Тревожные состояния у детей с гиперкинетическим расстройством
Аннотация
В статье обзорного характера раскрываются проблемы коморбидности гиперкинетического и тревожных расстройств. Показано, что рассматриваемые расстройства имеют общие этиологические и патогенетические факторы, а также клинические симптомы. Кроме того, терапия обоих патологических состояний имеет сходные мишени, что вызывает предположение о том, что гиперкинетическое расстройство и тревожные расстройства детского возраста можно назвать не просто сопутствующими, но и коморбидными.
Ключевые слова
Об авторах
Р. Ф. Гасанов
Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева
Россия
Россия
Гасанов Рауф Фаикович — кандидат медицинских наук, ведущий научный сотрудник отделения детской психиатрии
И. В. Макаров
Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева;
Северо-Западный государственный медицинский университет им. И.И. Мечникова
Россия
Россия
Макаров Игорь Владимирович — доктор медицинских наук, профессор, руководитель отделения детской психиатрии НМИЦ ПН им. В.М. Бехтерева, профессор кафедры психиатрии и наркологии СЗГМУ им. И.И. Мечникова, главный детский специалист-психиатр Минздрава России в СЗФО, председатель секции детской психиатрии РОП
Д. А. Емелина
Национальный медицинский исследовательский центр психиатрии и неврологии им. В.М. Бехтерева
Россия
Россия
Емелина Дарья Андреевна — кандидат медицинских наук, младший научный сотрудник отделения детской психиатрии
Список литературы
1. Гасанов Р.Ф. Гетерогенность путей трансформации моноаминергических систем головного мозга у детей с синдром дефицита внимания. Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева. 2014;4:3-15.
2. Гасанов Р.Ф. Роль серотониновой системы в патогенезе синдрома дефицита внимания с учетом гетерогенности расстройства. Обозрение психиатрии и медицинского психологии имени В.М. Бехтерева. 2015;4:39-50.
3. Гасанов Р.Ф. Современные представления об этиологии синдрома дефицита внимания (обзор литературы). Обозрение психиатрии и медицинского психологии имени В.М. Бехтерева. 2010;1:4-10.
4. Гасанов Р.Ф. Специфический когнитивный дефицит у детей с гиперкинетическим расстройством // Обозрение психиатрии и медицинской психологии им. В.М. Бехтерева. 2018;3:3-9. doi: 10.31363/2313-70532018-3-3-9
5. Гасанов Р.Ф., Макаров И.В. Роль моноаминов у детей с гиперкинетическим расстройством. Журнал неврологии и психиатрии им. С.С. Корсакова. 2017;117(11-2):88-91. doi: 10.17116/jnevro201711711288-91.
6. Голимбет В.Е., Коровайцева Г.И., Брусов О.С. Функциональное состояние серотонинергической системы и полиморфизм 5HTTLPR гена переносчика серотонина у больных шизофренией. Молекул. биол. 2010; (44-2): 251-256.
7. Abikoff H., McGough J., Vitiello B., McCracken J., Davies M., Walkup J., et al. Sequential pharmacotherapy for children with comorbid attention deficit / hyperactivity and anxiety disorders. J Am Acad Child Adolesc Psychiatry. 2005;44:418-427. doi: 10.1097/01.chi.0000155320.52322.37
8. Adams J., Crosbie J., Wigg K., Ickowicz A., Pathare T., Roberts W., et al. Glutamate receptor, ionotropic, N-methyl D-as-partate 2A (GRIN2A) gene as a positional candidate for attention deficit/hyperactivity disorder in the 16pl3 region. Molecular Psychiatry. 2004;9:494-499. doi: 10.1038/sj.mp.4001455
9. Angold A., Costello E.J., Erkanli A. Comorbidity. Journal of Child Psychology and Psychiatry, and Allied Disciplines. 1999;40:57–87. doi: 10.1017/s0021963098003448
