A novel view on Alzheimer’s disease pathogenesis: modern conceptof amyloid clearance
https://doi.org/10.31363/2313-7053-2018-2-22-28
Abstract
Alzheimer’s disease is the most common cause of dementia among the elderly. Te pathological changes characterize by the deposition of amyloid plaques and the formation of neurofybrillar tangles in the brain. Te most signifcant role in the pathogenesis of neurodegeneration development is deposition of β-amyloid, vascular risk factors, the presence of a genetic predisposition, and the dysregulation of the bloodbrain barrier. Recent studies have demonstrated the role of the glymphatic system in the clearance of betaamyloid through the perivascular spaces of Virchow-Robin.
About the Authors
V. Yu. Lobzin
Military Medical Academy, Saint Petersburg
Russian Federation
Russian Federation
K. A. Kolmakova
Military Medical Academy, Saint Petersburg
Russian Federation
Russian Federation
A. Yu. Emelin
Military Medical Academy, Saint Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Lobzin V.Yu., Kolmakova K.A., Emelin A.Yu. A novel view on Alzheimer’s disease pathogenesis: modern conceptof amyloid clearance. V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY. 2018;(2):22-28. (In Russ.) https://doi.org/10.31363/2313-7053-2018-2-22-28
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