In the article, using the example of the «identity integration disorder», the author’s conceptual framework, the application of the theory of psychophysiological isomorphism that originated in the framework of classical gestaltpsychology to the modern realities of the development of psychiatric science is considered. Te formation of the concept of «integration of identity» in the scientifc and historical aspect is traced. With the help of pathopsychological and neurophysiological methods of research, the hypothesis of uniting the four main «circles» of mental pathology in the composition of the psychic education under consideration is substantiated.

Te lecture presents modern concept of the symptoms, diagnosis and treatment of dementia with Lewy bodies (DLB), which accounts for about 10% of cases of dementia. Te nosological status of DLB and the problem of ratio of DLB and Parkinson’s disease which, apparently, represent two phenotypic variants of one neurodegenerative process («diseases with Lewy bodies») are considered in historical aspect. Approaches to the diagnosis and coding of DLB in accordance with ICD-10 are proposed. Te role of cholinesterase inhibitors, antipsychotics, levodopa, rasagiline and other drugs in the treatment of patients with DLB is аnalyzed.

Alzheimer’s disease is the most common cause of dementia among the elderly. Te pathological changes characterize by the deposition of amyloid plaques and the formation of neurofybrillar tangles in the brain. Te most signifcant role in the pathogenesis of neurodegeneration development is deposition of β-amyloid, vascular risk factors, the presence of a genetic predisposition, and the dysregulation of the bloodbrain barrier. Recent studies have demonstrated the role of the glymphatic system in the clearance of betaamyloid through the perivascular spaces of Virchow-Robin.

Te paper overviews the state of the art in one of the most rapidly developing areas of treatment of various drug-resistant diseases of the central nervous system. Different methods of vestibular neuromodulation and their comparative efcacy in the treatment of mental and neurological disorders are described. All those methods are based on neuroplasticity activation by means of application of physical, electrical or chemical stimuli on the peripheral part of the vestibular system, which leads to the restructuring of neural connections in the brainstem and in the midbrain.

Cognitive decline characterizes normal physiological aging and is aggravated by the development of age-related neurodegenerative pathology and traumatic brain damage (TBI). Te review analyzes widely discussed in the scientifc literature non-drug methods of rehabilitation of patients with TBI and elderly people suffering from cognitive decline, including the paradigm of enrichment of the environment, cognitive and physical training and various types of stimulation therapy and their shortcomings. Special attention is paid to the advantages of fractal stimulation of the brain by complex-structured optical signals and sensory stimuli of another modality. It is assumed that the use of new approaches to neurorehabilitation, which increase the potential of neuroplasticity will also allow strengthening the therapeutic and learning impacts of any other methods of training and treating the brain.

Te article describes the results of a study of risk factors for the development of PTSD in patients with rectum cancer, who underwent colostomia. Te results of a comparative analysis of social characteristics and developmental peculiarities among patients with PTSD and stress-resistant pations are presented. It was found that in the group of patients with PTSD previous traumatic events related to physical violence, the experience of divorce, and participation in road accidents were more frequent. As a result of the regression analysis, it was revealed that the following factors affect the level of PTSD severity: the «Constructive external I-delineation» scale of the «I-structural test of Ammon», the value of the dysfunctional fault indicator of the «SGSS», the «Risk» scale of « Te Hardness Lifestyle Test «. Risk factors for the development of PTSD were identifed: difculties in establishing boundaries with others, the presence of dysfunctional guilt, the tendency to avoid mistakes instead to accepting risk, an insufciently formed personal identity

Te article is concerned with the study of disturbances in psychosexual sphere, which are specifc for schizophrenia spectrum disorders. Te results of a comparison of two groups are presented: 29 people were diagnosed with schizophrenia and schizotypal disorder and a comparison group of 34 people without endogenous pathology. Te study outcomes of their gender self-consciousness with methods «MF», «CTAT», «Coding» are shown that the presence of endogenous disorder changes the psychosexual profle of patients on a number of signs. Persons with schizophrenia and schizotypal disorder, regardless of their comorbide diagnosis of paraphilia are characterized by lower value of masculinity, high distinction with the male role, absence of intention to line up with the man-image, in some cases instability of identity, altered emotional attitudes to sex-role stereotypes, emotional ambivalence.

We present data of studying female sexual feelings. Hypothesis: sexual feelings have a complicated multilevel structure reflecting the individual’s sexual experience with peculiarities of evaluating satisfaction and regulation of behavior. 429 women aged 18-60 years (mean age — 28,69±0,42 years) have been studied, among them 291 (67,83%) were married and 138 (32,17%) were single. Te mean age of starting sexual life was 18,22±0,12 years. 365 (85,08%) women experienced orgasm, while 64 (14,92%) did not. We used our authorial questionnaire including an instruction and a list of 204 signs characterizing emotions, states, qualitative descriptions of comprehension. Te women noted the signs corresponding to their ordinary experience during an ordinary sexual act. Sexual feelings were found to have a multilevel structure of estimating the person’s sexual experience presented by the correlation of satisfaction, sexual interest, internal comfort, shame, disphoria, intensity emotional reacting, non-corresponding to expectations, acuity of rectption, physical discomfort and distaste. Teir manifestation reflects the expressions of self-relation, of states with regard to attaining the goal and communication with the partner.

