The role of hematological coefficients of systemic inflammation in the diagnosis and risk assessment of affective disorders
https://doi.org/10.31363/2313-7053-2024-794
Abstract
The review article highlights the problem of using hematological coefficients of systemic inflammation in clinical practice, as well as the results of studies aimed at its use in the diagnosis and evaluation of therapeutic response in the treatment of mood disorders. The contribution of each individual link of the immune system to the pathogenesis of an inflammatory reaction is known, but currently of most interest are neutrophil-lymphocytic (NLR), monocyte-lymphocytic (MLR) and platelet-lymphocytic (PLR) ratios, as well as indices of systemic immune-inflammation (SII, platelet count x number of neutrophils / lymphocytes) and system inflammation response (SIRI, number of neutrophils x number of monocytes / lymphocytes). All coefficients are available for calculation based on a routine complete blood count. The analysis of the literature demonstrates the significance of these ratios, but emphasizes the need for further research. A more detailed study of these ratios will allow achieving their prognostic value and a more objective assessment of their validity and specificity for the diagnosis, prediction of risks and variants of the affective disorders course.
About the Authors
A. P. Gorbunova
V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology
Russian Federation
Russian Federation
Aleksandra P. Gorbunova
St. Petersburg
G. V. Rukavishnikov
V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology
Russian Federation
Russian Federation
Grigory V. Rukavishnikov
St. Petersburg
E. D. Kasyanov
V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology
Russian Federation
Russian Federation
Evgeny D. Kasyanov
St. Petersburg
G. E. Mazo
V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology
Russian Federation
Russian Federation
Galina E. Mazo
St. Petersburg
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Review
For citations:
Gorbunova A.P., Rukavishnikov G.V., Kasyanov E.D., Mazo G.E. The role of hematological coefficients of systemic inflammation in the diagnosis and risk assessment of affective disorders. V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY. 2024;58(1):47-55. (In Russ.) https://doi.org/10.31363/2313-7053-2024-794
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