10. Aston-Jones G., Rajkowski J., Cohen J. Role of locus coeruleus in attention and behavioral flexibility. Biological Psychiatry. 1999; (46-9):1309-1320. doi: 10.1016/s0006-3223(99)00140-7
11. Banerjee E., Sinha S., Chatterjee A., Gangopadhyay P.K., Singh M., Nandagopal K. A family-based study of Indian subjects from Kolkata reveals allelic association of the serotonin transporter intron2 (STin2) polymorphism and attention-deficithyperactivity disorder (ADHD). Am. J. Med. Genet. B. Neuropsychiatr. Genet. 2006;(141-4):361-366. doi: 10.1002/ajmg.b.30296
12. Barkley R.A. Behavioral inhibition, sustained attention, and executive functions: Constructing a unifying theory of AD/HD. Psychological Bulletin. 1997;121:65-94. doi: 10.1037/0033-2909
13. Barkley R.A., Grodzinsky G., DuPaul G.J. Frontal lobe functions inattention deficit disorder with and without hyperactivity: A review and research report. Journal of Abnormal Child Psychology. 1992;20:163–188. doi: 10.1007/bf00916547
14. Bedard A.C., Tannock R. Anxiety, methylphenidate response, and working memory in children with ADHD. Journal of Attention Disorders. 2007;11:546557. doi: 10.1177/1087054707311213
15. Biederman J., Faraone S., Spencer T., Wilens T., Mick E., Lapey K. Gender differences in a sample of adults with attention deficit hyperactivity disorder. Psychiat Re. 1994;53:13-29. doi: 10.1016/01651781(94)90092-2
16. Biederman J., Faraone S., Spencer T., Wilens T., Norman D., Lapey K., et al. Patterns of psychiatric comorbidity, cognition, and psychosocial functioning in adults with attention deficit hyperactivity disorder. Am. J. Psychiatry. 1993;(150-12): 17921798. DOI: 10.1176/ajp.150.12.1792
17. Blaya C., Salum G.A., Lima M.S., Leistner-Segal S., Manfro G.G. Lack of association between the serotonin transporter promoter polymorphism (5-HTTLPR) and panic disorder: A systematic review and meta-analysis. Behavioral and Brain Functions. 2007;3:41. doi:10.1186/1744-9081-341
18. Bowen R., Chavira D.A., Bailey K., Stein M.T., Stein M.B. Nature of anxiety comorbid with attention deficit hyperactivity disorder in children from a pediatric primary care setting. Psychiatry Res. 2008;157(1-3):201–209. doi: 10.1016/j.psychres.2004.12.015
19. Bradshaw J.L., Sheppard D.M. The neurodevelopmental frontostriatal disorders: Evolutionary adaptiveness and anomalous lateralization. Brain and Language. 2000;73:297320. doi: 10.1006/brln.2000.2308
20. Brown T.A., Campbell L.A., Lehman C.L., Grisham J.R., Mancill R.B. Current and lifetime comorbidity of the DSM—IV anxiety and mood disorders. Journal of abnormal psychology. 2001;110(4):585— 599. doi: 10.1037//0021-843x.110.4.585
21. Brown T.E.. Attention-deficit disorders and comorbidities in children adolescents, and adults. Washington, DC: American Psychiatric Press; 2000.
22. Carlson C.L., Mann M. Sluggish cognitive tempo predicts a different pattern of impairment in the attention deficit/hyperactivity disorder, predominently inattentive type. Journal of Clinical Child and Adolescent Psychology. 2002;31(1):123129. doi: 10.1207/s15374424jccp3101_14
23. Clayton C.I., Richards J.C. Selective attention in obsessive-compulsive disorder. Journal of Abnormal Psychology. 1999;108(1):171-175. doi: 10.1037//0021-843x.108.1.171
24. Crozier W.R., Alden L.E. International handbook of social anxiety: Concept, research, and interventions relating to the self and shyness. New York: John Wiley; 2001.