Te purpose of the current study was to identify an abuse potential of pregabalin in HIVinfected patients with opioid use disorder long time using pregabaline. A cross-sectional study was performed at the St. Petersburg Center for the prevention and control of HIV and infectious diseases. A cohort of 572 HIV-infected patients with opioid use disorder was examined. 96 patients (16,8% of the entire cohort) used pregabalin. 34 of them agreed to participate in the study. Te pregabalin addiction was diagnosed in 23 of 34 observed HIV-infected patients with opioid dependence. People with opioid dependence and presence of organic brain damage of various genesis (toxic exposure, neurological consequences of trauma or infection) are at risk of development of pregabalin dependence. Te use of pregabalin with for self-medication of opiod withdrawal was registered in 11 patients.

Currently, the problem of eating disorders is becoming important in the diagnostics of mental illness and in planning the work of the health care system. Tese types of disorders are typical for representatives of any age. A special group of risk consists of teenagers and young people under 30 years of age. Concern for thinness and social pressure are signifcant predictors of the risk of developing eating disorders in adolescent girls.

Te aim of the study was to explore the prevalence of quitting smoking during pregnancy and to determine factors associated with the latter. We used data from Murmansk County Birth registry from 2006 to 2011. Chi-squared tests and logistic regression were applied. We found that one-fourth smoking before pregnancy woman stopped to do it afer pregnancy recognition. Moreover, we made a social portrait of women who could quit smoking during pregnancy — urban, married women, with higher level of education, and without children (that is primiparous).

Te paper reports on the features of alexithymic space structure in patients with cardiovascular diseases, comparison of the obtained results with the group of healthy respondents. Tis information is useful for health psychologists to develop models of clinical-psychological support of patients of this category.

Primary headaches (migraine, tension-type headache and other primary headaches) cause 3% of all disability cases in adult population, fully decrease possibilities of social functioning. Te phenomenon of the central sensitization is one of the fundamental pathophysiological units of primary headaches. NMDA receptors are involved both in initiation and in maintaining of mechanisms of a long-term central sensitization. NMDA activation by glutamate play important role in the initiation of primary headaches. Cognitive impairment development also conducted with NMDA-excitotoxicity due to hyper excitability of NMDA receptors. Tus, it is evident that mechanisms of antinociceptive changes in primary headaches and development of a glutamate excitotoxicity are strongly interdependent. Relationship between somatic symptoms, such as headache in dementia and cognitive symptoms now is represented more widely than just a comorbidity. Te gravity of migraine, tension-type headache and severity of cognitive impairment are strongly connected. Tus, the reliable interrelation between development of primary headache and cognitive decrease is traced, considering a community of pathophysiological mechanisms that has important practical value due to possible correction by NMDA-antagonists. Memantine not only slows the progression of cognitive symptoms in dementia, but also signifcantly influences the frequency and expressiveness of primary headache.

Te article provides an overview of foreign and domestic literature on the development of complications associated with neuroleptic hyperprolactinaemia in patients with schizophrenia in the course of prolonged antiretroviral therapy with antipsychotics. Most researchers agree that long-term neuroleptic hyperprolactinemia signifcantly impairs the physical health of patients with mental disorders. Timely diagnosis and correction of this side effect of psychopharmacotherapy will signifcantly reduce the risk of complications and improve the social functioning of patients with schizophrenic disorders.

Frontotemporal dementia (FTD) is a progressive neurodegenerative disorder. It begins usually in the presenile age and affects predominantly the frontal lobes and anterior temporal lobes of the brain. Currently, there are three main clinical variant of FTD: behavioral variant frontotemporal dementia (bvFTD), which manifests early with behavioral and executive impairments; primary progressive aphasia (PPA), in which progressive speech disorders, grammatical, and verbal production; semantic variant primary progressive aphasia (svPPA). In psychiatric practice, patients with FTD occur not so rarely that requires a differential diagnosis with an endogenous mental disease and presenile dementia, especially with Alzheimer’s disease (AD). Te importance of correct diagnosis is determined by differences in the treatment of patients with dementia. In FTD, in contrast to patients with AD, the appointment of acetylcholinesterase inhibitors does not lead to a benefcial therapeutic effect and, therefore, is not appropriate. Te use of memantine, especially in the moderatesevere stages of FTD, can be useful to treat noncognitive symptoms. In the standard therapy of patients with bvFTD, should be included recommendations for the antipsychotic or the use of SSRI antidepressants, for correction of affective and behavioral disorders.

Tere are 44 patients (5 males and 39 females), aged 56 to 90 years were included in the study. To assess the tolerability and safety of the drug, undesirable events were recorded, associated and not associated with taking the drugwith taking the drug, a physical examination of patients was performed, an ECG was recorded and a biochemical blood test was performed at each visit of the patient to the center. During the observation period, two undesirable events chronologically associated with taking the drug were recorded During the study, none of the patients was excluded from the program due to the development of side effects and none of the patients refused to take the drug. We did not fnd any statistically signifcant increase in the incidence of cardiac pathology in patients taking the study drug, nor worsening of the already existing symptoms on the background of taking the drug for six months. Te observed growth trends in the level of blood creatinine a give grounds to recommend monitoring of kidney function in the patients taking the drug. In general, noogerone showed good tolerability, despite the elderly age of its patients and the high prevalence of concomitant somatic diseases in the sample.