Serotoninic and cholinergic approachers in treatment of asthenia and cognitive dysfunction

Neurochemical disorders following asthenia (A) in various parts of the brain are considered. For the first time, A presented as synaptic autoidosis caused by the imbalance of neurotransmitters (and other) systems in the brain structures responsible for emotional-volitional behaviour, motivation, cognitive and motor activity. We presented the hypothesis that choline replenishment with parallel enhancement of antioxidant activity with gincolydes can reduce A autocoidosis, and ameliorate A clinical symptoms. 40 patients with similar clinical course A (mild and moderate cognitive disorders, asthenic symptoms, etc.), received composition of choline strong which includes choline as such (550 mg), and standardized GINKGO biloba (60 mg) in a single capsule BID, for the period of 60 days. Evaluation of the Spielberg tests, depression (Beck Scale), the A and MOCA tests, as well as the Schulze test, and general clinical indicators, after processing the results showed a significant improvement in patient’s condition.

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