The article is devoted to the problem of the identity of psychiatry as a medical science in the descriptive categories of biological reductionism and humanitarian-anthropological approach. The positive and negative aspects of the use of biomedical principles of evidence-based medicine in psychiatric discourse are presented. The importance of cognition of a person as a synergistic (holistic) reality is emphasized, taking into account scientific prejudices. A systematic holistic description of pathokinesis and the content of a mental disorder is given through the study of the emergent qualities of a personality and its potential. The features of various types of biopsychosocial models are given, which, in the opinion of their adherents, provide a systematic approach to the relationship of the biological substrate (the brain) with mental phenomena and social behavior.

The purpose of this article is to highlight current ideas available in the world literature about high-risk state for psychosis as a promising diagnostic stage for identification risk groups for the development of schizophrenia in the near future, as well as to allocate and characterize the tools for screening the highrisk state for psychosis.

Identification and timely correction of risk factors is a relevant method for reducing the incidence of schizophrenia and improving the prognosis of the disease.

As a result of the literature data analysis with a summary of the available results of original researches, systematic reviews and meta-analyses the data about currently available approaches to unified standardized diagnostics of high-risk state for psychosis are presented, and their comparative characteristic is carried out.

According to the review of publications, none of the currently available tools fully covers all contemporary diagnostic approaches, and therefore, in order to achieve an optimal result in identifying a state of high risk of psychosis, the combined use of various tools seems to be the most reliable. In addition, the further development of available screening tools and their validation in the Russian population remains relevant.

Caring for cancer patients can have not only negative impact on the informal caregivers, but can also be a source of positive personality transformations in the challenging situation associated with cancer.

Aim: identification and synthesis of data on posttraumatic growth (PTG) and socio-demographic, clinical and psychological factors associated with PTG in relatives, caring for patients with cancer.

Methods: The review was conducted according to the statement of the PRISMA guidelines. The review used 2 search strategies: systematic electronic search in databases (Pubmed, Google Scholar, Cochrane, EBSCO, SAGE journals и eLIBRARY), manual search of articles in references lists of eligible articles.

Results: Psychological factors are crucial in development of PTG. Perceived social support (especially within the family) and constructive emotion- and problem-focused coping (such as positive reframing coping) are among the factors contributing to the PTG. The data on the positive relationship of with the severity of stressful experiences and emotional distress among caregivers predominate in the analyzed studies. At the same time, there is a lack of agreement on the contribution of psychological distress to the development of PTG.

Conclusion: Development of supportive social environment, constructive coping strategies training, increase of family satisfaction, work with existential and spiritual values, and creation of psychological readiness of caring relatives for loss in case of negative prognosis for patients’ survival should be considered as the main directions of psychological interventions aimed at facilitating PTG in relatives caring for cancer patients.

The Patient Health Questionnaire-4 (PHQ-4) is one of the most well-known and widely used instruments for assessing anxiety and depressive symptoms.

Objective. The aim of this study was to adapt the Russian-language version of the PHQ-4 in the general population.

Material and Methods. Data collection was carried out with the help of the service «Anketolog». The participants were 2,000 Russians (1,000 men and 1,000 women) aged 18 to 60 years (M = 38.78; SD = 9.25).

Results. The psychometric analysis confirmed the internal reliability and discriminative validity of the adapted questionnaire. The proof of the factor validity of the Russian version of the PHQ-4 was the identification of a two-factor structure describing the symptoms of anxiety and depression, and factor invariance by age, level of education, marital status, parental status, financial status and place of residence. Among the Russians, 44.9% had clinically significant anxiety symptoms and 42.9% had clinically significant depressive symptoms. Russians with anxiety and depressive symptoms more often sought counseling from a psychologist, coach, psychiatrist and neurologist, underwent psychopharmacological treatment in connection with psychological requests, contacted support groups and a psychological help hotline, used online products of automated or semi-automated psychological support, read psychological literature and used psychoactive substances.

Conclusion. The psychometric properties of the Russian-language version of the PHQ-4 turned out to be similar to the psychometric characteristics of the original version of the questionnaire, and therefore the adapted questionnaire can be recommended for screening anxiety and depression in the general Russianspeaking population.

Objective. To improve understanding of psychophysiological underpinnings of anxiety disorders a comprehensive study, that included the analysis of cognitive tasks performance, event-related potentials and psychometric scales, has been conducted.

