Interrelation of auto-immune process, endocrine disorders and depression
https://doi.org/10.31363/2313-7053-2020-1-8-19
Abstract
Disturbances in immune and endocrine regulation are closely interrelated with development of psychiatric diseases, including affective disorders. Depression may be a characteristic of at least 23 autoimmune diseases. Negative influence on the depression development have: an increased level of proinflammatory cytokines, impairment of T-regulatory cells, kynurenine pathway shift towards production of its potentially neurotoxic metabolites, overproduction of stress hormones, hyperleptinemia, hyperprolactinemia, hypothyroidism, as well as vitamin D, calcidiol and calcitriol deficiency. In this review we analysed the development and accumulation of ideas and facts regarding the interrelation between autoimmune and affective pathology.
About the Authors
M. A. Mayorova
Saint-Petersburg University
Russian Federation
Russian Federation
N. N. Petrova
Saint-Petersburg University
Russian Federation
Russian Federation
U. I. Stroev
Saint-Petersburg University
Russian Federation
Russian Federation
L. P. Churilov
Saint-Petersburg University
Russian Federation
Russian Federation
Y. Shoenfeld
Saint-Petersburg University; Zabludowicz Center for Autoimmune Diseases
Israel
Israel
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Mayorova M.A., Petrova N.N., Stroev U.I., Churilov L.P., Shoenfeld Y. Interrelation of auto-immune process, endocrine disorders and depression. V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY. 2020;(1):8-19. (In Russ.) https://doi.org/10.31363/2313-7053-2020-1-8-19
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