Association of MAOA-uVNTR gene polymorphism with hostility in an open population of males aged 45-64 in Russia / Siberia (international program: WHO «MONICA-psychosocial», «HAPIEE»)
https://doi.org/10.31363/2313-7053-2020-1-39-44
Abstract
Objective: to study the association of hostility with high and low-active variants of the MAOA gene in an open population of men 45-64 years old. Using the methods proposed by the WHO International Program “MONICA-psychosocial” and “HAPIEE”, a representative sample of men aged 45–64 years old (n = 781 men, average age was 56.48 ± 0.2 years) in 2003-2005. All respondents independently completed a questionnaire on hostility. From the surveyed sample, using the random number method, 156 men were selected who were genotyped for MAOA-uVNTR polymorphism. It was approved that the level of hostility in the population of men was 60.3%. It was revealed that among persons with low-active alleles of the MAOA-L gene (allele 2 and 3) a high level of hostility was more common — 50.9%. The results of building a logistic regression model showed that the presence of low-active alleles (2; 3) of the MAOA gene increases the likelihood of hostility OR = 2,103 (95% CI 1,137-3,889, p = 0.018). The results obtained allow us to conclude that the low-active allele of the MAOA-L gene is associated with hostility.
About the Authors
V. V. Gafarov
Institute of Internal and Preventive Medicine — branch of Institute of Cytology and Genetics SB RAS; Collaborative laboratory of Cardiovascular Diseases Epidemiology
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
E. A. Gromova
Institute of Internal and Preventive Medicine — branch of Institute of Cytology and Genetics SB RAS; Collaborative laboratory of Cardiovascular Diseases Epidemiology
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
D. O. Panov
Institute of Internal and Preventive Medicine — branch of Institute of Cytology and Genetics SB RAS; Collaborative laboratory of Cardiovascular Diseases Epidemiology
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
I. V. Gagulin
Institute of Internal and Preventive Medicine — branch of Institute of Cytology and Genetics SB RAS; Collaborative laboratory of Cardiovascular Diseases Epidemiology
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
V. N. Maksimov
Institute of Internal and Preventive Medicine — branch of Institute of Cytology and Genetics SB RAS
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
A. V. Gafarova
Institute of Internal and Preventive Medicine — branch of Institute of Cytology and Genetics SB RAS; Collaborative laboratory of Cardiovascular Diseases Epidemiology
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
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For citations:
Gafarov V.V., Gromova E.A., Panov D.O., Gagulin I.V., Maksimov V.N., Gafarova A.V. Association of MAOA-uVNTR gene polymorphism with hostility in an open population of males aged 45-64 in Russia / Siberia (international program: WHO «MONICA-psychosocial», «HAPIEE»). V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY. 2020;(1):39-44. (In Russ.) https://doi.org/10.31363/2313-7053-2020-1-39-44
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