Роль гематологических коэффициентов системного воспаления в диагностике и оценке риска аффективных расстройств

В обзорной статье освещена проблема использования в клинической практике гематологических коэффициентов системного воспаления, а также приводятся результаты исследований, посвященных их применению в диагностике и оценке терапевтического ответа при лечении аффективных расстройств. Известен вклад каждого отдельного звена иммунной системы в патогенез воспалительной реакции, однако в настоящее время наибольший интерес представляют нейтрофильно-лимфоцитарное (NLR), моноцитарно-лимфоцитарное (MLR) и тромбоцитарно-лимфоцитарное (PLR) соотношения, а также индексы системного иммунного воспаления (SII, количество тромбоцитов x количество нейтрофилов / лимфоцитов) и системной воспалительной реакции (SIRI, количество нейтрофилов х количество моноцитов / лимфоцитов), доступные расчету на основании рутинного клинического анализа крови. Проведенный анализ литературы демонстрирует значимость данных соотношений, однако подчеркивает необходимость их дальнейшего исследования. Более детальное изучение указанных показателей позволит достичь их прогностической ценности и более объективной оценки их валидности и специфичности для диагностики, прогнозирования риска и вариантов течения аффективных расстройств.

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