Multivariate polygenic models in personalized psychiatry
https://doi.org/10.31363/2313-7053-2019-4-1-55-57
Abstract
Personalizing patient care through the use of individual genome-wide information is one of the key challenges for psychiatry in the post-genomic era. Prognostic multivariate models incorporating polygenic risk scores (PGRS) seem to be a promising tool. The article discusses the potential of fully polygenic models, in which all predictors are represented as PGRS of the corresponding phenotypes, and models, in which the individual genetic information embedded in the PGRS is supplemented with epigenetic data.
References
1. Advancing our health: prevention in the 2020s — consultation document. https://www. gov.uk/government/consultations/advancing-ourhealth-prevention-in-the-2020s/advancing-ourhealth-prevention-in-the-2020s-consultationdocument#references. Accessed August 30, 2019.
2. Belsky DW, Domingue BW, Wedow R et al. Genetic analysis of social-class mobility in five longitudinal studies. Proc Natl Acad Sci USA. 2018;115:E7275E7284. doi: 10.1073/pnas.1801238115
3. Hüls A, Czamara D. Methodological challenges in constructing DNA methylation risk scores. Epigenetics. 2019. doi: 10.1080/15592294.2019.1644879. 4. Krapohl E, Hannigan LJ, Pingault J-B et al. Widespread covariation of early environmental exposures and trait-associated polygenic variation. Proc Natl Acad Sci USA. 2017;114(44):11727-11732. doi: 10.1073/pnas.1707178114
4. Li P, Marshall L, Oh G, et al. Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer’s disease pathology and cognitive symptoms. Nat Commun. 2019;10(1):2246. doi:10.1038/ s41467-019-10101-7
5. Pai S, Li P, Killinger B, et al. Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis. Nat Commun. 2019;10(1):2046. Published 2019 May 3. doi:10.1038/s41467-019-09786-7
6. Wald NJ, Old R. The illusion of polygenic disease risk prediction. Genet Med. 2019;21(8):1705-1707. doi: 10.1038/s41436-018-0418-5
7. Warren M. The approach to predictive medicine that is taking genomics research by storm. Nature. 2018;562(7726):181-183. doi: 10.1038/d41586-01806956-3
8. Watkeys, OJ, Cohen-Woods S, Quidé Y et al. Derivation of Poly-Methylomic Profile Scores for Schizophrenia. bioRxiv. Preprint first posted online Apr. 12, 2019; doi: http://dx.doi.org/10.1101/607309.
Review
For citations:
Alfimova М.V. Multivariate polygenic models in personalized psychiatry. V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY. 2019;(4-1):55-57. (In Russ.) https://doi.org/10.31363/2313-7053-2019-4-1-55-57
Views:
578
Email this article 