Treatment of cognitive impairment in the early postoperative period

On the basis of SPb GUZ «Nikolayevskaya hospital» assessed the efficacy and tolerability of the drug Gliatilin in the early postoperative period in patients undergoing General anesthesia for 2-2,5 hours. The study included 56 patients who received operative treatment in abdominal organs, mainly cholecystectomy, with transfusion therapy within 2-2,5 hours. All patients received anesthesia with Diprivan in a concentration of 1.5-2 mg/kg/h. Compared groups were statistically homogeneous for sex, age and baseline neuropsychiatric status (p<0.001). Monitoring of patients was performed before surgery, 3 hours, 24 hours, 48 hours and 5 days after surgery and anesthesia. We compared baseline neurological status (stroke Scale the National institutes of health NIHSS), the level of psychoemotional status (scale of depression of Montgomery-Asberg), higher cerebral functions (Mini mental test), including memory, understanding, logical thinking. While patients in the ICU they received standard intensive care, including complex of measures providing maintenance of life support systems. Pharmacotherapy the main and control groups differed only by the presence or absence of gliatilin. In group I (core) patients on the background of basic therapy were receiving gliatilin in the early postoperative period at a dosage of 1000 mg 2 times a day intravenously for 5 days, and in the II group (control) - only basic therapy. The obtained results indicate high efficiency of gliatilin in patients with ischemic-hypoxic brain damage after prolonged surgical interventions. Showed a significant influence of gliatilin on the processes of awakening, an earlier activation of the patients ‘ behaviours compared with the control group. It has been shown that gliatilin contributes to the normalization of the processes of memorization and reproduction of information improves the spatial and temporal orientation of patients has a positive effect on cognitive and behavioral reactions of patients, especially in the emotional-volitional sphere, reduces emotional lability, retraitement, improves mood. Thus, the use of gliatilin in the postoperative period allows you to quickly awaken the patient after prolonged anesthesia, faster and more efficiently to alleviate the effects of intraoperative ischemia / hypoxia of the brain, thereby reducing the risk of post anesthesia encephalopathy.

когнитивные послеоперационные нарушения, операция, наркоз, ишемия головного мозга, энцефалопатия, глиатилин, postoperative cognitive dysfunction, surgery, anesthesia, brain ischemia, encephalopathy, gliatilin