстройств и психотерапии</p><p>г. Санкт-Петербург</p></bio><bio xml:lang="en"><p>Dmitriy S. Radionov</p><p>Saint Petersburg</p></bio><email xlink:type="simple">dumradik@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр психиатрии и неврологии имени В.М. Бехтерева; Северо-Западный государственный медицинский университет им. И.И. Мечникова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.M. Bekhterev National medical research center for psychiatry and neurology; I.I. Mechnikov North-western Medical State University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр психиатрии и неврологии имени В.М. Бехтерева; Санкт-Петербургский государственный университет; Санкт-Петербургский государственный педиатрический медицинский университет; Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.M. Bekhterev National medical research center for psychiatry and neurology; Saint-Petersburg State University; Saint-Petersburg State Pediatric Medical University; National Medical Research Center of Oncology Named after N.N. Petrov</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр психиатрии и неврологии имени В.М. Бехтерева</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.M. Bekhterev National medical research center for psychiatry and neurology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>07</day><month>09</month><year>2023</year></pub-date><volume>57</volume><issue>3</issue><fpage>80</fpage><lpage>91</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Васильева А.В., Караваева Т.А., Радионов Д.С., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Васильева А.В., Караваева Т.А., Радионов Д.С.</copyright-holder><copyright-holder xml:lang="en">Vasileva A.V., Karavaeva T.A., Radionov D.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.bekhterevreview.com/jour/article/view/762">https://www.bekhterevreview.com/jour/article/view/762</self-uri><abstract><p>Посттравматическое стрессовое расстройство (ПТСР) - психическое расстройство, развивающееся вследствие мощного психотравмирующего воздействия угрожающего или катастрофического характера, сопровождающееся экстремальным стрессом, основными клиническими проявлениями выступают повторные переживания элементов травматического события в ситуации «здесь и сейчас» в форме флэшбеков, повторяющихся сновидений и кошмаров, что сопровождается чаще тревогой и паникой, но возможно также гневом, злостью, чувством вины или безнадежности, стремлением избегать внутренние и внешние стимулы, напоминающие или ассоциирующиеся со стрессором. ПТСР имеет тенденцию к формированию личностных нарушений, а также характеризуется высокой распространенностью коморбидной патологии. В последнее время накоплены данные об изменениях в системах нейромедиаторов головного мозга и нейроэндокринных нарушений у пациентов с ПТСР, а также о наличии морфофункциональных, нейровоспалительных и других нейробиологических особенностей. Совершенствование имеющихся и разработка новых алгоритмов лекарственной терапии является важной составляющей помощи, оказываемой пациентам с ПТСР. Несмотря на ведущую роль психотерапии в лечении этого расстройства, профилактики хронизации и рецидивов, для достижения быстрого эффекта и формирования приверженности пациентов к лечению, в рамках персонализированного подхода, рекомендуется применение психофармакотерапии, эффективность которой должна оцениваться в процессе всего курса терапии.</p></abstract><trans-abstract xml:lang="en"><p>Post-traumatic stress disorder (PTSD) is a mental disorder that develops as a result of a powerful psycho-traumatic effect of a threatening or catastrophic nature, accompanied by extreme stress, the main clinical manifestations are repeated experiences of elements of a traumatic event in a “here and now” situation in the form of flashbacks, recurring dreams and nightmares, which accompanied more often by anxiety and panic, but possibly also by anger, anger, feelings of guilt or hopelessness, a desire to avoid internal and external stimuli that resemble or are associated with the stressor. PTSD tends to form personality disorders, and is also characterized by a high prevalence of comorbid pathology. Recently, data have been accumulated on changes in the brain neurotransmitter systems and neuroendocrine disorders in patients with PTSD, as well as on the presence of morpho-functional, neuroinflammatory, and other neurobiological features. Improvement of existing and development of new pharmacotherapy algorithms is an important component of care provided to patients with PTSD. Despite the leading role of psychotherapy in the treatment of this disorder, prevention of chronicity and relapses, in order to achieve a quick effect and form patients' adherence to treatment, within the framework of a personalized approach, the use of psychopharmacotherapy is recommended, the effectiveness of which should be evaluated during the entire course of therapy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>посттравматическое стрессовое расстройство (ПТСР)</kwd><kwd>фармакотерапия</kwd><kwd>алгоритм лекарственной терапии</kwd><kwd>персонализированная медицина</kwd></kwd-group><kwd-group xml:lang="en"><kwd>post-traumatic stress disorder (PTSD)</kwd><kwd>pharmacotherapy</kwd><kwd>pharmacotherapy algorithm</kwd><kwd>personalized medicine</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Александровский Ю.А., Аведисова А.С., Павлова М.С. 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