Does psychiatric molecular genetics need to account for the birth cohort effect?
https://doi.org/10.31363/2313-7053-2019-4-1-28-30
Abstract
Major psychiatric disorders including alcohol use disorder are considered multigenic and the smallness of effects of individual genes may be attributed to either complex biological mechanisms or geneenvironment interactions. The latter explanation is highlighted by the relatively fast changes in secular trends and in cohort effects on alcohol use disorder. Interactions of candidate gene variants with birth cohort have been found in the Estonian Children Personality Behaviour and Health Study, a longitudinal investigation from 1998 with a sample highly representative of birth cohorts within a region. Such interactions regarding initiation of alcohol use or alcohol use disorder have been revealed for e.g., 5-HTTLPR, VMAT1, OXR and NRG1, and suggest that rapid alterations in the socioeconomic environment promote changes in the genetic vulnerability to environmental risks factors such as alcohol.
About the Authors
J. Harro
Division of Neuropsychopharmacology, Department of Psychology, University of Tartu
Estonia
Jaanus Harro — Division of Neuropsychopharmacology, Department of Psychology, University of Tartu, Estonian Centre of Behavioural and Health Sciences
Estonia
Jaanus Harro — Division of Neuropsychopharmacology, Department of Psychology, University of Tartu, Estonian Centre of Behavioural and Health Sciences
K. Laas
Division of Neuropsychopharmacology, Department of Psychology, University of Tartu
Estonia
Estonia
M. Vaht
Division of Neuropsychopharmacology, Department of Psychology, University of Tartu
Estonia
Estonia
D. Eensoo
Department of Family Medicine and Public Health, University of Tartu
Estonia
Estonia
T. Kurrikoff
Division of Sociology, Department of Social Studies, University of Tartu
Estonia
Estonia
K. Sakala
Department of Family Medicine and Public Health, University of Tartu; National Institute for Health Development
Estonia
Estonia
E. Kiive
Division of Special Education, Department of Education, University of Tartu
Estonia
Estonia
T. Veidebaum
Division of Special Education, Department of Education, University of Tartu
Estonia
Estonia
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Review
For citations:
Harro J., Laas K., Vaht M., Eensoo D., Kurrikoff T., Sakala K., Kiive E., Veidebaum T. Does psychiatric molecular genetics need to account for the birth cohort effect? V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY. 2019;(4-1):28-30. https://doi.org/10.31363/2313-7053-2019-4-1-28-30
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