Study of the polymorphic variants of the PIP5K2A gene association with the comorbidity of alcoholism and affective disorders
https://doi.org/10.31363/2313-7053-2019-4-1-124-126
Abstract
One of the common pathogenetic mechanisms of the formation of alcohol dependence and depressive disorders can be a violation of the neurotransmitter systems, in particular — dopamine. Phosphatidylinositol-4-phosphate-5-kinase type 2 alpha (PIP5K2A) plays an important role in the regulation of neuronal excitability and synaptic dopamine neurotransmission. The aim of this study was to assess the presence of associations of the PIP5K2A gene polymorphic variants with the comorbid course of alcohol dependence and depressive disorders. This study showed differences in the frequency of the genotype distribution of 3 PIP5K2A gene polymorphisms (rs946961, rs1132816, and rs1417374) both between patient groups compared with the control group, and between the patient group and the group with the comorbid course of disorders.
About the Authors
E. V. Mikhalitskaya
Mental Health Research Institute of TNRMC
Russian Federation
Russian Federation
O. V. Roshchina
Mental Health Research Institute of TNRMC
Russian Federation
Russian Federation
S. A. Ivanova
Mental Health Research Institute of TNRMC
Russian Federation
Russian Federation
N. A. Bokhan
Mental Health Research Institute of TNRMC
Russian Federation
Russian Federation
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Review
For citations:
Mikhalitskaya E.V., Roshchina O.V., Ivanova S.A., Bokhan N.A. Study of the polymorphic variants of the PIP5K2A gene association with the comorbidity of alcoholism and affective disorders. V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY. 2019;(4-1):124-126. (In Russ.) https://doi.org/10.31363/2313-7053-2019-4-1-124-126
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