25. Das M., Bhowmik A.D., Sinha S., Chattopadhyay A., Chaudhuri K., Singh M., Mukhopadhyay K. МАОА promoter polymorphism and attention deficit hyperactivity disorder (ADHD) in indian children. Am. J. Med. Genet. В Neuropsychiatr. Genet. 2006;141(6):637-642. doi: 642.10.1002/ajmg.b.30385
26. Domschke K., Deckert J., O’Donovan M.C., Glatt S.J. Metaanalysis of COMT val158met in panic disorder: Ethnic heterogeneity and gender specificity. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2007;144B:667– 673. doi: 10.1002/ajmg.b.30494
27. Epstein JN, Goldberg NA, Conners CK, March JS. The effects of anxiety on continuous performance test functioning in an ADHD clinic sample. Journal of Attention Disorders. 1997;2:45-52. doi: 10.1177/108705479700200106
28. Frustaci A., Pozzi G., Gianfagna F., Manzoli L., Boccia S. Meta-analysis of the brain-derived neurotrophic factor gene (BDNF) Val66Met polymorphism in anxiety disorders and anxietyrelated personality traits. Neuropsychobiology. 2008;58:163–170. doi: 10.1159/000182892
29. Geller D., Donnelly C., Lopez F., Rubin R., Newcorn J., Sutton V., et al. Atomoxetine treatment for pediatric patients with attentiondefi cit/hyperactivity disorder with comorbid anxiety disorder. J Am Acad Child Adolesc Psychiatry. 2007;46:1119-27. doi: 10.1097/chi.0b013e3180ca8385
30. Gershon J. A meta-analytic review of gender differences in ADHD. J. Atten. Disord. 2002;5(3):143-154. doi: 10.1177/108705470200500302
31. Goez H., Back-Bennet O., Zelnik N. Differential stimulant response on attention in children with comorbid anxiety and oppositional defiant disorder. J Child Neurol. 2007;22:538-42. doi: 10.1177/0883073807303221
32. Gomez R. Underlying processes in the poor response inhibition of children with attentiondeficit/ hyperactivity disorder. Journal of Attentional Disorders. 2003;6(3):111-122. doi: 10.1177/108705470300600303
33. Graziano P.A., Geffken G.R., McNamara J.P. Atypical behaviors and comorbid externalizing symptoms equally predict children with attentiondeficit/ hyperactivity disorder’s social functioning. Child Psychiatry Hum Dev. 2011;42(4):377–389. doi: 10.1007/s10578-011-0224-7
34. Greene R.W., Biederman J., Faraone S.V., Monuteaux M.C., Mick E., DuPre E.P., et al. Social impairment in girls with ADHD: patterns, gender comparisons, and correlates. J Am Acad Child Adolesc Psychiatry. 2001;40(6):704–710. doi: 10.1097/00004583-200106000-00016
35. Hartman C.A., Willcutt W.G., Rhee S.H., Pennington B.F. The relation between sluggish cognitive tempo and DSM IV ADHD. Journal of Abnormal Child Psychology. 2004;35(2):491-503. doi: 10.1023/b:jacp.0000037779.85211.29
36. Homack S. A meta-analysis of the sensitivity and specificity of the Stroop Color and Word Test with children. Archives of Clinical Neuropsychology. 2004;19:725–743. doi: 10.1016/j.acn.2003.09.003
37. Hoogman M., Bralten J., Hibar D.P., Mennes M., Zwiers M.P., van Hulzen KJE, et al. Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysis. Lancet Psychiatry. 2017;4:310–19. doi: 10.1016/S22150366(17)30049-4
38. Hoza B., Mrug S., Gerdes A.C., Hinshaw S.P., Bukowski W.M., Gold J.A., et al. What aspects of peer relationships are impaired in children with attention-deficit/hyperactivity disorder? J Consult Clin Psychol. 2005;73(3):411–423. doi: 10.1037/0022-006x.73.3.411
39. Hwang D.R., Kegeles L.S., Laruelle M. (-)-N-[(ll) C]propyl-norapomorphine: a positron-labeled dopamine agonist for PET imaging of D(2) receptors. Nucl Med Biol. 2000;27:533-539. doi: 10.1016/s0969-8051(00)00144-x
40. Jarrett M.A., Wolff J.C., Davis T.E., Cowart M.J., Ollendick T.H. Characteristics of Children With ADHD and Comorbid Anxiety. Journal of Attention Disorders. 2012;20(7):636-644. doi: 10.1177/1087054712452914
41. Jensen P.S., Hinshaw S.P., Kraemer H.C., Lenora N., Newcorn J.H., Abikoff H.B., et al. ADHD comorbidity findings from the MTA study: Comparing comorbid subgroups. Journal of the American Academy of Child & Adolescent Psychiatry. 2001;40(2):147-158. doi: 10.1097/00004583-200102000-00009
42. Jensen P.S., Cantwell D. Comorbidity in ADHD. Implications for research, practice, and DSM 5. Journal of the American Academy of Child & Adolescent Psychiatry. 1997;35:1065-1079. doi: 10.1097/00004583-199708000-00014
43. Karustis J.L., Power T.J., Rescorla L.A., et al. Anxiety and depression in children with ADHD: Unique associations with academic and social functioning. J Atten Disord. 2000;4(3):133–149. doi: 10.1177/108705470000400301
44. Laruelle M. Imaging synaptic neurotransmission with in vivo binding competition techniques: a critical review. J Cereb Blood Flow Metab. 2000;20:423451. doi: 10.1097/00004647-200003000-00001
45. Laruelle M., Huang Y. Vulnerability of positron emission tomography radiotracers to endogenous competition. New insights. Q J Nucl Med. 2001;45:124-138.
