Modern approaches to the therapy of schizophrenia with atypical neuroleptics (based on clinical observations)

Abstract

According to the lack of sufficient scientific data on the ratio, severity, and clinical pathomorphism of positive and negative symptoms in schizophrenia, a more detailed research of this issue is required. The ratio of positive and negative disorders in the structure of schizophrenia spectrum disorders is different in each specific case.
It is known that problems associated with the formation of stable remission in schizophrenia significantly affect the functional well-being, quality and life expectancy of patients. To ensure comprehensive, effective and safe treatment of patients with schizophrenia antipsychotic drugs with a broad spectrum of action are needed. Cariprazine is one of the more effective antipsychotics, both in relation to positive symptoms and in relation to negative and cognitive symptoms.
This paper presents a number of clinical observations that demonstrate the efficacy of the third-generation neuroleptic cariprazine as a potent antipsychotic drug with a favorable safety profile, providing high adherence to therapy and successfully used both in patients with the first psychotic episode and in patients with a disorder duration of more than five years. Also, the complex therapy schemes with psychosocial rehabilitation measures in the inpatient and outpatient departments of the Psychosocial Rehabilitation Center, located on the basis of the Regional Clinical Psychiatric Hospital, are described in detail.