Neurocognitive impairments in patients with schizophrenia and schizophrenia spectrum disorders: cluster analysis results
https://doi.org/10.31363/2313-7053-2020-1-45-51
Abstract
There are results of cluster analysis of neurocognitive impairments in 85 patients with schizophrenia spectrum disorders in the article. Three patient groups were discriminated based on the results. These groups differ from each other both by severity of general cognitive impairment and by severity of impairments of the specific cognitive functions. There are differences between groups by specific demographic and clinical parameters. However sensitivity analysis does not find influence of these clinical parameters on the cognitive differences between groups, which stay certain after symptoms are taken into account.
About the Authors
M. V. Karyakina
Moscow research institute of psychiatry — the branch of the FSBI «NMRC PN named after Serbsky»
Russian Federation
Russian Federation
A. B. Shmukler
Moscow research institute of psychiatry — the branch of the FSBI «NMRC PN named after Serbsky»
Russian Federation
Russian Federation
References
1. Gurovich IYa, Shmukler AB, Zaytseva YuS. Dynamics of neurocognitive functioning in patients in early stages of schizophrenia and schizophrenia spectrum disorders // Jurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2012; 112(8):7-14. (In Rus.)]
2. Gurovich IYa, Shmukler AB, Zaytseva YuS. Cognitive impairment path in patients with schizophrenia. V kn.: Psikhosocialnaya i kognitivnaya reabilitatsiya psikhicheski bolnykh. Prakticheskoe rukovodstvo: kollektivnaya monografiya. Pod red. I.Ya.Gurovicha, A.B. Shmuklera. M.: ID «Medpraktika-M». 2015: 94-112. (In Rus.)]
3. Sarkisyan GR, Gurovich IYa, Keefe RS. Normative data for the Russian population and standardization of the Brief Assessment of Cognition in Schizophrenia (BACS) scale. Socialnaya i klinicheskaya psikhiatriya. 2010; 20(3):13-19. (In Rus.)]
4. Semenkova EA. Neurocognitive deficit in patients with schizophrenia and schizophrenia spectrum disorders in nonacute condition: the effect of age. Socialnaya i klinicheskaya psikhiatriya. 2014; 24(2)18-23. (In Rus.)]
5. Yanushko MG, Ivanov MV, Sorokina AV. Cognitive disorders in endogenous psychoses: contemporary perspective in the light of dimensional approach. Socialnaya i klinicheskaya psikhiatriya. 2014; 24(1):90-95. (In Rus.)]
6. Antonova E, Sharma T, Morris R, Kumari V. The relationship between brain structure and neurocognition in schizophrenia: a selective review. Schizophr. Res. 2014; 70:117-145.
7. Barnes TR. A rating scale for drug-induced akathisia. Br. J. Psychiatry. 1989; 14:672–676.
8. Bora E, Pantelis C. Meta-analysis of cognitive impairment in first-episode bipolar disorder: comparison with first-episode schizophrenia and healthy controls. Schizophr. Bull. 2015; 41:1095-1104.
9. Castelnovo A, Ferrarelli F, D’Agostino A. Schizophrenia: from neurophysiological abnormalities to clinical symptoms. Front Psychol. 2015; 6:478. doi: 10.3389/fpsyg.2015.00478. eCollection 2015.
10. Cohen J. Statistical Power Analysis for the Behavioral Sciences (2nd ed.). Hillsdale, NJ: Lawrence Erlbaum Associates, Publishers. 1988.
11. Fioravanti M, Bianchi V, Cinti ME. Cognitive deficits in schizophrenia: an updated metanalysis of the scientific evidence. BMC Psychiatry. 2012; 12:64. doi: 10.1186/1471-244X-12-64.
12. Gold JM, Robinson B, Leonard CJ, Hahn B, Chen S, McMahon RP, Luck SJ. Selective Attention, Working Memory, and Executive Function as Potential Independent Sources of Cognitive Dysfunction in Schizophrenia. Schizophr. Bull. 2018; 44:1227-1234. doi: 10.1093/schbul/sbx155
13. Guy W. ECDEU Assessment for Psychopharmacology, Revised Edition. Rockville, MD: NIMH Publication. 1976.
14. Hoe M, Nakagami E, Green MF, Brekke JS. The causal relationships between neurocognition, social cognition and functional outcome over time in schizophrenia: a latent difference score approach. Psychol. Med. 2012; 42:2287-2299.
15. Kay SR, Fiszbein A, Opler LA. The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia. Schizophr. Bull. 1987; 13:261–276. https://doi.org/10.1093/schbul/13.2.261
16. Keefe RS, Goldberg TE, Harvey PD, Gold JM, Poe MP, Coughenour L. The Brief Assessment of Cognition in Schizophrenia: reliability, sensitivity, and comparison with a standard neurocognitive battery. Schizophr Res. 2004; 68:283-297.
17. Simpson GM, Angus JW. A rating scale for extrapyramidal side effects. Acta Psychiatr. Scand. 1970; 212(Suppl):11–19.
Review
For citations:
Karyakina M.V., Shmukler A.B. Neurocognitive impairments in patients with schizophrenia and schizophrenia spectrum disorders: cluster analysis results. V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY. 2020;(1):45-51. (In Russ.) https://doi.org/10.31363/2313-7053-2020-1-45-51
Views:
1093
Email this article 