The opportunity of application of neurophysiological tests — schizophrenia endophenotypes for studying the role of genetic factors in cognitive processes in healthy subjects and in psychiatric diseases
https://doi.org/10.31363/2313-7053-2019-4-1-70-72
Abstract
The study of effects of genetic polymorphisms implicated in dopamine (COMT, DRD2) and GABA (GAD1) activities in the prefrontal cortex on antisaccades (AS) and evoked potential P300 measures was conducted with participation of 55 healthy subjects and 72 schizophrenic patients. The significant interaction of genotype and disease was found for most of the studied AS and P300 measures. The worse task performance and decreased efficacy of cortical activation were revealed for the associated with schizophrenia risk polymorphisms.
About the Authors
A. V. Kirenskaya
Federal State Budgetary Institution “V. Serbsky National Medical Research Centre for Psychiatry and Narcology” of the Ministry of Health
Russian Federation
Russian Federation
Z. I. Storozheva
Federal State Budgetary Institution “V. Serbsky National Medical Research Centre for Psychiatry and Narcology” of the Ministry of Health
Russian Federation
Russian Federation
F. O. Kibitov
Federal State Budgetary Institution “V. Serbsky National Medical Research Centre for Psychiatry and Narcology” of the Ministry of Health
Russian Federation
Russian Federation
References
1. Beste C, Stock AK, Epplen JT, Arning L. Dissociable electrophysiological subprocesses during response inhibition are differentially modulated by dopamine D1 and D2 receptors. European Neuropsychopharmacology. 2016;26(6):1029-1036. doi: 10.1016/j. euroneuro.2016.03.002.
2. Chen J, Lipska BK, Halim N. et al. Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. American Journal of Human Genetics. 2004;75(5):807–821. doi: 10.1086/425589.
3. Gottesman I, Gould T. The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions. American Journal of Psychiatry. 2003;160(4):636-645. doi: 10.1176/appi. ajp.160.4.636.
4. Straub RE, Lipska BK, Egan MF. et al. Allelic variation in GAD1 (GAD67) is associated with schizophrenia and inluences cortical function and gene expression. Molecular Psychiatry. 2007;129:854– 869. https://doi.org/10.1038/sj.mp.4001988.
Review
For citations:
Kirenskaya A.V., Storozheva Z.I., Kibitov F.O. The opportunity of application of neurophysiological tests — schizophrenia endophenotypes for studying the role of genetic factors in cognitive processes in healthy subjects and in psychiatric diseases. V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY. 2019;(4-1):70-72. (In Russ.) https://doi.org/10.31363/2313-7053-2019-4-1-70-72
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