Materials and Methods. Participants were patients with generalized anxiety disorder (GAD group — 12 s.), mixed anxiety and depressive disorder (ADD group — 16 s.) and healthy volunteers (control group — 16 s.). The psychometric techniques included the questionnaires of Spielberger, HADS (Hospital Anxiety and Depression Scale) and Carver-White (BIS/BAS Scale). Psychophysiological methods included antisaccade task (AS) and event-related evoked potentials P300 that were recorded during auditory oddball task.

Results. The significantly increased anxiety and depression scales, as well as the decreased BAS Reward Responsiveness scale, was found in patients of both clinical groups compared to control one; the increased BIS scale was revealed only in ADD group. In GAD and ADD groups AS performance was worse in response to stimuli in left hemi-field that are initially processed in right hemisphere; on the contrary, decreased number of target stimuli omissions was found in oddball task in clinical groups. P300 amplitude was larger, and P300 latency was shorter for patients with ADD compared to controls. Analysis of asymmetry demonstrated that P300 amplitudes were greater over the frontal-central right than over the left hemisphere in ADD group.

Conclusion. The study demonstrated that anxiety disorders are accompanied by reallocation of attentional resources and changes in functional organization of brain networks involved in attention and executive functions. With the same direction, the shifts were greater in ADD group.

Negative affectivity (NA) and social inhibition (SI) inherent in type D personalities produce chronic distress, which leads to an increased risk of developing cardiovascular disease (CVD). Currently, a search is underway for mechanisms that mediate the psychosomatic connections of a type D personality. The purpose of the study is to identify the features of amplitude-time ECG parameters in type D personalities and to establish associations of amplitude-time ECG patterns in a non-cardiological sample of women with type D indicators and its components — NA and SI. ECG records were obtained from 68 women with gynecological pathology without a history of CVD and at the time of the study, and all of them completed the questionnaire DS 14. Personality type D was confirmed in 39.7%, on the ECG recording in this group, the average amplitude of the R wave, the duration of the QT and RR intervals turned out to be significantly higher than in individuals without type D, and the duration of the QRS complex was significantly lower in the group of respondents with higher scores against a group with low scores. The group with higher NA values showed a significantly higher R wave amplitude, and with higher SI values, a significantly shorter QRS duration than the corresponding groups with low values of these D-type components. More than a third of a non-cardiac sample of women exhibits type D personality. Analysis of amplitude-time ECG patterns in type D personalities indicates increased ventricular excitability and excessive sympathetic reactivity. A specific pathogenic contribution of the synergism of negative affectivity and social inhibition of the expression of negative feelings to the functional organization of electrophysiological processes in the myocardium was found. Amplitude-time ECG patterns of type D individuals indicate an autonomous imbalance of cardiovascular reactivity at the basis of increased vulnerability to CVD.

The aim of this study is to examine the relationship between the severity and duration criteria of COVID-19 and the psychopharmacotherapy administered to patients in within a psychiatric hospital.

Materials and Methods. We analyzed 169 case histories involving completed clinical cases of COVID-19 treatment in a specialized infectious psychiatric department in St. Petersburg, covering the period from May 2020 to January 2021. Correlation, dispersion, and regression analyses were employed to evaluate severe and mild COVID-19 progression indicators, as well as the duration of persistent SARS-CoV-2 viral shedding. We assessed the clinical and laboratory parameters in patients, along with the psychopharmacotherapy administered, including antidepressants, antipsychotics, and acid sphingomyelinase inhibitors (FIASMA-active drugs).

Results. Cardiovascular diseases emerged as a predictor of severe COVID-19 when combined with an increasing platelet-to-lymphocyte ratio (PLR), increasing the risk of severe course by over two-fold. The use of any psychotropic agents was associated with a 0.9% increase in the risk of severe course of COVID-19 for each unit increase in the systemic inflammation index PLR, specifically in patients with intellectual disability (ICD-10 codes F70-79), when compared to patients with schizophrenia (ICD-10 codes F20-29). High PLR values and the use of FIASMA-active drugs were associated with prolonged COVID-19 duration, while antidepressant therapy and elevated C-reactive protein levels were associated with a reduced predicted duration of viral shedding in 13.8% of variance. Additional consideration of the nosology of psychiatric disorders in the regression model increased the proportion of explained variance to 22.8%.

Conclusion. Consideration should be given to thymoanaleptic therapy for individuals with psychiatric disorders during periods of increased disease incidence leading up to potential SARS-CoV-2 infection, as it may serve as a protective factor against COVID-19. Furthermore, there is no evidence to suggest adverse effects of antipsychotics on the severity and duration of COVID-19. Further research is required to investigate the effects of FIASMA-active psychopharmacological agents within nosologically homogeneous groups.

