Case Report: Cariprazine Use in the Management of Bipolar Disorder with Non-compliance
https://doi.org/10.31363/2313-7053-2026-2-1327
Abstract
This article presents a challenging rehabilitation case of a female patient with bipolar disorder (BD). The described case details the onset of the disease, its subsequent progression, and personalized therapy selection, culminating in the prescription of cariprazine, which improved the patient’s compliance. The significance of this case for professional discussion lies in the empirically demonstrated efficacy of cariprazine in patients with low adherence to medical recommendations, particularly due to side effects of medications and complex prophylactic treatment regimens.
Supporting agencies: The study was carried out in accordance with the budgetary financing of the state assignment of the Mental Health Research Institute No. 075-00491-26-00 as part of the complex research topic «Personalized Therapy for Patients with Schizophrenic and Affective Spectrum Disorders Based on Clinically Verified Constellations of Markers of Their Morphological, Biochemical, and Cognitive Phenotypes» (registration number 126022417834-4. Protocol of the LEC No. 189/3.2025 dated December 9, 2025.
About the Authors
E. D. Schastnyy
Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
Evgeny D. Schastnyy
I. I. Ukraintsev
Siberian State University
Russian Federation
Russian Federation
Igor I. Ukraintsev
References
1. Kibitov AO, Shumskaia DS, Pinakhina DV. et al. Specific metabolic and inflammatory profiles of patients with hyperglycemia in bipolar affective disorder, recurrent depression and schizophrenia: results of a transdiagnostic study. Siberian Herald of Psychiatry and Addiction Psychiatry. 2025; 4 (129): 43-56. https://doi.org/10.26617/1810-3111-2025-4(129)-43-56
2. Arvilommi P, Pallaskorpi S, Linnaranta O, et al. Long-term work disability due to type I and II bipolar disorder: findings of a six-year prospective study. Int J Bipolar Disord. 2022;10(1):19. https://doi.org/10.1186/s40345-022-00264-6
3. Fountoulakis KN, Ioannou M, Tohen M, et al. Antidepressant efficacy of cariprazine in bipolar disorder and the role of its pharmacodynamic properties: A hypothesis based on data. Eur Neuropsychopharmacol. 2023;72:30–39. https://doi.org/10.1016/j.euroneuro.2023.03.009
4. Grande I, Goikolea M, de Dios C, et al. Occupational disability in bipolar disorder: analysis of predictors of being on severe disablement benefit (PREBIS study data). Acta Psychiatr Scand. 2013;127 (5):403-411. https://doi.org/10.1111/acps.12003
5. Hong J, Reed C, Novick D, et al. Clinical and economic consequences of medication non adherence in the treatment of patients with a manic/mixed episode of bipolar disorder: results from the European mania in bipolar longitudinal evaluation of medication (EMBLEM) study. Psychiatry Res. 2011;190:110–114. https://doi.org/10.1016/j.psychres.2011.04.016
6. Li K, Liao Y, Yang Z, et al. Case Report: Paliperidone Palmitate in the Management of Bipolar I Disorder With Non-complianceFront Psychiatry. 2021;111:529672. https://doi.org/10.3389/fpsyt.2020.529672
7. Mazza M, Marano G, Traversi G, et al. Cariprazine in bipolar depression and mania: State of the art. CNS Neurol Disord Drug Targets. 2018;17(10):723–727. https://doi.org/10.2174/1871527317666180828120-256
8. Merikangas KR, Jin R, He JP, et al. Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative. Arch Gen Psychiatry. 2011;68(3):241-251. https://doi.org/10.1001/archgenpsychiatry.2011.12
9. Pezzin LE, Larson ER, Lorber W, et al. Music instruction intervention for treatment of posttraumatic stress disorder: a randomized pilot study. BMC Psychol. 2018;6:60. https://doi.org/10.1186/s40359-018-0274-8
10. Rybakowski JK. Mood stabilizers of first and second generation. Brain Sci. 2023;13(5):741. https://doi.org/10.3390/brainsci13050741
11. Schaffer A., Isometsa E.T., Tondo L. et al. Epidemiology, neurobiology and pharmacological interventions related to suicide deaths and suicide attempts in bipolar disorder: part I of a report of the International society for bipolar disorders task force on suicide in bipolar disorder // Aust N Z J Psychiatry. — 2015. — No 49. — P. 785–802. https://doi.org/10.1177/0004867415594427
12. Torres-Llenza V, Lakshmin P, Lieberman DZ. Spotlight on once-monthly long-acting injectable aripiprazole and its potential as maintenance treatment for bipolar I disorder in adult patients. Neuropsychiatr Dis Treat. 2018;14:285–292. https://doi.org/10.2147/NDT.S129559
Review
For citations:
Schastnyy E.D., Ukraintsev I.I. Case Report: Cariprazine Use in the Management of Bipolar Disorder with Non-compliance. V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY. 2026;60(2):109-113. (In Russ.) https://doi.org/10.31363/2313-7053-2026-2-1327
Views:
311
JATS XML
Email this article 