25 лет исследований эффективности и безопасности применения различных лекарственных форм налтрексона для лечения синдрома зависимости от опиоидов

В обзоре представлены результаты двойных слепых рандомизированных исследований применения различных лекарственных форм антагониста опиоидных рецепторов налтрексона (пероральной, имлантируемой, инъекционной) для стабилизации ремиссии и профилактики рецидива у больных с синдромом зависимости от опиоидов (СЗО), выполненных авторами в течение последней четверти века. По данным этих исследований, депо-формы налтрексона (имплантируемая и инъекционная) являются более эффективными, чем пероральная, и позволяют отчасти решить проблему приверженности терапии, возникающую при использовании пероральной лекарственной формы налтрексона. Имплантат налтрексона эффективнее перорального препарата улучшал результаты лечения СЗО, и за счёт этого – приверженность и результаты антиретровирусной терапии ВИЧ-инфекции у больных с зависимостью от опиоидов. Лекарственные формы налтрексона пролонгированного действия характеризуются высокой эффективностью, хорошей переносимостью и открывают новые перспективы в терапии опиоидной зависимости.

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