Modern dilemma in the therapy of the schizophrenia: neurocognition and social cognition
https://doi.org/10.31363/2313-7053-2019-3-3-9
Abstract
Recent research data make it evident that the last generations of antypsychotics being successful in elimination of the positive psychotic symptoms still seem to be incapable to sufficiently lower exacerbation frequency and to improve social functioning. The primary reason for that is considered to be an insufficient response of the patients’ cognitive deficit to the action of antipsychotics. The importance to differentiate between neurocognition and social cognition in view of the schizophrenia treatment general strategy optimization is discussed.
About the Authors
N. B. Lutova
V.M. Bekhterev national research medical center for psychiatry and neurology
Russian Federation
Russian Federation
V. D. Wied
V.M. Bekhterev national research medical center for psychiatry and neurology
Russian Federation
Russian Federation
References
1. Dorofeykova M.V. Changes in levels of neuromarkers and cognitive functioning of patients with treatmentresistant schizophrenia. Obozrenie psikhiatrii i meditsinkoi psikhologii im. V.M. Bekhtereva. 2016; 3:38-43. (In Rus.).
2. Yanushko M.G., Ivanov M.V., Sorokina A.V. Cognitive disorders in endogenous psychoses: contemporaryperspective in the light of dimensional approach. Sotsial’naya I klinicheskaya psikhiatriya. 2014; 24:90-95. (In Rus.).
3. Bellack A.S., Morrison R.L., Wixted J.T., Mueser K.T. An analysis of social competence in schizophrenia//Brit. J. Psychiatry. — 1990. — Vol.156. — P.809-818. DOI: 10.1192/bpj.156.6.809
4. Brekke J., Kay D.D., et al. Biosocial pathways to social outcome in schizophrenia: a path analytic model. — Schizophr. Res. — 2005. — Vol. 80, — P.213-225. DOI: 10.1016/j.schres.2005.07.008
5. Chan J.Y.H., Ng S.S,W., Lo A.W.Y., et al. Correlation of neurocognition with social cognition in people with schizophrenia. — Int. J. Psychol. Behav. Anal. — 2018. — №4. — P.139. DOI: 10.15344/2018/2455-3867/139
6. Corrigan P., Toomey R. Interpersonal problem solving and information processing deficits in schizophrenia. — Schizophr. Bull. — 1995. — Vol.21 — P.395-403.
7. Deckler E. et al. Social cognition and neurocognition in schizophrenia and healthy controls: intercorrelation of performance and effects of manipulations aimed at increasing task difficulty. — Front. Psychiatry. — 2018. — Vol.7. DOI: 10.3389/fpsyt.2018.00356.
8. Fett A.K., Viechtbauer W., Dominquez M.P., et al. The ralationship between neurogognition and social cognition with functional outcomes in schizophrenia: a meta-analysis. — Neurosci. — Biobehav. Rev. — 2011. –Vol.35. — P.573-588. DOI: 10.1016/j.neubiorev. 2010.07.001.
9. Green M., Nuechterlein K. The MATRICS Initiative: Developing a consensus cognitive battery for clinical trials. — Schizophr. Res. — 2004. – Vol.72. –P.1-3. DOI: 10.1016/j.schres.2004.09.006
10. Haefner H., Riecher-Rossler A., Hambrecht M.,et al. IRAOS — an instrument for the assessment of the onset and early course of schizophrenia. — Schizophr. Res. –1992. — Vol.6. — P.209-223. DOI:10.1016/0920-9964(92)90004-O
11. Heinrichs R.W., Zakzanis K.K. Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. — Neuropsychology. — 1998. –№12. — P.426-445. DOI: 10.1037/0894-4105.12.3.126
12. Hoe M., Nakagami E., Green M.F., et al. The causal relationships between neurocognition, social cognition and functional outcome over time in schizophrenia: a latent difference score approach. — Psychol. Med.– 2012. DOI:10.1017/S0033291712000578.
