Роль дофамина и норадреналина в алкоголь-зависимом поведении: от корреляций к механизмам

Используя модели на животных, воспроизводящие ключевые характеристики алкогольной зависимости, был достигнут значительный прогресс в идентификации нейрохимических субстратов данного заболевания, ведущую роль среди которых играют дофамин и норадреналин. Последние внедрения оптогенетических технологий в область алкогольных исследований предоставили возможность идентифицировать в пределах дофаминергической и норадренергической систем специфические паттерны нейропередачи, которые формируют этанол-зависимое поведение. Представляемый обзор литературы преимущественно сфокусирован на экспериментальных исследованиях, демонстрирующих эффективность современных технологий в раскрытии катехоламиновых механизмов аддиктивного поведения, направленного на употребление алкоголя.

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