Механизмы формирования коморбидности депрессии и ожирения
Аннотация
В статье представлены современные данные о коморбидности депрессии и ожирения с точки зрения причинно-следственных связей, общих патофизиологических механизмов формирования и развития, а также влияния одного из коморбидных заболеваний на успешность терапии другого заболевания в рамках поиска путей повышения эффективности терапии депрессии. Показана целесообразность выделения специфического депрессивно-метаболического эндофенотипа, что позволит получить новые знания об этиологии и патогенезе депрессии, а также оптимизировать терапию.
Ключевые слова
депрессия,
ожирение,
генетика,
эпигенетика,
антидепрессанты,
сертралин,
depression,
obesity,
genetics,
epigenetics,
antidepressants,
sertraline
Об авторах
Галина Элевна Мазо
ФГБУ «НМИЦ ПН им. В.М. Бехтерева» Минздрава России
Россия
Россия
Александр Олегович Кибитов
ФГБУ «НМИЦ ПН им. В.П. Сербского» Минздрава России; ФГБУ «НМИЦ ПН им. В.М. Бехтерева» Минздрава России
Россия
Россия
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Рецензия
Для цитирования:
Мазо Г.Э., Кибитов А.О. Механизмы формирования коморбидности депрессии и ожирения. Обозрение психиатрии и медицинской психологии имени В.М.Бехтерева. 2018;(1):65-78.
For citation:
Mazo G.E., Kibitov A.O. Mechanisms of formation comorbidity depression and obesity. V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY. 2018;(1):65-78. (In Russ.)
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