13. Jain M., Singh S., Dalal R.K. et al. A crosssectional study of cognitive functions and disability in schizophrenia from a tertiary care hospital in North India. — Med. J. DY Patil Univ. — 2016. — №9. — P.457-464. DOI:10.4103/0975-2870.186056
14. Jaramillo P., Fuentes I., Ruiz I., Ruiz J.C. Cognition, social cognition and social functioning in schizophrenia. Psychology, Society & Education. — 2009. — Vol.1. — P.13-24.
15. Kaneko K. Negative symptoms and cognitive impairments in schizophrenia: two key symptoms negatively influencing social functioning. Yonago Acta Med. — 2018. — Vol. 61(2). — P.91-102.
16. Kim J.H., Byun H.J., Ann J.H., et al. Relationship between subjective experiences and psychopathological dimensions in schizophrenics. Aust N Z J Psychiat. — 2010. — Vol.44. — P.952-957.
17. Lindenmayer J.P., McGurk S.R., Khan A., et al. Improvement of social cognition in schizophrenia:a pilot intervention combining computerized social cognition training with cognitive remediation. Schizophr. Bull. — 2017. — Vol.39. — P.507-517. DOI:10.1093/schbul/sbs120.
18. Lindenmayer J.P., Khan A., McGurk S.R., et al. Does social cognition training augment respond to computer assisted cognitive remediation for schizophrenia? Schizophr. Res. — 2018. — Vol.201. — P.180-186. DOI: 10.1016/j.schres.2018.06.012.
19. Lyman DR., Kurtz MM., Farkas M., Dougherty RH., Daniels AS., et al. Skill building: assessing the evidence. Psychiatr Serv. — 2014. — Vol.65. — P.727-738. DOI:10.1176/appi.ps.201300251
20. Medalia A., Thysen J. Insight into neurocognitive dysfunction in schizophrenia. Schizophr. Bull. — 2008. — Vol.34. — P.1221-1230. DOI:10.1093/schbul/sbm144.
21. Mehta U.M., Thirthalli J., Subbakrishna D.K., et al. Social and neurocognition as distinct cognitive factors in schizophrenia: a systematic review. Schizophr. Res. — 2013. — Vol.148. — P.3-11. DOI:10.1016/schres.2013.05.009.
22. Naber D. Subjective effects of antipsychotic treatment. Acta Psychiatr Scand. — 2005. — Vol.111(2). — P.81-83. DOI:10.1111/j.1600-0447.2004.0047x.
23. Nahum M., Fisher M., Loewy K., et al. A novel, online cognitive training program for young adults with schizophrenia: a pilot study. Schizophrenia Research: Cognition. –2014. — Vol.1(1). — P.11-19. DOI:10.1016/j.scog.2014.01.003.
24. Palumbo D., Mucci A., Piegari G., et al. SoCIAL training cognition in schizophrenia — a pilot study. Neuropsychiatr. Dis. Treat. — 2017. — Vol.13. — P.1947-1956. DOI:10.2147/NDT.S136732.
25. Penn D.L., Spaulding W., Reed D., Sullivan M. The relationship of social cognition to ward behavior in chronic schizophrenia. Schizophr. Res. — 1996. — Vol.20. — P.327-335. DOI:10.1016/0920-9964(96)00010-2.
26. Prouteau A., Verdoux H., Briand C., et al. Cognitive predictions of psychosocial functioning outcome in schizophrenia: a follow-up subjects participating in a rehabilitation program. — Schizophr. Res. — 2005. –Vol.77. — P.343-353. DOI: j.schres.2005.03.001
27. Reeder C., Smedley N., Butt K., et al. Cognitive predictors of social functioning improvements following cognitive remediation for schizophrenia. Schizophr. Bull. –2006. –Vol.32. — P.123- 131. DOI:10.1093/schbul/sbl019.
