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V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY

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Candidate processes for autism spectrum disorders revealed by copy number variation analysis

https://doi.org/10.31363/2313-7053-2019-4-1-101-102

Abstract

Despite the large number of candidate genes for mental disorders, molecular mechanisms of the majority remain unknown. To fill this gap, we have studied genomic networks-candidates (instead of genes) in a group of children with brain disorders. The identification of such processes seems to be more promising for developing therapeutic strategies in contrast to candidate gene identification.

About the Authors

M. A. Zelenova
Mental Health Research Center; Academician Y.E. Veltishchev Research Clinical Institute of Pediatrics
Russian Federation


S. G. Vorsanova
Mental Health Research Center; Academician Y.E. Veltishchev Research Clinical Institute of Pediatrics
Russian Federation


I. Y. Iourov
Mental Health Research Center; Academician Y.E. Veltishchev Research Clinical Institute of Pediatrics; Russian Medical Academy of Continuous Postgraduate Education
Russian Federation


References

1. Iourov IY, Vorsanova SG, Liehr T, Kolotii AD, Yurov YB. Increased chromosome instability dramatically disrupts neural genome integrity and mediates cerebellar degeneration in the ataxia-telangiectasia brain. Human Molecular Genetics. 2009:18:26562669. doi:10.1093/hmg/ddp207

2. Iourov IY, Vorsanova SG, Voinova VY, Yurov YB. 3p22.1p21.31 microdeletion identifies CCK as Asperger syndrome candidate gene and shows the way for therapeutic strategies in chromosome imbalances. Molecular Cytogenetics. 2015:8:82. doi:10.1186/s13039-015-0185-9.

3. Iourov IY, Vorsanova SG, Zelenova MA, Korostelev SA, Yurov YB. Genomic Copy Number Variation Affecting Genes Involved in the Cell Cycle Pathway: Implications for Somatic Mosaicism. International Journal of Genomics. 2015:2015:757680. doi: 10.1155/2015/757680.

4. Vorsanova SG, Yurov YB, Iourov IY. Neurogenomic pathway of autism spectrum disorders: linking germline and somatic mutations to geneticenvironmental interactions. Current Bioinformatics. 2017:12:19-26. doi:10.2174/1574893611666160606 164849


Review

For citations:


Zelenova M.A., Vorsanova S.G., Iourov I.Y. Candidate processes for autism spectrum disorders revealed by copy number variation analysis. V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY. 2019;(4-1):101-102. (In Russ.) https://doi.org/10.31363/2313-7053-2019-4-1-101-102

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ISSN 2313-7053 (Print)
ISSN 2713-055X (Online)