46. Lee S.S., Falk A.E., Aguirre V.P. Association of comorbid anxiety with social functioning in school-age children with and without attention-deficit/hyperactivity disorder (ADHD). Psychiatry Res. 2012;197:90–96. doi: 10.1016/j.psychres.2012.01.018
47. Levy F. Synaptic gating and ADHD: A biological theory of comorbidity of ADHD and anxiety. Neurospychopharmacology. 2004;29:1589-1596. doi: 10.1038/sj.npp.1300469
48. Li J., Kang C., Wang Y., Zhou R., Wang B., Guan L., et al. Contribution of 5-HT2A receptor gene — 1438A>G polymorphism to outcome of attention-deficit/hyperactivity disorder in adolescents. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 2006;141 (5):473 — 476. doi: 10.1002/ajmg.b.30320
49. Manassis K., Tannock R., Barbosa J. Dichotic listening and response inhibition in children with comorbid anxiety disorders and ADHD. Journal of the American Academy of Child & Adolescent Psychiatry. 2000;39:1152-1159. doi: 10.1097/00004583-200009000-00015
50. Mancini C., van Ameringen M., Oakman J.M., Fiqueiredo D. Childhood attention deficit/ hyperactivity disorder in adults with anxiety disorders. Psychological Medicine. 1999;29(3):515— 525. doi: 10.1017/s0033291798007697
51. March J.S., Swanson J.M., Arnold E.L., Hoza B., Conners C.K., Hinshaw S.P., et al. Anxiety as a predictor and outcome variable in the multimodal treatment study of children with ADHD (MTA). Journal of Abnormal Child Psychology. 2000;28(6):527-541. doi: 10.1023/A:1005179014321
52. Martinuseen R., Hayden J., Hogg-Johnson S., Tannock R. A meta-analysis of working memory impairments in children with attentiondeficit/ hyperactivity disorder. Journal of the American Academy of Child & Adolescent Psychiatry. 2005;44:377-384. doi: 10.1097/01.chi.0000153228.72591.73
53. Mathew S.J., Coplan J.D., Gorman J.M. Gorman Neurobiological Mechanisms of Social Anxiety Disorder. American journal of psychiatry. 2001;158(10):1558-1567. doi: 10.1176/appi.ajp.158.10.1558
54. McGrath L.M., Weill S., Robinson E.B., Macrae R., Smoller J.W. Bringing a developmental perspective to anxiety genetics. Development & Psychopathology. 2012;24:1179 — 1193. doi: 10.1017/S0954579412000636
55. Mikami A.Y., Ransone M.L., Calhoun C.D. Influence of anxiety on the social functioning of children with and without ADHD. J Atten Disord. 2010;15(6):473– 484. doi: 10.1177/1087054710369066
56. MTA Cooperative Group Moderators and mediators of treatment response for children with Attention Deficit/Hyperactivity Disorder: The multimodal treatment study of children with Attention-Deficit/ Hyperactivity Disorder. Archives of General Psychiatry. 1999;56(12):1088-1096. doi: 10.1001/archpsyc.56.12.1088
57. Oosterlaan J., Logan G.D., Sergeant J.A. Response inhibition in AD/HD, CD, cormorbid AD/HD and CD, anxious, and control children: A metaanalysis of studies with the stop task. Journal of Child Psychology and Psychiatry. 1998;39(3):411425. doi: 10.1111/1469-7610.00336
58. Oosterlaan J., Sergeant J.A. Response inhibition and response re-engagement in attention deficit/ hyperactivity disorder, disruptive, anxious, and normal children. Behavioral Brain Research. 1998;94(1):33-43. doi: 10.1016/s01664328(97)00167-8
59. Pliszka S.R. Effect of anxiety on cognition, behavior, and stimulant response in ADHD. Journal of the American Academy of Child & Adolescent Psychiatry. 1989;28(6):882-887. doi: 10.1097/00004583-198911000-00012
60. Pliszka S.R, Carlson C., Swanson J.M. ADHD with comorbid disorders: Clinical assessment and management. New York: Guilford; 1999.