The addictive disorder often becomes a difficult experience for the all family. Studying the factors influencing the level of psychological distress of addicted patients’ relatives is necessary to create an effective system of psychological assistance for them.

Purpose: to reveal the interrelations between the subjective assessment of the mental state and the perception of family relationships among relatives of patients with pathological gambling (PG) and relatives of patients with stimulant use disorder (SUD).

Materials and methods. In a cross-sectional study 100 and 41 patients’ relatives were included in the PG and SUD groups respectively. The Symptom Checklist-90-Revised (SCL-90-R) and the Family Environment Scale (FES) was used as an assessment tools. Socio-demographic and clinical data were also collected.

Results. The analysis of interrelations between the severity of psychopathological symptoms and the perception of family relationships in the studied groups determined both general and specific correlations. In both groups there are multiple negative correlations between the majority of SCL-90-R scales and the “Cohesion” scale (FES). The specific interrelations included, for example, multidirectional correlations between the “Expressiveness” scale (FES) and psychopathological symptoms scales of the SCL-90-R. Increased expressiveness in the PG group was associated with less severity of psychopathological symptoms and level of distress, and, on the contrary, a greater severity of psychological distress in respondents of the SUD group. Analysis of the correlations in PG compared to SUD showed greater predictability of the connections between psychopathological symptoms and perception of family relationships in the PG group. Thus, the indicators of psychopathological symptoms and psychological distress are negatively associated with parameters reflecting the perception of family cohesion, trust in intrafamily relations, social activity and family organization and, at the same time, have positive interrelations with the indicator of conflict in family relationships.

Conclusion. The perception of the family cohesion function as the intrapsychic protection that facilitate the relatives’ adaptation in the emerging life situation, regardless of the form of patients’ addiction.

A description of a clinical case of the logopenic form of the syndrome of primary progressive aphasia in the onset of Alzheimer’s disease is presented. The disease manifested itself in the form of 

speech and writing disorders, a sharp disorder in labor skills with the preservation of self-service and orientation, affective fluctuations, in connection with which it was supposed to diagnose cognitive functions, psychopathological changes and instrumental research. Differential diagnostics with mental spectrum diseases, various neurodegenerative diseases, vascular lesions of the brain were carried out. However, the nature, as well as the existing features of cognitive impairment and speech impairment of the manifestation of the disease, suggested a logopenic warrant of the PPA syndrome, and the presence of a general cognitive decline and disease progression in a short time was Alzheimer’s disease with an atypical onset.

Hyperprolactinemia is one of the common undesirable phenomena of antipsychotic therapy, as it is associated with a number of mental and somatic complications. To date, there are several strategies for the correction of antipsychotics induced hyperprolactinemia, the most evidential basis of which has an addition to the current treatment of partial dopamine agonist — aripiprazole.

Other drugs in this group, cariprazine and brexpiprazole, due to a similar mechanism of action with aripiprazole, belong to prolactin-saving drugs. However, their differences in pharmacodynamics may determine features in prolactin effects and attract attention for further study of their prolactin-saving activity.

In 2023, 80 years have passed since the liberation of Stavropol from the Nazi invaders. The staff and patients of the psychiatric hospital were subjected to the horrors of the fascist regime. 660 patients and 30 employees of the Stavropol Psychiatric Hospital died in the gas chambers. The hospital honors the memory and does its best to preserve the story of people selflessly fulfilling their duty in difficult times for her and the whole country.

The purpose of the study. In honor of the anniversary memorable date, the authors of the article want to tell about the history of the Stavropol Regional Psychiatric Hospital in chronological order from the day of its foundation to the present day.

Materials and methods: a systematic analysis of scientific literature, archival data of the hospital was carried out, the A.J. Dorsht foundation, stored in the Museum of History of Stavropol State Medical University, was used.

Results and discussion. The authors tell about the life of the hospital in different historical periods of our country. Special attention is paid to the period of the Great Patriotic War. It tells about the horrors that the hospital experienced during the German occupation, about the victims among patients and employees whose lives were claimed by the Great Patriotic War. The period of leadership of the outstanding chief physician, man and teacher, Adolf Yakovlevich Dorsht, is described with great respect and recognition.

The article summarizes the history of the development of modern psychiatric services in the Stavropol Territory, the prevention of suicidal behavior among adolescents, the provision of psychiatric care to the population during a pandemic and a special military operation.

Conclusion. Having survived many trials in its lifetime, at present the Stavropol Regional Psychiatric Hospital has been awarded numerous awards for asceticism in the field of mental health and is the largest in the North Caucasus.