bekhterevОбозрение психиатрии и медицинской психологии имени В.М.БехтереваV.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY2313-70532713-055XV. M. BEKHTEREV NATIONAL RESEARCH MEDICAL CENTER FOR PSYCHIATRY AND NEUROLOGY OF THE RUSSIAN FEDERATION MINISTRY OF HEALTH10.31363/2313-7053-2024-794bekhterev-921Research ArticleНАУЧНЫЕ ОБЗОРЫSCIENTIFIC REVIEWРоль гематологических коэффициентов системного воспаления в диагностике и оценке риска аффективных расстройствThe role of hematological coefficients of systemic inflammation in the diagnosis and risk assessment of affective disordershttps://orcid.org/0009-0005-0351-7157ГорбуноваА. П.GorbunovaA. P.

Горбунова Александра Петровна – ординатор отделения социальной нейропсихиатрии

Санкт-Петербург, 192019, ул. Бехтерева, д. 3

Aleksandra P. Gorbunova

St. Petersburg

gorbunovasashaa@gmail.comhttps://orcid.org/0000-0002-5282-2036РукавишниковГ. В.RukavishnikovG. V.

Рукавишников Григорий Викторович – к.м.н., ведущий научный сотрудник, руководитель отделения социальной нейропсихиатрии

192019, Санкт-Петербург, ул. Бехтерева, д.3

Grigory V. Rukavishnikov

St. Petersburg

grigory_v_r@mail.ruhttps://orcid.org/0000-0002-4658-2195КасьяновЕ. Д.KasyanovE. D.

Касьянов Евгений Дмитриевич - младший научный сотрудник отделения социальной нейропсихиатрии

Санкт-Петербург, 192019, ул. Бехтерева, д. 3

Evgeny D. Kasyanov

St. Petersburg

ohkasyan@yandex.ruhttps://orcid.org/0000-0001-7910-9129МазоГ. Э.MazoG. E.

Мазо Галина Элевна – доктор медицинских наук, заместитель директора по инновационному научному развитию, главный научный сотрудник, руководитель института трансляционной психиатрии

192019, Санкт-Петербург, ул. Бехтерева, д.3

Galina E. Mazo

St. Petersburg

galina-mazo@yandex.ruНациональный медицинский исследовательский центр психиатрии и неврологии им. В.М. БехтереваРоссияV.M. Bekhterev National Medical Research Center for Psychiatry and NeurologyRussian Federation2024080220245814755Copyright © Горбунова А.П., Рукавишников Г.В., Касьянов Е.Д., Мазо Г.Э., 20232023Горбунова А.П., Рукавишников Г.В., Касьянов Е.Д., Мазо Г.Э.Gorbunova A.P., Rukavishnikov G.V., Kasyanov E.D., Mazo G.E.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.bekhterevreview.com/jour/article/view/921

В обзорной статье освещена проблема использования в клинической практике гематологических коэффициентов системного воспаления, а также приводятся результаты исследований, посвященных их применению в диагностике и оценке терапевтического ответа при лечении аффективных расстройств. Известен вклад каждого отдельного звена иммунной системы в патогенез воспалительной реакции, однако в настоящее время наибольший интерес представляют нейтрофильно-лимфоцитарное (NLR), моноцитарно-лимфоцитарное (MLR) и тромбоцитарно-лимфоцитарное (PLR) соотношения, а также индексы системного иммунного воспаления (SII, количество тромбоцитов x количество нейтрофилов / лимфоцитов) и системной воспалительной реакции (SIRI, количество нейтрофилов х количество моноцитов / лимфоцитов), доступные расчету на основании рутинного клинического анализа крови. Проведенный анализ литературы демонстрирует значимость данных соотношений, однако подчеркивает необходимость их дальнейшего исследования. Более детальное изучение указанных показателей позволит достичь их прогностической ценности и более объективной оценки их валидности и специфичности для диагностики, прогнозирования риска и вариантов течения аффективных расстройств.

The review article highlights the problem of using hematological coefficients of systemic inflammation in clinical practice, as well as the results of studies aimed at its use in the diagnosis and evaluation of therapeutic response in the treatment of mood disorders. The contribution of each individual link of the immune system to the pathogenesis of an inflammatory reaction is known, but currently of most interest are neutrophil-lymphocytic (NLR), monocyte-lymphocytic (MLR) and platelet-lymphocytic (PLR) ratios, as well as indices of systemic immune-inflammation (SII, platelet count x number of neutrophils / lymphocytes) and system inflammation response (SIRI, number of neutrophils x number of monocytes / lymphocytes). All coefficients are available for calculation based on a routine complete blood count. The analysis of the literature demonstrates the significance of these ratios, but emphasizes the need for further research. A more detailed study of these ratios will allow achieving their prognostic value and a more objective assessment of their validity and specificity for the diagnosis, prediction of risks and variants of the affective disorders course.

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The authors declare that there are no conflicts of interest present.