61. Pliszka S.R., Hatch J.P., Borcherding S.H., Rogeness G.A. Classical conditioning in children with attention deficit hyperactivity disorder (ADHD) and anxiety disorders: A test of Quay’s model. Journal of Abnormal Child Psychology. 1993;21:411-423. doi: 10.1007/bf01261601
62. Posner M.I., Peterson S. The attention system of the human brain. Annual Review of Neuroscience. 1990; 13:25-42. doi: 10.1146/annurev.ne.13.030190.000325
63. Quay H. The behavioral reward and inhibition system in childhood behavioral disorder, in attention deficit disorder. New York: Pergamon; 1998.
64. Roth R.M., Wishart H.A., Flashman L.A., Riordan H.J., Huey L., Saykin A.J. Contribution of organizational strategy to verbal learning and memory in adults with attention-deficit/ hyperactivity disorder. Neuropsychology. 2004;18(1):78-85. doi: 10.1037/0894-4105.18.1.78
65. Roy A.K., Vasa R.A., Bruck M., Mogg K., Bradley B.P., Sweeney M., et al. Attention bias toward threat in pediatric anxiety disorders. Journal of the American Academy of Child and Adolescent Psychiatry. 2008;47:1189–1196. doi: 10.1097/chi.0b013e3181825ace
66. Schachar R., Tannock R., Marriott M., Logan G.D. Deficient inhibitory control and attention deficit hyperactivity disorder. Journal of Abnormal Child Psychology. 1995;23(4):411-437. doi: 10.1007/bf01447206
67. Schatz D.B., Rostain A.L. ADHD with comorbid anxiety: a review of the current literature. J Atten Disord. 2006;10(2):141–149. doi: 10.1177/1087054706286698
68. Schneier F.R. Low dopamine D2 receptor binding potential in social phobia. Am J Psychiatry. 2000;157:457-459. doi: 10.1176/appi.ajp.157.3.457
69. Sciberras E., Mulraney M., Anderson V., Rapee R.M., Nicholson J.M., Efron D., et al. Managing anxiety in children with ADHD using cognitivebehavioral therapy: a pilot randomized controlled trial. Journal of attention disorders. 2015;22(5): 515-520. doi: 10.1177/1087054715584054
70. Sergeant J. The cognitive-energetic model: An empirical approach to attention-deficit hyperactivity disorder. Neuroscience and Biobehavioral Review. 2000;24:7-12. doi: 10.1016/s0149-7634(99)00060-3
71. Skirbekk B., Hansen B.H., Oerbeck B., Kristensen H. The relationship between sluggish cognitive tempo, subtypes of attention-deficit/hyperactivity disorder, and anxiety disorders. Journal of Abnormal Child Psychology. 2011;39:513-525. doi: 10.1007/s10802011-9488-4
72. Tannock R. ADHD with anxiety disorders. In T.E. Brown (Ed.), ADHD comorbidities: Handbook for ADHD complications in children and adults. Washington, DC: American Psychiatric Publishing; 2009:131-155.
73. Tannock R., Ickowicz A., Schachar R. Differential effects of methylphenidate on working memory in ADHD children with and without comorbid anxiety. Journal of the American Academy of Child & Adolescent Psychiatry. 1995;34:886-896. doi: 10.1097/00004583-199507000-00012
74. Tiihonen J., Kuikka J., Bergstrom K., Lepola U., Koponen H., Leinonen E. Dopamine reuptake site densities in patients with social phobia. Am J Psychiatry. 1997;154:239-242. doi: 10.1176/ajp.154.2.239
75. Vloet T.D., Konrad K., Herpetz-Dahlmann B., Polier G.G., Gunther T. Impact of anxiety on attentional functions in children with ADHD. Journal of Affective Disorders. 2010;124:283-290 doi: 10.1016/j.jad.2009.11.017
Для цитирования:
Гасанов Р.Ф., Макаров И.В., Емелина Д.А. Тревожные состояния у детей с гиперкинетическим расстройством. Обозрение психиатрии и медицинской психологии имени В.М.Бехтерева. 2019;(2):3-12. https://doi.org/10.31363/2313-7053-2019-2-3-12
For citation:
Gasanov R.F., Makarov I.V., Emelina D.A. Anxiety in children with hyperkinetic disorder (literature review). V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY. 2019;(2):3-12. (In Russ.) https://doi.org/10.31363/2313-7053-2019-2-3-12
Просмотров: 509
Послать статью по эл. почте 