28. Rich M., Caldwell H. A role of oxytocin in the etiology and treatment of schizophrenia. Front. Endocrinol. — 2015. — Vol.6. — P.90. DOI:10.3389/fendo.2015.00090.
29. Roberts D.L., Velligan D.I. Can social functioning in schizophrenia be improved through targeted social cognition intervention? Rehabilitation Research and Practice. — 2012. — Article ID742106. DOI:10.1155/2012/742106.
30. Rund B.R., Borg N.E. Cognitive deficits and cognitive training in schizophrenic patients: a review. Acta Psychiat. Scand. — 1999. — Vol.100. — P. 85-95. DOI:10.1111/j.1600-0447.1999.tb10829.x.
31. Savla G.N., Vell L., Armstrong C.C., et al. Deficits in domains of social cognition in schizophrenia: a meta-analysis of the empirical evidence. Schizophrenia Bull. — 2013. — Vol.39 (5). — P.979-992. DOI:10.1093/schbul/sbs080.
32. Schmidt S.J., Mueller D.R., Roder V. Social cognition as a mediator variable between neurocognition and functional outcome in schizophrenia: empirical review and new results by structural equation modeling. Schizophr. Bull. — 2011. — Vol37. — P.41-54. DOI:10.1093/schbul/sbr079.
33. Shilling P., Feifel D. Potential of oxytocin in the treatment of schizophrenia. — CNS Drugs. — 2016. — Vol.30(3). — P.193-208. DOI:10.1007/s40263-016-0315-x
34. Shin Y.J., Yoo Y.H., Kim Y.H. Self-perceived cognitive deficits and their relationship with internalized stigma and quality of life in patients with schizophrenia. — Neuropsychiatr. Disease. Treat. — 2016. — Vol.12. — P.1411-1417. DOI:10.2147/NDT.S108537.
35. Sterea R. The relationship between social condition and functional outcomes in schizophrenia. — Procedia — Social and Behavioral Sciences. — 2015. — Vol.187. — P.256-260. DOI:10.1016/j.sbspro.2015.03.048.
36. Subramaniam K., Luks T.L., Garret C.,et al. Intensive cognitive training in schizophrenia enhances working memory and associated prefrontal cortical efficiency in a manner that drives long-term functional gains. — Neuroimage. — 2014. –Vol.99. — P. 81-292. Doi:10.106/j.neuroimage.2014.05.057.
37. Tripathi А. et al. Cognitive deficits in schizophrenia: understanding the biological correlates and remediation strategies. Clin. Psychopharmacol. Neurosci. — 2018. — Vol.16. — P.7-17. DOI:10.9758/cpn.2018.16.1.7.
38. Vauth R., Rusch N., Wirtz M., Corrigan P.W. Does social cognitive influence the relation between neurocognitive deficits and vocational functioning in schizophrenia? Psychiatr. Res. — 2004. — Vol.128. — P.155-165. DOI:10.1016/j.psychres.2004.05.018.
39. Velligan D. I., Prihoda T.J., Sui D., et al. The effectiveness of quetiapine versus conventional antipsychotics in improving cognitive and functional outcomes in standard treatment settings. J. Clin. Psychiatry. — 2003. — Vol. 64(5). — P.524-531.
40. Verdoux H., Monello E., Goumilloux A., et al. Self-perceived cognitive deficit and occupational outcome in persons with schizophrenia. Psychiat. Res. — 2010 Jul. — Vol.178. — P.437-439. DOI:10.1016/j.psychres.2010.04.031.
41. Wiener D., Rybakowski J. Disturbances of social cognition in schizophrenia. Psychiatr. Pol. — 2006. — Vol.40. — P.205-218.
Review
For citations:
Lutova N.B., Wied V.D. Modern dilemma in the therapy of the schizophrenia: neurocognition and social cognition. V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY. 2019;(3):3-9. (In Russ.) https://doi.org/10.31363/2313-7053-2019-3-3-9
Views:
1647
Email this article 